REACTION: R05692
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Entry
R05692 Reaction
Name
GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)
Definition
GDP-L-fucose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+
Equation
C00325
+
C00006
<=>
C01222
+
C00005
+
C00080
Comment
two-step reaction (see
R07059+R07060
), bifunctional enzyme
Reaction class
RC00001
C00005_C00006
RC01014
C00325_C01222
Enzyme
1.1.1.271
Pathway
rn00051
Fructose and mannose metabolism
rn00520
Amino sugar and nucleotide sugar metabolism
rn00541
Biosynthesis of various nucleotide sugars
rn01100
Metabolic pathways
rn01250
Biosynthesis of nucleotide sugars
Brite
Enzymatic reactions [BR:
br08201
]
1. Oxidoreductase reactions
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.271
R05692 GDP-L-fucose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+
BRITE hierarchy
Orthology
K02377
GDP-L-fucose synthase [EC:
1.1.1.271
]
Other DBs
RHEA:
18888
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