Anolis carolinensis (green anole): 100564297 Help Entry 100564297         CDS       T01608                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism acs  Anolis carolinensis (green anole) Pathway acs04020   Calcium signaling pathway acs04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:acs00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100564297 (ryr3)    04020 Calcium signaling pathway     100564297 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:acs04040]     100564297 (ryr3) Ion channels [BR:acs04040]  Voltage-gated cation channels   Ryanodine receptor    100564297 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 CCDC106 Motif Other DBs NCBI-GeneID:  100564297 NCBI-ProteinID:  XP_016847140 Ensembl:  ENSACAG00000015401 LinkDB All DBs Position 1:33180397..33517223 Genome browser AA seq 4872 aa AA seqDB search MAEGGDGGEDEIQFLRTDDEVVLQCVANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCICNFVLEQSLSVRALQEMLANTGDNSSEGFIRKAAQGGGHRTLLYGHAILLHHSFS GMYLTCLTTSRSQTDKLAFDVGLQENAAGEACWWTIHPASKQRSEGEKVRIGDDLILVSV SSERYLHLSVAYGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVLRLFHGHDECLTI PSTEQNDSPHKXAIYESGGAGVRARSLWRVEPLRISWSGSNIRWAQPFRLRHITTGQFLA LTEDLGLVLLDREKADTKTTSFCFRASKEKLESIHKRDIEGMGVPEIKYGDSVCFVQHVA SSLWLTYKAQDAKTTRLGPVKRKVILHQEGHMDDGLTLQRCQHEESQAARIILNTTRLFS QFISGNNRTSSPITLPIGEVLQTLQDLITYFLPPEEELEHEDKQNKLRSLKNRQNLFKEE GMLALVLNCIDRLNVYYSTAHFTGVGREENSTAWKEILNLLYKLLAALIRGNRNNCAQFS NNLDWLISKLDRLESSSGILEALHCILIESPEALNLIEEGHIKSIISLLDKHGRNHKVLD VLCSLCLCNGVAVRANQNLICDNLLPRRDLLLQTRLVNDVTSMRPNIFLGIAEGSAQYKK WYFELIIDQVDPFLTAEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHL WSGRIPRAVASVNQHLIASEDVVSCCLDLGAPSISFRINGQPVQGMFENFNIDGLFFPVV SFSAGVKVRFLMGGRHGEFKFLPPTGYVPCYEALLPKEKMKLEPVKEYKRDSNGIRDLLG TTQFVSQANFIPCPISTSQIVLPLHLEKIRDKLAENIHELWGMNKIELGWTYGKIRDDNK RQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIVHTNPGAEEDLKKIKLPKNYMM SNGYKPAPLDLSEVKLLPPQEALVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRL VPYTLLDERTKKSNRDSLREAVRTFAGYGYNIEPPDQELADQTVEKISIDKIRFFRVEKS YAVKTGKWYFEFEAVTGGDMRVGWARPGCRPDLELGADDQAFVFEGSKGQRWHEGSSFFG RNWQPGDVVGCMINLDDKSIIFTLNGELLITNKGSELAFADFEINNGLVPICSLGLSQIG RMNFGRDASTFKYYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKNHSHIAVTRI DGNIDSPPRLKVTHKTFGTQNSNADMIYCRLSMPIEFHSSFNYITSLELVDGFQKRKQIQ EFPFHAITYYYSVRIFAGQDPSSVWIGWVTPDYHFYSEHFNLNKNCTVTVTLGDERGRVH ESVKRNNCYLVWGGEAAVNSQRSGRGNVDLEIGCLVELASGMLSFTANGKELGTFYQVEP NTKLFPAVFLQPTSTNLFQFELGKLKNTMPLSAAIFKSEERNPIPQCPPRLDVQTITPVV WSRMPNYFLKVDADRVSDRHGWLVQCLEPLQMMALHIPEESRCIDILELCEQEDLMRFHF HTLKLYSSVCALGNNRVAYALCSHVDISQLFYTIDNQYLPGLLRSGFYDLLISIHLEYSK EAKLMMNNEFIIPITDETRKIKLFPDESKRHGLPGVGLSTCLKPDFKFSTPCFILSQEDH