Astyanax mexicanus (Mexican tetra): 103045174 Help Entry 103045174         CDS       T05042                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X2   KO K04963   ryanodine receptor 3 Organism amex  Astyanax mexicanus (Mexican tetra) Pathway amex04020   Calcium signaling pathway amex04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:amex00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103045174 (ryr3)    04020 Calcium signaling pathway     103045174 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:amex04040]     103045174 (ryr3) Ion channels [BR:amex04040]  Voltage-gated cation channels   Ryanodine receptor    103045174 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 Motif Other DBs NCBI-GeneID:  103045174 NCBI-ProteinID:  XP_022541391 Ensembl:  ENSAMXG00000004818 LinkDB All DBs Position 1:76186222..76295018 Genome browser AA seq 4851 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVATIQKENRKFCLSAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLANTGQNGEGTPDHDRWAGQGGGHRTLLYGHAILLRHSF SGMYLACLKTSRSLTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSSERFLHLSMSNGNIQVDASFMQTLWNVQPTCSGSNVAVGYLLGGHVIRLFHGHDESLT VPGSDQSGEQQRVANYEAGKGGSRARSLWRLEPLRISWSGSHIRWGQPFRLRHLSTGHYL GQTEDRGLVLLDREKSDTTATAFCFRPSKEKVDSGSKRDIEGMGVAEIKYGDSVCFIMHV ATGLWLSYQAPDAKSSRLGLLKRRAFLYPEGHMDDGLILQLCQHEESRAARIIRNTTQLF TQFISGLDELKGEKASEVSLPVGEVMQTLDDLITYFQQPDPDLEHEEKQRQLRSLIKRQD LFKEEGMLTLVSVCIDRLNVYSSAAEFEEFAGEEAGEAWKDILNLLYELLAALIQGNRPN CTQFSRKLDWLISKLERLESSSGILEALHCILTESPEALNIIQKVHIKSIISLLYKHGRN HKILDILCSLCVCNGVAVRTNQNFISEHLLPRRDVLLQTKLVNDVQSMRPNIFLGMSEGS AQYRKWYFELIIDQVDHFVTGEPTHLRVGWATTKGYAPYPGGGEGWGGNGVGDDLYSYSF DGLHLWSGRIPRAVASINQHLLTSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTDGF FFPVVSFSAGVKVRFLLGGRHGDFKFMPPSGYAPCYEALLPKEKMRVEPVKEYKRDLEGV RDLLGTTKLLSQASFIPIPVNTAEIVLPPHLENVRDKLAENIHELWGMNKIELGWTYGKI RDDNKRQHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCHVAQVQVDAEEDLKRIKLP KDYMMSNGYKPAPLELSEVKLTPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSR RNPRLVPYALLDERTKKSNRDSLREAIRTLIGYGYNIDPPDQETANVIEKLNVENIRFFR VEKTYAVTSGKWYFEFEAVTGGEMCVGWARPGCRPDIELGLDDQAFVFDGCRGRRVHMGS HFFGRSWNKGDVVGCMINMEDKSMIFTLNGEILITNRGSELCFADFDTEGGFIPVCSLGL SQIGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNRDVTMWFSKRLPTFVNVPEDHKHIE VTRIDGTVDTPPCLKVTHRTFGTQASNNDMIYCRLSMPVEFYPGPRKTTNINEVIADDQN VKKDDSGKTDYGSITKYFYSVRVFAGQDPAAVWVGWVTPDYHYYSKHFSLNKVRTVTVTL GDERGRVHESVRRSNCYMVCAGEISNSSSGRSNTDLEIGCHIDLASGLVSFTANGNELPT AYQVEPNTKLFPAVFIEPTSPNLFQFEFPKIQDAMPLSSAIFKSLHRNPEPQCPPRLDVQ TIVSVLWSRMPNSFLSVETARVSERHGWVVQCLEPLQMMAVHIPEENRCIDIMELSENED LRMFHYQTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLTGQLREGFYDVLISI CLETAKEARLMMNNEFIIPVTDETRSIRLFPDESKRHSLPGVGLSTSLTPRLNFNPPCFI TTKREHTYSPQIPLGILKEKAISMLTEAVQGGGTHIRDPVGGSVEYQFVPILKLIGTLLI MGALTSEEVRLILLLIEPNVFADNKEEEKPAAEEAVEKEEASSNEEKTVEAGEEESKDSK QAPKGLLEKSLPEPVKRQMCELLNYFCDCELKQRIEAIVAFSDHFVAKLQYNQKFRYNEL MQAFNMSAAVTAKKTKEFRSPPQEQINILLNFSAGEDCPCPEEIQEELQNFHDDLRLHCG IPMEEEEEEQDTSIKGRLLSLLYKIKGRPQKTEEEPSEQEQATPTNLKELISQTMVSWAQ ECTIQDPELVRIMFSLLRRQYDGIGELLRAMRKSYTISEKSVQDAINLLASLGQIRSLLS VRMGEEEGQLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSKEIAFPK MVASCCRFLCYFCRISRENQKAMFDHLSYLLENSSVGLACPAMRGSTPLDVAASSVMDNN SLALALEEPDLEKVVTYLAGCGLQSCPMLVAKGYPDIGWNPIEGERYLSFLRFAVFVNGE SVEENANVVVKLLIRHPECFGPALRGEGGQGLLAAMLEAIKISEDPTLDLPNLPEGGGPV IGEDREEEEVAHMGNSIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILRSLVPTKD LVGIISIPLKVPVINKDGTVTEPDMNSSFWPDHKSPMVLFLDRVYGIEDQSFLLNLVEVG FLPDLRASASLDTEVLSTTETALAMNRYIGSAVLPLLTRCASLFAHTEHYAQLVDSTLHT IYRLSKGRSLTKAQRDSIEECLLAICQHLRPSMLQQLLRRLVFDVPQLTEYCKMPIKLLT NHYEQNWKYYCLPSGLGSYGMASEEELHLTKKLFWGLFDALSQKKYDSELFKMAMPCLSA IGGALPPDYVDTSPTTTLVKQVSVDTQGNFDPKPINTANISLPEKLEYIANKYAEHCHEK WSSEKFAQGWTAGEKVNEQAKTHPLLKPYKALSEKDRETYRYPVKESLKSMLAMSWNIER TKEGEAMFQQRETEKLKTTEPSQGDGFNPTPVDLDNVILSRELQSMVETVAENYHNIWAK KKKMELSSKGGGTHPLLVPYDTLTAKEKYRDREKAQELFKFLQLNGYALSRGFKDMEQDS SSMEKRTAYKFLKRLLSYVDSAQEFIAHLEAMASSGKTDKSPHEQEIKFFAKVLLPLIDQ YFKNHCLYFLSSPSISLSSSGYASNKEKEMITSLFCKLASLVRHRISLFGSDSATMVSCL HILACSLDFRTVMKSGSELVKAGVRTFFENAAEDLEKTMENLKLGKLGQSRTQMKGVAQI IVYTSTALLPILTALFQHVTQHQFGVDLLLDDVQLSCYRILTSLYSLGTGKNSYVEKQLP ALGECLATLVGAMPVAFLEPDLNMHNPCSVFNTKTPRERAILSMPDTVEEMCPEMPRLDG LMKDIHDISESGARYTDMPHVIEVILPMLCNYLSYWWEKGPENSPSDMDCCTTVTSEHLS LILGNILRILNNNLGIEEASWMKRLAVYTQPIISKAGADLLRTHFLPTLEKLKKKTVKVV SEEELLRAESRADTQEAELQILDEFAVLCRDLYAFYPMLIRYVDNNRSKWLKKPHADSTE LFKMVAEIFILWCKSHNFKREEQNFVVQNEINNLAFLTGDSKSKMSKSGGQDQERRGKKR KRELYSVQTSLIVSAHKKLLPIGLNMCTPGDQMLISLAKIRYCLKDTDDEVKDHLKQNLH LQEKSEDPGVQWQLNLYKDVEMKSEEASDVEHTVERIQGISAAVFHLEQVELPLRNKKLV AQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLTGYQRLWIVAEEYSFEEKLVQDLAK TPMVVEKEEEEAEAEVQPDPLNQLILHFSHNALTERSFLEIDPLYIAYADMMAKSCAEDE EEEEEGKEKTFEEKEMEKQKTLYQQARLHARGAAEMVLQMISASKGRLGPMVTCTLKLGI SILNGGNVVVQQKMLDYLKEKRDAGFFKSLSGLMMSCSVLDLNAFERQNKAESLGMVTEE GSSSKVLQNDDFTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTTTVNIIISTVDYLLRLQE SISDFYWYYSGKDIIDEQGQRNFSKALAVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDA VVGFLHVFANMQMKLSQDSSQIELLKELMDLQKDMVVMMLSLLEGNVVNGTIGKQMVDTL VESSSNVEMILKFFDMFLKLKDLTTSDNFKEYDPEGKGMISKKEFQKSMESQKQYTQSEI EFLLSCTEADENDMFNYAEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLGTFLDLAE