KEGG   REACTION: R04440
Entry
R04440                      Reaction                               
Name
(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
Definition
(R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ <=> 3-Hydroxy-3-methyl-2-oxobutanoic acid + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC00726  C04181_C04272
Enzyme
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.86
     R04440  (R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ <=> 3-Hydroxy-3-methyl-2-oxobutanoic acid + NADPH + H+
Orthology
K00053  ketol-acid reductoisomerase [EC:1.1.1.86]
Other DBs
RHEA: 31142
LinkDB

KEGG   RCLASS: RC00726
Entry
RC00726                     RClass                                 
Definition
C1c-C5a:*-*:C1d+C6a+O1a-C1d+C6a+O5a
Reactant pair
Related class
Reaction
Enzyme
1.1.1.86        1.1.1.169
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn00770  Pantothenate and CoA biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
rn01240  Biosynthesis of cofactors
RModule
RM033  Branched-chain addition (branched-chain amino acid synthesis)
Orthology
K00053  ketol-acid reductoisomerase [EC:1.1.1.86]
K00077  2-dehydropantoate 2-reductase [EC:1.1.1.169]
K24263  2-dehydropantoate 2-reductase [EC:1.1.1.169]

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