Acinonyx jubatus (cheetah): 106969802 Help Entry 106969802         CDS       T04657                                  Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism aju  Acinonyx jubatus (cheetah) Pathway aju04020   Calcium signaling pathway aju04371   Apelin signaling pathway aju04713   Circadian entrainment aju04921   Oxytocin signaling pathway aju04970   Salivary secretion aju05010   Alzheimer disease aju05012   Parkinson disease aju05020   Prion disease aju05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:aju00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     106969802    04020 Calcium signaling pathway     106969802  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     106969802   09154 Digestive system    04970 Salivary secretion     106969802   09159 Environmental adaptation    04713 Circadian entrainment     106969802  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     106969802    05012 Parkinson disease     106969802    05020 Prion disease     106969802    05022 Pathways of neurodegeneration - multiple diseases     106969802  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:aju04040]     106969802 Ion channels [BR:aju04040]  Voltage-gated cation channels   Ryanodine receptor    106969802 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  106969802 NCBI-ProteinID:  XP_053080189 UniProt:  A0ABM3Q8D2 LinkDB All DBs Position B3:67487880..68013662 Genome browser AA seq 4864 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIASIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRAKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQCEESQAARIIRNTTALFSQ FVSGNNRTAAPISLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILRLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDVEGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKTRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAGEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRID GTMDSPPCLKVTHKTFGTQNSNANMIYLRLSMPVECHSSFSHSPCLDSDAFQKRKQMQEI LSHTTTQCYYAIRVFAGQDPSCVWVGWVTPDYHLYSEKFDLSKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGVLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDVLELCEQEDLMQFHYH TLRLYSAVCALGNSRVAYALCGHVDLSQLFYAIDNKYLPGRLRSGFYDLLISIHLANAKE RKLMMKNEYIIPITSTTRKICLYPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTSEEHQ KQSPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHSGETENRAEKEEVTQVEEKAVEAGEKASKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFRLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEEEED TSWAGKLRALVYKIKGPPKPAKEQPTEEEERCPTTLKELISQTMIRWAQEDQIQDAELVR MMFNLLRRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVTEDGEYEEEIVHM GNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPS LNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGVKDQTFLLHLLEVGFLPDLRASASLDT VSLSTTEAALALNRYLCSAVLPLLTRCAPLFAGAEHYTSLIDSTLQTIYRLSKGRSLTKA QRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLP SGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTR ISATLEKQISVDADGNFDPKPINTMNFSLPEKWEYIVTKYAEHSHDKWACDKSQNGWKYG ISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWSVERTKEGEALVQQREN EKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGG SHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRFAYKFL KKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSS PLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTV MKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPIL TSIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAA IPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEISDLAESG ARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNILKIIN NNLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAVKTVQEEEQLKADTK GDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFIL WCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDLYSIQTSL IVAALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDEEVKEHVRNNLHLQEKSDDPAVK WQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRA VVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKCPKVEEEEEEET DKHPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEEDKEKTFEE KEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQK MLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVL QNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYW YYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHV FANMQMKLSQDSNQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNV EMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCA EADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFE PYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFV NFCEDTIFEMQLASQISESDSAERPEEEGEDEDSSYTLEIEGEEEDDKSFESASAFAMAC ASVKKNVANFLKKATLKNFRKQYRKVKKMTVKELVKVFFSFFWMLFVGLFQLFFTILGGI FQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAMEAERAEVTEPGITPELVH FVKGEKGDADIMSDLFGFRSKKEGGLKHGPEVGLGDLSEIIGKDEPPTLESTVQKKRRAQ AAEMKASHEAEGKVEPEKTDMEDGEKEGMAKEEEQADALWAEVTKKKKRRRGQKVEKPEA FMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDVA NLWNSFNDEEEEEAMVFFVLQESTGYMAPALRALAIIHTIISLVCVVGYYCLKVPLVVFK REKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLY GAERIAELLGLDKNALDFSPVEESKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLA WYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTV VAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYR IVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPH GFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYE DQLG NT seq 14595 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagttcctgaggactgaggatgaa gtggttctccagtgcatcgcaagcattcacaaggagcagaggaagttctgcctggcagcc gagggcctgggaaaccgcctgtgcttcctggaacccacttcagaagccaagtatgttcct ccagatctctgcgtctgcaattttgtgctggaacagtccctctctgtgagagctctgcag gaaatgcttgccaatacaggtgaaaatggcggcgaaggggcagcacaagggggtggccac aggaccctgctatatggccacgcgattctcctgcgacactccttcagcggaatgtatcta acatgtttgaccacatcaagatcccagacagataaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggaccatacatcctgcttccaaacagagatcc gagggagagaaagttcgaattggtgatgacctcatcctcgtcagcgtgtcctctgaaaga taccttcatctctccgtatcaaatgggaacatacaagtggatgcctcttttatgcaaaca ctctggaatgtacatcccacgtgctcaggaagtagcatcgaagaaggttacctacttggt gggcatgtagtacgtctcttccatggtcatgatgagtgtttgacgataccatctacagac cagaatgactcccagcacaggaggatattctatgaagctgggggagctgggacacgagcc agatctctgtggagagtggaaccccttcggataagttggagtggcagtaacatcagatgg ggccaggctttccgcctccggcatctcaccacaggccactacctggccttgacagaggac caaggccttatactgcaggaccgggcgaagtcagacaccaagtccacagccttctctttc cgggcttccaaggaaatcaaggagaaattggattctagtcacaagcgggatatagaaggc atgggagttccagaaatcaaatatggagattccgtctgctttgtccagcatatagccagt ggtctgtgggtgacctacaaagcacaagatgccaagacctcccgccttggacctctgaaa agaaaggtcatactccatcaggaaggccacatggatgacgggctaacactgcagagatgc cagtgcgaggagtcccaagctgctcggatcatccggaacacgacagccttattcagccag tttgtaagtggaaacaatcgtacggcggcccccatcagcctgccgatagaagaggtcctg cagaccttacaggacctgatcgcctacttccagcccccagaggaggagatgcaacacgaa gacaaacagaacaagctccgctcacttaagaacagacagaatcttttcaaggaagaagga atgttggcccttgtgttaaactgcatcgatcgcttaaacatctacaacagcgtggcgcac tttgcaggaattgcaagggaggagagtggcatggcttggaaagagatcctgcgcctgcta tacaaactgctggctgctctcattcgtggaaacagaaacaactgtgctcaattctctaat aaccttgattggctaatcagcaaattggatagactagaatcttcctcaggtatcttggaa gttttgcactgcatcttgactgaaagcccagaagccttaaatctgatagcagagggccac atcaagtctatcatctccctgttggataagcatgggcggaatcacaaggttctggatgtg ctgtgctccctctgtctctgcaatggggtcgccgtgagagccaaccagaatctgatttgt gacaacttgctgccccggagaaacctgctcctgcagacgcggctgattaacgacgtgaca agcattcggccaaacatcttcctgggagttgctgagggctcagcacagtacaagaagtgg tacttcgaactgatcatagaccaagtggaccccttcctaacagctgagcccacacaccta cgggtgggctgggcctcttcctcaggctatgctccgtaccctggaggtggagaaggatgg ggaggcaatggtgttggagacgacctgtattcctatggctttgatggccttcacctttgg tcaggccgcatacccagagccgtggcctccatcaaccagcacctcctgagatcagacgac gtggtaagctgttgcctcgacctcggggtgcccagcatctctttccgcatcaacgggcag cctgtgcaggggatgtttgagaacttcaacacagatgggctcttctttcctgtggtgagc ttctcagcaggtgtcaaagtacgtttcctgatgggtggacgtcatggagaatttaagttc ctgcctccctctggctatgccccttgctacgaagccttacttccaaaagaaaagatgaga ttggagcctgtcaaagaatataaacgcgatgttgaaggagttagagatctgttgggtacc acccagttcctctctcaagcctctttcatcccatgccccatagacaccagtcaggtggtt ttgccacctcacctagagaagatccgagacagactggctgaaaacatccacgaactttgg ggaatgaataaaatagagcttggctggacttttggcaagacacgggatgacaataaaaga caacacccctgtcttgtggagttttcaaagctgcctgaaactgagaagaattataaccta caaatgtcaacggaaaccttaaaaacccttctggccctggggtgccacattgctcacgtt aatccagctgctggggaggatctcaagaaagtcaagttgcccaaaaactatatgatgtcc aatggctataagccagcccctttggatttgtctgatgtgaagctattacctcctcaagaa attttggtggataaacttgcagaaaatgcacataatgtttgggccaaagacagaataaaa caaggatggacctatggcatccaacaggatttgaagaacaaaagaaatccccggctggtg ccatacgcattactggatgagcgtacgaagaagtccaatagggacagccttcgtgaagct gttcgcacatttgttggttatggctataacattgagccgtcagaccaagaactagctgac ccagctgtggagaaagtcagcatagataaaattcgatttttccgggtagagcggtcttac