KEGG   REACTION: R05666
Entry
R05666                      Reaction                               
Name
toluene,NADH:oxygen oxidoreductase (4-hydroxylating)
Definition
Toluene + NADH + H+ + Oxygen <=> 4-Cresol + NAD+ + H2O
Equation
Reaction class
RC00490  C01455_C01468
Enzyme
Pathway
rn00623  Toluene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.236
     R05666  Toluene + NADH + H+ + Oxygen <=> 4-Cresol + NAD+ + H2O
Orthology
K15760  toluene monooxygenase system protein A [EC:1.14.13.236 1.14.13.-]
K15761  toluene monooxygenase system protein B [EC:1.14.13.236 1.14.13.-]
K15762  toluene monooxygenase system ferredoxin subunit
K15763  toluene monooxygenase system protein D [EC:1.14.13.236 1.14.13.-]
K15764  toluene monooxygenase system protein E [EC:1.14.13.236 1.14.13.-]
K15765  toluene monooxygenase electron transfer component [EC:1.18.1.3]
Other DBs
RHEA: 41383
LinkDB

KEGG   RCLASS: RC00490
Entry
RC00490                     RClass                                 
Definition
C8x-C8y:*-O1a:C8x+C8x-C8x+C8x
Reactant pair
Related class
Reaction
Enzyme
1.1.7.1         1.14.11.59      1.14.13.58      1.14.13.172     
1.14.13.189     1.14.13.209     1.14.13.217     1.14.13.236     
1.14.13.244     1.14.13.-       1.14.14.1       1.14.14.75      
1.14.14.81      1.14.14.91      1.14.14.92      1.14.14.103     
1.14.14.118     1.14.14.136     1.14.14.186     1.14.14.-       
1.14.15.31      1.14.16.1       1.14.16.4       1.14.16.6       
1.14.16.7       1.14.99.26      1.14.-.-        1.97.1.2
Pathway
rn00130  Ubiquinone and other terpenoid-quinone biosynthesis
rn00360  Phenylalanine metabolism
rn00361  Chlorocyclohexane and chlorobenzene degradation
rn00362  Benzoate degradation
rn00364  Fluorobenzoate degradation
rn00380  Tryptophan metabolism
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00402  Benzoxazinoid biosynthesis
rn00404  Staurosporine biosynthesis
rn00623  Toluene degradation
rn00626  Naphthalene degradation
rn00627  Aminobenzoate degradation
rn00643  Styrene degradation
rn00901  Indole alkaloid biosynthesis
rn00940  Phenylpropanoid biosynthesis
rn00941  Flavonoid biosynthesis
rn00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
rn00982  Drug metabolism - cytochrome P450
rn00999  Biosynthesis of various plant secondary metabolites
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
RModule
RM006  Dihydroxylation of aromatic ring, type 2 (two monooxygenase reactions)
RM013  Ortho-cleavage of aromatic ring, type 4x
RM026  Hydoxylation and decarboxylation motif
RM027  Hydroxylation and methylation motif
Orthology
K00487  trans-cinnamate 4-monooxygenase [EC:1.14.14.91]
K00500  phenylalanine-4-hydroxylase [EC:1.14.16.1]
K00502  tryptophan 5-monooxygenase [EC:1.14.16.4]
K03185  2-octaprenyl-6-methoxyphenol hydroxylase [EC:1.14.13.-]
K04107  4-hydroxybenzoyl-CoA reductase subunit gamma [EC:1.1.7.1]
K04108  4-hydroxybenzoyl-CoA reductase subunit alpha [EC:1.1.7.1]
K04109  4-hydroxybenzoyl-CoA reductase subunit beta [EC:1.1.7.1]
K07415  cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]
K07824  benzoate 4-monooxygenase [EC:1.14.14.92]
K12696  tabersonine 16-hydroxylase [EC:1.14.14.103]
K13229  2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase [EC:1.14.11.59]
K14578  naphthalene 1,2-dioxygenase ferredoxin component
K14581  naphthalene 1,2-dioxygenase ferredoxin reductase component [EC:1.18.1.7]
K15760  toluene monooxygenase system protein A [EC:1.14.13.236 1.14.13.-]
K15761  toluene monooxygenase system protein B [EC:1.14.13.236 1.14.13.-]
K15762  toluene monooxygenase system ferredoxin subunit
K15763  toluene monooxygenase system protein D [EC:1.14.13.236 1.14.13.-]
K15764  toluene monooxygenase system protein E [EC:1.14.13.236 1.14.13.-]
K15765  toluene monooxygenase electron transfer component [EC:1.18.1.3]
K16242  phenol/toluene 2-monooxygenase (NADH) P3/A3 [EC:1.14.13.244 1.14.13.243]
K16243  phenol/toluene 2-monooxygenase (NADH) P1/A1 [EC:1.14.13.244 1.14.13.243]
K16244  phenol/toluene 2-monooxygenase (NADH) P2/A2 [EC:1.14.13.244 1.14.13.243]
K16245  phenol/toluene 2-monooxygenase (NADH) P4/A4 [EC:1.14.13.244 1.14.13.243]
K16246  phenol/toluene 2-monooxygenase (NADH) P5/A5 [EC:1.14.13.244 1.14.13.243]
K16249  phenol/toluene 2-monooxygenase (NADH) P0/A0
K17475  tryprostatin B 6-hydroxylase [EC:1.14.14.118]
K17689  cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
K17709  cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]
K17712  cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]
K17719  cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
K18242  salicylate 5-hydroxylase large subunit [EC:1.14.13.172]
K18243  salicylate 5-hydroxylase small subunit [EC:1.14.13.172]
K20089  protodeoxyviolaceinate monooxygenase [EC:1.14.13.217]
K20420  2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
K21177  cytochrome P450 hydroxylase [EC:1.14.-.-]
K24541  tryptamine 5-hydroxylase [EC:1.14.14.186]
K27786  strychnine 10-hydroxylase

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