QKPSPEIPLDMLKSRAISMLTEAVYCSGAHIRDPVGGKVEFQFVPVLKLIGTLLIMGVFD DHDVKQILLLIDPYVFGEPKEETLEKTEKEDVTQIEEKAVEAGEKAIKETKTPIKGLLQT RLTESVKLQMCELLNYFCDCELKHRVEAIVSFADTYVSKLQYNQKYRYNELMQALNMSAA LTARKTKEFRSPPQEQINMLLNFQLGEDCPCPDEIREELYEFHDDLLMHCGIPLEEEEVE DKDISWAGKLRSLIYKIKGAPKTEVRETTEEEEKYPTTLKKLISRTMVSWAQEDQIQDPE LVRIMFNLLRRQYDSIGELLLALRKSYTISAASVQDTINLLAALGQIRSLLSVRMGKEEE LLMINGLGYENYFIXLLKDQFKIGILNLYLLILDYSKSILSTLSLKIAFPKMVASCCRFL CYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALEEP DLEKVVTYLAGCGLQSCPMLLAAGYPDTGWNPIEGERYLSFLRFAVFVNGESVEENASVV VKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKRDFSLDEDEEEEG VVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPL KLPTVNKDGTVSEPDMSAGFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVGFLPDLRACA SLDTVSLSTTETALALNRYICTAVFPLLTRCASLFSGTEHYVSLIDSTLHTIYRLSKGRS LTKAQRDTIEECLLAICHYLRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQCWKY YCLPSGWGNYGIAAEEELHLTEKLFWGIFDSLSSKKYDPDLFRMALPCLSAIAGALPPDY LDIQIASILEKQTSVDAEGNFDPKPVNTVNFILPEKLEYIVNKYAEHSHDKWACDKSNSG WKYAASVDENMKMHPLIRPFKTLTDKEKEIYRWPARESLKTMLAMGWSLERTKEGESTVQ QRENEKLRSVSQSSQGNGYNPAPLDLSNVVLSRELQGMVEIVAENYHNIWAKKKKIELES KGGGSHPLLVPYDTLTAKEKARDREKAQELFRFLLVNGVAITRGLNDMALDASSMEKRFA YKFLKKILKYVDSAQDFIAHLEAIVTSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHCLY FLSSPTKPLSSSGYASNKEKEMVASLFCKLAALVRHRISLFGNDATTMVSCLHILAQSLD TRTVMKSGSELVKAGLCAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVAL LPILTSIFEHVAQHHFGTDLLLGDVQVSCYRILCSLYSLGTGKNIYVERQRPALGECLAS LAAAIPVAFLEPSLNLYNPLSVFNTKTTRERAILGIPETVEEMCPEIPNLDDLMKEINNL AESGARYTEMPHVIEVTLPMLCNYLSYWWERGPENICESAGPCCTMVTSEHLSIILGNIL KIINNNLGIDEATWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAIKIVMEEEQLK ADSKTDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKKPDADSDELFRMVAE VFILWCKSHNFKREEQNFVIQNEINNLAFLTGDNKSKMSKAIQVKSGGHDQERKKSKRRG DLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYKDTEEEIKEHLRNNLHLQ EKSDDPAVKWQLNLYKDILKTDEPADSEKTVERVQRISAAVYHLEQVEQPLRSKKAVWHK LLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQKYWIETEEYSFEEKLVQDLATLPQ KSEEDEEEIEKHPDPLHQIILHFSRNALTERSKLENDPLYTAYSAMMAKSCQSGEDDDEE EEEKEKTFEEKEMEKQKTLYQQSRLHERGAAEMVLQMISASKGEMGPMVVETLKLGIAVL NGGNSVVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTL IVRERGEKVLQNDEFTKDLFRFLQLLCEGHNNDFQNYLRTQMGNTTTVNIIISTVDYLLR LQESISDFYWYYSGKDVIDDSGQRNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRL WDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLKDMVVMLLSLLEGNVVNGTIGKQMV DTLVESSSNVEMILKFFDMFLKLKDLTSSEAFKEYDPEGKGVISKKEFQKAMEGQKQYTQ SEIEFLLSCAETDENDMFNYADFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQTLLD PAGSVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEG GEQEKMELFVNFCEDTIFEMQLASQISESDTTDRPEEEEEDEHCYVREVGEDEKEEQSLE SASAFALACATAKKNATTIIKTIRLKNLRKQYRKVKKMTLKELVKVFFSFLWMLFIGFFQ MLFAIIWGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDVLESEKAEVTE HGITAEIVQFVKNEKEESDILSDIFGIHTNKESGSKHGHDIGLGDIADIIGSETPPSLES AVHKKKKAQTGEIGRDDESETRTESEKADIENGEKQDKIKDDEYSEHLEIDESKKRKRRR GQKIEKPDAVMANFFKVLEVYQTKMLHCLARNFYNLRFLALFVAFAINFILLFYKVTEEP FEEMEEDSDLWHALDEDEDEDGVVFYVLQESTGYMAPTLRALAVIHTIISFVCVIGYYCL KVPLVVFKREKDIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKV INKYGDLYGAERIAELLGLDKNALDFSPVEHTELEEASLISWLSSVDAKYRIWKLGVVFT DNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLA VVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPA GDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGN DYFDTTPHGFEMHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAG DCFRKQYEDQLG NT seq 14619 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggcgacggaggggaagacgaaatacagttcctgcgaactgatgatgaa gtggtgcttcagtgtgttgccaacattcacaaagaacagcgaaagttctgcctggcagct gagggacttggaaatcgcctgtgctttttagagccgacttcagaagctaaatatgtccct cccgacctttgcatctgtaactttgtgctggaacagtctctgtctgtgagagccctccag gaaatgcttgccaatacaggagacaattccagtgaagggtttataagaaaggctgctcaa ggtggtggtcataggacactactgtatggccatgctatcctgcttcatcattcattcagt ggaatgtatttgacttgtttgactacatcaagatctcagacggataaacttgcatttgat gttggactacaagagaatgcagcaggtgaagcatgctggtggactatacatcctgcttct aaacaaaggtctgaaggagaaaaagtgcggattggagatgatcttatcctggttagtgtg tcttctgaaagatacctgcatctgtctgtagcatatggaaacatacaagtggatgcctcc tttatgcaaactttgtggaacgtgcatcccacttgttcaggaagtagcattgaagaagga tacctactcggagggcatgtattacgtttatttcatggccacgatgagtgtttgacaatc ccatcaacagaacagaatgattcaccacataagtaagctatttatgaatcaggaggagct ggtgtccgggcaaggtctctgtggagagtagaaccacttagaataagctggagtggaagt aacatacgttgggcacagccctttcgtcttcgacacattacaacaggacagtttttggcc ttgactgaagacctgggtttagtcttattagacagagaaaaggctgacacaaaaacaaca tcattttgttttagagcatcaaaggaaaaactggagtccattcacaagcgcgatattgag ggcatgggagttcctgaaataaagtatggtgattctgtttgtttcgtgcagcatgtagcc agtagtttgtggctgacgtacaaagctcaggatgctaaaacaacacgtttaggaccagtg aaaagaaaggttatattacatcaagaaggccacatggatgatggtctcacattgcaaagg tgtcaacatgaggagtcccaggctgctagaataattctaaatacaacaagattatttagt caatttataagtggaaacaatagaacttcatctcccatcaccttacccattggagaagta cttcagactctgcaagatctgattacatattttcttcctccagaggaggagctagaacac gaggataaacaaaataaacttcgttcactcaagaacagacaaaatctatttaaagaagag gggatgttggcactggttttgaactgcattgatagattaaatgtctattatagcaccgct cactttactggagttggtagagaagaaaatagtacagcatggaaagaaattctgaatctt ctttacaagctattggctgctctcatccgtggtaatagaaacaattgtgctcaattttcc aataatcttgattggctgattagtaaattggaccgactagaatcttcttcaggtattttg