gcagtgagatctggaaagtggtattttgagtttgaggtggtgaccggaggagacatgcgc gttggctgggccaggccgggctgtcggcccgacgttgagctgggagccgatgatcaagcc tttgtgtttgaaggcagcaggggccagcgttggcatcaaggcagtgggtattttggacgt acgtggcagccaggagatgtggttggatgtatgattaaccttgatgatgcttcaatgatc ttcacactgaatggggagctgctgattaccaacaaaggctctgaacttgccttcgctgat tatgagattgagaatggcttcgtgcccatctgctctctgggactgtctcagatcggccgc atgaatcttgggatggatgccagtaccttcaagttttataccatgtgcggcctccaagag ggctttgagccttttgctgtcaacatgaaccgagacgtggcgatgtggttcagcaagcgc ctcccgacatttgtcaatgtgccaaaggatcatccgcacatagaggttgtgaggatagat ggcactatggacagccctccatgcctcaaggtgacccacaagacattcggcacacagaat agcaatgccaacatgatctacctacgcctgagcatgcctgtcgaatgccactcctccttc agccacagcccctgcttggacagtgacgcattccagaaaaggaaacagatgcaagaaata ctctctcatacaacaacacagtgctactatgcaatccgcgtcttcgctggacaggacccc tcctgcgtctgggtcggatgggtgactccggactatcacttgtacagcgagaagtttgac ctgagtaaaaactgcacggtgactgttactctaggggatgaaagaggccgggtccacgaa agcgtgaaacgcagcaactgctacatggtctggggcggggatattgtggccacttcgcaa agatcaagccggagcaacgtggacctggagatcggctgcctcgtggatctggcgatgggc gtgttgtctttctcagccaatgggagagagctgggtacctgctatcaggtggagcccaat accaaagtgtttccagcagtcttcctgcagcccacgagcacttcattgtttcagtttgaa cttgggaagctgaagaatgcgatgcccttgtcggcggccatatttaaaagtgaagagaag aacccagttccacagtgtccacctcggctggacgtccaaaccatccagcctgtgctctgg agccgcatgcccagcagcttcctgaaggtggagacagagcgggtgagcgagcgccatggc tgggtggtgcagtgcctggagcccctgcagatgatggcgctccacatccctgaggagaac aggtgtgtggatgtcctggagctctgtgagcaggaggacctgatgcagttccattaccac acgctgcgactctacagtgcagtgtgtgccctgggaaacagccgcgtggcctacgcccta tgcggccacgtggatctctcccagctgttctacgccattgacaacaagtacctccctggc cgccttcggtctggtttctatgacctgctcatcagcatccatctggccaacgctaaggag aggaagctaatgatgaagaatgagtacatcatccccatcaccagcaccaccagaaaaatc tgcctgtatccagatgagtccaagaggcacgggctgcctggggtgggcctgagaacgtgc ctcaagccagggttcaggttctccaccccttgctttgtcgtgaccagtgaggagcaccag aagcagagccctgagatccccttggagattctcaagacgaaggcactgagcatgctgacg gaggcagtgcagcacagtggggctcacatccgggaccctgtcggtgggtctgtagagttc cagtttgtgcctgtgctgaaactcatcgggaccctgctggtcatgggggtgtttgatgac gatgacgtcaggcagatcctcctcctgatcgatccctctgtgtttggggagcacagtggg gagacggagaacagagcagagaaggaggaagtgacccaggtggaggagaaggcagtggag gccggagaaaaggccagcaaggaggctccagtcaaaggcttgttgcagacccgactgcca gagtccgtcaagctgcagatgtgtgagctcctcagctatctctgtgactgtgagctgcag catcgagtggaggccattgtggcatttggcgacatttatgtctctaagctccaggcaaat cagaagttccgctacaacgagctcatgcaggccttgaacatgtctgcagccctgactgcc cggaaaaccagggagttccgctcacccccccaggagcagatcaacatgcttcttaacttt cgactgggagagaattgcccctgcccagaagagatccgagaggagctatatgacttccat gaggaccttctcattcactgtggtgttcccctggaggaggaagaagaggaggaggaagac acatcctgggctgggaaactccgtgccttggtgtataaaatcaaaggccctcccaagcct gcgaaggaacagccaacagaggaggaagagagatgccctacgaccttgaaggagctcatc tcacagaccatgatccgctgggctcaggaggaccagatccaggatgcggagttggtccgg atgatgttcaacctcctccggaggcagtacgacagcatcggggagctgctgcaggcgctg cggaagacctacaccatcagtcaggcctccgtgagcgacaccatcaacctgctggccgcc ctgggccagatccgttgcctcctcagtgtcagaatgggcaaggaagaggagctgctcatg