REACTION: R13338
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Entry
R13338 Reaction
Definition
Strychnine <=> 10-Hydroxystrychnine
Equation
C06522
<=>
C22929
Comment
unclear reaction
strychnine 10-hydroxylase
Reaction class
RC00490
C06522_C22929
Pathway
rn00901
Indole alkaloid biosynthesis
rn01100
Metabolic pathways
rn01110
Biosynthesis of secondary metabolites
Orthology
K27786
strychnine 10-hydroxylase
Reference
1 [PMID:
35794473
]
Authors
Hong B, Grzech D, Caputi L, Sonawane P, Lopez CER, Kamileen MO, Hernandez Lozada NJ, Grabe V, O'Connor SE
Title
Biosynthesis of strychnine.
Journal
Nature 607:617-622 (2022)
DOI:
10.1038/s41586-022-04950-4
LinkDB
All DBs
RCLASS: RC00490
Help
Entry
RC00490 RClass
Definition
C8x-C8y:*-O1a:C8x+C8x-C8x+C8x
Reactant pair
C00078_C00643
C00079_C00082
C00079_C20807
C00146_C01407
C00156_C00180
C00180_C00587
C00223_C00540
C00398_C00780
C00423_C00811
C00423_C12621
C00512_C02949
C00512_C05195
C00544_C05852
C00628_C00805
C00642_C07086
C01059_C02502
C01108_C03743
C01455_C01467
C01455_C01468
C01984_C03198
C05011_C07108
C05593_C07086
C05629_C11457
C06522_C22929
C06868_C16601
C06868_C16602
C07096_C07097
C07501_C16584
C09239_C11635
C09244_C11643
C11004_C16570
C15204_C15609
C15772_C18062
C16247_C16248
C16546_C16547
C17552_C19858
C20394_C21081
C20512_C20513
C20803_C20805
C20856_C20857
C21131_C21134
C21306_C21307
C21876_C21884
» show all
Related class
DB search
Reaction
R01295
R01427
R01795
R01814
R02253
R02449
R03206
R03562
R03794
R04297
R05316
R05448
R05450
R05666
R05828
R05855
R06780
R06781
R06790
R06791
R07211
R07213
R07370
R07709
R07710
R07784
R08267
R08270
R08301
R08303
R08313
R08317
R08815
R08972
R10042
R10321
R10725
R10729
R10796
R11056
R11134
R11158
R11363
R12071
R12540
R12542
R12543
R12658
R12659
R13338
Enzyme
1.1.7.1
1.14.11.59
1.14.13.58
1.14.13.172
1.14.13.189
1.14.13.209
1.14.13.217
1.14.13.236
1.14.13.244
1.14.13.-
1.14.14.1
1.14.14.75
1.14.14.81
1.14.14.91
1.14.14.92
1.14.14.103
1.14.14.118
1.14.14.136
1.14.14.186
1.14.14.-
1.14.15.31
1.14.16.1
1.14.16.4
1.14.16.6
1.14.16.7
1.14.99.26
1.14.-.-
1.97.1.2
Pathway
rn00130
Ubiquinone and other terpenoid-quinone biosynthesis
rn00360
Phenylalanine metabolism
rn00361
Chlorocyclohexane and chlorobenzene degradation
rn00362
Benzoate degradation
rn00364
Fluorobenzoate degradation
rn00380
Tryptophan metabolism
rn00400
Phenylalanine, tyrosine and tryptophan biosynthesis
rn00402
Benzoxazinoid biosynthesis
rn00404
Staurosporine biosynthesis
rn00623
Toluene degradation
rn00626
Naphthalene degradation
rn00627
Aminobenzoate degradation
rn00643
Styrene degradation
rn00901
Indole alkaloid biosynthesis
rn00940
Phenylpropanoid biosynthesis
rn00941
Flavonoid biosynthesis
rn00945
Stilbenoid, diarylheptanoid and gingerol biosynthesis
rn00982
Drug metabolism - cytochrome P450
rn00999
Biosynthesis of various plant secondary metabolites
rn01059
Biosynthesis of enediyne antibiotics
rn01100
Metabolic pathways
rn01110