gaagcgttacattgcatcttaattgaaagtccagaagctttaaatttgatagaagaagga catatcaaatctataatctcattgctggataaacatgggcgcaatcataaggtccttgat gtactgtgctccctctgtctctgtaatggagtagcagtgcgtgctaatcagaacttaatc tgtgacaatcttcttccacgaagagatttactcttgcaaacacgactggtgaatgatgtg acaagtatgagaccaaatatattcctgggaattgctgaaggctcagcacagtataagaaa tggtattttgaactaattattgatcaagtggacccctttttaacagcagagcctacacat ctacgggttggctgggcctcaacatcgggctatgctccttatcctggaggtggagaaggt tggggaggcaatggagtcggtgatgacctatactcatatggttttgatggacttcatcta tggtctggtcgaatacccagagctgttgcatctgtgaatcaacatttgatagcttcggaa gatgtagtcagctgttgcttggatttaggtgcaccgagcatttcgttccgtattaatgga cagcctgtgcaaggaatgtttgagaattttaacattgatggactttttttcccagtagta agcttttctgcaggtgtcaaagtgcgtttcttaatgggtggacgtcatggagagttcaag tttctacctcctactggctatgtgccttgctatgaagctttgcttcctaaagagaagatg aaattggagccagtgaaagaatataagagagattccaatggaattagagatttgcttggc acaacacaatttgtctcccaagctaattttatcccttgtccaattagcaccagccagatt gtattgcctcttcatcttgagaagattagagataagcttgctgaaaatattcatgaactt tggggaatgaataaaatagaacttggctggacttatggcaagatacgagatgataacaaa aggcagcacccttgtctggtggaattttcaaaattacctgaaacagagaagaattataac ttgcaaatgtcaacagaaactctgaaaactcttttggctcttggatgccatattgtacat acaaatccaggagcagaggaagaccttaaaaaaataaaacttccaaaaaattatatgatg tcaaatggctataagccagcccctctagacctctctgaagtaaaattgttgcctccccaa gaagcattggttgataaacttgcagagaatgcacataacgtctgggcaaaagacagaata aaacaaggatggacatatggcattcaacaggatctcaaaaacaaaagaaatccacgattg gtgccatatacattattagatgaacgtactaagaagtcaaacagagatagcctacgtgaa gctgttcgcacctttgctggttatggatataacattgaaccaccagatcaagaattagct gaccaaactgtggaaaaaataagcatagataagatacgtttcttcagagtggagaagtct tacgcagtgaagactggaaaatggtattttgaatttgaagcggttacaggaggagacatg cgtgttggatgggcaaggccaggttgtcggcctgaccttgaactaggagctgatgaccaa gcatttgtgtttgaaggcagcaaaggtcagcgttggcacgaagggagtagcttctttgga cgaaattggcaaccaggagatgtagtgggatgcatgatcaatctagatgacaaatcaata atatttacactgaatggagaattgcttattaccaacaaaggttcagaacttgcttttgca gactttgagataaataatggtttggtgcctatatgctcactgggtctgtctcagattggc cgtatgaattttggaagggacgccagcaccttcaaatattataccatgtgtggtcttcaa gaaggctttgaaccttttgctgttaacatgaacagagatgttgctatgtggtttagcaaa cgtttgccaacgtttgtcaatgtgcctaaaaaccactctcatattgcggtgacaagaata gatgggaacattgacagcccaccacgcttaaaagtaacccataaaacatttggaacacag aatagcaatgcagatatgatatactgtcgcctgagcatgccaattgaatttcactcatct tttaactacatcactagtttggaacttgttgatggtttccaaaaaagaaaacaaattcag gagtttccttttcatgccataacgtattattattcagtgcgaatctttgctggacaagac ccatcttcagtttggattggttgggtgactcctgactaccacttttacagtgaacatttt aacctaaataagaattgcacagtaacagttactttgggagatgaaagaggcagagttcat gaaagtgtaaaacgcaacaattgctacttggtctggggaggagaagctgctgttaactca caaagatcaggtcgtggtaatgttgatttagaaattggatgccttgttgaattggcttct