KEGG   REACTION: R04224
Entry
R04224                      Reaction                               
Name
(S)-3-hydroxyisobutyryl-CoA hydro-lyase
Definition
2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA
Equation
C03460 + C00001 <=> C06000
Reaction class
RC01103  C03460_C06000
Enzyme
4.2.1.17
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17
     R04224  2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA
IUBMB reaction hierarchy [BR:br08202]
 4. Lyase reactions
  4.2.1.17
   R02685  (3S)-3-Hydroxyacyl-CoA <=> trans-2,3-Dehydroacyl-CoA
    R04224  (S)-3-Hydroxyisobutyryl-CoA <=> 2-Methylprop-2-enoyl-CoA
Orthology
K01692  enoyl-CoA hydratase [EC:4.2.1.17]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
Other DBs
RHEA: 31178
LinkDB

KEGG   RCLASS: RC01103
Entry
RC01103                     RClass                                 
Definition
C1b-C2a:O1a-*:C1c-C2c
C1c-C2c:*-*:C1a+C1b+C5a-C1a+C2a+C5a
Reactant pair
C03460_C06000
Related class
Reaction
R04224
Enzyme
4.2.1.17
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn01100  Metabolic pathways
RModule
RM019  Acyl-CoA conversion via dicarboxylate semialdehyde
Orthology
K01692  enoyl-CoA hydratase [EC:4.2.1.17]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]

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