KEGG   REACTION: R04854
Entry
R04854                      Reaction                               
Name
20alpha-hydroxycholesterol:oxygen oxidoreductase (side-chain-cleaving)
Definition
20alpha-Hydroxycholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 20alpha,22beta-Dihydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Equation
C05500 + C00007 + 2 C00662 + 2 C00080 <=> C05501 + C00001 + 2 C00667
Comment
second step of R02724 (R01454+R04854+R03933)
Reaction class
RC01223  C05500_C05501
Enzyme
1.14.15.6
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6
     R04854  20alpha-Hydroxycholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 20alpha,22beta-Dihydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]
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