Aotus nancymaae (Ma's night monkey): 105729095 Help Entry 105729095         CDS       T10127                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism anan  Aotus nancymaae (Ma's night monkey) Pathway anan04020   Calcium signaling pathway anan04371   Apelin signaling pathway anan04713   Circadian entrainment anan04921   Oxytocin signaling pathway anan04970   Salivary secretion anan05010   Alzheimer disease anan05012   Parkinson disease anan05020   Prion disease anan05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:anan00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105729095 (RYR3)    04020 Calcium signaling pathway     105729095 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     105729095 (RYR3)   09154 Digestive system    04970 Salivary secretion     105729095 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     105729095 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     105729095 (RYR3)    05012 Parkinson disease     105729095 (RYR3)    05020 Prion disease     105729095 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     105729095 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:anan04040]     105729095 (RYR3) Ion channels [BR:anan04040]  Voltage-gated cation channels   Ryanodine receptor    105729095 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_1 EF-hand_7 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  105729095 NCBI-ProteinID:  XP_064230891 Ensembl:  ENSANAG00000028782 LinkDB All DBs Position Unknown AA seq 4865 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRAKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDVKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPITLPIEEVLKTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDI LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGR MNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRID GTMDSPPCLKVTHKTFGTQNSNADMIYCRLSVPVECHSSFSHSPCLDSEAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELSTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPNSFLKVETERVSERHGWVVQCMEPLQMMALHIPEENRCVDILELCEQEDLMRFHYH TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAKE RKLMMKNEYIIPITSTTRNICLFPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVIGEEHQ KQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLVDPSVFGEHSAETEEGAEKEEVTQVEEKAVEAGEKASKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTKEFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEKEEEED ASWTGKLRALIYKIKGPPNPEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDAELVR MMFNLLRRQYDSIGELLQALRKTYTISHASVSDTINLLAALGQIRSLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGDGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTEDNEEEEEIVH MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP SLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD TVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTK AQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL PSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDT RITATLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQNGWKY GISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRE NEKLRSVSQTNQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG GSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQVNGVIVSRGMKDMELDASSMEKRFAYKF LKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHHLYFLS SPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT VMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPI LTSIFEHVAQHQFGMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAA AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAES GARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSIILGNILKII NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADG KGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFI LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDLYSIQTS LIVAALKKMLPIGLNMCTPGDQELISLAKSRYGHRDTDEEVKEHLRNNLHLQEKSDDPAV KWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKR AVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEE TERQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEDEDKEKTFE EKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQ KMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKV LQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFY WYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLH VFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTN VEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSETDFLLSC AEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYF EPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELF VNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSFEPASAFAMA CASVKRNVANFLKRATLKNLRKQYRNVKKMTAKELVKVFFSFFWMLFVGLFQLFFTILGG IFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVTEPGITAELV HFIKGEKGDADIMSDLFGLHPKKEGSLKHGPEVGLGDLLELTGKDEPPTLESTVRKKRKA QAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKRRRGQKVEKPE AFTANFFKGLEVYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDV ANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAVIHTIISLVCVVGYYCLKVPLVVF KREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDL YGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYL AWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYT VVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMY RIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTP HGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQY EDQLG NT seq 14598 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagtttctgaggactgaggatgaa gtggtactccagtgcatcgccaccattcacaaggagcagaggaagttctgcctcgcagcc gagggacttgggaatcgcctgtgctttttggaacccacttcagaagccaagtacattcct ccagatctctgcgtctgcaattttgtgctggaacagtccctatctgtcagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggcgaaggggcagcacaaggaggtggccac aggaccctgttatatggccatgcaattctcctgaggcactctttcagtggaatgtatcta acatgtttgactacatcaagatctcagacagacaaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggactatacatcctgcttccaaacagaggtcc gaaggagagaaagttcgaattggcgatgacctcatccttgtcagcgtgtcctctgaaaga taccttcatctctcagtatcaaatggtaacatacaagtggatgcctcctttatgcaaaca ctctggaacgtacatcctacctgctcaggaagtagcatcgaagaaggatacctgcttggt gggcatgtagtacgtcttttccatggtcatgatgagtgtttgacgataccatctacagac cagaatgattcccagcacaggaggatattctatgaagctgggggagctgggactcgagcc aggtctctgtggagagtggaaccccttcggataagctggagtggcagtaacatcagatgg ggccaggctttccgactgcggcatctcaccacaggccactacctggccttgacagaggac caaggccttatactgcaagaccgggcaaagtcagacaccaagtccacagctttctctttc agggcatcaaaggaaatcaaggagaaattagattccagtcacaaacgagatatagaaggc atgggagttccagaaatcaagtatggagattctgtctgctttgtgcagcatatagccagt ggtctctgggtgacctacaaagcacaagatgtcaaaacttcccgcctggggcctctaaaa agaaaggtcatactccaccaggaaggccacatggatgatggattaacactgcagagatgc cagcgtgaagagtcccaggctgctcggatcatccggaacactacagccttattcagtcag tttgtcagcggaaacaatcgcacagctgcccccatcaccctgcctatagaagaagtcctg aagaccctacaggacttgattgcctacttccagcccccagaggaggagatgcgacacgaa