atcaatgggctgggggacattatgaacaacaaggtgttctaccagcatcccaacctcatg cgagtccttggcatgcacgagacagtgatggaggtgatggtgaacgtgctggggacagag aagtctcagattgcctttccaaaaatggttgctagctgttgccgcttcctctgctacttc tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctaagttacctgttggag aacagcagtgttggcctagcctccccttcgatgaggggatctaccccgctggatgtggca gcttcctccgtgatggacaacaacgagttagccctgggcttagaggaaccagaccttgag aaggtggtgacctacttggcaggctgtggcctgcagagctgccccatgcttctagccaaa gggtaccctgacgtcggctggaaccccatcgaaggggagcgctacctgtccttcctgagg tttgccgtctttgtgaacagtgaaagtgtggaagaaaatgctagcgtcgtggtcaagctg ctcatcagacgcccagagtgcttcggcccagccttgcgaggtgaaggaggaaacggtcta ttggcagccatgcagggtgccattaagatctctgagaacccagctctcgacctcccctct cagggatataagagagaagtcacggaggacggtgaatatgaagaagagatcgtgcacatg ggcaatgcaattatgtctttctattcagcccttatagatctcctgggccgctgtgctcct gaaatgcatcttatccagacaggaaagggggaagccatccggatcaggtcaatcctgcgc tccctggtccccactgaggacctggttgggatcatcagcatccccttgaagctgccttcc ctgaacaaagatgggtcggtcagcgagccagatatggcagccaacttctgccctgaccac aaggcacccatggtgctgttcttggatcgtgtttatggcgttaaggatcaaacttttctg ctccacttgctagaggttggatttttacctgacttaagagcctctgcctctctagataca gtttccctaagcaccacagaggccgcgcttgcactaaatagatatctatgttctgctgtg cttccactcctcacaagatgcgcccctctctttgccggagcagaacactacacctctttg atcgattctacactacagacaatatataggctttccaagggacgttccctcaccaaagct cagagggacaccatagaagaatgtttgcttgccatttgcaatcacttgaggccttcaatg ttacagcaactcttgcgacgtcttgtctttgatgtgccgcagctcaacgaatactgcaaa atgcctcttaagcttctgacaaatcactatgaacagtgctggaagtattactgtctgcct tcaggatgggggagctacgggctagctgtggaggaggaattgcacctgacggagaagctc ttctgggggattttcgactccctctcccataagaagtatgacccagaccttttccgaatg gcccttccttgtctcagtgctatagctggggcactaccaccagattacttagataccaga atctcagccacgttggagaaacagatctcagtggatgcagatggcaactttgaccccaaa cccatcaacaccatgaatttttccttgcctgaaaaatgggagtacatcgtcaccaagtac gcggagcattcacatgacaaatgggcctgtgacaagagtcagaatggatggaaatatgga atttccctggatgaaaatgtgaagacccatcccctgataaggcctttcaagacattaaca gaaaaggagaaggaaatttaccgctggcctgctagagagtccctgaaaaccatgctggct gtgggctggtctgtggagaggaccaaagagggagaggccctggtgcaacagcgggaaaat gagaagcttcggagcgtgtcccaggccagccagggcaacagctacagtcctgctcccctg gacctctccaacgttgtgctctccagagagctccagggaatggtggaggtcgtggccgag aactatcacaacatctgggccaagaagaagaagctggaactggagagcaaaggtggcggc agtcaccctctgttggtaccatatgacaccttgacagccaaggagaagttcagggaccga gaaaaggcacaggacctgtttaaattcctccaggtgaacggcatcgtggtttctagaggt atgaaggatatggagctggatgcctcctccatggaaaagaggtttgcctataaatttttg aagaagatcctgaaatatgttgattccgcccaagagtttattgcccatttggaagccatt gtcagcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgccaaa gttctcctcccgctggttgaccagtacttcaccaatcaccgcctctacttcctgtcatcc cctctaaaacccctcagcagcagtggctatgcctcccataaggagaaagaaatggtggcc agcctgttctgcaaactcgctgctcttgttcgacacaggatttccctctttggaagtgat tctactacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtc atgaagtcaggctcagagctggtgaaggctgggttacgagctttctttgaaaatgcggcg gaagacttagagaagacttcggaaaatctgaagctcgggaagtttacgcattccagaaca