KEGG   REACTION: R08255
Entry
R08255                      Reaction                               
Definition
Irinotecan + H2O <=> SN-38 + 1,4'-Bipiperidine-1'-carboxylic acid
Equation
C16641 + C00001 <=> C11173 + C16836
Comment
carboxylesterase
Reaction class
RC00475  C16641_C16836
RC00476  C11173_C16641
Enzyme
3.1.1.1
Pathway
rn00983  Drug metabolism - other enzymes
Orthology
K01044  carboxylesterase 1 [EC:3.1.1.1]
K03927  carboxylesterase 2 [EC:3.1.1.1 3.1.1.84 3.1.1.56]
LinkDB

KEGG   RCLASS: RC00476
Entry
RC00476                     RClass                                 
Definition
O1a-O7a:*-C7a:C8y-C8y
Reactant pair
C00090_C07734    C00146_C00548    C00530_C13636
C00530_C18216    C00805_C01405    C01424_C01572
C01839_C02868    C03081_C03837    C11173_C16543
C11173_C16641    C15583_C15584
Related class
Reaction
R00053 R00054 R01241 R02942 R04141 R05361 R06893 R07342
R08255 R08258 R09105
Enzyme
3.1.1.1         3.1.1.2         3.1.1.20        3.1.1.40        
3.1.1.55        3.1.1.56        3.1.1.-         3.7.1.-
Pathway
rn00363  Bisphenol degradation
rn00621  Dioxin degradation
rn00983  Drug metabolism - other enzymes
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Orthology
K01044  carboxylesterase 1 [EC:3.1.1.1]
K03927  carboxylesterase 2 [EC:3.1.1.1 3.1.1.84 3.1.1.56]
K22717  2-hydroxy-6-oxo-6-(2-hydroxyphenoxy)-hexa-2,4-dienoate hydrolase [EC:3.7.1.-]

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