ggaatgctgtcatttacagccaatggaaaagagctgggaactttctaccaggttgaacca aacacaaaactatttccagcagtttttttacagcctacaagcacaaacctgtttcagttt gaactgggtaaattaaagaacacaatgcctttatcagcagcaatatttaaaagtgaagag cgaaaccctattccccagtgccctccacgactggatgttcaaacaatcacacctgttgtg tggagcagaatgccaaactatttcttaaaagtagacgctgaccgagtcagtgaccgacat gggtggttggtgcagtgcctggaacctttgcagatgatggcccttcatattccagaagaa agcaggtgtattgatattttggagctatgcgaacaagaagatctgatgaggttccatttc catacgttaaaactgtatagttcagtttgtgcactgggaaacaacagagtagcttatgca ctttgcagccatgtggatatttcccagttattttatacaatagataatcaatatttacct gggttattgcgttctggattttatgacttgctgatcagcattcatttagaatactccaaa gaggctaagctgatgatgaacaatgaatttataattccaattacagatgaaactagaaaa atcaaattatttccagatgaatcaaagagacatggtttgccaggagttgggcttagcacc tgcctgaaaccagattttaagttttctaccccttgcttcattttgtctcaagaggatcat cagaagcccagtccagaaataccacttgatatgcttaaatccagggctataagcatgctt acagaagcagtttattgtagtggagctcacatacgagatcctgttggagggaaagttgaa ttccagtttgttcctgtacttaaacttataggaactttgctcataatgggagtctttgat gatcatgatgtgaaacagattttacttctcatcgatccatatgtttttggtgaaccaaaa gaagaaacactagagaaaacagagaaggaggatgttacacaaattgaagaaaaagcagta gaggcgggagaaaaggcaatcaaggaaacaaaaacgccaattaaaggcttgctgcaaaca agattgactgaatctgttaaactccagatgtgtgagctgctaaattatttctgcgactgt gagctgaaacacagagtggaagccattgtatctttcgcagacacatatgtctcaaagttg cagtataatcagaaatacagatataatgaacttatgcaagctttgaatatgtctgctgct ttgactgccaggaagaccaaggaatttcgctcccctcctcaagagcagattaatatgtta ctaaattttcaactgggggaagattgtccttgtccagatgagattcgggaagagctttat gagtttcatgatgatctcctgatgcattgtggtattcctttagaggaagaagaggtggaa gataaagatatatcatgggctgggaaactacgttcattgatatataaaataaaaggtgca ccaaaaactgaagtgagagaaactacagaagaagaagaaaaatatcccactacattgaag aagttgatatctcggacgatggtttcctgggctcaggaagaccagatccaagacccagaa ttagttcgtattatgtttaatctccttcgacgacaatatgacagcattggtgaactgctg ctggctctgaggaagtcctatactatcagtgctgcctctgtgcaggatacaataaactta ctagcagcactgggtcaaattcgctctcttcttagtgtcagaatgggaaaagaagaagaa ttgcttatgattaatggtcttgggtatgaaaattattttatatgactccttaaagaccag tttaagatcggaatattaaacctttatttattgatccttgattatagtaaatccattctg tcaactctgtctctaaaaattgcttttccaaaaatggtagcaagttgttgtcggtttctg tgctatttctgtcgaatcagtcgccagaatcaaaaagccatgtttgaacacctcagctac ttacttgaaaatagcagtgtgggacttgcttctccttccatgaggggttctactccacta gatgtagcagctgcttctgtaatggataataatgagcttgcacttgcattggaggagcca gacttagaaaaggttgtaacctacttggcaggttgtggacttcagagttgcccaatgttg ctagctgcaggataccctgatacaggctggaatccaatagagggtgaacgatatctatcc tttttaaggtttgcagtttttgttaatggtgaaagtgttgaggaaaatgccagtgttgtt gtcaagcttcttattcgacgcccagaatgttttggtcctgctcttagaggagaaggagga aatggtttgttggctgctatgcaaggagcaattaagatctctgagaacccagctcttgat ctcccctctcaaggatacaagagagatttcagtcttgatgaagatgaagaagaggaagga gtagtgcacatgggcaatgcaattatgtccttttactctgctcttatagatttacttgga