REACTION: R08251
Help
Entry
R08251 Reaction
Name
isoniazid amidohydrolase
Definition
Isoniazid + H2O <=> Isonicotinic acid + Hydrazine
Equation
C07054
+
C00001
<=>
C07446
+
C05361
Comment
hepatic amidase
carboxylesterases (ec
3.1.1.1
) also have some amidohydrolase activities
Reaction class
RC00162
C07054_C07446
Enzyme
3.1.1.1
3.5.1.-
Pathway
rn00983
Drug metabolism - other enzymes
Orthology
K01044
carboxylesterase 1 [EC:
3.1.1.1
]
LinkDB
All DBs
RCLASS: RC00162
Help
Entry
RC00162 RClass
Definition
C5a-C6a:N1b+*-*+O6a:C8y+O5a-C8y+O6a
Reactant pair
C00180_C01586
C00180_C02253
C00196_C05821
C00253_C05380
C00415_C00921
C01606_C06374
C04751_C04823
C07054_C07446
C07446_C07585
C07446_C16623
C12458_C12471
C12458_C20629
C12477_C20637
Related class
DB search
Reaction
R01424
R01425
R01723
R02237
R04591
R05167
R06776
R06777
R07644
R08249
R08251
R08252
R10453
Enzyme
3.1.1.1
3.5.1.32
3.5.1.40
3.5.1.79
3.5.1.-
6.3.1.15
6.3.2.6
6.3.2.12
6.3.2.14
6.3.2.17
Pathway
rn00230
Purine metabolism
rn00401
Novobiocin biosynthesis
rn00760
Nicotinate and nicotinamide metabolism
rn00790
Folate biosynthesis
rn00983
Drug metabolism - other enzymes
rn01053
Biosynthesis of siderophore group nonribosomal peptides
rn01100
Metabolic pathways
rn01110
Biosynthesis of secondary metabolites
rn01240
Biosynthesis of cofactors
Orthology
K01044
carboxylesterase 1 [EC:
3.1.1.1
]
K01252
bifunctional isochorismate lyase / aryl carrier protein [EC:
3.3.2.1
6.3.2.14
]
K01451
hippurate hydrolase [EC:
3.5.1.32
]
K01587
phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:
4.1.1.21
6.3.2.6
]
K01923
phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:
6.3.2.6
]
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
K02362
enterobactin synthetase component D [EC:
6.3.2.14
2.7.8.-]
K02363
2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:
6.3.2.14
6.2.1.71
]
K02364
L-serine---[L-seryl-carrier protein] ligase [EC:
6.3.2.14
6.2.1.72
]
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
K12709
8-demethylnovobiocic acid synthase [EC:
6.3.1.15
]
K13713
fusion protein PurCD [EC:
6.3.2.6
6.3.4.13
]
K20457
dihydrofolate synthase [EC:
6.3.2.12
]
K22099
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
K24102
dihydrofolate synthase / dihydropteroate synthase [EC:
6.3.2.12
2.5.1.15
]
DBGET
integrated database retrieval system