SVLSYFEPYLGRIEIMGGAKRIERVYFEISESSREQWEKPQVKESKRQFIFDVVNEGGES EKMEMFVNFCEDTIFEMQLASQISEQDAAERPEEEEEELQSLLEELAEGEDGSQESASAF TLACTSVKKKMSNFRQMLTIKSMRKQFKKFKKLTIKEMITGFFSFFWMLFTGFFKGIFGL IFGFFHIIWSSMFGGGLVEGAKNMKVTDILGNMPDPTQFGIHGDVLEAEKMESSDFVVST EMVQMAGAGDKMEPDSIIDLINPAPKREGKHGPETGLGDVSEIMTEVSQPVEKKKSQKAA TEESEPEKADTEHQEKEDKAKEEKPEEPVVEEKPAPRKRHGTAKEAAPAFMASFFAGLEV YKTKMLNYLARNFYNLRMLALLVAFAINFILLFYKVSGETEEEEEDESPWGGDDEDEDGG GMEFFVLQESTGYMAPTLTFLAVLHTIISLLCVVGYYCLKVPLVVFKREKEIARTLEFDG LYITEQPSDDDIKGQWDRLVIATPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDK SALDFDPTEEAVVKEASLLSWLSSIDTKYHIWKMGVVLTDNSYLYLIWYTTMSILGHYNN FFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKS EDEDAPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIV ILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLA NYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14556 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggagaaggagaagacgaaattcagttcttacgaactgatgatgaagtg gtgctccagtgtgtcgctaccattcagaaggaaaaccgcaagttttgcctctcagcagag ggacttggaaatcgactgtgttacctagagcctacctcggaagccaagtatgttccccct gacctgtgcatatgtaactttgtgttggagcagtcgctctcagtgcgggccctgcaggag atgctggctaacacagggcaaaatggggaaggaactcctgatcatgaccgatgggcaggg caggggggcggacatcggacactgctgtacggtcacgccatcctactgaggcattccttt agtggaatgtatctggcctgtctcaagacttcaaggtctttgactgacaagttgtcattt gatgtaggcttgcaagaggattcaacaggggaggcttgttggtggaccatccacccagcc tcaaagcagagatctgagggtgaaaaggttagaattggtgatgatctcatcttagtcagt gtgtcttcagagcggttcctgcacctgtccatgtccaatggaaatatacaagtggacgct tcttttatgcaaacactgtggaatgtgcagcctacctgctctggcagcaacgtggcagtg ggatatttgttgggtgggcatgtgatacgtttgttccatgggcacgatgagagtttgact gtaccaggatctgatcagtctggggaacagcagagggtggcgaactacgaggctgggaaa ggagggtccagggccaggtctctgtggaggttggagccacttcggatcagttggagtgga agccatattcgatggggtcagcccttccgcttgcggcatctgtctactggacactacctg ggtcagacagaagaccgtggcctagtgctgctggacagagagaagtctgataccactgcc acagctttctgcttcaggccaagcaaggagaaagtggactctggctcaaagcgggatatt gaaggcatgggggtggcggagatcaagtatggagattctgtttgcttcatcatgcacgtg gctacaggcttgtggctctcctaccaggcaccggatgcaaaatcctctcgcttggggctg ctaaagagaagggccttcctctatccagaaggccatatggacgacggtttaattctgcag ctctgccagcacgaggagtccagagcggcccgcatcatccgtaacaccacacagctcttc acacagttcatcagtgggctggacgagctgaagggtgagaaggcctcggaggtgagcctg cctgtgggagaagtgatgcagacactcgacgacctcatcacgtacttccaacagcctgac cctgacttggagcacgaggagaaacagagacagctgcgctcactcatcaaacgccaggac ctctttaaagaggaggggatgctaacacttgtctcagtctgcatcgaccggctcaacgtt tacagcagtgcagctgagtttgaggagttcgctggcgaggaagctggagaagcctggaaa gacatccttaacctcctttatgagcttcttgctgccctgatccaaggaaacagacccaac tgcactcagttctcccgcaaactggactggctgatcagcaaactggagcgactggagtcc