KEGG   REACTION: R10880
Entry
R10880                      Reaction                               
Definition
5 ATP + 3 L-4-Hydroxyphenylglycine + L-Arginine + L-Serine + H2O <=> 5 AMP + 5 Diphosphate + Nocardicin G + L-4-Hydroxyphenylglycyl-L-arginine
Equation
Comment
nocardicin nonribosomal peptide synthetase
(1) 3 L-pHPG + L-Arg + L-Ser + 5 ATP <=> Pro-nocardicin G + 5 AMP + 5 Diphosphate
(2) Pro-nocardicin G + H2O <=> Nocardicin G + L-pHPG-L-Arg
Reaction class
RC00064  C00062_C20910
RC00141  C12323_C20910
RC03296  C12323_C17355
RC03297  C12323_C17355
RC03298  C00065_C17355
Pathway
rn00261  Monobactam biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00736  Nocardicin A biosynthesis, L-pHPG + arginine + serine => nocardicin A
Orthology
K05375  MbtH protein
K19102  nocardicin nonribosomal peptide synthetase NocA
K19103  nocardicin nonribosomal peptide synthetase NocB
Reference
1  [PMID:25624104]
  Authors
Gaudelli NM, Long DH, Townsend CA
  Title
beta-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis.
  Journal
Nature 520:383-7 (2015)
DOI:10.1038/nature14100
Reference
2  [PMID:24531841]
  Authors
Gaudelli NM, Townsend CA
  Title
Epimerization and substrate gating by a TE domain in beta-lactam antibiotic biosynthesis.
  Journal
Nat Chem Biol 10:251-8 (2014)
DOI:10.1038/nchembio.1456
LinkDB

KEGG   RCLASS: RC03296
Entry
RC03296                     RClass                                 
Definition
C1c-C1c:*-*:C5a+C8y+N1a-C6a+C8y+N1a
C5a-C6a:N1b+*-*+O6a:C1c+O5a-C1c+O6a
Reactant pair
Related class
Reaction
Pathway
rn00261  Monobactam biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K05375  MbtH protein
K19102  nocardicin nonribosomal peptide synthetase NocA
K19103  nocardicin nonribosomal peptide synthetase NocB

KEGG   RCLASS: RC03297
Entry
RC03297                     RClass                                 
Definition
C1c-C1c:*-*:C6a+C8y+N1a-C6a+C8y+N1y
N1a-N1y:*+*-C1x+C5x:C1c-C1c
Reactant pair
Related class
Reaction
Pathway
rn00261  Monobactam biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K05375  MbtH protein
K19102  nocardicin nonribosomal peptide synthetase NocA
K19103  nocardicin nonribosomal peptide synthetase NocB

KEGG   RCLASS: RC03298
Entry
RC03298                     RClass                                 
Definition
C1b-C1x:O1a+*-*+N1y:C1c-C1y
C6a-C5x:O6a+*-*+N1y:C1c+O6a-C1y+O5x
N1a-N1b:*-C5a:C1c-C1y
Reactant pair
Related class
Reaction
Pathway
rn00261  Monobactam biosynthesis
rn01100  Metabolic pathways
Orthology
K05375  MbtH protein
K19102  nocardicin nonribosomal peptide synthetase NocA
K19103  nocardicin nonribosomal peptide synthetase NocB

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