KEGG REACTION: R04441

REACTION: R04441

Entry

R04441                      Reaction

Name

(R)-2,3-dihydroxy-3-methylbutanoate hydro-lyase

Definition

(R)-2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O

Equation

C04272 <=> C00141 + C00001

Reaction class

RC00468

C00141_C04272

Enzyme

4.2.1.9

Pathway

rn00290

Valine, leucine and isoleucine biosynthesis

rn00770

Pantothenate and CoA biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

rn01210

2-Oxocarboxylic acid metabolism

rn01230

Biosynthesis of amino acids

Module

M00019

Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine

Brite

Enzymatic reactions [BR:br08201]
4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.9
     R04441  (R)-2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O
IUBMB reaction hierarchy [BR:br08202]
4. Lyase reactions
  4.2.1.9
   R01209  2,3-Dihydroxy-3-methylbutanoate
    R04441  (R)-2,3-Dihydroxy-3-methylbutanoate

Orthology

K01687

dihydroxy-acid dehydratase [EC:4.2.1.9]

Other DBs

RHEA:

24812

LinkDB

RCLASS: RC00468

Entry

RC00468                     RClass

Definition

C1c-C1d:*-O1a:C1a+C1a+C5a-C1a+C1a+C1c
C5a-C1c:*-*:C1c+C6a+O5a-C1d+C6a+O1a

Reactant pair

C00141_C04039 C00141_C04272

Related class

Reaction

R01209 R04441