KEGG   REACTION: R03316
Entry
R03316                      Reaction                               
Definition
3-Carboxy-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + Thiamin diphosphate
Equation
C05381 + C15972 <=> C16254 + C00068
Comment
2-oxoglutarate dehydrogenase complex: 2-oxoglutarate dehydrogenase (see R01700)
TPP-dependent enzymatic reaction (see R00621+R03316)
following after R00621
Reaction class
RC00027  C00068_C05381
RC00627  C15972_C16254
RC02883  C05381_C16254
Enzyme
1.2.4.2
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00785  Lipoic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.2
     R03316  3-Carboxy-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + Thiamin diphosphate
Orthology
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
LinkDB

KEGG   RCLASS: RC00027
Entry
RC00027                     RClass                                 
Definition
C8x-C8y:*-C1c:N5y+S2x-N5y+S2x
Reactant pair
C00068_C05125    C00068_C05381    C00068_C13378
C00068_C15974    C00068_C15976    C00068_C15978
C00068_C21017    C00068_C22667
Related class
Reaction
R00014 R00621 R00755 R03050 R03270 R03316 R04672 R04673
R06861 R06862 R06863 R07599 R07600 R07601 R07602 R07603
R07604 R10996 R10997 R13166 R13167
Enzyme
1.2.4.1         1.2.4.2         1.2.4.4         1.2.4.-         
2.2.1.1         2.2.1.3         2.2.1.6         4.1.1.1
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00310  Lysine degradation
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
rn00785  Lipoic acid metabolism
Orthology
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00166  2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4]
K01568  pyruvate decarboxylase [EC:4.1.1.1]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
K01652  acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
K01653  acetolactate synthase I/III small subunit [EC:2.2.1.6]
K11258  acetolactate synthase II small subunit [EC:2.2.1.6]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
K15791  2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-]

KEGG   RCLASS: RC02883
Entry
RC02883                     RClass                                 
Definition
C1c-C5a:C8y+*-*+S2a:C1b+O1a-C1b+O5a
Reactant pair
C05381_C16254    C06157_C22667    C15974_C15975
C21017_C21018
Related class
Reaction
R03316 R07602 R10997 R13167
Enzyme
1.2.4.2         1.2.4.4         1.2.4.-
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00310  Lysine degradation
rn00640  Propanoate metabolism
rn00785  Lipoic acid metabolism
rn01100  Metabolic pathways
Orthology
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00166  2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
K15791  2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-]

KEGG   RCLASS: RC00627
Entry
RC00627                     RClass                                 
Definition
S1a-S3x:*-S3x:C1c-C1y
S2a-S3x:C5a+*-*+S3x:C1b-C1x
Reactant pair
C06157_C15972    C15972_C15975    C15972_C15977
C15972_C15979    C15972_C16254    C15972_C16255
C15972_C21018
Related class
Reaction
R01699 R01700 R01701 R01702 R01940 R03270 R03316 R04225
R07600 R07602 R07604 R10997 R13167
Enzyme
1.2.4.1         1.2.4.2         1.2.4.4         1.2.4.-
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00310  Lysine degradation
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
rn00785  Lipoic acid metabolism
Orthology
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00166  2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
K15791  2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-]

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