tcttcaggcattcttgaggccctgcactgtatcctaacagagagtccagaggctctgaac atcatccagaaagtccacatcaaatccatcatctctctcctctacaagcacgggcgtaac cacaagattctggatattctctgctctctctgtgtctgcaatggagtggcagtaagaacc aatcagaacttcatctctgaacacctgcttcccaggagggatgtgcttctccagacaaaa ttggtcaatgatgtgcaaagtatgagacccaacattttcctgggcatgagtgaaggttcg gcgcagtatagaaagtggtacttcgagctgataatcgatcaagtggatcactttgtgacc ggcgaacccacacatcttcgcgtcggctgggctaccactaaaggctacgctccgtaccca ggaggtggagagggctggggagggaatggcgtaggtgatgatctctactcctacagtttt gatggtcttcatctgtggtcagggcgaatcccacgagccgtggcctccattaaccagcac ttgctgacctcggatgatgtggtaagctgctgtttggacctcggcgcccccagtatgtcc ttccgcatcaacggccagcctgtgcagggaatgtttgaggactttaacacggacggcttc ttcttccccgtcgtcagcttctcagcaggggtcaaggttcgtttcctgttgggaggtcgc catggtgactttaagttcatgcccccatcaggctatgcaccttgttatgaggctctgctt ccaaaggaaaaaatgcgcgtggagcctgtgaaggagtataagagagatttagagggagtg agagacttgctgggcaccaccaaattgctttctcaagcctccttcatccccataccagtc aataccgccgagattgttctgcctccacatcttgaaaatgtgcgtgacaaactagctgag aacatccatgaactgtggggtatgaacaaaatcgagcttggctggacttatggcaagata cgagatgacaacaagagacagcatccctgcctggttgacttctccaagctgcctgaaaca gaaaagaattataacctgcagatgtcgactgaaaccttaaagaccttactagctttggga tgccatgttgcacaagtccaagttgatgccgaggaagatctaaaaagaattaaacttccc aaagactacatgatgtcgaatggttataaacccgcaccactagagctttctgaagtgaaa ctgacacctggtcaggaggttctggttgataaactggctgaaaacgctcacaacgtttgg gccaaagatcgcatcaagcaaggatggacctatggtattcagcaggatttgaagagcaga cgcaatcctcggctggtgccatatgctttgttagacgaacgcacgaagaaatccaacaga gacagccttcgagaggcaatacgaacactaattggatatggatacaacatcgacccccct gaccaagagactgccaatgtgatagagaagctgaatgttgaaaatatccgtttcttccgt gtggagaagacgtatgcagtgacatcggggaagtggtattttgagtttgaggctgtgact ggaggagaaatgtgtgtgggctgggctcgtcctggctgtagacccgacatcgaacttggc ttggatgaccaggccttcgtttttgatggctgtcgaggtcggcgggtacatatgggcagt cacttttttggaagatcatggaacaagggtgacgtggtggggtgcatgattaacatggaa gacaagtccatgatcttcaccctcaatggagagatccttatcaccaacaggggctctgaa ctctgctttgccgactttgacacagaaggagggttcatcccagtctgcagcttgggtctc tcacagataggccgcatgaacctgggcaaggatgcaagcacctttaagtactacaccatg tgtggcctgcaggaaggttttgaaccttttgctgttaatatgaaccgagacgtcaccatg tggttcagcaaacgtcttcccacgtttgtcaatgtgccagaggaccacaagcacattgag gtgactagaattgatgggactgtggacacaccaccgtgtctgaaagtaacccacaggacc tttgggacacaggctagcaataacgacatgatctactgccgactgagcatgccagttgag ttttatccaggtccaaggaagaccacaaacattaacgaggtaatcgctgatgaccaaaat gtcaagaaagacgacagcggaaaaacagattatggaagcattacaaagtacttctactct gtgagagtgtttgcaggacaggatccagctgcagtatgggtgggctgggtaacccctgac tatcactactacagcaaacacttcagcctgaacaaggtccgaacagtgacagtaactctc ggggacgagcgaggccgtgtgcatgaaagtgtgaggaggagtaattgctacatggtgtgt gctggagagatttccaacagctcctctggacgcagtaatactgacctggaaatcggctgc