KEGG   REACTION: R07372
Entry
R07372                      Reaction                               
Name
cholest-5-ene-3beta,26-diol,[NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating)
Definition
Cholest-5-ene-3beta,26-diol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 7alpha,27-Dihydroxycholesterol + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C15610 + C03024 + C00007 <=> C06341 + C03161 + C00001
Reaction class
RC00524  C06341_C15610
Enzyme
1.14.14.23      1.14.14.29
Pathway
rn00120  Primary bile acid biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.23
     R07372  Cholest-5-ene-3beta,26-diol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 7alpha,27-Dihydroxycholesterol + [Oxidized NADPH---hemoprotein reductase] + H2O
    1.14.14.29
     R07372  Cholest-5-ene-3beta,26-diol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 7alpha,27-Dihydroxycholesterol + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K00489  cholesterol 7alpha-monooxygenase [EC:1.14.14.23]
K07430  25/26-hydroxycholesterol 7alpha-hydroxylase [EC:1.14.14.29]
Other DBs
RHEA: 19044
LinkDB

KEGG   RCLASS: RC00524
Entry
RC00524                     RClass                                 
Definition
C1x-C1y:*-O1a:C1y+C2x-C1y+C2x
Reactant pair
C00187_C03594    C00521_C01123    C01227_C18045
C01953_C18038    C06341_C15610    C08521_C08532
C08616_C19942    C13550_C15518    C15519_C15520
C17333_C17335    C18226_C20150    C19678_C21922
C20534_C20535    C22049_C22050
Related class
Reaction
R01463 R02469 R07208 R07209 R07372 R08727 R08943 R08961
R09815 R09866 R10357 R11753 R12131 R12267
Enzyme
1.14.13.-       1.14.14.23      1.14.14.26      1.14.14.29      
1.14.14.99      1.14.14.112     1.14.14.150     1.14.14.152     
1.14.14.169
Pathway
rn00120  Primary bile acid biosynthesis
rn00140  Steroid hormone biosynthesis
rn00403  Indole diterpene alkaloid biosynthesis
rn00902  Monoterpenoid biosynthesis
rn00904  Diterpenoid biosynthesis
rn00950  Isoquinoline alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K00489  cholesterol 7alpha-monooxygenase [EC:1.14.14.23]
K07430  25/26-hydroxycholesterol 7alpha-hydroxylase [EC:1.14.14.29]
K07439  24-hydroxycholesterol 7alpha-hydroxylase [EC:1.14.14.26]
K15089  (S)-limonene 3-monooxygenase [EC:1.14.14.99]
K16084  ent-cassa-12,15-diene 11-hydroxylase / oryzalexin D synthase [EC:1.14.14.112 1.14.14.123]
K17875  beta-amyrin 11-oxidase [EC:1.14.14.152]
K18388  cytochrome P450 monooxygenase [EC:1.14.13.-]

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