KEGG   PATHWAY: acd03440
Entry
acd03440                    Pathway                                
Name
Homologous recombination - Acinetobacter oleivorans
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
acd03440  Homologous recombination
acd03440

Other DBs
GO: 0000724
Organism
Acinetobacter oleivorans [GN:acd]
Gene
AOLE_00795  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
AOLE_00960  ssDNA-binding protein controls activity of RecBCD nuclease [KO:K03111]
AOLE_00015  recombination protein F [KO:K03629]
AOLE_04580  DNA repair protein RecO [KO:K03584]
AOLE_10360  recR; recombination protein RecR [KO:K06187]
AOLE_07375  recA; recombinase A [KO:K03553]
AOLE_16400  DNA polymerase I(POL I) [KO:K02335] [EC:2.7.7.7]
AOLE_04390  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:5.6.2.4]
AOLE_04385  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
AOLE_11085  ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.21.10]
AOLE_02015  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
AOLE_17645  ATP-dependent exoDNAse (exonuclease V) beta subunit [KO:K03582] [EC:3.1.11.5]
AOLE_17650  exonuclease V, gamma chain [KO:K03583] [EC:3.1.11.5]
AOLE_17640  exonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
AOLE_11360  DNA polymerase III DnaE [KO:K02337] [EC:2.7.7.7]
AOLE_00010  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
AOLE_06955  DNA polymerase III, tau and gamma subunits [KO:K02343] [EC:2.7.7.7]
AOLE_16740  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
AOLE_10850  hypothetical protein [KO:K02341] [EC:2.7.7.7]
AOLE_14070  bifunctional ribonuclease HI/DNA polymerase III subunit epsilon [KO:K14159] [EC:3.1.26.4 2.7.7.7]
AOLE_18265  DNA polymerase III chi subunit, HolC family protein [KO:K02339] [EC:2.7.7.7]
AOLE_17590  primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
LinkDB

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