KEGG   PATHWAY: acx03070
Entry
acx03070                    Pathway                                
Name
Bacterial secretion system - Azotobacter chroococcum
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
acx03070  Bacterial secretion system
acx03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Azotobacter chroococcum [GN:acx]
Gene
Achr_26820  Type I secretion outer membrane protein, TolC family [KO:K12340]
Achr_15720  hlyD; Type I secretion membrane fusion protein, HlyD family [KO:K11003]
Achr_15710  Type I secretion system ABC transporter, HlyB family [KO:K11004]
Achr_18680  type II and III secretion system protein [KO:K02453]
Achr_36010  gspD; general secretion pathway protein D [KO:K02453]
Achr_8610  General secretion pathway protein D [KO:K02453]
Achr_35990  general secretion pathway protein C [KO:K02452]
Achr_19150  gspF; Type II secretion system protein F [KO:K02455]
Achr_36030  gspF; General secretion pathway protein F [KO:K02455]
Achr_18690  G protein signal peptide-like secretion type II protein [KO:K02456]
Achr_18700  Type II secretion system protein G [KO:K02456]
Achr_19160  gspG1; General secretion pathway protein G [KO:K02456]
Achr_36040  gspG; general secretion pathway protein G [KO:K02456]
Achr_36050  general secretion pathway protein H [KO:K02457]
Achr_36060  general secretion pathway protein I [KO:K02458]
Achr_36070  general secretion pathway protein J [KO:K02459]
Achr_36080  gspK; General secretion pathway protein K [KO:K02460]
Achr_36090  gspL; general secretion pathway protein L [KO:K02461]
Achr_36100  general secretion pathway protein M [KO:K02462]
Achr_18630  Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [KO:K02454] [EC:7.4.2.8]
Achr_36020  gspE; general secretion pathway protein E [KO:K02454] [EC:7.4.2.8]
Achr_36250  Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [KO:K02454] [EC:7.4.2.8]
Achr_9970  secD; Preprotein translocase subunit SecD [KO:K03072]
Achr_9980  secF; preprotein translocase subunit SecF [KO:K03074]
Achr_35230  secE; Preprotein translocase subunit SecE [KO:K03073]
Achr_7780  secG; Preprotein translocase subunit SecG [KO:K03075]
Achr_34870  secY; preprotein translocase, SecY subunit [KO:K03076]
Achr_9960  yajC; Preprotein translocase subunit YajC [KO:K03210]
Achr_40770  putative inner membrane protein translocase component YidC [KO:K03217]
Achr_29320  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
Achr_37470  ftsY; Signal recognition particle receptor FtsY [KO:K03110]
Achr_36400  secB; preprotein translocase subunit SecB [KO:K03071]
Achr_10670  ffh; Signal recognition particle protein Ffh [KO:K03106] [EC:3.6.5.4]
Achr_6430  tatA; Sec-independent protein translocase protein TatA (Precursor) [KO:K03116]
Achr_6420  tatB; Sec-independent protein translocase protein TatB (Precursor) [KO:K03117]
Achr_6410  tatC; Sec-independent protein translocase protein TatC [KO:K03118]
Achr_c180  traG; Conjugal transfer coupling protein TraG [KO:K03205] [EC:7.4.2.8]
Achr_9450  Hypothetical protein [KO:K11903]
Achr_40580  Serine/threonine protein kinase PpkA related protein [KO:K11912] [EC:2.7.11.1]
Achr_24380  Hypothetical protein [KO:K11912] [EC:2.7.11.1]
Compound
C00002  ATP
Reference
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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