Alosa sapidissima (American shad): 121678265 Help Entry 121678265         CDS       T11137                                  Symbol obscna Name (RefSeq) obscurin isoform X1   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism asad  Alosa sapidissima (American shad) Pathway asad04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:asad00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     121678265 (obscna)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:asad01001]     121678265 (obscna)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:asad04131]     121678265 (obscna) Enzymes [BR:asad01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      121678265 (obscna) Protein kinases [BR:asad01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    121678265 (obscna) Membrane trafficking [BR:asad04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     121678265 (obscna) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Pkinase PK_Tyr_Ser-Thr Ig_5 Ig_4 Izumo-Ig SOS1_NGEF_PH RhoGEF C2-set_2 Ig_6 Kdo PH fn3 IQ Pkinase_fungal Adeno_E3_CR1 APH IQ_SEC7_PH RHG20_PH Motif Other DBs NCBI-GeneID:  121678265 NCBI-ProteinID:  XP_041913572 LinkDB All DBs Position 12:22384200..22431881 Genome browser AA seq 6004 aa AA seqDB search MNDKTNPKLNMALKKIQVVRGLEDLELLETESCSFEVTLSHGYVDGSWTKDGTRLKSKPN CRISTQGKRHILTLTRVSLGDTGVFSFQAEGIQTSARLVVRARDIRILRDLLDADVTERE SVSFVCEVNLEDVAGQWYINNSRLKARDNVKVKHEGKKHTLIIKSVKPEDAGEIKFTAES ASSTATLSVEELPVQIIKPLKVKIAMYKHRGLLECQVSRASAQVKWYKNNREIAAGQKFQ IHSDDVYRQLIIEDVASSDEDTYTCDAGDDKTSCQLLVEEQAISIVRGLTSVVVIEPKEA KFRVETSIKSVRPPKWTLNGQVLVDSQEVRIEKEGTMHWLIFTSTNSTMSGPVQFTFGKS KSTAQLTVKERPLAVVQPLEDTTTKEHGSITLSCGFNPSPRLVRWFKGKNLLSDSGKYSI KREKNRAELTIQNLRGADSGEYRCLAGGSESKGILTVEVRRLKIIKHLEHVEVEEDANVT FTCELNYEVPSVQWILNDRILHTNNIHKINSTGKIHSLTLRRLSPQQSRVTFKAPGVSEA AILKVKERPAVFLRSLEDMSGEERSDISLTCEASKPNVVPTWRKDEIVLEASEKYEILQS GGSLALIIHNLCKDDAGEYVCDLGTSQTKATVTVHDLHITIAKRLKTTSVLVGDNCSFEC VLSHELLEEAFWFLNGQLVVSNGRMLLSSNGRRHKMNIDEVAISDAGDIIFTIKDLSCQT VLFVQEKPVRVFRDMLNLRVTPGEDAELSCEITRPETSIKWLKNGHVIRESPKYEISQKD HLVKLIIHNATLMDSGEYCCEAEGIATRAKLVVKDLQHTFAKELRDTRAEEKSMVILECE TKQPATKVTWLKGMMVISTGSKYLTKQKGVYLSLTIFNLEWSDEDVYTCDVGTMQSKAQL TVHGRKVLILDELEDIECLEGDTAMLRCRICPSDFIEVKWYLDETQLYTNDLNEIQVNPG GYHSLAIKRLARKDSGTISFVAGDKRSYASLLVRERRPTILRPLEDTEAIEGGTLVLSCR TSKPCHILWYKDGFLVWNSSRFWTSRSGNEARLTIREVIDTDAGVYECDAGAVSTKATVT VKAVPAEFTRKLEDVDGKEGQSVTLSCEFSLPGVVYIWRRGAETLRAGDKYQMKQKKFAI LLTINDLKVHDSGDYSCVCRDQKTTASLIVNAIPISFRRELRNQEVEEGRSVTLRCELSK