KEGG   REACTION: R03202
Entry
R03202                      Reaction                               
Name
(S)-6-hydroxynicotine:oxygen oxidoreductase
Definition
(S)-6-Hydroxynicotine + H2O + Oxygen <=> 6-Hydroxypseudooxynicotine + Hydrogen peroxide
Equation
C01056 + C00001 + C00007 <=> C01297 + C00027
Comment
two-step reaction (see R11048+R11049)
Reaction class
RC00875  C01056_C01297
RC02755  C00007_C00027
Enzyme
1.5.3.5
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.5
     R03202  (S)-6-Hydroxynicotine + H2O + Oxygen <=> 6-Hydroxypseudooxynicotine + Hydrogen peroxide
Orthology
K19826  (S)-6-hydroxynicotine oxidase [EC:1.5.3.5]
Other DBs
RHEA: 11883
LinkDB

KEGG   REACTION: R11048
Entry
R11048                      Reaction                               
Definition
(S)-6-Hydroxynicotine + Oxygen <=> 5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + Hydrogen peroxide
Equation
C01056 + C00007 <=> C21075 + C00027
Comment
the first step of two-step reaction (see R03202, R11048+R11049)
Reaction class
RC02755  C00007_C00027
RC03336  C01056_C21075
Enzyme
1.5.3.5
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Module
M00810  Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.5
     R11048  (S)-6-Hydroxynicotine + Oxygen <=> 5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + Hydrogen peroxide
Orthology
K19826  (S)-6-hydroxynicotine oxidase [EC:1.5.3.5]
Other DBs
RHEA: 46979 46999
LinkDB

KEGG   REACTION: R11049
Entry
R11049                      Reaction                               
Definition
5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O <=> 6-Hydroxypseudooxynicotine
Equation
C21075 + C00001 <=> C01297
Comment
spontaneous
the second step of two-step reaction (see R03202, R11048+R11049 / R07170, R11050+R11049)
Reaction class
RC02086  C01297_C21075
Enzyme
1.5.3.5         1.5.3.6
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Module
M00810  Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.5
     R11049  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O <=> 6-Hydroxypseudooxynicotine
    1.5.3.6
     R11049  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O <=> 6-Hydroxypseudooxynicotine
LinkDB

KEGG   REACTION: R07170
Entry
R07170                      Reaction                               
Name
(R)-6-hydroxynicotine:oxygen oxidoreductase
Definition
(R)-6-Hydroxynicotine + H2O + Oxygen <=> 6-Hydroxypseudooxynicotine + Hydrogen peroxide
Equation
C03043 + C00001 + C00007 <=> C01297 + C00027
Reaction class
RC00875  C01297_C03043
RC02755  C00007_C00027
Enzyme
1.5.3.6
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.6
     R07170  (R)-6-Hydroxynicotine + H2O + Oxygen <=> 6-Hydroxypseudooxynicotine + Hydrogen peroxide
Orthology
K19890  (R)-6-hydroxynicotine oxidase [EC:1.5.3.6]
Other DBs
RHEA: 10015
LinkDB

KEGG   REACTION: R11050
Entry
R11050                      Reaction                               
Definition
(R)-6-Hydroxynicotine + Oxygen <=> 5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + Hydrogen peroxide
Equation
C03043 + C00007 <=> C21075 + C00027
Comment
the first step of two-step reaction (see R07170, R11050+R11049)
Reaction class
RC02755  C00007_C00027
RC03336  C03043_C21075
Enzyme
1.5.3.6
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Module
M00810  Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.6
     R11050  (R)-6-Hydroxynicotine + Oxygen <=> 5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + Hydrogen peroxide
Orthology
K19890  (R)-6-hydroxynicotine oxidase [EC:1.5.3.6]
Other DBs
RHEA: 46991
LinkDB

KEGG   REACTION: R11049
Entry
R11049                      Reaction                               
Definition
5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O <=> 6-Hydroxypseudooxynicotine
Equation
C21075 + C00001 <=> C01297
Comment
spontaneous
the second step of two-step reaction (see R03202, R11048+R11049 / R07170, R11050+R11049)
Reaction class
RC02086  C01297_C21075
Enzyme
1.5.3.5         1.5.3.6
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Module
M00810  Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.5
     R11049  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O <=> 6-Hydroxypseudooxynicotine
    1.5.3.6
     R11049  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O <=> 6-Hydroxypseudooxynicotine
LinkDB

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