KEGG   REACTION: R04426
Entry
R04426                      Reaction                               
Name
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
Definition
(2R,3S)-3-Isopropylmalate + NAD+ <=> (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+
Equation
Comment
subsequently R01652
Reaction class
RC00001  C00003_C00004
RC00084  C04236_C04411
Enzyme
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
Module
M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.85
     R04426  (2R,3S)-3-Isopropylmalate + NAD+ <=> (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+
Orthology
K00052  3-isopropylmalate dehydrogenase [EC:1.1.1.85]
K21360  3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:1.1.1.85 1.1.1.-]
Other DBs
RHEA: 10895
LinkDB

KEGG   RCLASS: RC00084
Entry
RC00084                     RClass                                 
Definition
C1c-C5a:*-*:C1c+C6a+O1a-C1c+C6a+O5a
Reactant pair
Related class
Reaction
Enzyme
1.1.1.42        1.1.1.43        1.1.1.85        1.1.1.87        
1.1.1.93        1.1.1.215       1.1.1.286       1.1.1.290       
1.1.1.397       1.1.3.27        1.1.99.3
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00030  Pentose phosphate pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn00630  Glyoxylate and dicarboxylate metabolism
rn00750  Vitamin B6 metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01240  Biosynthesis of cofactors
RModule
RM001  2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway
Orthology
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
K00032  phosphogluconate 2-dehydrogenase [EC:1.1.1.43]
K00052  3-isopropylmalate dehydrogenase [EC:1.1.1.85]
K00090  glyoxylate/hydroxypyruvate/2-ketogluconate reductase [EC:1.1.1.79 1.1.1.81 1.1.1.215]
K03473  erythronate-4-phosphate dehydrogenase [EC:1.1.1.290]
K05824  homoisocitrate dehydrogenase [EC:1.1.1.87]
K06151  gluconate 2-dehydrogenase alpha chain [EC:1.1.99.3]
K06152  gluconate 2-dehydrogenase gamma chain [EC:1.1.99.3]
K07246  tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase [EC:1.1.1.93 4.1.1.73 1.1.1.83]
K10978  methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
K17753  isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
K21360  3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:1.1.1.85 1.1.1.-]
K22229  2-ketogluconate reductase [EC:1.1.1.215]

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