| Entry |
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| Name |
N3-fumaroyl-L-2,3-diaminopropanoate:L-glutamine amido-ligase (AMP-forming)
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| Definition |
N3-Fumaroyl-L-2,3-diaminopropanoate + L-Glutamine + ATP + H2O <=> 3-{[(2E)-4-Amino-4-oxobut-2-enoyl]amino}-L-alanine + L-Glutamate + AMP + Diphosphate
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| Equation |
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| Comment |
proposed pathway
not yet characterized sufficiently
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| Reaction class |
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| Enzyme |
6.3.5.-
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| Pathway |
| rn00998 | Biosynthesis of various antibiotics |
| rn01110 | Biosynthesis of secondary metabolites |
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| Module |
| M00904 | Dapdiamides biosynthesis, L-2,3-diaminopropanoate => dapdiamide A/B/C |
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| Brite |
Enzymatic reactions [BR:br08201]
6. Ligase reactions
6.3 Forming carbon-nitrogen bonds
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.3.5.-
R12352 N3-Fumaroyl-L-2,3-diaminopropanoate + L-Glutamine + ATP + H2O <=> 3-{[(2E)-4-Amino-4-oxobut-2-enoyl]amino}-L-alanine + L-Glutamate + AMP + Diphosphate
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| Orthology |
| K01957 | N-3-fumaroyl-(S)-2,3-diaminopropanoate amidotransferase [EC:6.3.5.-] |
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| Reference |
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| Authors |
Hollenhorst MA, Clardy J, Walsh CT |
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| Title |
The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics. |
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| Journal |
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| LinkDB |
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