| Entry |
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| Symbol |
pikAI
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| Name |
(KEGG) 10-deoxymethynolide/narbonolide synthase
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| KO |
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| Taxonomy |
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| Lineage |
Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces |
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| Organism |
Streptomyces venezuelae
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| AA seq |
4613 aa
MSSAGITRTGARTPVTGRGAAAWDTGEVRVRRGLPPAGPDHAEHSFSRAPTGDVRAELIR
GEMSTVSKSESEEFVSVSNDAGSAHGTAEPVAVVGISCRVPGARDPREFWELLAAGGQAV
TDVPADRWNAGDFYDPDRSAPGRSNSRWGGFIEDVDRFDAAFFGISPREAAEMDPQQRLA
LELGWEALERAGIDPSSLTGTRTGVFAGAIWDDYATLKHRQGGAAITPHTVTGLHRGIIA
NRLSYTLGLRGPSMVVDSGQSSSLVAVHLACESLRRGESELALAGGVSLNLVPDSIIGAS
KFGGLSPDGRAYTFDARANGYVRGEGGGFVVLKRLSRAVADGDPVLAVIRGSAVNNGGAA
QGMTTPDAQAQEAVLREAHERAGTAPADVRYVELHGTGTPVGDPIEAAALGAALGTGRPA
GQPLLVGSVKTNIGHLEGAAGIAGLIKAVLAVRGRALPASLNYETPNPAIPFEELNLRVN
TEYLPWEPEHDGQRMVVGVSSFGMGGTNAHVVLEEAPGGCRGASVVESTVGGSAVGGGVV
PWVVSAKSAAALDAQIERLAAFASRDRTDGVDAGAVDAGAVDAGAVARVLAGGRAQFEHR
AVVVGSGPDDLAAALAAPEGLVRGVASGVGRVAFVFPGQGTQWAGMGAELLDSSAVFAAA
MAECEAALSPYVDWSLEAVVRQAPGAPTLERVDVVQPVTFAVMVSLARVWQHHGVTPQAV
VGHSQGEIAAAYVAGALSLDDAARVVTLRSKSIAAHLAGKGGMLSLALSEDAVLERLAGF
DGLSVAAVNGPTATVVSGDPVQIEELARACEADGVRARVIPVDYASHSRQVEIIESELAE
VLAGLSPQAPRVPFFSTLEGAWITEPVLDGGYWYRNLRHRVGFAPAVETLATDEGFTHFV
EVSAHPVLTMALPGTVTGLATLRRDNGGQDRLVASLAEAWANGLAVDWSPLLPSATGHHS
DLPTYAFQTERHWLGEIEALAPAGEPAVQPAVLRTEAAEPAELDRDEQLRVILDKVRAQT
AQVLGYATGGQIEVDRTFREAGCTSLTGVDLRNRINAAFGVRMAPSMIFDFPTPEALAEQ
LLLVVHGEAAANPAGAEPAPVAAAGAVDEPVAIVGMACRLPGGVASPEDLWRLVAGGGDA
ISEFPQDRGWDVEGLYHPDPEHPGTSYVRQGGFIENVAGFDAAFFGISPREALAMDPQQR
LLLETSWEAVEDAGIDPTSLRGRQVGVFTGAMTHEYGPSLRDGGEGLDGYLLTGNTASVM
SGRVSYTLGLEGPALTVDTACSSSLVALHLAVQALRKGEVDMALAGGVAVMPTPGMFVEF
SRQRGLAGDGRSKAFAASADGTSWSEGVGVLLVERLSDARRNGHQVLAVVRGSALNQDGA
SNGLTAPNGPSQQRVIRRALADARLTTSDVDVVEAHGTGTRLGDPIEAQALIATYGQGRD
DEQPLRLGSLKSNIGHTQAAAGVSGVIKMVQAMRHGLLPKTLHVDEPSDQIDWSAGAVEL
LTEAVDWPEKQDGGLRRAAVSSFGISGTNAHVVLEEAPVVVEGASVVEPSVGGSAVGGGV
TPWVVSAKSAAALDAQIERLAAFASRDRTDDADAGAVDAGAVAHVLADGRAQFEHRAVAL
GAGADDLVQALADPDGLIRGTASGVGRVAFVFPGQGTQWAGMGAELLDSSAVFAAAMAEC
EAALSPYVDWSLEAVVRQAPGAPTLERVDVVQPVTFAVMVSLARVWQHHGVTPQAVVGHS
QGEIAAAYVAGALPLDDAARVVTLRSKSIAAHLAGKGGMLSLALNEDAVLERLSDFDGLS
VAAVNGPTATVVSGDPVQIEELAQACKADGFRARIIPVDYASHSRQVEIIESELAQVLAG
LSPQAPRVPFFSTLEGTWITEPVLDGTYWYRNLRHRVGFAPAIETLAVDEGFTHFVEVSA
HPVLTMTLPETVTGLGTLRREQGGQERLVTSLAEAWVNGLPVAWTSLLPATASRPGLPTY
AFQAERYWLENTPAALATGDDWRYRIDWKRLPAAEGSERTGLSGRWLAVTPEDHSAQAAA
VLTALVDAGAKVEVLTAGADDDREALAARLTALTTGDGFTGVVSLLDGLVPQVAWVQALG
DAGIKAPLWSVTQGAVSVGRLDTPADPDRAMLWGLGRVVALEHPERWAGLVDLPAQPDAA
ALAHLVTALSGATGEDQIAIRTTGLHARRLARAPLHGRRPTRDWQPHGTVLITGGTGALG
