KEGG   REACTION: R05468
Entry
R05468                      Reaction                               
Name
proclavaminate,2-oxoglutarate:oxygen oxidoreductase (cyclyzing)
Definition
Proclavaminic acid + Oxygen + 2-Oxoglutarate <=> Dihydroclavaminic acid + CO2 + Succinate + H2O
Equation
Comment
Reaction class
RC01390  C06658_C06659
Enzyme
Pathway
rn00331  Clavulanic acid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00674  Clavaminate biosynthesis, arginine + glyceraldehyde-3P => clavaminate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.21
     R05468  Proclavaminic acid + Oxygen + 2-Oxoglutarate <=> Dihydroclavaminic acid + CO2 + Succinate + H2O
Orthology
K12675  clavaminate synthase [EC:1.14.11.21]
Reference
1  [PMID:9614345]
  Authors
McGowan SJ, Bycroft BW, Salmond GP.
  Title
Bacterial production of carbapenems and clavams: evolution of beta-lactam antibiotic pathways.
  Journal
Trends Microbiol 6:203-8 (1998)
DOI:10.1016/S0966-842X(98)01251-7
Other DBs
RHEA: 12776 19788
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