cagattaaaggcgtgtctcagaatattaactataccacggtggctctgctccccatcctg acgtccatctttgagcatgttgctcagcatcagttcggggtggatttactcttaggtgat gtgcagatttcatgctaccacatactctgcagtctctactcccttgggaccggaaagaac atctacgttgaaaggcaacgtcctgcccttggagaatgtctggcctcactggcagctgcc ataccagtggcattcttggagcccactcttaaccgctacaatccactctcagtcttcaac accaaaacccccagagagaggtctattctggggatgccagacacagtggaagagatgtgt cctgacatccctcagctggaaggcctgatgaaggaaatcagcgacctggccgagtcaggg gcccggtacacggagatgccccacgtcatcgaggtgatcttgcccatgctgtgcaactac ctgtcctactggtgggagcgggggccagagcacctgccccccagcacggggccctggtgc accaaggtcacctctgaacacctcagcgtcatcctgggaaacattctgaaaatcatcaac aacaacctgggcatcgacgaggcatcctggatgaagcgcatcgcagtgtatgcccagcca atcatcagcaaagccaggccggacctgctgaaaagccacttcatcccaactctggagaag ctgaagaaaaaggctgtgaagactgtgcaggaggaggagcagctgaaggctgacaccaaa ggagacactcaggaggcggagctcctcatcctggatgagtttgcagtcctctgcagagac ctctatgccttctaccccatgctcatccgctacgtggacaacaacagatcgaactggctc aaaagtcccgatgctgattctgaccagctcttccgcatggtggcagaggtcttcatcctg tggtgcaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaatgaaatt aataatttggcatttttaactggagacagcaaaagcaagatgtcgaaatctggaggacag gaccaggaacggaagaagaccaagcggaggggagacttgtactccatccagacctctctc atcgtggctgcgctcaagaaaatgctgcccattggtttgaatatgtgcacgccaggtgat caggagctaatctcccttgcaaagtcacgatacagctatagggacaccgatgaagaggtg aaagaacatgtgcggaataacttgcacctgcaggaaaagtcagatgacccagcagtaaag tggcagctgaacctctacaaagatgttttgaagagtgaagaaccttccaatccagaaaag accgtagagcgcgtacagagaatttctgcagctgtcttccatctggagcaggttgaacag cctttgaggtccaagaaggcagtctggcacaaactgttatcaaagcagcggaaacgggca gtggtggcctgtttcaggatggcccctctgtacaacttgcccaggcaccgctccattaac ctcttcctccatggctatcagagattttggatagaaacagaggagtattcctttgaagag aaactagtacaggacttggctaaatgccccaaggtggaagaggaggaggaggaggaaaca gacaagcacccagacccacttcatcagatcattctccattttagccgcaatgctctcacg gagaggagcaaattggaagacgaccccttgtacacctcctattccagcatgatggccaag agttgtcagagtggggaggacgaagaagaagaggaagacaaggaaaagacatttgaagag aaggaaatggaaaagcagaaaaccctctaccaacaagctcgactgcatgagcgtggggct gcagagatggtcctccagatgataagtgccagcaaaggtgagatgagccccatggtggtt gagactctgaagctggggatcgccattctgaatgggggcaacgctggtgtacaacagaaa atgctagattacctaaaggagaaaaaggatgctggattctttcaaagcctttccggcctt atgcagtcttgcagtgtccttgatttgaatgcatttgagaggcagaataaagctgaaggc ctggggatggttactgaggaaggaacactcattgtccgtgagcgtggtgaaaaagtactc cagaatgacgagtttacacgagatctctttagattcctgcagttactttgtgaaggacat aacagtgacttccagaacttcctgcggactcagatgggcaacaccaccactgtaaatgtc atcatcagtaccgtggactatctcctgcgtctgcaggaatcaatcagtgatttctactgg tattattcagggaaggacatcattgatgaatctggacagcacaacttttccaaagctctg gcagtcacgaagcagattttcaattctcttacagaatacatccagggcccttgcattggg aaccaacagagcctggctcacagcaggctgtgggatgcagtggtcggcttcctgcacgta tttgctaacatgcagatgaaactctctcaggattccaatcagatcgagctgctgaaggaa ctcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaatgtg gtaaatggaactattggcaagcagatggttgacacgctggtagagtcatctaccaatgta gaaatgatcttgaaattctttgacatgttcttgaaacttaaagacctaaccagctcagac accttcaaagaatatgacccagatggtaaagggattatctccaaaaaagaattccagaag