KEGG   REACTION: R03182
Entry
R03182                      Reaction                               
Name
7,8-diaminononanoate:carbon-dioxide cyclo-ligase
Definition
ATP + 7,8-Diaminononanoate + CO2 <=> ADP + Orthophosphate + Dethiobiotin
Equation
C00002 + C01037 + C00011 <=> C00008 + C00009 + C01909
Comment
two-step reaction (see R12933+R12934)
Reaction class
RC00002  C00002_C00008
RC00868  C01037_C01909
Enzyme
6.3.3.3
Pathway
rn00780  Biotin metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00123  Biotin biosynthesis, pimeloyl-ACP/CoA => biotin
M00573  Biotin biosynthesis, BioI pathway, long-chain-acyl-ACP => pimeloyl-ACP => biotin
M00577  Biotin biosynthesis, BioW pathway, pimelate => pimeloyl-CoA => biotin
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.3
     R03182  ATP + 7,8-Diaminononanoate + CO2 <=> ADP + Orthophosphate + Dethiobiotin
Orthology
K01935  dethiobiotin synthetase [EC:6.3.3.3]
K19562  bifunctional dethiobiotin synthetase / adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:6.3.3.3 2.6.1.62]
Other DBs
RHEA: 15808
LinkDB

KEGG   REACTION: R12933
Entry
R12933                      Reaction                               
Definition
7,8-Diaminononanoate + CO2 <=> 8-Amino-7-(carboxyamino)nonanoate
Equation
C01037 + C00011 <=> C22458
Comment
the first step of two-step reaction (see R03182, R12933+R12934)
Enzyme
6.3.3.3
Pathway
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.3
     R12933  7,8-Diaminononanoate + CO2 <=> 8-Amino-7-(carboxyamino)nonanoate
Orthology
K01935  dethiobiotin synthetase [EC:6.3.3.3]
K19562  bifunctional dethiobiotin synthetase / adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:6.3.3.3 2.6.1.62]
Other DBs
RHEA: 63683
LinkDB

KEGG   REACTION: R12934
Entry
R12934                      Reaction                               
Definition
8-Amino-7-(carboxyamino)nonanoate + ATP <=> Dethiobiotin + ADP + Orthophosphate
Equation
C22458 + C00002 <=> C01909 + C00008 + C00009
Comment
the second step of two-step reaction (see R03182, R12933+R12934)
Enzyme
6.3.3.3
Pathway
rn00780  Biotin metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00950  Biotin biosynthesis, BioU pathway, pimeloyl-ACP/CoA => biotin
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.3
     R12934  8-Amino-7-(carboxyamino)nonanoate + ATP <=> Dethiobiotin + ADP + Orthophosphate
Orthology
K01935  dethiobiotin synthetase [EC:6.3.3.3]
K19562  bifunctional dethiobiotin synthetase / adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:6.3.3.3 2.6.1.62]
LinkDB

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