KEGG   REACTION: R04203
Entry
R04203                      Reaction                               
Name
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
Definition
(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + NAD+ <=> 2-Methylacetoacetyl-CoA + NADH + H+
Equation
C04405 + C00003 <=> C03344 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00525  C03344_C04405
Enzyme
1.1.1.35        1.1.1.178
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35
     R04203  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + NAD+ <=> 2-Methylacetoacetyl-CoA + NADH + H+
    1.1.1.178
     R04203  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + NAD+ <=> 2-Methylacetoacetyl-CoA + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.35
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04203  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylacetoacetyl-CoA
Orthology
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K08683  3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178]
Other DBs
RHEA: 13284
LinkDB

KEGG   RCLASS: RC00525
Entry
RC00525                     RClass                                 
Definition
C1c-C5a:*-*:C1a+C1c+O1a-C1a+C1c+O5a
Reactant pair
C00188_C03508    C00272_C21640    C00466_C03046
C00810_C03044    C00810_C20657    C01769_C03046
C01769_C20657    C03344_C04405    C03508_C05519
C04000_C04561    C12389_C18711
Related class
Reaction
R01465 R02344 R02946 R03707 R04203 R04370 R09354 R10504
R10505 R10851 R11764
Enzyme
1.1.1.4         1.1.1.21        1.1.1.35        1.1.1.76        
1.1.1.103       1.1.1.178       1.1.1.217       1.1.1.381       
1.1.1.-
Pathway
rn00260  Glycine, serine and threonine metabolism
rn00280  Valine, leucine and isoleucine degradation
rn00650  Butanoate metabolism
rn00790  Folate biosynthesis
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
RModule
RM018  Beta oxidation in acyl-CoA degradation
Orthology
K00004  (R,R)-butanediol dehydrogenase / meso-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.4 1.1.1.- 1.1.1.303]
K00011  aldehyde reductase [EC:1.1.1.21]
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K00060  threonine 3-dehydrogenase [EC:1.1.1.103]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K03366  meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.- 1.1.1.76 1.1.1.304]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K08683  3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178]
K15789  threonine 3-dehydrogenase [EC:1.1.1.103]
K15967  ketoreductase
K16066  3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-]
K18009  meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.- 1.1.1.76 1.1.1.304]

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