cacattgacctggcctctggtctcgtctcattcactgccaatggcaatgagctgcccact gcttatcaggttgagcccaacacaaaactgttccctgctgtatttattgagcccacaagc cccaacctgttccagtttgaatttccaaagattcaggatgcaatgcccttgtcatcagcc attttcaagagcttacaccgtaacccggagccccagtgtcctccacggctggatgtgcag accattgtatctgttctgtggagcagaatgcccaattccttcctctcagtagagacagcg cgggtcagtgagaggcatggctgggtggtgcagtgtctggaacctctacagatgatggca gtacacattcctgaggagaacaggtgcattgacatcatggagctctctgagaatgaggac ctgcggatgttccattaccagactttgaagctctactgcgctctctgtgctctgggaaac actcgtgtagcccatgccctctgcagtcaccttgatcagtctcagctcctctacactatc gataaccagtatttgactgggcagctgcgagagggtttctacgatgttctcatcagcatc tgcctggagacggctaaagaagctcgcctcatgatgaacaacgagttcatcattcccgta actgacgagacccgaagcattcgcctcttccctgacgaatccaagcgtcactctttgcct ggcgtgggtctcagcacctcgctcacccctcgcctcaactttaaccctccgtgcttcatt accaccaagcgggagcacacctacagcccccagatccccctgggcatcctgaaggagaaa gctatcagcatgttgacggaggcggtgcagggcggtggcacccatatccgagacccagtg ggtggcagtgtggagtaccagtttgtgcccattcttaaactgattggcactctgttgatc atgggtgctttgaccagcgaagaagtgaggctgatactgcttcttatcgagcccaacgtg tttgcagacaacaaagaggaggagaaacctgcagcagaggaggctgtggagaaggaggag gccagcagcaacgaggagaaaactgtggaggctggagaagaggaaagtaaggactccaag caggcccctaaaggacttctggagaagagtctacctgagccagtcaagcgtcaaatgtgt gaactgctgaattatttctgtgactgtgagctgaagcagcgtattgaggccattgtggcc ttctcagatcactttgtggccaagctacaatacaaccagaaattccgctacaatgaactc atgcaagccttcaacatgtctgctgcagtcactgcaaagaagaccaaggaattccgctct cctcctcaagagcagattaacatactactgaactttagtgctggagaggactgcccctgc cctgaggaaatccaagaggagcttcagaacttccatgatgacctgcgactgcactgcggc attcccatggaagaagaagaggaagagcaggatacctctatcaaaggtcgtctgctttcc ctgttgtacaaaatcaaaggtcgcccacagaaaactgaggaggagccttctgagcaagaa caagcaactccaactaacctgaaggagctgatctctcagacgatggtgagctgggctcaa gagtgcaccatccaggacccggagctggtgcgcatcatgttcagcctgctgaggaggcag tatgatggcattggagagctgctgcgcgccatgcggaagagctacaccatcagcgaaaag tctgtgcaggatgccatcaacctgctggcatccctgggccagattcgctcgctgcttagc gtccgcatgggtgaagaagagggtcagcttatgatcgatggcttgggggatattatgaac aacaaagtgttttaccagcatccaaatctgatgcgtgttctgggcatgcatgagacagtc atggaggtcatggtcaacgtgctcggaggcgacaagtctaaggagattgctttccccaaa atggtggccagctgctgccgcttcctctgttacttctgccgcatcagccgtgagaatcag aaagccatgtttgaccacctgagctacctgctggagaacagcagcgtaggactggcctgt ccagccatgaggggctccactccactggatgtggctgcatcctcagtgatggacaacaac agtctggctctggctttagaagagccagacctggaaaaggtggtgacatacttggctggt tgtgggctccagagctgcccaatgcttgtagccaagggataccctgacatcggctggaat cccatagaaggagagcgctacctgtccttcctccgatttgctgtctttgtcaacggtgaa agtgtggaggagaatgctaatgtggtggtgaagctgttgatcaggcatcctgagtgcttt gggccagctctgaggggagagggtggacagggtcttctggctgccatgttggaggccatt aagatctcggaggatcccacactagacctgcctaatctgcctgaaggaggaggacctgtg