KEGG   REACTION: R13263
Entry
R13263                      Reaction                               
Name
very-long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein]:NADP+ oxidoreductase
Definition
Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ <=> Very-long-chain 3-oxoacyl-[acyl-carrier protein] + NADPH + H+
Equation
C22863 + C00006 <=> C22862 + C00005 + C00080
Comment
general reaction
Reaction class
RC00029  C22862_C22863
Enzyme
1.1.1.-
Pathway
rn00074  Mycolic acid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00885  Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)
M00886  Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R13263  Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ <=> Very-long-chain 3-oxoacyl-[acyl-carrier protein] + NADPH + H+
Orthology
K11610  meromycolic acid 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.-]
Reference
1  [PMID:12079383]
  Authors
Cohen-Gonsaud M, Ducasse S, Hoh F, Zerbib D, Labesse G, Quemard A.
  Title
Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved  in long-chain fatty acid biosynthesis.
  Journal
J Mol Biol 320:249-61 (2002)
Reference
2  [PMID:11932442]
  Authors
Marrakchi H, Ducasse S, Labesse G, Montrozier H, Margeat E, Emorine L, Charpentier X, Daffe M, Quemard AK.
  Title
MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain  fatty acid elongation system FAS-II.
  Journal
Microbiology (Reading) 148:951-960 (2002)
DOI:10.1099/00221287-148-4-951
Reference
3  [PMID:20178986]
  Authors
Veyron-Churlet R, Zanella-Cleon I, Cohen-Gonsaud M, Molle V, Kremer L.
  Title
Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier  protein reductase MabA regulates mycolic acid biosynthesis.
  Journal
J Biol Chem 285:12714-25 (2010)
DOI:10.1074/jbc.M110.105189
Reference
4  [PMID:17059223]
  Authors
Silva RG, de Carvalho LP, Blanchard JS, Santos DS, Basso LA.
  Title
Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein (ACP) reductase:  kinetic and chemical mechanisms.
  Journal
Biochemistry 45:13064-73 (2006)
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