KEGG   REACTION: R04617
Entry
R04617                      Reaction                               
Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate:D-alanyl-D-alanine ligase(ADP-forming)
Definition
ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate + D-Alanyl-D-alanine <=> ADP + Orthophosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
Equation
C00002 + C04877 + C00993 <=> C00008 + C00009 + C04882
Reaction class
RC00002  C00002_C00008
RC00064  C00993_C04882
RC00141  C04877_C04882
Enzyme
6.3.2.10
Pathway
rn00300  Lysine biosynthesis
rn00550  Peptidoglycan biosynthesis
rn01100  Metabolic pathways
Orthology
K01798  Alr-MurF fusion protein [EC:5.1.1.1 6.3.2.10]
K01929  UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
K15792  MurE/MurF fusion protein [EC:6.3.2.13 6.3.2.10]
Other DBs
RHEA: 28377
LinkDB

KEGG   RCLASS: RC00141
Entry
RC00141                     RClass                                 
Definition
C5a-C6a:N1b+*-*+O6a:C1c+O5a-C1c+O6a
Reactant pair
C00041_C20942    C00051_C00669    C00062_C21099
C00082_C02993    C00082_C07027    C00097_C01419
C00097_C19703    C00133_C00993    C00133_C04457
C00133_C19719    C00151_C16116    C00522_C00864
C00669_C04544    C00692_C01212    C01042_C12270
C01042_C20776    C01050_C01212    C01050_C04877
C01217_C18802    C01392_C05234    C02170_C20846
C02713_C02999    C02882_C05729    C03001_C04303
C03492_C18911    C04506_C20120    C04650_C06457
C04702_C05892    C04702_C06432    C04804_C04882
C04877_C04882    C05726_C05729    C05727_C20732
C05951_C05952    C12270_C20776    C12323_C20910
C17949_C17950    C19152_C19153    C19709_C19710
C19709_C19713    C20277_C20278    C20917_C20918
C21015_C21016
 » show all
Related class
Reaction
R00497 R00735 R00899 R01150 R02473 R02474 R02741 R02783
R03193 R04112 R04113 R04369 R04573 R04611 R04617 R04730
R04951 R05055 R05671 R07642 R07651 R08850 R08872 R09379
R09399 R09591 R09592 R09594 R09595 R09722 R09845 R10011
R10617 R10678 R10679 R10687 R10688 R10693 R10778 R10821
R10880 R10891 R10892 R10901 R10994 R11064 R11085 R11481
R12514
Enzyme
2.3.2.-         3.4.11.1        3.4.11.2        3.4.11.23       
3.4.13.22       3.4.13.23       3.4.13.-        3.4.15.6        
3.4.17.8        3.4.17.21       3.4.22.-        3.4.24.84       
3.4.-.-         3.5.1.22        3.5.1.28        3.5.1.72        
3.5.1.95        3.5.1.115       6.3.1.13        6.3.2.1         
6.3.2.3         6.3.2.4         6.3.2.8         6.3.2.9         
6.3.2.10        6.3.2.16        6.3.2.23        6.3.2.24        
6.3.2.25        6.3.2.29        6.3.2.31        6.3.2.33        
6.3.2.35        6.3.2.36        6.3.2.41        6.3.2.42        
6.3.2.44        6.3.2.45        6.3.2.48        6.3.2.49        
6.3.2.59        6.3.2.-
 » show all
Pathway
rn00240  Pyrimidine metabolism
rn00250  Alanine, aspartate and glutamate metabolism
rn00261  Monobactam biosynthesis
rn00270  Cysteine and methionine metabolism
rn00300  Lysine biosynthesis
rn00440  Phosphonate and phosphinate metabolism
rn00470  D-Amino acid metabolism
rn00480  Glutathione metabolism
rn00550  Peptidoglycan biosynthesis
rn00590  Arachidonic acid metabolism
rn00680  Methane metabolism
rn00770  Pantothenate and CoA biosynthesis
rn00790  Folate biosynthesis
rn00900  Terpenoid backbone biosynthesis
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Orthology
K01255  leucyl aminopeptidase [EC:3.4.11.1]
K01256  aminopeptidase N [EC:3.4.11.2]
K01270  dipeptidase D [EC:3.4.13.-]
K01446  peptidoglycan recognition protein
K01447  N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]
K01448  N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]
K01449  N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]
K01798  Alr-MurF fusion protein [EC:5.1.1.1 6.3.2.10]
K01918  pantoate--beta-alanine ligase [EC:6.3.2.1]
K01920  glutathione synthase [EC:6.3.2.3]
K01921  D-alanine-D-alanine ligase [EC:6.3.2.4]
K01924  UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]
K01925  UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]
K01929  UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
K05375  MbtH protein
K06013  STE24 endopeptidase [EC:3.4.24.84]
K07751  PepB aminopeptidase [EC:3.4.11.23]
K08658  prenyl protein peptidase [EC:3.4.22.-]
K09722  4-phosphopantoate---beta-alanine ligase [EC:6.3.2.36]
K11140  aminopeptidase N [EC:3.4.11.2]
K11142  cytosol aminopeptidase [EC:3.4.11.1 3.4.11.5]
K12234  coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase [EC:6.3.2.31 6.3.2.34]
K12631  puromycin biosynthesis protein Pur6
K12911  phosphinothricin tripeptide synthetase PhsA
K12912  phosphinothricin tripeptide synthetase phsB [EC:6.2.1.67]
K12913  phosphinothricin tripeptide synthetase PhsC
K13037  L-alanine-L-anticapsin ligase [EC:6.3.2.49]
K13282  cyanophycinase [EC:3.4.15.6]
K13799  pantoate ligase / CMP/dCMP kinase [EC:6.3.2.1 2.7.4.25]
K14592  glutamate carboxypeptidase II (folate hydrolase 1) [EC:3.4.17.21]
K15428  Cys-Gly metallodipeptidase DUG1 [EC:3.4.13.-]
K15740  tetrahydromethanopterin:alpha-L-glutamate ligase [EC:6.3.2.33]
K15792  MurE/MurF fusion protein [EC:6.3.2.13 6.3.2.10]
K16181  3-methylornithine--L-lysine ligase [EC:6.3.2.59]
K18310  beta-citrylglutamate/N-acetylaspartylglutamate synthase [EC:6.3.1.17 6.3.2.41]
K18311  N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase [EC:6.3.2.41 6.3.2.42]
K19102  nocardicin nonribosomal peptide synthetase NocA
K19103  nocardicin nonribosomal peptide synthetase NocB
K19111  putative tabtoxin peptidase [EC:3.4.-.-]
K19112  L-Amino acid ligase [EC:6.3.2.-]
K19795  ureidomalonase [EC:3.5.1.95]
K21456  glutathione synthase [EC:6.3.2.3]
K24998  dehydro coenzyme F420 reductase / coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase [EC:1.3.8.17 6.3.2.31 6.3.2.34]

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