KEGG   REACTION: R13460
Entry
R13460                      Reaction                               
Name
21-deoxycortisol,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)
Definition
21-Deoxycortisol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 11beta-Hydroxyandrost-4-ene-3,17-dione + Acetate + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C05497 + C03024 + C00007 <=> C05284 + C00033 + C03161 + C00001
Reaction class
RC00607  C05284_C05497
Enzyme
1.14.14.32
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.32
     R13460  21-Deoxycortisol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 11beta-Hydroxyandrost-4-ene-3,17-dione + Acetate + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K00512  steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
Reference
1  [PMID:29277706]
  Authors
Kamrath C, Wettstaedt L, Boettcher C, Hartmann MF, Wudy SA.
  Title
Androgen excess is due to elevated 11-oxygenated androgens in treated children  with congenital adrenal hyperplasia.
  Journal
J Steroid Biochem Mol Biol 178:221-228 (2018)
DOI:10.1016/j.jsbmb.2017.12.016
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