atcggggaggacagggaggaggaagaggttgcgcacatgggcaactccatcatgtccttc tactcagccctcatcgatctgctgggacgctgtgcccctgagatgcatttaattaacaag ggcaaaggtgaagctttgcgtattcgtgccatcttgcgctcactggtgcctaccaaagac ttagtgggcattatcagcatacctctcaaagttcctgtcatcaacaaagatggcactgtg acagagccagacatgaattcaagtttctggccagaccacaaatccccaatggtgctcttc ctggaccgtgtctatggtatcgaggaccaaagcttccttctgaacctggtggaggtgggc ttcctgcctgacctgcgtgcctctgcctctctggacacggaggtgctgagtaccacagag acagccttggccatgaacaggtatataggttcagccgttcttccactgttgacccgctgt gcctcgctcttcgctcatacagagcactacgcccagcttgttgactccacacttcacacg atctaccggctatctaaaggccgctcactcaccaaagcccagagagactccatagaggag tgcctgcttgccatctgccagcacctgcggccttctatgctgcagcagctcctgcgccgc ctcgtttttgatgtgccacaactcacagaatactgcaagatgcctataaagcttttgacc aatcattatgagcagaattggaaatattactgcctgccttccggcttagggagctatggc atggcttccgaggaggagctccacctcaccaagaaactcttctggggtctttttgatgcc ctttctcagaagaaatacgattcagagcttttcaaaatggccatgccgtgtctgagtgcc ataggtggagctcttccaccagactacgtagatacgagcccaaccactactttggtgaaa caggtctctgtggatactcagggcaactttgatcccaaacccatcaacactgccaatatc tccttgcccgaaaaattggaatacattgccaataagtatgctgaacactgccatgagaaa tggtcttctgagaagtttgcacaaggctggactgcaggggagaaggtgaatgaacaagct aaaactcatcctctgctgaaaccatataaagcactgagtgagaaggatagggaaacctac cgctacccagtgaaggagtctctgaagagcatgctggctatgagctggaacattgagagg accaaagagggagaggccatgttccagcagcgtgagacagagaagctcaagacaacagag ccttcccagggtgatggatttaacccaacccctgtggatttggataatgtaatcctatcc agagagttacagagtatggtggagaccgtagcagagaattaccacaacatttgggcaaag aagaagaaaatggaactcagcagcaaaggaggtggaactcatcctctgctggtgccatat gataccctcacagctaaggagaagtatagagaccgagagaaggcacaggagctcttcaaa tttttgcaactcaatggctacgcacttagcagaggttttaaagatatggagcaggactct tcctcgatggaaaagagaactgcctacaagttccttaaaaggctgctaagctacgtggac tctgcacaggagttcatagcacatcttgaggctatggccagcagtggaaaaacagacaaa tctcctcacgaacaagagattaagttctttgcaaaggtcttgctgcctctgattgatcag tactttaagaaccactgcctttacttcctgtcctcccccagcatcagtttaagcagcagt ggctacgcttctaacaaagaaaaggagatgatcaccagcctcttctgcaagctggcatct cttgtcaggcacagaatttctctgtttggtagtgactctgccacaatggtgagctgtctg cacatcttggcatgttcactagacttcaggacagtgatgaagtctggctcagagctggtg aaggcaggagtgaggacgttctttgagaatgcagcagaagacctggaaaaaaccatggag aacctgaagctgggaaagctgggccagtcacgaacccagatgaaaggagttgcacagatc atcgtctacacctcaacggctcttttgcccattcttactgctcttttccagcacgtcact caacaccagtttggagtggacttgctgttggatgatgttcagttgtcctgctatcgcatc ctgaccagtctctactccttgggcactggcaagaacagctatgttgagaaacagctccct gcactaggggagtgtttggccactcttgtgggtgccatgccagtggctttcctggagcct gatctgaacatgcacaacccctgctctgtcttcaacacaaaaacacctcgagagcgagca attctgagcatgcctgacacagtggaggaaatgtgtcctgagatgcctcgtctggacggc ctcatgaaggacatccatgatatctcagagtctggggcgcgctacactgatatgccacac