SHAARWMAHHGAEHLLLVSRSGEQAPGATQLTAELTASGARVTIAACDVADPHAMRTLLD
AIPAETPLTAVVHTAGALDDGIVDTLTAEQVRRAHRAKAVGASVLDELTRDLDLDAFVLF
SSVSSTLGIPGQGNYAPHNAYLDALAARRRATGRSAVSVAWGPWDGGGMAAGDGVAERLR
NHGVPGMDPELALAALESALGRDETAITVADIDWDRFYLAYSSGRPQPLVEELPEVRRII
DARDSATSGQGGSSAQGANPLAERLAAAAPGERTEILLGLVRAQAAAVLRMRSPEDVAAD
RAFKDIGFDSLAGVELRNRLTRATGLQLPATLVFDHPTPLALVSLLRSEFLGDEETADAR
RSAALPATVGAGAGAGAGTDADDDPIAIVAMSCRYPGDIRSPEDLWRMLSEGGEGITPFP
TDRGWDLDGLYDADPDALGRAYVREGGFLHDAAEFDAEFFGVSPREALAMDPQQRMLLTT
SWEAFERAGIEPASLRGSSTGVFIGLSYQDYAARVPNAPRGVEGYLLTGSTPSVASGRIA
YTFGLEGPATTVDTACSSSLTALHLAVRALRSGECTMALAGGVAMMATPHMFVEFSRQRA
LAPDGRSKAFSADADGFGAAEGVGLLLVERLSDARRNGHPVLAVVRGTAVNQDGASNGLT
APNGPSQQRVIRQALADARLAPGDIDAVETHGTGTSLGDPIEAQGLQATYGKERPAERPL
AIGSVKSNIGHTQAAAGAAGIIKMVLAMRHGTLPKTLHADEPSPHVDWANSGLALVTEPI
DWPAGTGPRRAAVSSFGISGTNAHVVLEQAPDAAGEVLGADEVPEVSETVAMAGTAGTSE
VAEGSEASEAPAAPGSREASLPGHLPWVLSAKDEQSLRGQAAALHAWLSEPAADLSDADG
PARLRDVGYTLATSRTAFAHRAAVTAADRDGFLDGLATLAQGGTSAHVHLDTARDGTTAF
LFTGQGSQRPGAGRELYDRHPVFARALDEICAHLDGHLELPLLDVMFAAEGSAEAALLDE
TRYTQCALFALEVALFRLVESWGMRPAALLGHSVGEIAAAHVAGVFSLADAARLVAARGR
LMQELPAGGAMLAVQAAEDEIRVWLETEERYAGRLDVAAVNGPEAAVLSGDADAAREAEA
YWSGLGRRTRALRVSHAFHSAHMDGMLDGFRAVLETVEFRRPSLTVVSNVTGLAAGPDDL
CDPEYWVRHVRGTVRFLDGVRVLRDLGVRTCLELGPDGVLTAMAADGLADTPADSAAGSP
VGSPAGSPADSAAGALRPRPLLVALLRRKRSETETVADALGRAHAHGTGPDWHAWFAGSG
AHRVDLPTYSFRRDRYWLDAPAADTAVDTAGLGLGTADHPLLGAVVSLPDRDGLLLTGRL
SLRTHPWLADHAVLGSVLLPGAAMVELAAHAAESAGLRDVRELTLLEPLVLPEHGGVELR
VTVGAPAGEPGGESAGDGARPVSLHSRLADAPAGTAWSCHATGLLATDRPELPVAPDRAA
MWPPQGAEEVPLDGLYERLDGNGLAFGPLFQGLNAVWRYEGEVFADIALPATTNATAPAT
ANGGGSAAAAPYGIHPALLDASLHAIAVGGLVDEPELVRVPFHWSGVTVHAAGAAAARVR
LASAGTDAVSLSLTDGEGRPLVSVERLTLRPVTADQAAASRVGGLMHRVAWRPYALASSG
EQDPHATSYGPTAVLGKDELKVAAALESAGVEVGLYPDLAALSQDVAAGAPAPRTVLAPL
PAGPADGGAEGVRGTVARTLELLQAWLADEHLAGTRLLLVTRGAVRDPEGSGADDGGEDL
SHAAAWGLVRTAQTENPGRFGLLDLADDASSYRTLPSVLSDAGLRDEPQLALHDGTIRLA
RLASVRPETGTAAPALAPEGTVLLTGGTGGLGGLVARHVVGEWGVRRLLLVSRRGTDAPG
ADELVHELEALGADVSVAACDVADREALTAVLDAIPAEHPLTAVVHTAGVLSDGTLPSMT
TEDVEHVLRPKVDAAFLLDELTSTPAYDLAAFVMFSSAAAVFGGAGQGAYAAANATLDAL
AWRRRAAGLPALSLGWGLWAETSGMTGELGQADLRRMSRAGIGGISDAEGIALLDAALRD
DRHPVLLPLRLDAAGLRDAAGNDPAGIPALFRDVVGARTVRARPSAASASTTAGTAGTPG
TADGAAETAAVTLADRAATVDGPARQRLLLEFVVGEVAEVLGHARGHRIDAERGFLDLGF
DSLTAVELRNRLNSAGGLALPATLVFDHPSPAALASHLDAELPRGASDQDGAGNRNGNEN
GTTASRSTAETDALLAQLTRLEGALVLTGLSDAPGSEEVLEHLRSLRSMVTGETGTGTAS
GAPDGAGSGAEDRPWAAGDGAGGGSEDGAGVPDFMNASAEELFGLLDQDPSTD |
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| Reference |
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| Authors |
Xue Y, Zhao L, Liu HW, Sherman DH |
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| Title |
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity. |
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| Journal |
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