KEGG   REACTION: R04534
Entry
R04534                      Reaction                               
Name
(3R)-3-hydroxydecanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase
Definition
(3R)-3-Hydroxydecanoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxodecanoyl-[acp] + NADPH
Equation
C04619 + C00006 <=> C05753 + C00005
Reaction class
RC00001  C00005_C00006
RC00029  C04619_C05753
Enzyme
1.1.1.100       1.1.1.-         2.3.1.85        2.3.1.86        
2.3.1.-
Pathway
rn00061  Fatty acid biosynthesis
rn01100  Metabolic pathways
rn01212  Fatty acid metabolism
Module
M00083  Fatty acid biosynthesis, elongation
Orthology
K00059  3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
K00665  fatty acid synthase, animal type [EC:2.3.1.85]
K00667  fatty acid synthase subunit alpha, fungi type [EC:2.3.1.86]
K11533  fatty acid synthase, bacteria type [EC:2.3.1.-]
K11539  carbonyl reductase 4 / 3-oxoacyl-[acyl-carrier protein] reductase beta subunit [EC:1.1.1.-]
Reference
1  [PMID:25203508]
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
2  [PMID:30508570]
  Authors
Hiltunen JK, Kastaniotis AJ, Autio KJ, Jiang G, Chen Z, Glumoff T.
  Title
17B-hydroxysteroid dehydrogenases as acyl thioester metabolizing enzymes.
  Journal
Mol Cell Endocrinol 489:107-118 (2019)
DOI:10.1016/j.mce.2018.11.012
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