gacaagcagaacaagctccgctcactcaaaaacagacaaaatcttttcaaggaagaggga atgttggcccttgtcttaaattgcattgaccgcttaaatatctacaatagcgtagcacac tttgcagggattgcaagggaagagagtggcatggcctggaaagaaattctgaacctccta tacaaattgctggctgctctcattcgtggaaacagaaacaattgcgctcaattctccaat aaccttgattggctcatcagtaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcttaactgaaagcccagaagccttaaacctgatagcagagggccac atcaagtccatcatctccctgttggataagcacgggcggaatcacaaggttctggatata ctgtgctccctgtgtctctgcaatggggttgcagtgagagccaaccagaatctgatctgt gacaacttgctgccccggagaaacctgctgctgcagacacgactgattaacgatgtaacc agtatccggccaaacatcttcctgggagtcgcagagggctcagcccagtacaagaagtgg tacttcgagctgattatcgaccaggtggaccccttcctaacagcagagcccacacatctg cgggtgggctgggcctcttcctcaggctatgccccatacccaggaggtggagaaggatgg ggaggcaatggtgttggcgatgacctgtactcctatggctttgatggacttcacctttgg tcgggccggatacccagagctgtggcttccatcaaccagcaccttctgagatcagatgac gtggtaagctgctgcctggacctcggggtgcccagcatctcattccgcatcaatgggcag cccgtgcaggggatgtttgagaacttcaacacagacgggctcttcttccctgtgatgagc ttttcagcaggtgtcaaagtacgtttcctgatgggtggacgtcatggagagtttaagttc ctgcctccctcgggctatgccccttgctatgaagccttacttccaaaagagaagatgaga ttggagccagtcaaagaatataaacgtgatgccgatggtgttagagatctcttgggtacc acccagttcctctcccaagcctctttcatcccatgtcccatagacaccagtcaggttgtt ttaccgcctcacctagagaagatccgagacaggctagctgaaaacatccatgagctttgg ggaatgaataaaatagagcttggctggactttcggcaagatacgagatgacaataaaaga caacatccttgccttgtggagttttcaaagctccccgaaactgagaagaattataacctg caaatgtcgactgaaaccttaaaaaccctcctggccctggggtgccacattgcccatgtt aacccagctgctgaggaggatctcaagaaagtcaaacttcccaaaaactatatgatgtcc aatggctataagccagcccctttggatttgtctgatgtgaagctcttacctcctcaagaa attttagtggataagcttgcagaaaacgcacacaatgtttgggcgaaagacagaataaaa cagggatggacctatggcatccaacaggatttgaagaacaaacgaaatccccgtctggtg ccatatgcgttactagacgagcgtaccaagaagtcaaacagggacagcctgcgggaagct gtgcgcacttttgttggttacgggtataacattgagccatcagaccaagaactagctgac ccggctgtggagaaagtcagcatagacaagatccggtttttccgggtagagcgatcttat gcagtgagatctggaaagtggtattttgagtttgaggtggtaactggaggagacatgcga gtcggctgggccaggccaggctgtcgtcctgatgtcgagctgggggccgatgaccaagcc tttgtgtttgaaggcagcaggggccaacgttggcatcaaggaagtgggtattttgggcgc acttggcagccaggggatgtggtcggatgtatgattaacctggatgatgcttcaatgatc ttcacgttgaatggggagctgctgatcaccaacaaaggctctgaacttgccttcgctgac tacgagattgaaaatggcttcgtgcccatctgctgtctggggctatctcagatcggccgc atgaatctcgggacagatgccagtaccttcaagttttataccatgtgtggtctccaggag ggctttgagccttttgctgtcaacatgaacagagatgttgccatgtggttcagcaagcgc ctcccgacgtttgtcaacgtgccaaaggatcatccgcacatagaggtcgtgaggattgat ggtaccatggacagccctccgtgtctcaaggtgacccataagacgtttggcacacagaat agcaatgccgacatgatctattgccgcttgagcgtgcccgtggagtgccactcttccttc agccacagcccctgtctggacagtgaagctttccagaaaaggaaacagatgcaagaaata ctctctcatacaacaacacagtgctactatgccatccgcatctttgctggacaggatcca tcctgtgtctgggtcggatgggtgactccagactatcacttgtacagtgaaaagtttgac ctgaataaaaactgcacagtgactgtcaccctaggggatgaaagaggccgggtccatgaa agtgtgaaacgcagcaactgctacatggtctggggtggggatattgtggccagttcccag agatcaaatcggagcaacgtggacctggagatcggctgtctcgtggatctggcaatgggc atgttgtccttctcagccaatggaaaagaactgagcacctgctaccaggtggagcctaat accaaagtgtttccagcagttttcctgcagcctacaagtacttctttgtttcagttcgaa cttggaaagctgaagaatgcaatgcccctgtcggcggccatattcaagagtgaagagaag aacccagtcccacagtgtccacctcgactggatgtccaaaccatccagcccgtgctctgg agccgcatgcccaacagcttcctgaaagtggagactgagcgggtgagcgagcgccacggc tgggtggtgcagtgcatggagcccctgcagatgatggcactccacatccccgaggagaac aggtgtgtggatatcctcgagctctgtgagcaggaggacctgatgcgcttccattaccac