KEGG   REACTION: R05336
Entry
R05336                      Reaction                               
Name
acetyl-CoA:4-hydroxybutanoate CoA-transferase
Definition
4-Hydroxybutanoic acid + Acetyl-CoA <=> 4-Hydroxybutyryl-CoA + Acetate
Equation
C00989 + C00024 <=> C11062 + C00033
Reaction class
RC00012  C00024_C00033
RC00014  C00989_C11062
Enzyme
2.8.3.-
Pathway
rn00650  Butanoate metabolism
rn01100  Metabolic pathways
rn01200  Carbon metabolism
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.8  Transferring sulfur-containing groups
   2.8.3  CoA-transferases
    2.8.3.-
     R05336  4-Hydroxybutanoic acid + Acetyl-CoA <=> 4-Hydroxybutyryl-CoA + Acetate
Orthology
K18122  4-hydroxybutyrate CoA-transferase [EC:2.8.3.-]
LinkDB

KEGG   RCLASS: RC00014
Entry
RC00014                     RClass                                 
Definition
C5a-C6a:S2a+*-*+O6a:C1b+O5a-C1b+O6a
Reactant pair
C00025_C18006    C00042_C00091    C00042_C03174
C00083_C00383    C00099_C02335    C00100_C00163
C00120_C01894    C00136_C00246    C00149_C04348
C00154_C00249    C00158_C00566    C00164_C00332
C00219_C02249    C00222_C05989    C00249_C05764
C00249_C17202    C00264_C01656    C00318_C20750
C00356_C03761    C00383_C01209    C00412_C01530
C00489_C00527    C00490_C00531    C00497_C20747
C00510_C00712    C00582_C07086    C00638_C03371
C00638_C20683    C00642_C05338    C00695_C01794
C00712_C01203    C00815_C01011    C00846_C02232
C00989_C11062    C01011_C02614    C01013_C05668
C01063_C02656    C01181_C20749    C01530_C04088
C01571_C05755    C01595_C02050    C01607_C02060
C02041_C06425    C02528_C05337    C02612_C20746
C02679_C05223    C02730_C03160    C02804_C03237
C03035_C06426    C03188_C04025    C03242_C03595
C03990_C21449    C04483_C15560    C04780_C16327
C05752_C06423    C05761_C06424    C05998_C20827
C06104_C14143    C06108_C19775    C06427_C16162
C06428_C16165    C06429_C16169    C07114_C07118
C07160_C20271    C08276_C20870    C08281_C16528
C08316_C16531    C08320_C16529    C08323_C16532
C08362_C16520    C10447_C21175    C11405_C11407
C11419_C11421    C11949_C11950    C14179_C19685
C14862_C14863    C16166_C16513    C16170_C16527
C16179_C16522    C16180_C16525    C16272_C16273
C16317_C16339    C16462_C16464    C16526_C16530
C16533_C16645    C20199_C20838    C20851_C21108
C21308_C21309    C21326_C21327    C21399_C21400
C21446_C21506    C21448_C21507    C21452_C21453
C21925_C21926    C21925_C21927
 » show all
Related class
Reaction
R00389 R00405 R00406 R00407 R00410 R00432 R00499 R00727
R00743 R00914 R00920 R00925 R00928 R01075 R01176 R01179
R01256 R01274 R01280 R01322 R01323 R01357 R01358 R01359
R01365 R01406 R01407 R01449 R01559 R01598 R01706 R01780
R02083 R02084 R02402 R02404 R02405 R02406 R02407 R02539
R02699 R02794 R02814 R02955 R02990 R03153 R03154 R03157
R03158 R03209 R03631 R03974 R04014 R04030 R04057 R04157
R05336 R05452 R05588 R06396 R06397 R06415 R06515 R06904
R06944 R07124 R07295 R07296 R07832 R07887 R07902 R08088
R08157 R08158 R08159 R08162 R08163 R08174 R08175 R08176
R08177 R08178 R08179 R08180 R08181 R08182 R08183 R08184
R08185 R08186 R08187 R08188 R08189 R08190 R08191 R08192
R08273 R08602 R08743 R08905 R08944 R09279 R09286 R09643
R09840 R10003 R10343 R10600 R10612 R10640 R10641 R10643
R10644 R10758 R10759 R10769 R10820 R10904 R10947 R11187
R11206 R11367 R11392 R11462 R11539 R11542 R11632 R11922
R11924 R12148 R12300 R12329 R13030 R13035 R13299
 » show all
Enzyme
2.3.1.85        2.3.1.187       2.3.1.315       2.8.3.1         
2.8.3.2         2.8.3.3         2.8.3.5         2.8.3.6         
2.8.3.8         2.8.3.9         2.8.3.10        2.8.3.11        
2.8.3.13        2.8.3.14        2.8.3.15        2.8.3.18        
2.8.3.20        2.8.3.21        2.8.3.22        2.8.3.23        
2.8.3.24        2.8.3.25        2.8.3.26        2.8.3.-         
3.1.2.2         3.1.2.3         3.1.2.4         3.1.2.5         
3.1.2.11        3.1.2.13        3.1.2.14        3.1.2.21        
