KEGG   REACTION: R04746
Entry
R04746                      Reaction                               
Name
(S)-hydroxyoctanoyl-CoA hydro-lyase
Definition
(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O
Equation
C05266 <=> C05276 + C00001
Reaction class
RC01095  C05266_C05276
Enzyme
4.2.1.17        4.2.1.74
Pathway
rn00062  Fatty acid elongation
rn00071  Fatty acid degradation
rn01100  Metabolic pathways
rn01212  Fatty acid metabolism
Module
M00085  Fatty acid elongation in mitochondria
M00087  beta-Oxidation
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17
     R04746  (S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O
    4.2.1.74
     R04746  (S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O
IUBMB reaction hierarchy [BR:br08202]
 4. Lyase reactions
  4.2.1.17
   R02685  (3S)-3-Hydroxyacyl-CoA <=> trans-2,3-Dehydroacyl-CoA
    R04746  (S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA
  4.2.1.74
   R02685  (3S)-3-Hydroxyacyl-CoA <=> trans-2,3-Dehydroacyl-CoA
    R04746  (S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA
Orthology
K01692  enoyl-CoA hydratase [EC:4.2.1.17]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
K13767  enoyl-CoA hydratase [EC:4.2.1.17]
Other DBs
RHEA: 31202
LinkDB

KEGG   RCLASS: RC01095
Entry
RC01095                     RClass                                 
Definition
C1b-C2b:*-*:C1c+C5a-C2b+C5a
C1c-C2b:O1a-*:C1b+C1b-C1b+C2b
Reactant pair
C03063_C05601    C03221_C05262    C04619_C05754
C04620_C05751    C04633_C05763    C04688_C05760
C05258_C05272    C05260_C05273    C05264_C05275
C05266_C05276    C05268_C05271    C05747_C05748
C05757_C05758    C06714_C06723    C14144_C14145
C16217_C16218    C16220_C16221    C16328_C16329
C16332_C16333    C16336_C16337    C16374_C16375
C16387_C16388    C20373_C20374    C20377_C20378
C20748_C20750    C22859_C22860
Related class
Reaction
R04131 R04170 R04535 R04537 R04544 R04568 R04738 R04740
R04744 R04746 R04749 R04954 R04965 R05601 R06942 R07760
R07764 R07889 R07893 R07897 R07935 R07951 R10117 R10121
R10675 R13260
Enzyme
2.3.1.85        2.3.1.86        2.3.1.-         4.2.1.17        
4.2.1.59        4.2.1.74        4.2.1.119       4.2.1.134       
4.2.1.149       4.2.1.-
Pathway
rn00061  Fatty acid biosynthesis
rn00062  Fatty acid elongation
rn00071  Fatty acid degradation
rn00360  Phenylalanine metabolism
rn00362  Benzoate degradation
rn00780  Biotin metabolism
rn00930  Caprolactam degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01212  Fatty acid metabolism
rn01240  Biosynthesis of cofactors
RModule
RM018  Beta oxidation in acyl-CoA degradation
RM020  Fatty acid synthesis using acetyl-CoA (reversal of RM018)
RM021  Fatty acid synthesis using malonyl-CoA
Orthology
K00665  fatty acid synthase, animal type [EC:2.3.1.85]
K00668  fatty acid synthase subunit beta, fungi type [EC:2.3.1.86]
K01692  enoyl-CoA hydratase [EC:4.2.1.17]
K01716  3-hydroxyacyl-[acyl-carrier protein] dehydratase / trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:4.2.1.59 5.3.3.14]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K02372  3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K08299  crotonobetainyl-CoA hydratase [EC:4.2.1.149]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
K10703  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [EC:4.2.1.134]
K11533  fatty acid synthase, bacteria type [EC:2.3.1.-]
K12405  (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2 [EC:1.1.1.- 4.2.1.107 4.2.1.119]
K13767  enoyl-CoA hydratase [EC:4.2.1.17]
K16363  UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59]
K22540  3-hydroxyacyl-thioester dehydratase, animal type [EC:4.2.1.-]
K22541  3-hydroxyacyl-thioester dehydratase, fungi type [EC:4.2.1.-]
K27071  meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA [EC:4.2.1.-]
K27072  meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB [EC:4.2.1.-]
K27689  meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadAB [EC:4.2.1.-]

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