acgctgagactctacagtgcggtgtgcgccctgggaaacagccgcgtggcctacgccctg tgcagccacgtggacctctcccagctcttctatgccattgacaacaagtacctccccggc ctccttcgatcgggtttctatgacctcctcatcagcatccacctggccaacgccaaggag aggaagctgatgatgaagaacgagtacatcatccccattaccagcactaccaggaacatc tgcctcttcccggatgagtccaagaggcacggactgcctggggtgggcctcagaacatgt ctcaagcccgggttcaggttttccaccccttgctttgttgtgattggtgaggagcaccaa aagcagagccctgagattcccttggagagtctcaggactaaggctctgagtatgctgaca gaggcggtgcagtgcagcggggcacacatccgagaccccgtgggggggtctgtggagttc cagtttgtgcctgtgctgaaactcattggaacgctgctggtcatgggggtgtttgacgat gatgatgttcggcagatcctcctcctggttgatccctctgtgtttggggagcatagtgcg gagacagaggagggagcagaaaaggaggaagtgacccaggtggaggagaaggctgtggag gctggggagaaggccagcaaggaggctcctgtcaaaggcttgttgcagactcgattacct gagtcggtcaagctacagatgtgtgagctcctcagctatctctgtgactgtgagctgcag caccgggtggaggccattgtggcatttggtgacatttatgtctccaagctgcaggcaaat cagaagttccgctacaatgagctcatgcaggccctgaacatgtctgcggccctgactgcc cggaagacaaaggagttccgctcaccgccgcaggagcagatcaacatgctgcttaacttt caactgggagagaactgcccctgcccagaggagattcgggaggagctgtatgacttccat gaggaccttctccttcactgtggggttcctttggaagaagagaaagaggaggaggaggac gcctcctggacaggaaaactccgtgccttgatttacaaaatcaaaggcccacccaatcca gagaaggagcagccgacggaggaagaggagagatgccccacaacattgaaggaactcatc tcacagacgatgatctgctgggcccaggaggaccagatccaggacgcagagctggtccga atgatgttcaacctcctccggaggcagtacgacagcatcggggagctgctgcaggcactg cggaagacctacaccatcagccacgcctctgtaagcgacaccatcaacctgctggctgcc ctgggccaaattcgctccctcctgagtgtcaggatgggcaaggaagaggagttgctcatg atcaatgggctgggagacataatgaacaacaaggtgttttaccagcatcccaacctcatg agagtcctgggcatgcacgagacggtgatggaggtgatggtgaacgtgttgggtacagag aaatctcagattgcatttccaaagatggttgctagctgctgccgtttcctttgctatttc tgtcgaattagccggcagaatcagaaggccatgtttgagcatctgagttatcttctggag aacagcagtgttggcctagcctccccatcgatgaggggatccaccccgctggatgtggca gcgtcctccgtgatggacaacaacgagttagcgctgggcttagaggaaccagaccttgag aaggtggtgacgtacttagcaggctgtggcctacagagctgccccatgcttctggccaaa ggataccctgacgtcggctggaaccccattgaaggggaacgctacctgtccttcctgagg tttgccgtctttgtgaacagtgagagtgtggaagaaaatgccagtgttgtggtcaagctg ctgatcagacgcccagagtgcttcggcccagccctgcggggtgacgggggaaacgggctg ttggcggccatgcagggtgccattaagatctctgagaaccctgcgcttgacctcccatct caaggatacaagagagaagtcagcacggaggacaatgaagaggaagaagaaatcgtgcac atgggcaatgcaattatgtcattttattcggcacttatagatctactgggccgctgtgct cctgaaatgcatctcatccagacaggaaagggggaagccatccgcatcaggtccatcctg cgctccctggtccccacagaagacctggttgggatcatcagtatccccttgaaactgccc tccctcaacaaagatgggtcagtcagtgagccagatatggcggccaacttctgccctgac cacaaggcacctatggtgctgttcttggaccgtgtttatggcattaaggatcaaactttt ctgctccacttgctggaggttggatttttacctgacctaagagcctctgcctctctagat acagtttccctaagcaccacagaggctgcgcttgcactcaataggtatatatgttctgct gtgctcccgctcctcacaagatgtgccccgctctttgctggaaccgaacactgcacctct cttattgattctaccctgcagacaatatacaggctttccaagggacgttccctcaccaaa gcacaaagggacactatagaagaatgtctgcttgccatttgcaatcacttgaggccttcc atgttacagcagctcctgcgacgcctcgtttttgatgtgccacaactcaatgaatactgc aaaatgcctctcaagcttctgacgaatcactatgaacagtgctggaagtattactgcctg ccttcaggatgggggagctatgggctagctgtggaagaagagctgcacctaacagagaag cttttctgggggatttttgactctctctcccataagaaatatgacccagatcttttccga atggccctgccttgtctcagtgcgatagctggcgccttgccaccagattatttagatacg agaatcacagccacgctggagaaacagatctcagtggatgcagatggcaactttgaccca aaacctatcaacaccatgaatttttccttgcctgaaaaattggaatacatcgtcaccaag tatgctgagcattcacatgataaatgggcctgtgacaagagtcagaatggatggaaatat gggatttccctggatgaaaatgtgaagacccacccactgataaggcccttcaagacatta acggagaaggagaaggaaatttatcgctggcctgcccgagagtccctgaaaaccatgctg