KEGG   REACTION: R03444
Entry
R03444                      Reaction                               
Name
(R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase
Definition
(R)-2-Hydroxybutane-1,2,4-tricarboxylate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
Equation
C01251 <=> C04002 + C00001
Comment
first step of two-step reaction (see R09720, R03444+R04371)
Reaction class
RC00498  C01251_C04002
Enzyme
4.2.1.114       4.2.1.-
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.114
     R03444  (R)-2-Hydroxybutane-1,2,4-tricarboxylate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
    4.2.1.-
     R03444  (R)-2-Hydroxybutane-1,2,4-tricarboxylate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
Orthology
K16792  methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  methanogen homoaconitase small subunit [EC:4.2.1.114]
K17450  homoaconitase [EC:4.2.1.-]
Other DBs
RHEA: 26104
LinkDB

KEGG   RCLASS: RC00498
Entry
RC00498                     RClass                                 
Definition
C1b-C2b:*-*:C1d+C6a-C2c+C6a
C1d-C2c:O1a-*:C1b+C1b+C6a-C1b+C2b+C6a
Reactant pair
C00158_C00417    C01251_C04002    C04115_C04434
C16583_C20581    C16598_C20582
Related class
Reaction
R01325 R03444 R04478 R10392 R10395
Enzyme
4.2.1.3         4.2.1.83        4.2.1.114       4.2.1.-
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00300  Lysine biosynthesis
rn00362  Benzoate degradation
rn00630  Glyoxylate and dicarboxylate metabolism
rn00680  Methane metabolism
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
RModule
RM001  2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway
Orthology
K01681  aconitate hydratase [EC:4.2.1.3]
K01682  aconitate hydratase 2 / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]
K10220  4-oxalmesaconate hydratase [EC:4.2.1.83]
K16515  4-oxalomesaconate hydratase [EC:4.2.1.83]
K16792  methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  methanogen homoaconitase small subunit [EC:4.2.1.114]
K17450  homoaconitase [EC:4.2.1.-]
K27802  aconitate hydratase A / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]

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