Entry Symbol tylF
Name (KEGG) macrocin O-methyltransferase (EC:2.1.1.101)
KO Taxonomy Lineage Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces
Organism Streptomyces fradiae
Taxonomy Module 1906_M00773 Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
SSDB Ortholog Paralog GFIT Motif Motif Other DBs LinkDB All DBs AA seq 256 aa AA seq DB search Reference Authors Kreuzman AJ, Turner JR, Yeh WK
Title Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism.
Journal J Biol Chem 263:15626-33 (1988)