cgttgtgcaccagaaatgcatcttatccaaactggaaaaggagaagctattcgaatccgg tccatcttgcgttccctggtaccaaccgaagatttggttggaataataagcataccatta aaattaccaacagtcaacaaggatggaactgttagtgagccagacatgtctgcaggtttc tgccctgaccataaggcacccatggtcctctttctagatcgtgtctatggtataaaggat caaagttttcttctccatctccttgaagttggatttttaccagatttaagagcttgtgca tcattagatacagtttctttgagtactacagagacagctcttgctctaaatagatatatt tgcacagctgtgtttccattactcacacgatgtgcttctctcttttcgggaactgagcat tatgtctcactgattgattccacacttcatacaatatatcgcctatccaaaggacgctct ctaacaaaagcacaaagggacactattgaagaatgcttgcttgctatctgtcactattta cgtccttccatgctacagcagcttttgcgacgactagtctttgatgtacctttacttaat gaatattgtaaaatgcctcttaagcttttaacaaatcactatgagcaatgctggaaatat tactgtttgccttcaggatggggaaattatggaattgcagctgaagaagagctacattta actgaaaaacttttctggggaatatttgattctctttcttctaagaagtatgatccagat ctcttccgtatggccttgccttgtttaagtgcaatagctggggctttgccaccagattat ttagacatccaaattgcctcaattttagaaaagcaaacttcagtggatgctgaaggaaac tttgatcccaaacctgttaacacagtgaattttatacttcctgagaagttggaatatatt gtcaacaagtatgctgaacattcacatgataaatgggcctgtgacaagagtaatagtgga tggaagtatgctgcttcagttgatgaaaatatgaagatgcatcctttaataagacccttt aaaacattgactgacaaggaaaaggaaatctaccgatggcctgccagagaatcacttaaa accatgttagcaatgggatggagtctagaaaggaccaaagaaggcgaatcgacagtccag cagcgtgaaaatgagaagctccgcagtgtatcacagtccagccaaggaaatggatacaac ccagcaccacttgatctttcaaacgttgtactctctagagaacttcagggaatggtggaa atagtggcagaaaactatcataacatttgggctaaaaagaagaaaattgaattagaaagt aaaggtggtggtagtcatcctttattggtcccatatgacactttaacagccaaagaaaag gctcgagatagggagaaagcacaagaacttttcagatttcttctagtgaatggtgttgct ataacaaggggcttaaatgacatggcattggatgcttcatccatggagaagcgatttgct tataaatttctgaagaagattctcaaatatgttgattctgctcaagacttcattgcacat ttagaagccattgtcaccagtggaaaaacagaaaaatccccacatgaccaagaaatcaaa ttttttgccaaagttctgctgccattagttgatcagtattttaccaatcattgcctgtac tttctctcttcccccaccaaacctctcagcagtagtgggtatgcttcaaataaagaaaag gaaatggtagcaagccttttctgcaaacttgctgctcttgttagacatagaatttcactt tttggtaatgatgctactacaatggtgagctgcctacatattttggctcagtcattagat acaagaaccgtcatgaaatctggctcagaactggttaaagctgggttatgtgccttcttt gaaaatgcagctgaagatcttgagaagacatcagaaaatcttaaacttggaaaatttacc cattcccgaacacaaattaaaggagtttctcagaatatcaactacacaacagtcgcactc ttgcctattttgacatctatttttgaacatgttgcacagcatcattttggcactgattta cttttaggtgatgtccaagtttcatgttacagaattctttgtagcctatattcccttgga actgggaagaacatttatgtcgagaggcaaaggccagcacttggtgagtgcttggcttct cttgcagcagcaattccagtggcctttcttgaaccttcactcaacctttacaatcccctc tctgtcttcaacacaaaaactaccagagagagagctattttaggcatacctgaaactgta gaagaaatgtgtccagaaattcctaacttggatgacttaatgaaagaaataaacaacttg gcagaatcaggagccagatataccgaaatgcctcatgtgattgaagtgaccttgcccatg ctgtgcaattacctatcatactggtgggaaaggggacccgaaaacatctgtgaaagtgct