KEGG   REACTION: R04125
Entry
R04125                      Reaction                               
Name
[protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)
Definition
[Protein]-S8-aminomethyldihydrolipoyllysine + Tetrahydrofolate <=> Dihydrolipoylprotein + 5,10-Methylenetetrahydrofolate + Ammonia
Equation
Comment
a part step of glycine cleavage system (see R01221, R03425+R04125+R03815)
Reaction class
RC00022  C00101_C00143
RC00069  C01242_C02972
Enzyme
Pathway
rn00260  Glycine, serine and threonine metabolism
rn00670  One carbon pool by folate
rn01100  Metabolic pathways
Orthology
K00605  aminomethyltransferase [EC:2.1.2.10]
Other DBs
RHEA: 16948
LinkDB

KEGG   RCLASS: RC00022
Entry
RC00022                     RClass                                 
Definition
N1b-N1y:*-C1x:C1b+C8y-C1x+C8y
N1x-N1y:*-C1x:C1y+C8y-C1y+C8y
Reactant pair
Related class
Reaction
Enzyme
1.4.1.27        2.1.1.74        2.1.1.148       2.1.2.1         
2.1.2.7         2.1.2.8         2.1.2.10        2.1.2.11        
2.1.5.1
Pathway
rn00260  Glycine, serine and threonine metabolism
rn00670  One carbon pool by folate
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01200  Carbon metabolism
rn01240  Biosynthesis of cofactors
Orthology
K00281  glycine dehydrogenase [EC:1.4.4.2]
K00282  glycine dehydrogenase subunit 1 [EC:1.4.4.2]
K00283  glycine dehydrogenase subunit 2 [EC:1.4.4.2]
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
K00600  glycine hydroxymethyltransferase [EC:2.1.2.1]
K00605  aminomethyltransferase [EC:2.1.2.10]
K00606  3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11]
K02437  glycine cleavage system H protein
K03465  thymidylate synthase (FAD) [EC:2.1.1.148]
K19796  dCMP hydroxymethylase [EC:2.1.2.8]
K22578  sesamin methylene transferase [EC:2.1.5.1]

KEGG   RCLASS: RC00069
Entry
RC00069                     RClass                                 
Definition
S1a-S2a:*-C1b:C1b-C1b
Reactant pair
Related class
Reaction
Enzyme
1.1.1.306       1.8.1.5         1.8.3.5         1.8.3.6         
2.1.2.10        2.5.1.18        2.5.1.48        2.5.1.58        
2.5.1.134       3.3.1.1         4.2.1.22        4.4.1.1         
4.4.1.13        4.4.1.21        4.4.1.22        4.4.1.23        
4.5.1.5
Pathway
rn00260  Glycine, serine and threonine metabolism
rn00270  Cysteine and methionine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Orthology
K00153  S-(hydroxymethyl)mycothiol dehydrogenase [EC:1.1.1.306]
K00605  aminomethyltransferase [EC:2.1.2.10]
K00799  glutathione S-transferase [EC:2.5.1.18]
K00816  kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase [EC:2.6.1.7 4.4.1.13 2.6.1.64]
K01251  adenosylhomocysteinase [EC:3.3.1.1]
K01697  cystathionine beta-synthase [EC:4.2.1.22]
K01739  cystathionine gamma-synthase [EC:2.5.1.48]
K01758  cystathionine gamma-lyase [EC:4.4.1.1]
K01760  cysteine-S-conjugate beta-lyase [EC:4.4.1.13]
K03396  S-(hydroxymethyl)glutathione synthase [EC:4.4.1.22]
K04097  prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]
K05906  prenylcysteine oxidase / farnesylcysteine lyase [EC:1.8.3.5 1.8.3.6]
K05954  protein farnesyltransferase subunit beta [EC:2.5.1.58]
K05955  protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [EC:2.5.1.58 2.5.1.59]
K07173  S-ribosylhomocysteine lyase [EC:4.4.1.21]
K10150  cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase [EC:2.5.1.47 2.5.1.65 4.2.1.22]
K13299  glutathione S-transferase kappa 1 [EC:2.5.1.18]
K14155  cysteine-S-conjugate beta-lyase [EC:4.4.1.13]
K17216  cystathionine beta-synthase (O-acetyl-L-serine) [EC:2.5.1.134]
K17217  cystathionine gamma-lyase / homocysteine desulfhydrase [EC:4.4.1.1 4.4.1.2]
K23790  glutathione S-transferase P [EC:2.5.1.18]

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