KEGG   REACTION: R13276
Entry
R13276                      Reaction                               
Definition
Trehalose monomycolate + NADP+ <=> Trehalose mycolic-beta-ketoester + NADPH + H+
Equation
C22876 + C00006 <=> C22875 + C00005 + C00080
Comment
general reaction
Reaction class
RC00089  C22875_C22876
Pathway
rn00074  Mycolic acid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00887  Mycolic acid biosynthesis, meromycolic acid + alpha-carboxyacyl-CoA + trehalose => TMM => TDM/mAGP/GMM
Orthology
K27306  mycolic acid reductase
Reference
1  [PMID:31785114]
  Authors
Javid A, Cooper C, Singh A, Schindler S, Hanisch M, Marshall RL, Kalscheuer R, Bavro VN, Bhatt A.
  Title
The mycolic acid reductase Rv2509 has distinct structural motifs and is essential  for growth in slow-growing mycobacteria.
  Journal
Mol Microbiol 113:521-533 (2020)
DOI:10.1111/mmi.14437
Reference
2  [PMID:27268593]
  Authors
Quemard A.
  Title
New Insights into the Mycolate-Containing Compound Biosynthesis and Transport in  Mycobacteria.
  Journal
Trends Microbiol 24:725-738 (2016)
DOI:10.1016/j.tim.2016.04.009
LinkDB

KEGG   RCLASS: RC00089
Entry
RC00089                     RClass                                 
Definition
C1c-C5a:*-*:C1b+C1c+O1a-C1b+C1c+O5a
Reactant pair
C00199_C01068    C00204_C04349    C00231_C19674
C00257_C01062    C00273_C10906    C00770_C01062
C00836_C02934    C01096_C02888    C01620_C03064
C01697_C21523    C02022_C16884    C02780_C06473
C02780_C15673    C02782_C03926    C03827_C20781
C03979_C20781    C04349_C20680    C05448_C05449
C05467_C15614    C06055_C07335    C11947_C11948
C16651_C16652    C21285_C21294    C22875_C22876
Related class
Reaction
R00871 R01524 R01525 R01542 R01738 R01740 R02978 R03234
R03733 R04049 R04810 R04812 R05681 R05683 R05684 R05823
R06413 R07153 R08335 R08573 R08878 R09544 R10690 R11035
R11339 R11341 R11342 R11637 R13276
Enzyme
1.1.1.69        1.1.1.102       1.1.1.124       1.1.1.125       
1.1.1.127       1.1.1.129       1.1.1.137       1.1.1.162       
1.1.1.262       1.1.1.264       1.1.1.274       1.1.1.301       
1.1.1.346       1.1.1.366       1.1.1.389       1.1.1.401       
1.1.1.402       1.1.1.403       1.1.1.405       1.1.1.406       
1.1.1.434       1.1.1.-         1.1.99.4        1.1.-.-
Pathway
rn00040  Pentose and glucuronate interconversions
rn00051  Fructose and mannose metabolism
rn00053  Ascorbate and aldarate metabolism
rn00074  Mycolic acid biosynthesis
rn00120  Primary bile acid biosynthesis
rn00600  Sphingolipid metabolism
rn00750  Vitamin B6 metabolism
rn00907  Pinene, camphor and geraniol degradation
rn00982  Drug metabolism - cytochrome P450
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
RModule
RM018  Beta oxidation in acyl-CoA degradation
Orthology
K00065  2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase [EC:1.1.1.127]
K00097  4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262]
K00098  L-idonate 5-dehydrogenase [EC:1.1.1.264]
K04708  3-dehydrosphinganine reductase [EC:1.1.1.102]
K05352  ribitol-5-phosphate 2-dehydrogenase (NADP+) [EC:1.1.1.405]
K06221  2,5-diketo-D-gluconate reductase A [EC:1.1.1.346]
K12405  (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2 [EC:1.1.1.- 4.2.1.107 4.2.1.119]
K18335  2-dehydro-3-deoxy-L-fuconate 4-dehydrogenase [EC:1.1.1.434]
K19956  L-sorbose 1-phosphate reductase [EC:1.1.1.-]
K21680  ribulose-5-phosphate 2-dehydrogenase [EC:1.1.1.137]
K21681  ribitol-5-phosphate 2-dehydrogenase (NADP+) / D-ribitol-5-phosphate cytidylyltransferase [EC:1.1.1.405 2.7.7.40]
K21883  2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+) [EC:1.1.1.401]
K27306  mycolic acid reductase

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