gggccctgctgcacaatggtcacctctgaacatcttagcataatactgggaaacattttg aaaataatcaacaacaaccttgggatagatgaagcaacctggatgaaaagaattgcagtg tatgctcagccaatcattagtaaagccagaccagatttgttgaaaagtcatttcattcca accctggaaaaactaaagaagaaggccataaagattgtgatggaagaagaacagttgaaa gcagacagtaaaactgatactcaagaagcagaacttctcattctggatgaattcgcagtt ctttgccgagacctttatgctttttatcctatgttgatccgatatgtagacaacaacaga tcaaactggcttaaaaagccagatgcagattctgatgaacttttccgaatggtagctgaa gtttttatcctctggtgtaaatcacataatttcaagagagaagaacaaaattttgtgatt cagaatgaaatcaacaatttggcatttttgacaggagataacaaaagtaagatgtcaaag gccattcaagtaaagtctggtggtcatgatcaagaacgaaagaaatcaaaacgcagagga gatttgtactcaatacagacttctctaattgtagctgcacttaaaaaaatgcttcccatc ggattgaatatgtgtactcctggagatcaagaattaatttctcttgctaagtccagatat agctataaagacacagaagaagagatcaaagaacatttacgcaataatttgcatttacag gagaagtcagatgacccagctgtgaaatggcagttgaatctatacaaagacatcttgaaa actgatgaacctgctgattctgagaaaactgtggaacgtgtgcagaggatctcagctgct gtgtatcatctggaacaggttgagcaaccattaagatcaaagaaagcagtttggcacaaa ctcttgtcaaagcaacgtaaaagagctgttgttgcttgtttcaggatggcaccattgtat aatctaccaaggcaccgttctattaacctgttcctccatggctatcagaaatattggata gaaacagaggaatattcctttgaggagaaactagttcaggatctggctactctcccacaa aaaagtgaagaggatgaggaagagattgaaaagcatcctgaccctcttcatcagattatt cttcatttcagtcggaatgctctcactgagagaagcaaattggaaaatgaccctttgtat actgcatattcagcaatgatggcaaagagctgccagagtggagaagatgatgatgaagag gaagaggaaaaagagaaaacatttgaggaaaaagaaatggaaaagcaaaaaacactgtat caacaatctcggcttcatgaacgtggagctgctgagatggtactacagatgattagtgcc agtaaaggtgaaatggggccaatggtagttgaaaccttaaaacttggcattgctgttcta aatggaggtaactcagttgttcaacagaaaatgttggattatctgaaggagaaaaaagat gctggattttttcagtctctgtctggcttaatgcagtcttgcagtgttcttgacttgaat gcctttgagagacaaaataaagcagaaggccttgggatggttactgaagaaggaacactc atcgtacgtgagcgtggtgagaaagtactacagaatgatgagtttactaaagatctgttt agatttttacaactgctgtgtgaaggccataacaatgattttcagaattatttacgtact cagatgggcaatactacaacagtgaatattattattagcacagttgactatctattacgt cttcaggaatccattagtgacttctattggtactactctggaaaagatgtaattgatgat tctggacaacgtaacttctctaaagcattagctgtcaccaagcagatttttaattcactt actgaatatattcaaggtccttgtattggaaaccaacagagcctggctcacagcagattg tgggatgcagttgttggctttcttcatgtttttgctaacatgcaaatgaaactttctcag gattccagccaaattgaactgctgaaggagctattggatcttctgaaggatatggtggtg atgctgttgtcactacttgaaggtaatgtcgtaaatggcacaattgggaaacagatggtg gacactctggtcgagtcatctagcaatgtagaaatgatcttgaagttcttcgacatgttt ctcaagctgaaagatctaacaagttctgaagcattcaaagagtatgatccagaaggcaaa ggtgtaatctcaaagaaggaattccagaaagccatggaaggtcaaaagcaatatacacaa tcagagattgagttcctgttgtcctgtgcagaaacagatgaaaatgacatgtttaattat gctgactttgttgaaagatttcatgagccagccaaagatattggatttaatgtggcagta ctcttaacaaacctttcagaacatatgccaaatgattcacggcttcagactttgttagat