Biosynthesis of secondary metabolites
rn01120
Microbial metabolism in diverse environments
rn01220
Degradation of aromatic compounds
rn01230
Biosynthesis of amino acids
rn01240
Biosynthesis of cofactors
RModule
RM006
Dihydroxylation of aromatic ring, type 2 (two monooxygenase reactions)
RM013
Ortho-cleavage of aromatic ring, type 4x
RM026
Hydoxylation and decarboxylation motif
RM027
Hydroxylation and methylation motif
Orthology
K00487
trans-cinnamate 4-monooxygenase [EC:
1.14.14.91
]
K00500
phenylalanine-4-hydroxylase [EC:
1.14.16.1
]
K00502
tryptophan 5-monooxygenase [EC:
1.14.16.4
]
K03185
2-octaprenyl-6-methoxyphenol hydroxylase [EC:1.14.13.-]
K04107
4-hydroxybenzoyl-CoA reductase subunit gamma [EC:
1.1.7.1
]
K04108
4-hydroxybenzoyl-CoA reductase subunit alpha [EC:
1.1.7.1
]
K04109
4-hydroxybenzoyl-CoA reductase subunit beta [EC:
1.1.7.1
]
K07415
cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]
K07824
benzoate 4-monooxygenase [EC:
1.14.14.92
]
K12696
tabersonine 16-hydroxylase [EC:
1.14.14.103
]
K13229
2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase [EC:
1.14.11.59
]
K14578
naphthalene 1,2-dioxygenase ferredoxin component
K14581
naphthalene 1,2-dioxygenase ferredoxin reductase component [EC:
1.18.1.7
]
K15760
toluene monooxygenase system protein A [EC:
1.14.13.236
1.14.13.-]
K15761
toluene monooxygenase system protein B [EC:
1.14.13.236
1.14.13.-]
K15762
toluene monooxygenase system ferredoxin subunit
K15763
toluene monooxygenase system protein D [EC:
1.14.13.236
1.14.13.-]
K15764
toluene monooxygenase system protein E [EC:
1.14.13.236
1.14.13.-]
K15765
toluene monooxygenase electron transfer component [EC:
1.18.1.3
]
K16242
phenol/toluene 2-monooxygenase (NADH) P3/A3 [EC:
1.14.13.244
1.14.13.243
]
K16243
phenol/toluene 2-monooxygenase (NADH) P1/A1 [EC:
1.14.13.244
1.14.13.243
]
K16244
phenol/toluene 2-monooxygenase (NADH) P2/A2 [EC:
1.14.13.244
1.14.13.243
]
K16245
phenol/toluene 2-monooxygenase (NADH) P4/A4 [EC:
1.14.13.244
1.14.13.243
]
K16246
phenol/toluene 2-monooxygenase (NADH) P5/A5 [EC:
1.14.13.244
1.14.13.243
]
K16249
phenol/toluene 2-monooxygenase (NADH) P0/A0
K17475
tryprostatin B 6-hydroxylase [EC:
1.14.14.118
]
K17689
cytochrome P450 family 3 subfamily A4 [EC:
1.14.13.32
1.14.14.55
1.14.14.56
1.14.14.57
1.14.14.73
1.14.14.-]
K17709
cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]
K17712
cytochrome P450 family 2 subfamily D6 [EC:
1.14.14.1
]
K17719
cytochrome P450 family 2 subfamily C9 [EC:
1.14.14.51
1.14.14.52
1.14.14.53
1.14.14.-]
K18242
salicylate 5-hydroxylase large subunit [EC:
1.14.13.172
]
K18243
salicylate 5-hydroxylase small subunit [EC:
1.14.13.172
]
K20089
protodeoxyviolaceinate monooxygenase [EC:
1.14.13.217
]
K20420
2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:
1.14.15.31
]
K21177
cytochrome P450 hydroxylase [EC:1.14.-.-]
K24541
tryptamine 5-hydroxylase [EC:
1.14.14.186
]
K27786
strychnine 10-hydroxylase
DBGET
integrated database retrieval system