gccatggaaggacaaaaacagtacacacagtcagagattgactttcttctttcatgtgca gaagctgatgagaatgatatgtttaattacattgattttgtagaccggtttcatgagccg gccaaggacatagggtttaatgtggcagtgttattgacaaatctctccgaacacatgcca aatgattctcgccttaagtgcctattggacccagcggaaagtgtactaaattacttcgaa ccctacctaggacgtattgagatcatgggtggggccaagaaaattgagcgcgtttatttt gagatcagtgaatccagtcgaacccagtgggagaagccccaagtgaaggaatctaagcgg cagttcatctttgatgtggtcaatgaaggtggagagcaagaaaagatggaactgtttgtg aacttctgtgaggataccatctttgaaatgcagttagcgtctcagatctctgaatctgac tcagccgaaaggccagaagaagagggggaagatgaagattcttcttacacgttagaaatt gagggggaagaggaggatgacaagtcttttgagtctgcctctgcatttgccatggcctgt gcctcagtgaagaaaaacgttgccaacttcctgaagaaggcaaccctgaagaacttcagg aagcagtacaggaaggtgaagaagatgaccgtgaaggagctggtgaaggtgttcttctct ttcttctggatgttatttgtggggctattccagttgttcttcaccatattgggaggaatc tttcagatcctctggaacacagtgtttggagggggcctagtggaaggggcaaagaacatc agagtgaccaagatcctgggtgacatgcctgacccaacccagtttggtatccatgacgat gccatggaggctgagcgggcagaggtgactgagccaggtattacaccagaactagtccac ttcgtcaagggtgagaaaggagatgcagatatcatgtcagatctctttggattccgctca aagaaagaaggtggcttaaagcatgggcctgaagtgggtttgggtgatctctctgagatt attggcaaggatgaaccccctacactagagagtactgtacagaagaaaaggagagcacag gcagcagaaatgaaagcatcacatgaagcagaaggaaaagtggagcctgagaagacagac atggaagatggggagaaggagggtatggccaaggaggaagagcaagctgacgccctgtgg gcagaagtgacaaagaagaagaagcggcgacggggccagaaagttgagaagcctgaagcc ttcatggctaatttcttcaaagggctggaaatctatcagaccaagttactgcattacctg gccaggaatttctacaacctgaggttcctcgctctgtttgtagccttcgctatcaacttc atcctgctcttttacaaggtcactgaagagcctttagaagaagagacagaggacgttgca aacctgtggaattcctttaatgatgaggaagaggaagaagcgatggtgttctttgtccta caggagagcactgggtatatggcaccagcactgcgggccttggccattatccacaccatc atctctttggtctgtgtggtgggctattactgcctgaaggtccctttggtggtgttcaaa agagaaaaagaaattgccaggaagctggagttcgatggcctgtatatcactgaacagcca tctgaagatgacatcaaggggcagtgggaccgcttggtaatcaacacaccatcttttcct aataactactgggacaagtttgtaaagagaaaggtgattaacaagtatggtgatctctac ggagcagaacgcattgctgaactcctaggtttggataaaaatgcccttgatttcagccca gtagaagaaagcaaagcagaggcggcctctctggtgtcatggctgagttccatcgacatg aagtaccatatctggaagctgggagttgtttttaccgataactcctttctctaccttgcc tggtatacaaccatgtcgatcctgggccactacaacaatttcttctttgctgcccatctg ctagacattgcaatgggcttcaagacgctgaggactattctgtcatctgtaactcacaac ggcaaacagctggttctgactgtgggtctcctggccgtggtggtttacctctacaccgtg gtggccttcaacttcttccgcaagttctacaacaaaagtgaagatgacgatgagcctgat atgaagtgtgacgacatgatgacatgttacctattccacatgtatgtgggagtaagagca ggaggcggcattggcgacgaaattgaagaccctgctggtgatccttacgaaatgtaccgc attgtctttgatatcacgttcttcttctttgtcattgtcatcttgctggccatcattcaa ggtcttattattgatgcttttggagagctaagagaccaacaggaacaggtgcgagaagat atggagactaaatgtttcatctgcgggattggcaatgactactttgacacgacccctcat ggttttgaaacacacaccttacaggagcacaacttagccaactatttgttcttcctgatg tatctgattaacaaagatgaaacagaacacacgggtcaggaatcttatgtctggaagatg taccaagaaaggtgttgggatttcttcccagctggtgactgctttcggaaacaatacgaa gatcagcttggataa

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