KEGG REACTION: R05270

REACTION: R05270

Entry

R05270                      Reaction

Name

6-deoxyerythronolide-B,reduced ferredoxin:oxygen oxidoreductase

Definition

6-Deoxyerythronolide B + 2 Reduced ferredoxin + 2 H+ + Oxygen <=> Erythronolide B + 2 Oxidized ferredoxin + H2O

Equation

C03240 + 2 C00138 + 2 C00080 + C00007 <=> C06635 + 2 C00139 + C00001

Reaction class

RC01315

C03240_C06635

Enzyme

1.14.15.35

Pathway

rn00522

Biosynthesis of 12-, 14- and 16-membered macrolides

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00774

Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.35
     R05270  6-Deoxyerythronolide B + 2 Reduced ferredoxin + 2 H+ + Oxygen <=> Erythronolide B + 2 Oxidized ferredoxin + H2O

Orthology

K14366

6-deoxyerythronolide B hydroxylase [EC:1.14.15.35]

Other DBs

RHEA:

40302

LinkDB

RCLASS: RC01315