gctgtgggctggactgtggagaggaccaaagagggagaagctttggttcaacagcgggaa aatgagaagcttcgaagtgtgtcccagaccaaccagggcaacagctacagccctgctccc ctcgacctctcaaatgttgtgctctccagagagctccagggaatggtggaggtcgtggct gagaactatcacaatatctgggccaagaagaagaagctggagctggagagcaaaggtggt ggtagtcaccctcttttggtaccatatgacaccttgactgccaaggaaaagttcaaggac cgggagaaggcacaggacctgtttaagttccttcaagtgaatggcgtcatagtttccagg ggtatgaaagatatggagctggacgcttcctccatggaaaagaggtttgcctataagttc ttgaagaagatcctgaaatatgttgattccgctcaagaatttattgctcatttagaagcc attgtcagcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgct aaagttctcctcccactggttgaccagtacttcaccaatcatcacctctacttcttgtca tcccctctgaagccccttagcagcagcggatatgcctcccataaggaaaaagaaatggtg gccagcctgttctgcaagcttgctgctcttgttagacacaggatttccctctttggtagt gattctactacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggact gtcatgaagtcaggctcagagctggtgaaggctgggttgcgagcattctttgaaaatgct gcagaagacttggagaagacttcagaaaacctgaaactaggaaagttcacccattcccga acgcagattaaaggtgtttctcagaatattaactatactacagtggctctactccccatc ctgacgtccatctttgagcatgtcgctcagcatcagtttggaatggacctactcttaggt gatgtgcagatttcatgctaccacatactgtgcagcctctactcccttgggacaggaaag aacatttacgttgaaaggcaacgccctgcccttggagaatgtctggcctcgctggcagct gccataccagtggcattcctggagcccacccttaatcgctacaatccactctcggtcttc aacactaaaacccccagggaaaggtctattctggggatgccagacacggtggaagacatg tgtcctgacatcccgcagctggaaggcctgatgaaggaaatcaatgacctggccgagtca ggggcccggtacacagagatgccccatgtcatcgaggtgatcttacccatgctctgcaac tacctgtcctactggtgggagcgggggcctgagaacctaccccccagcacagggccatgc tgcaccaaggtcacctctgaacacctcagtatcatcctgggcaacattctgaaaatcatc aacaacaacctgggcatcgatgaggcctcctggatgaagcgcattgcagtgtatgcacag cccatcatcagcaaagccaggcccgacctgctgagaagccacttcatcccaactctggag aagctgaagaaaaaggccgtcaagactgtgcaggaggaggagcagctgaaagccgacggc aaaggggacacccaggaggcagagctcctcatcctggatgagttcgcggtcctctgcaga gatctctatgccttctaccccatgctgatccgctacgtggacaacaacagatctaactgg ctcaaaagtcctgatgctgattctgaccagctcttccgcatggtggcagaagtcttcatc ctgtggtgtaaatctcataacttcaagagggaagagcaaaattttgtgattcagaatgaa attaataatttggcatttttaactggagacagcaaaagcaagatgtcaaaatctggagga caggaccaggagcggaagaagacaaagcggcggggagacttgtattccatccagacctcc ctcatcgtggctgcactcaagaaaatgctgcccattggtttgaatatgtgcactccagga gaccaggagctgatctcccttgcaaaatcacgatacggccatagggacacagatgaagag gtcaaagaacatctgcggaacaacttgcacttgcaggaaaagtctgatgacccagctgta aaatggcaactgaacctctacaaggatgttttgaagagtgaagaacctttcaatccagaa aagacagtagagcgtgtgcagagaatttcagcagctgttttccacctggaacaggtggaa cagcctttgaggtccaagaaggccgtctggcacaaactgttatcaaagcaacgtaaacgg gcagtggtggcctgtttcagaatggcccctctctacaacctgcccaggcaccgctctatt aacctcttcctccatggctatcagagattttggatagaaacagaggagtattcctttgaa gagaaactagtacaggatttggctaaatctccaaaggtggaagaggaggaggaggaagag acagaaagacaacctgacccactacatcagatcattctctattttagccgcaacgctctc acggagaggagcaaattggaagacgaccctttgtacacgtcctattccagcatgatggcc aagagttgtcaaagtggtgaggatgaagaagaagacgaagacaaggaaaaaacatttgaa gagaaagagatggagaagcagaaaaccctgtatcagcaagctcggctgcatgagcgtggt gctgcagagatggtccttcagatgataagtgccagcaaaggtgagatgagccccatggtg gttgaaactctgaagctagggatcgccattctgaatggaggcaatgccggtgtgcaacag aaaatgctagattacctaaaggagaaaaaggatgctggattctttcaaagcctttctggt cttatgcagtcttgcagtgtccttgatttgaatgcatttgagaggcagaataaagctgaa ggcctggggatggtgactgaagaaggaacactcattgttcgtgaacgtggtgaaaaagta ctccagaatgacgagttcacgcgtgatctctttagattcctacagttactttgtgaggga cataatagtgactttcagaacttcctgcggactcagatgggcaacaccaccaccgtaaat gtcatcatcagcactgtggactaccttctgcgtctgcaggaatcaatcagtgatttctac