3.1.2.22        3.1.2.27        3.1.2.29        3.1.2.30        
3.1.2.31        3.1.2.32        3.1.2.-         3.2.1.-         
4.2.1.155       6.2.1.1         6.2.1.2         6.2.1.3         
6.2.1.4         6.2.1.5         6.2.1.6         6.2.1.7         
6.2.1.9         6.2.1.11        6.2.1.13        6.2.1.14        
6.2.1.15        6.2.1.16        6.2.1.17        6.2.1.18        
6.2.1.19        6.2.1.20        6.2.1.23        6.2.1.24        
6.2.1.26        6.2.1.30        6.2.1.36        6.2.1.38        
6.2.1.39        6.2.1.40        6.2.1.41        6.2.1.44        
6.2.1.47        6.2.1.48        6.2.1.51        6.2.1.56        
6.2.1.76        6.2.1.-
 » show all
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00061  Fatty acid biosynthesis
rn00062  Fatty acid elongation
rn00071  Fatty acid degradation
rn00120  Primary bile acid biosynthesis
rn00130  Ubiquinone and other terpenoid-quinone biosynthesis
rn00280  Valine, leucine and isoleucine degradation
rn00310  Lysine degradation
rn00333  Prodigiosin biosynthesis
rn00350  Tyrosine metabolism
rn00360  Phenylalanine metabolism
rn00362  Benzoate degradation
rn00405  Phenazine biosynthesis
rn00410  beta-Alanine metabolism
rn00430  Taurine and hypotaurine metabolism
rn00524  Neomycin, kanamycin and gentamicin biosynthesis
rn00592  alpha-Linolenic acid metabolism
rn00627  Aminobenzoate degradation
rn00630  Glyoxylate and dicarboxylate metabolism
rn00640  Propanoate metabolism
rn00642  Ethylbenzene degradation
rn00650  Butanoate metabolism
rn00660  C5-Branched dibasic acid metabolism
rn00680  Methane metabolism
rn00720  Other carbon fixation pathways
rn00780  Biotin metabolism
rn00903  Limonene degradation
rn00907  Pinene, camphor and geraniol degradation
rn00920  Sulfur metabolism
rn00930  Caprolactam degradation
rn00980  Metabolism of xenobiotics by cytochrome P450
rn00984  Steroid degradation
rn00997  Biosynthesis of various other secondary metabolites
rn01040  Biosynthesis of unsaturated fatty acids
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01212  Fatty acid metabolism
rn01220  Degradation of aromatic compounds
rn01240  Biosynthesis of cofactors
RModule
RM017  Ring cleavage via Baeyer-Villiger oxidation
RM019  Acyl-CoA conversion via dicarboxylate semialdehyde
Orthology
K00665  fatty acid synthase, animal type [EC:2.3.1.85]
K01026  propionate CoA-transferase [EC:2.8.3.1]
K01027  3-oxoacid CoA-transferase [EC:2.8.3.5]
K01028  3-oxoacid CoA-transferase subunit A [EC:2.8.3.5]
K01029  3-oxoacid CoA-transferase subunit B [EC:2.8.3.5]
K01031  3-oxoadipate CoA-transferase, alpha subunit [EC:2.8.3.6]
K01032  3-oxoadipate CoA-transferase, beta subunit [EC:2.8.3.6]
K01034  acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
K01035  acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
K01041  glutaryl-CoA transferase [EC:2.8.3.-]
K01068  acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]
K01071  medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21]
K01074  palmitoyl-protein thioesterase [EC:3.1.2.22]
K01895  acetyl-CoA synthetase [EC:6.2.1.1]
K01896  medium-chain acyl-CoA synthetase [EC:6.2.1.2]
K01897  long-chain acyl-CoA synthetase [EC:6.2.1.3]
K01899  succinyl-CoA synthetase alpha subunit [EC:6.2.1.4 6.2.1.5]
K01900  succinyl-CoA synthetase beta subunit [EC:6.2.1.4 6.2.1.5]
K01902  succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]
K01903  succinyl-CoA synthetase beta subunit [EC:6.2.1.5]
K01905  acetate---CoA ligase (ADP-forming) subunit alpha [EC:6.2.1.13]
K01906  6-carboxyhexanoate--CoA ligase [EC:6.2.1.14]
K01907  acetoacetyl-CoA synthetase [EC:6.2.1.16]
K01908  propionyl-CoA synthetase [EC:6.2.1.17]
K01909  long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:6.2.1.20]
K01911  o-succinylbenzoate---CoA ligase [EC:6.2.1.26]
K01912  phenylacetate-CoA ligase [EC:6.2.1.30]
K01913  acetate/butyrate---CoA ligase [EC:6.2.1.1 6.2.1.2]
K02182  carnitine-CoA ligase [EC:6.2.1.48]