gtcattgaggtcatcctgcccatgttgtgtaactatctttcatactggtgggaaaaaggc cctgagaactcaccgagtgatatggactgctgtaccaccgtcacctcagagcacctcagc cttatcctggggaacatcctaaggatcctcaacaacaacctgggcattgaagaagcctcc tggatgaagaggcttgcggtgtacactcagccaatcattagcaaggcaggagcagacctc ctgcgaactcatttccttcccacactggaaaagctgaagaagaagacagtgaaggtggtg tctgaagaggagctgctgagggcagagagcagggctgatactcaggaggctgaactgcag attttagatgaatttgctgttctctgcagagacctgtatgccttttaccccatgctcatc cgctatgtggacaacaacaggtctaaatggctgaagaaacctcatgcagattcaacggag ctgtttaaaatggtggcagagattttcatcctctggtgtaaatctcataatttcaaaaga gaggaacaaaactttgtggttcaaaatgaaatcaacaacctggccttccttactggagat agcaagagcaagatgtcaaagtcaggaggccaggatcaggagagaagagggaagaagagg aaaagggaattgtactctgttcagacgtccctaatcgtatccgctcataagaagttgctg cccattggtcttaatatgtgcacccctggagatcagatgcttatctctctggccaagatt cgttactgtctgaaagacacagatgatgaagtgaaggatcacctgaaacagaacctccat cttcaagagaagtcagaggatccaggagtacagtggcagctgaacctctacaaggatgtg gaaatgaagagtgaggaggcttcagatgttgaacacactgtagaaagaatacaagggatc tcggctgctgtgttccatttggagcaggtggaactgcctcttaggaacaagaaactggtg gcgcagaagctgctgtccaagcaacgcaagcgagctgtggtcgcctgcttccgtatggcc ccactgtataacctgcctaggcatcgctctattaatctcttcctcacgggctatcagaga ctttggatagtagcagaggagtactcctttgaggagaagctagtgcaggacctggcaaaa acacccatggttgtggaaaaggaggaggaggaagcagaagctgaggttcagccagatcct ctcaaccagctcatccttcacttcagtcacaatgccctcactgagagaagcttccttgaa atagatcctttgtatattgcatatgctgatatgatggcaaagagctgtgccgaagatgaa gaggaggaggaagagggtaaagaaaagacatttgaggagaaggaaatggagaagcagaaa actctgtaccagcaggccaggctgcacgcccgtggagctgctgagatggtgctccagatg atcagtgccagcaaagggcggcttggacccatggtgacttgtactctaaaacttggaata tcaattcttaatggaggcaacgtggttgttcaacagaaaatgctggactacttgaaagaa aaaagagatgctggatttttcaaaagtttatctggactcatgatgtcttgcagtgtgctg gacttgaatgcatttgagagacaaaataaggcagagagccttggcatggtaactgaagaa gggtcaagttccaaagtgctacaaaacgatgactttacaaaggatttatttaggtttttg cagcttctctgtgagggccacaacaatgatttccaaaacttcctgcgaactcagacagga aacacaaccacagttaatatcattatcagcacagtggactacctgctacgtctacaggag tccataagtgatttttactggtattattctggaaaagatatcattgatgagcaaggacag cgtaacttctccaaagccttggcagtagccaaacagatcttcaactcactgactgagtac attcagggcccttgtattgggaatcagcagagtcttgctcacagcagattgtgggatgca gtggttggattcctgcatgtctttgccaacatgcaaatgaaactatcacaggactctagc cagattgagctgctaaaggaactgatggatttgcagaaggatatggtggttatgatgtta tctctactagagggtaatgtggtgaatggaaccatcggcaagcagatggtcgacactcta gtggagtcctcaagcaacgtagaaatgatcctcaaattcttcgacatgttcctgaaattg aaggatcttactacctctgacaacttcaaagagtatgaccccgaaggaaaaggaatgatt tctaagaaggagttccagaagtctatggaaagccaaaagcaatacacacagtccgagatc gagtttctcctctcctgcactgaagcagatgaaaatgacatgttcaactacgctgagttt gtggaacgcttccatgagcctgccaaggacattggcttcaatgtggccgtgctgctcacc