KEGG REACTION: R05640

REACTION: R05640

Entry

R05640                      Reaction

Name

lanosterol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving)

Definition

Lanosterol + 3 [Reduced NADPH---hemoprotein reductase] + 3 Oxygen <=> 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + Formate + 3 [Oxidized NADPH---hemoprotein reductase] + 4 H2O

Equation

C01724 + 3 C03024 + 3 C00007 <=> C11455 + C00058 + 3 C03161 + 4 C00001

Reaction class

RC01442

C01724_C11455

Enzyme

1.14.14.154

Pathway

rn00100

Steroid biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00101

Cholesterol biosynthesis, FPP => cholesterol

M00102

Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.154
     R05640  Lanosterol + 3 [Reduced NADPH---hemoprotein reductase] + 3 Oxygen <=> 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + Formate + 3 [Oxidized NADPH---hemoprotein reductase] + 4 H2O
IUBMB reaction hierarchy [BR:br08202]
1. Oxidoreductase reactions
  1.14.14.154
   R12118  14alpha-Methylsteroid <=> Delta14-Steroid
    R05640  Lanosterol <=> 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol

Orthology

K05917

sterol 14alpha-demethylase [EC:1.14.14.154 1.14.15.36]

Other DBs

RHEA:

25289

LinkDB

RCLASS: RC01442

Entry

RC01442                     RClass

Definition

C1x-C2x:*-*:C1x+C1z-C1x+C2y
C1z-C2y:C1a-*:C1x+C1z+C2y-C2x+C1z+C2y

Reactant pair

C01724_C11455 C01943_C11508

Related class

Reaction

R05640 R05731 R12323