KEGG   REACTION: R13267
Entry
R13267                      Reaction                               
Name
ultra-long-chain-mono-unsaturated-(3R)-3-hydroxyacyl-[acyl-carrier protein]:NADP+ oxidoreductase
Definition
Ultra-long-chain mono-unsaturated (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ <=> Ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + NADPH + H+
Equation
C22867 + C00006 <=> C22866 + C00005 + C00080
Comment
general reaction
Reaction class
RC00029  C22866_C22867
Enzyme
1.1.1.-
Pathway
rn00074  Mycolic acid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00885  Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)
M00886  Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R13267  Ultra-long-chain mono-unsaturated (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ <=> Ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + NADPH + H+
Orthology
K11610  meromycolic acid 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.-]
Reference
1  [PMID:20178986]
  Authors
Veyron-Churlet R, Zanella-Cleon I, Cohen-Gonsaud M, Molle V, Kremer L.
  Title
Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier  protein reductase MabA regulates mycolic acid biosynthesis.
  Journal
J Biol Chem 285:12714-25 (2010)
DOI:10.1074/jbc.M110.105189
Reference
2  [PMID:17059223]
  Authors
Silva RG, de Carvalho LP, Blanchard JS, Santos DS, Basso LA.
  Title
Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein (ACP) reductase:  kinetic and chemical mechanisms.
  Journal
Biochemistry 45:13064-73 (2006)
LinkDB

KEGG   RCLASS: RC00029
Entry
RC00029                     RClass                                 
Definition
C1c-C5a:*-*:C1b+C1b+O1a-C1b+C1b+O5a
Reactant pair
C00093_C00111    C00111_C00623    C00116_C00184
C00487_C02636    C00681_C03372    C01192_C04036
C02232_C14145    C02636_C15025    C02975_C03864
C02975_C03865    C03715_C03968    C03826_C05406
C04619_C05753    C04620_C05750    C04633_C05762
C04688_C05759    C05258_C05259    C05260_C05261
C05262_C05263    C05264_C05265    C05266_C05267
C05268_C05269    C05746_C05747    C05756_C05757
C06714_C06715    C12441_C12442    C16216_C16217
C16219_C16220    C16329_C16330    C16333_C16334
C16337_C16338    C16375_C16376    C16388_C16389
C20372_C20373    C20376_C20377    C20877_C20878
C22858_C22859    C22862_C22863    C22866_C22867
C22870_C22871
 » show all
Related class
Reaction
R00842 R00844 R00846 R00848 R00849 R01034 R01039 R01045
R01921 R02395 R02756 R03357 R04105 R04106 R04360 R04375
R04534 R04536 R04543 R04566 R04737 R04739 R04741 R04743
R04745 R04748 R04953 R04964 R05305 R05679 R05680 R06642
R06941 R07759 R07763 R07890 R07894 R07898 R07936 R07952
R08657 R10116 R10120 R10826 R13259 R13263 R13267 R13271
Enzyme
1.1.1.6         1.1.1.8         1.1.1.35        1.1.1.94        
1.1.1.100       1.1.1.101       1.1.1.108       1.1.1.156       
1.1.1.157       1.1.1.211       1.1.1.254       1.1.1.259       
1.1.1.261       1.1.1.279       1.1.1.280       1.1.1.330       
1.1.1.-         1.1.3.21        1.1.5.3         1.1.99.22       
2.3.1.85        2.3.1.86        2.3.1.-
Pathway
rn00061  Fatty acid biosynthesis
rn00062  Fatty acid elongation
rn00071  Fatty acid degradation
rn00074  Mycolic acid biosynthesis
rn00253  Tetracycline biosynthesis
rn00360  Phenylalanine metabolism
rn00362  Benzoate degradation
rn00561  Glycerolipid metabolism
rn00564  Glycerophospholipid metabolism
rn00565  Ether lipid metabolism
rn00780  Biotin metabolism
rn00930  Caprolactam degradation
rn01056  Biosynthesis of type II polyketide backbone
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01212  Fatty acid metabolism
rn01240  Biosynthesis of cofactors
RModule
RM018  Beta oxidation in acyl-CoA degradation
RM020  Fatty acid synthesis using acetyl-CoA (reversal of RM018)
RM021  Fatty acid synthesis using malonyl-CoA
Orthology
K00005  glycerol dehydrogenase [EC:1.1.1.6]
K00006  glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K00057  glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]
K00059  3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
K00074  3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]
K00096  glycerol-1-phosphate dehydrogenase [NAD(P)+] [EC:1.1.1.261]
K00105  alpha-glycerophosphate oxidase [EC:1.1.3.21]
K00111  glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]
K00112  glycerol-3-phosphate dehydrogenase subunit B [EC:1.1.5.3]
K00113  glycerol-3-phosphate dehydrogenase subunit C
K00665  fatty acid synthase, animal type [EC:2.3.1.85]
K00667  fatty acid synthase subunit alpha, fungi type [EC:2.3.1.86]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K06123  1-acylglycerone phosphate reductase [EC:1.1.1.101]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K07516  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K10251  17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase [EC:1.1.1.62 1.1.1.330]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
K11533  fatty acid synthase, bacteria type [EC:2.3.1.-]
K11539  carbonyl reductase 4 / 3-oxoacyl-[acyl-carrier protein] reductase beta subunit [EC:1.1.1.-]
K11610  meromycolic acid 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.-]
K12405  (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2 [EC:1.1.1.- 4.2.1.107 4.2.1.119]
K12420  ketoreductase [EC:1.1.1.-]
K18097  glycerol 2-dehydrogenase (NADP+) [EC:1.1.1.156]
K22251  glycerol dehydrogenase [EC:1.1.1.6]

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