ccagcaggaagtgttcttaattattttgaaccttacctgggacgcattgaaatcatggga ggtgccaagaagatagagcgggtttattttgagatcagtgaatctagtaggacacagtgg gaaaagcctcaagttaaagaatcgaagcgtcagtttatttttgatgttgtaaacgaaggt ggagaacaagaaaaaatggaactttttgtaaacttttgcgaagacactatttttgaaatg cagttggcatctcagatctctgaatcggacacaactgacagacctgaggaggaggaggag gatgaacattgctatgtgagggaagttggagaagatgagaaagaagagcaatctcttgaa tcagcttcagcttttgctttagcatgtgctacagcaaagaaaaatgctaccaccattatt aaaacaattagactgaaaaatctaagaaaacagtatagaaaagtgaaaaagatgacttta aaagaattggtgaaagtgtttttttcttttctgtggatgctattcatagggttcttccaa atgcttttcgccataatatggggtattttccagattctttggagcactgtgtttgggggt ggcctagtggaaggagccaaaaatataagagttaccaaaattttaggagatatgcctgat ccaacccagtttggaatccacgatgatgtcctagaatcagagaaagctgaagttacagaa catggtattacggctgaaattgttcaatttgtaaaaaatgaaaaagaagaaagtgacatc ttgtctgatatttttggcattcatacgaataaagaaagtggatcaaaacatggccatgac attggccttggggatattgcagatattattggatccgaaacgcctccttctttggaaagt gcagttcacaagaagaaaaaagcacagacaggtgaaatcggaagggatgatgaatcagaa acaagaacagaatctgagaaggctgacattgagaatggtgagaaacaagataaaataaag gatgacgaatactctgaacatttggaaattgacgaatccaagaaaagaaaacgaagacgt gggcaaaaaatagagaagcctgatgcagttatggctaatttttttaaagtgctggaagtg tatcagacaaaaatgttgcactgtttggccagaaatttctacaatttacgatttcttgca ctttttgttgcatttgccatcaactttattctactgttctacaaggtgacagaggagcca tttgaagagatggaagaagattctgatctttggcatgctttagatgaggatgaagatgaa gatggagtggtgttctatgtcttacaagagagtacaggctatatggcaccaacactgaga gctctagctgttattcacacgatcatctcttttgtatgtgttattggatattattgttta aaggttccccttgttgttttcaaacgagagaaggacattgcaaggaaactagaatttgat ggtttgtacattactgaacagccctctgaagatgatattaaaggacagtgggatcggcta gtcataaacactccgtcttttccaaataattattgggacaaatttgtaaaacgaaaggta atcaacaagtatggtgatttatatggagcagaacgcattgcagaacttttgggtctggat aaaaacgctttggatttcagtcctgtagaacatactgaactagaggaagcatctcttatt tcatggttaagttctgttgatgccaagtatcgtatctggaaacttggtgtagttttcact gataattccttcttgtacttagcgtggtacacaactatgtctatccttggtcactacaac aacttcttctttgctgctcacttgcttgatattgctatgggctttaagacactacgtacc atcctgtcttctgtaacccacaatggtaaacagctcgtgttgactgttggactcttggct gtagtggtgtacctatatacagttgttgcattcaacttcttccgcaaattttataacaag agtgaagatgaagatgagccagacatgaaatgcgatgatatgatgacatgttacctgttc catatgtatgtgggtgtaagagcaggcggaggcatcggagatgaaattgaagaccctgca ggagatccatacgaaatgtatagaattgtttttgatatcacatttttcttttttgttatt gtcatcctactggccatcattcaaggtctgattattgatgcctttggcgaattaagagac cagcaagagcaagttaaagaagacatggagaccaaatgctttatttgtggaattggtaat gactattttgacacaactccccatggatttgaaatgcatactttacaagagcacaacctg gccaattatctgttctttctgatgtatcttattaataaggatgaaactgagcacactgga caggaatcatatgtgtggaaaatgtatcaagaaagatgctgggatttcttcccagctgga gactgcttccgaaaacagtatgaagatcaacttggatga

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