KEGG   REACTION: R10027
Entry
R10027                      Reaction                               
Name
L-isoleucine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)
Definition
L-Isoleucine + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> N-Hydroxy-L-isoleucine + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C00407 + C00007 + C03024 <=> C20310 + C03161 + C00001
Comment
the first step of three-step reaction (see R09403, R10027+R10028+R10029)
Reaction class
RC00001  C00005_C00006
RC00365  C00407_C20310
Enzyme
1.14.14.38      1.14.14.39
Pathway
rn00460  Cyanoamino acid metabolism
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.38
     R10027  L-Isoleucine + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> N-Hydroxy-L-isoleucine + [Oxidized NADPH---hemoprotein reductase] + H2O
    1.14.14.39
     R10027  L-Isoleucine + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> N-Hydroxy-L-isoleucine + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K13401  valine N-monooxygenase [EC:1.14.14.38]
K14984  isoleucine N-monooxygenase [EC:1.14.14.39]
Other DBs
RHEA: 30482
LinkDB

KEGG   RCLASS: RC00365
Entry
RC00365                     RClass                                 
Definition
N1a-N1b:*-O1b:C1c-C1c
Reactant pair
C00078_C19716    C00079_C19712    C00082_C03004
C00151_C05710    C00183_C20313    C00407_C20310
C21534_C21536
Related class
Reaction
R00730 R01260 R09579 R09583 R10027 R10031 R11647
Enzyme
1.14.13.-       1.14.14.36      1.14.14.38      1.14.14.39      
1.14.14.40      1.14.14.42      1.14.14.156
Pathway
rn00460  Cyanoamino acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K12153  phenylalanine N-monooxygenase [EC:1.14.14.40]
K13027  tyrosine N-monooxygenase [EC:1.14.14.36]
K13401  valine N-monooxygenase [EC:1.14.14.38]
K14984  isoleucine N-monooxygenase [EC:1.14.14.39]

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