aacctgtccgagcacatgccacacgattcacgtctgggcaccttcctggacctggctgag agcgtgctcagctactttgagccttacttgggccgtattgagatcatgggtggcgccaag cggattgagcgagtctactttgagatcagtgagtccagcagggagcagtgggagaagccc caggtcaaagagtccaagcgacagtttatcttcgacgtggtcaatgagggaggcgagagc gagaaaatggagatgtttgtgaacttctgcgaggacaccatctttgagatgcagctggct tctcagatatctgaacaagacgctgcagagcggcccgaggaagaggaggaggagctgcag agtctgttggaggaactggctgaaggcgaagatggctcccaagagtcagcctcagcattt acactcgcctgcacctctgtgaagaagaaaatgtccaatttccgtcagatgctgaccatt aagagcatgcgtaaacagttcaagaagttcaagaaattgaccattaaagaaatgatcacc ggcttcttctctttcttctggatgctcttcactggattcttcaaaggcattttcggcctg atctttggattcttccatattatatggtcctcgatgtttggaggaggtctcgttgagggg gccaaaaacatgaaggtcacagacatcttgggcaacatgccagatcccacacagttcgga atacacggggatgtactggaggcagaaaaaatggagagtagtgactttgtagtgtctaca gaaatggtccaaatggctggtgcaggggacaaaatggagcccgattccattatagatcta ataaatccggcgccgaagagagagggaaagcatggacctgagactggactgggagatgtg tctgagatcatgacagaagtcagccaacctgtcgaaaagaagaaaagccagaaagccgct actgaggagtcagaaccagagaaagcagacaccgagcaccaggaaaaagaggacaaggcc aaggaggaaaagcctgaagagccagtagtggaggagaagccggccccaagaaaacgccat ggcacagcaaaagaggcagctcctgctttcatggccagcttcttcgctggcttagaggtc tacaagaccaagatgctgaactacttggctcgtaatttctacaacctccgtatgctggct ttgttagtggcgttcgcgatcaacttcatcctgctcttctacaaggtgtctggtgaaact gaagaggaggaggaagatgaaagtccatggggtggtgacgatgaggatgaggatggtggc ggtatggaattttttgtacttcaggagagcactggttatatggcacccactctgacgttc ctggctgtactgcacaccatcatttcactactgtgtgtggtggggtattattgccttaag gttcccttggtggtgttcaagcgagagaaggagattgcaagaacgctggagtttgatggc ttgtacatcactgaacagccctctgatgatgacattaaaggacagtgggatcgcttggtg attgctactccgtcattccccaacaattactgggacaaatttgtgaagagaaaggtaatc aacaaatatggggatttgtatggagctgagcgcatcgctgagcttctcggtctggataag agtgcacttgactttgatcccactgaggaggctgtggtgaaggaggcgtctttgctgtcc tggttgagctctattgataccaagtaccatatctggaaaatgggagttgtccttactgac aactcttacctctacctgatctggtacaccaccatgtctattctgggacactacaacaac ttcttctttgctgctcacttgctggacattgccatgggcttcaagaccttgaggaccatc ctgtcctctgtgactcacaacggcaaacagctggtgttgactgtgggtctgctggcggtg gtggtctacctgtacactgtggtggctttcaactttttccgcaagttctacaacaaaagc gaggatgaggatgcgcctgacatgaagtgtgatgatatgatgacttgctacctgttccac atgtatgtgggcgtgagagctggcggtggtattggtgacgagatcgaggacccagctgga gacccttacgagctttaccgcatcctgttcgacattaccttcttcttcttcgtcatcgtc atcctactggccatcattcagggtttgatcattgatgcctttggcgaattgagagaccag caggagcaagtaaaggaggacatggagactaaatgcttcatctgcggcattgggaatgac tactttgacaccacaccgcacggctttgagactcacaccttacaagagcacaaccttgcc aactacctattcttcctgatgtatctcattaacaaagatgagactgaacacacgggtcag gagtcttatgtttggaagatgtatcaggagagatgctgggacttcttccctgctggagac tgtttccgcaagcaatatgaggaccagctgggctaa

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