tggtattattcagggaaggacatcattgatgaatctggacagcacaatttttccaaagct ctggcagtcaccaagcagattttcaattctcttacagaatacatccagggcccttgcatt ggtaaccagcagagcctggctcacagcaggctgtgggacgcagtggttggcttcctccat gtctttgctaatatgcagatgaaactctctcaggattccagtcagatcgagctgctgaag gaactcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaat gtggtaaatggcaccattggcaagcagatggttgacacactggtagaatcatctaccaat gtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagacttaaccagctca gacaccttcaaagagtatgacccagatggtaaaggaattatctccaaaaaagaattccag aaggccatggaagggcaaaaacagtacacacagtcagagactgactttctcctttcgtgt gcagaagctgatgagaatgacatgtttaattacattgattttgtagaccgattccatgag ccagccaaggacatagggtttaatgtggctgtgttattgacaaatctttctgaacacatg ccaaacgattcccgcctgaagtgtctgctggacccagcagaaagtgtgctaaattacttc gaaccatacctaggacgtatcgagatcatgggtggggccaagaaaattgagcgtgtttat tttgagatcagtgaatccagtcgcactcagtgggagaagccccaggtgaaggaatctaag cgacagttcatttttgatgttgtcaacgaaggtggggagcaggaaaagatggagctgttt gtgaacttctgcgaggacaccatctttgaaatgcagttagcatctcagatctctgaatct gattcagctgacagaccagaagaggaggaagaagatgaagattcttcttatgtgttagaa attgcgggtgaagaggaggaagatgggtctttcgagccggcctctgcatttgctatggcc tgtgcctctgtgaagaggaatgtcgccaactttctgaagagagcaaccctgaagaacctc aggaagcagtacaggaacgtgaaaaagatgactgcgaaggagctggtgaaggtgttcttc tcctttttctggatgctgtttgtggggctattccagttgttcttcaccatcctgggagga atctttcagatcctctggagcacagtgtttggagggggcctggtagaaggggcaaagaac atcagagtgaccaagatcctgggtgacatgcctgacccaacccaatttggtatccatgat gacactatggaggctgagagggcagaggtgacggagccaggtatcaccgctgaactagta cacttcataaagggtgagaagggcgatgcagatatcatgtcagacctctttggactccac ccaaagaaagagggcagcttaaagcatgggcctgaagtgggtttgggtgacctcttagaa cttactggcaaggatgaaccccctacgttagagagtactgtacggaagaagaggaaagca caggcagcagagatgaaagcagcaaatgaagcagaaggaaaagtggaatccgagaaggca gacatggaagatggagagaaggaagacaaagacaaagaagaggagcaagccgagtacctg tggacagaagtgacaaaaaagaagaagcgacggcgtggtcagaaggttgagaagccagaa gctttcacggcgaatttctttaaagggctggaagtctatcagaccaagttactgcattac ctggccaggaatttctacaacctgaggttccttgctctgtttgtagccttcgctatcaac ttcatcctgcttttttataaggtcactgaagaacctttagaagaagagacagaggatgtt gcaaacctgtggaattcctttaatgatgaggaagaggaagaagcgatggtgttctttgtc cttcaggagagcactgggtatatggcaccaacgctgcgggccctggctgtcatccacacc atcatctctctagtctgtgtggtgggatactactgcctgaaggtccctttggtagtattc aaaagggaaaaagaaatagccaggaagctggagtttgatggcttatatatcaccgaacag ccatccgaagatgacatcaaggggcagtgggaccgcctggtgatcaacacaccatctttt cctaataactattgggacaagtttgtaaagagaaaggtgatcaacaagtatggagatctc tacggagcagaacgcattgctgaacttctgggtttggacaaaaatgctcttgactttagc ccagtagaagagaccaaagcagaggcggcctctctggtgtcatggttaagttccattgac atgaagtatcatatctggaagctgggagttgtttttactgacaattcctttctctacctt gcctggtatacaaccatgtcagttctgggccactacaataacttcttctttgctgctcac ctgctggatatcgcaatgggctttaagacactgaggaccattctttcatctgtaactcac aacggcaaacagttggttctgactgtgggtctcctggccgtggtggtttatctatatact gtggtggctttcaacttcttccgcaagttctacaacaaaagtgaagacgatgacgagccg gatatgaaatgtgatgacatgatgacgtgttaccttttccacatgtacgtgggagtgaga gcaggaggtggcattggcgatgaaattgaagaccctgctggtgatccttacgaaatgtat cgcattgtctttgacattacctttttcttctttgtcattgtcatcttgctcgccatcatt caaggtcttattattgatgcttttggagagctgagagaccagcaggaacaagtgcgagaa gacatggagactaaatgtttcatctgtgggattggcaatgactactttgacacgaccccg catggttttgaaacacatacattacaagagcacaacttggccaactacttgttctttctg atgtatttgattaataaagatgaaacagaacacacgggtcaggaatcttatgtctggaag atgtaccaagaaaggtgttgggatttcttcccagccggtgactgctttcgtaaacaatat gaagatcagcttggataa

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