KEGG   REACTION: R10791
Entry
R10791                      Reaction                               
Name
dihydromonacolin L acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3-hydroxylating)
Definition
Dihydromonacolin L acid + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> 3alpha-Hydroxy-3,5-dihydromonacolin L acid + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C20851 + C00007 + C03024 <=> C20852 + C03161 + C00001
Comment
the first step of two-step reaction (see R10793, R10791+R10792)
Reaction class
RC03280  C20851_C20852
Enzyme
1.14.14.124
Pathway
rn00997  Biosynthesis of various other secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00893  Lovastatin biosynthesis, malonyl-CoA => lovastatin acid
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.124
     R10791  Dihydromonacolin L acid + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> 3alpha-Hydroxy-3,5-dihydromonacolin L acid + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K20980  dihydromonacolin L/monacolin L hydroxylase [EC:1.14.14.124 1.14.14.125]
Other DBs
RHEA: 12207
LinkDB

KEGG   REACTION: R10792
Entry
R10792                      Reaction                               
Name
3alpha-hydroxy-3,5-dihydromonacolin L acid hydro-lyase
Definition
3alpha-Hydroxy-3,5-dihydromonacolin L acid <=> Monacolin L acid + H2O
Equation
C20852 <=> C20853 + C00001
Comment
spontaneous
the second step of two-step reaction (see R10793, R10791+R10792)
Reaction class
RC03281  C20852_C20853
Enzyme
1.14.14.124
Pathway
rn00997  Biosynthesis of various other secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00893  Lovastatin biosynthesis, malonyl-CoA => lovastatin acid
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.124
     R10792  3alpha-Hydroxy-3,5-dihydromonacolin L acid <=> Monacolin L acid + H2O
Orthology
K20980  dihydromonacolin L/monacolin L hydroxylase [EC:1.14.14.124 1.14.14.125]
Other DBs
RHEA: 24335
LinkDB

DBGET integrated database retrieval system