KEGG   REACTION: R04371
Entry
R04371                      Reaction                               
Name
homoisocitrate hydro-lyase
Definition
Homoisocitrate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
Equation
C05662 <=> C04002 + C00001
Comment
the second step of two-step reaction (see R09720, R03444+R04371)
Reaction class
RC00618  C04002_C05662
Enzyme
4.2.1.36        4.2.1.114
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.36
     R04371  Homoisocitrate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
    4.2.1.114
     R04371  Homoisocitrate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
Orthology
K01705  homoaconitate hydratase [EC:4.2.1.36]
K16792  methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  methanogen homoaconitase small subunit [EC:4.2.1.114]
Other DBs
RHEA: 15488
LinkDB

KEGG   RCLASS: RC00618
Entry
RC00618                     RClass                                 
Definition
C1c-C2b:O1a-*:C1c+C6a-C2c+C6a
C1c-C2c:*-*:C1b+C1c+C6a-C1b+C2b+C6a
Reactant pair
C00311_C00417    C04002_C05662    C16597_C20581
C16600_C20582
Related class
Reaction
R01900 R04371 R10393 R10396
Enzyme
4.2.1.3         4.2.1.36        4.2.1.114
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00300  Lysine biosynthesis
rn00630  Glyoxylate and dicarboxylate metabolism
rn00680  Methane metabolism
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
RModule
RM001  2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway
Orthology
K01681  aconitate hydratase [EC:4.2.1.3]
K01682  aconitate hydratase 2 / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]
K01705  homoaconitate hydratase [EC:4.2.1.36]
K16792  methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  methanogen homoaconitase small subunit [EC:4.2.1.114]
K27802  aconitate hydratase A / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]

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