K02614  acyl-CoA thioesterase [EC:3.1.2.-]
K05605  3-hydroxyisobutyryl-CoA hydrolase [EC:3.1.2.4]
K05939  acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase / long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:2.3.1.40 6.2.1.20]
K07543  benzylsuccinate CoA-transferase BbsE subunit [EC:2.8.3.15]
K07544  benzylsuccinate CoA-transferase BbsF subunit [EC:2.8.3.15]
K08298  L-carnitine CoA-transferase [EC:2.8.3.21]
K08692  malate-CoA ligase subunit alpha [EC:6.2.1.9]
K08748  solute carrier family 27 (fatty acid transporter), member 5 [EC:6.2.1.7]
K10526  OPC-8:0 CoA ligase 1 [EC:6.2.1.-]
K10781  fatty acyl-ACP thioesterase B [EC:3.1.2.14 3.1.2.21]
K10782  fatty acyl-ACP thioesterase A [EC:3.1.2.14]
K10804  acyl-CoA thioesterase I [EC:3.1.2.- 3.1.2.2 3.1.1.2 3.1.1.5]
K10805  acyl-CoA thioesterase II [EC:3.1.2.-]
K10806  acyl-CoA thioesterase YciA [EC:3.1.2.-]
K11992  acyl-CoA thioesterase 8 [EC:3.1.2.27]
K13559  [BtrI acyl-carrier protein]--L-glutamate ligase [EC:6.2.1.39]
K13776  citronellyl-CoA synthetase [EC:6.2.1.-]
K13929  malonate decarboxylase alpha subunit [EC:2.3.1.187]
K14067  malate-CoA ligase subunit beta [EC:6.2.1.9]
K14451  (3S)-malyl-CoA thioesterase [EC:3.1.2.30]
K14466  4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40]
K14467  4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40]
K14469  acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase [EC:1.3.1.84 4.2.1.116 6.2.1.36]
K14471  succinyl-CoA:(S)-malate CoA-transferase subunit A [EC:2.8.3.22]
K14472  succinyl-CoA:(S)-malate CoA-transferase subunit B [EC:2.8.3.22]
K14747  benzoylacetate-CoA ligase [EC:6.2.1.-]
K14760  o-succinylbenzoate---CoA ligase [EC:6.2.1.26]
K15013  long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
K15018  3-hydroxypropionyl-coenzyme A synthetase [EC:6.2.1.36]
K15232  citryl-CoA synthetase large subunit [EC:6.2.1.18]
K15233  citryl-CoA synthetase small subunit
K15569  naphthyl-2-methylsuccinate CoA transferase subunit [EC:2.8.3.-]
K15570  naphthyl-2-methylsuccinate CoA transferase subunit [EC:2.8.3.-]
K15871  bile acid CoA-transferase [EC:2.8.3.25]
K17360  acyl-coenzyme A thioesterase 7 [EC:3.1.2.2]
K18118  succinyl-CoA:acetate CoA-transferase [EC:2.8.3.18]
K18122  4-hydroxybutyrate CoA-transferase [EC:2.8.3.-]
K18288  itaconate CoA-transferase [EC:2.8.3.-]
K18289  itaconate CoA-transferase [EC:2.8.3.- 2.8.3.22]
K18313  succinyl-CoA---D-citramalate CoA-transferase [EC:2.8.3.20]
K18593  4-hydroxybutyrate---CoA ligase (ADP-forming) [EC:6.2.1.56]
K18594  3-hydroxypropionyl-CoA synthetase (ADP-forming) [EC:6.2.1.-]
K18660  malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.76 6.2.1.-]
K18687  HIP---CoA ligase [EC:6.2.1.41]
K18861  4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40]
K19280  succinyl-CoA:mesaconate CoA transferase [EC:2.8.3.26]
K19282  bifunctional (S)-malyl-CoA lyase/thioesterase [EC:4.1.3.24 3.1.2.30]
K19709  acetate CoA-transferase [EC:2.8.3.8]
K20034  3-(methylthio)propionyl---CoA ligase [EC:6.2.1.44]
K20257  2-aminobenzoylacetyl-CoA thioesterase [EC:3.1.2.32]
K20882  (R)-2-hydroxy-4-methylpentanoate CoA-transferase [EC:2.8.3.24]
K20985  dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase [EC:3.1.2.31]
K21059  4-hydroxyphenylalkanoate adenylyltransferase [EC:6.2.1.51]
K21107  medium-chain-fatty-acid---[acyl-carrier-protein] ligase [EC:6.2.1.47]
K21182  (S)-beta-tyrosine adenylation enzyme [EC:6.2.1.-]
K21228  (R)-2-aza-beta-tyrosine adenylation enzyme [EC:6.2.1.-]
K21791  thioesterase
K22224  acetate---CoA ligase (ADP-forming) subunit beta [EC:6.2.1.13]
K23756  medium-chain acyl-CoA ligase / lipoate-activating enzyme [EC:6.2.1.2]
K24012  acetate---CoA ligase (ADP-forming) [EC:6.2.1.13]
K25774  4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40]
K26005  sulfoacetate-CoA ligase [EC:6.2.1.-]
K27540  succinyl-CoA:cyclohexane-1-carboxylate CoA transferase [EC:2.3.1.315]

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