PGAPFEWKKGAERLTSEGPYQIKQRDLMVELIIKKALVQHSGMYSCVCGDHITTATLKVN AQPVTFRQKLRSVVVEEGSTVSLRCELSKAGASVEWRRAEALLWSGDKYHMKQRDIVVEM KILNATLADSGLYSCICGYQKTTATVTVNIIQVTFKEKLKDQTIEEGNNLTLRCELSKAG VPVEWRKGGELIEPGERFQMRLRQATAELFIFEAVPEDSGVYSCVYAEQKTKATIKVTGV PATFIQSLKHQEVLEGGEVVFRCEISKAGVPVEWYRGDMGIQAGPKYQMKHDGRFAELQI RDLQPEDAGPFSCVTGGQKTTAEVKVNAHPVTFNREPQDQTAKEGDSAVFSCEISKPGAP VEWRRGRLILKSGEKYEIRQDGKYNKLVVRKVEESDAGRYTCKTKDAQVGAELNVKALPP TFIKELKNLEAEEGNSVMLRCELSKPGASVEWRKGAELLRTGEKYQTRQREGVVELLIRK ALPEDSGVYTCVCKEQKTAAIVSITATPVTFKQNLKNQEAVEGYTITLRCEMSKTGVMVK WRKENELLTAGVKYEMKREGKIVELLINDVSLEDTGIYSCSVGDLKTTAEVKVRALPVTF KRELQDQASKEGDTVVFRCELSKPGAPIEWRKGRVVLMHGDKYEMKQEGKFTKLVISSVE ESDAGKYTCKSKDSESSAELTVKVPPITFKKKLANQEVEEGNSITLSCMLSKPGIPVEWR KGDEVLKSGQTYQIIQKDATMELFIKKAQKEDSGVYSCVCGDQKTKATIKIFAIPVTFKQ SLKNQEASEGGVVILRCELSKAGVSVEWWKGEDEILPSTKYAIKYEGQFAELQINNVKPK DVGEYSCVIGEMRTTAEVNVRAAASVYFEKELEDLEATEGESVTLTCELSNPNAPVIWKK DAEMLSQGARVSLEQQGNTHVLEIRRVRPEDAGVYTCNTRGKVTSAKLKVKENVKIVSGL RDLSVTAGEDAHFVCEVSHDDYADGVWWLGSTVLQRNEMNQMSCRGREHHLVLTRATAEE AGIVAFAVGNERTSARLRVLSKPKVLIEQKLKDTTIFEGGTATLSCVTSDMRTPVAWKRK NVVLLAGEKYELRKEGKLNLLLIHSVEKEDTGLYTCDTGDMQCSATLTVKEHPLRFQEEL QGKEVEEGDTVLLCCELSKPGVRVEWRKGRVLLRPGEKYEMKQDGCELQLRIHDVSAQDK GDYTCSAGDLQTTAIVKVKEHPLFFREELQSQRVDEGETVVLCCELSKPGVPAEWRKGRV LLRPGEKYEMRQDGCELQLRIQDVSPQDKGDYTCSAGDQQTTGSLRVKEKPLFFQEELQS QEVDEGETVLLCCELSKPGVRVEWRKGRVLLRPGEKYEMKQDGCELQLRIHDVSAQDKGD YTCSAGDQQTTAQVRVKEHPLFFEKELQSQEVEEGDTVLLCCELSKPGVPVEWRKGRVLL RPGGKYEMKQDGCELQLRIQDVSPQDKGDYKCAAGDQYTTASIRVKEHPLFFQGELQSQE VDEGETVLLCCELSKPGVPVEWRKGRVLLRPGGKYEMRQDGCELQLRIQDVSPQDKGDYT CSAGDQQTKATITVKEYPLFFQKELESLESKEGETIFLNCELSKPGIPVQWRKGRVLLRP GGKYEMKHIDCELQLCIHDVSPQDKGDYTCSTGDQQTTAFVKVKEVPLVFHKELQNQEAE EGDTLILYCELSKPGVTAQWKKENAPLRSGLKYEIKQNGCQLELRIININPQDKGCYTCS AGTVQTTASVAVKEVRPVPKDEPKPKPDTVKPGVPPAKPVAKAGKVELEKETVVKQPETD VSDNKKVDKDLRKKTLTRQKVEDDGVSKIEESNYAKEEPTELAPKVVSRSVGQQRQGSVS IQDEGLREAVLPKEAVKEPIKEPIKETTKETVKETAKETIKGAEQLPVPPKRRRSLRPTE VKHEETAKSKETIKSPVEVTKDTAAIQKNKVVVSASTDNKDEITVSPQESKAHIKSPTEV TKEPRKSEEPTKEITVTKESAVSIQTNQESVKTAKKGIEEITVPVRRSKMAGQISKEGPG ETTALIQKNGEPSKAAENTPEEYSAAVQKKDESNKTLRRPSEGQIPAVQKNNEPVKTTTE LPEVPTVPVRKNKVSIKAAAAPPEQPAALVETDKNAITGKQPVDGEPTIEKNKEPNKIAA KDTVESTVPVHKNGEPVKLATATKDESTITVQKNKEPTKIATRHPEESIVSLQKNGEPIK PGTTPKENSIIPVQENKEPTKTGARHPEESIVSIQKDEEPIKPSTTPKEESIIPVQQNNE PIKTAQQTPEESKPVQINKQPIVISAGHKEEAIISEQQLTELEEQKASSIDINVEEEPEM LEAAIKIQAVFKGYKTRKDMRPVFKEVFKNQSVELNGTIRLQCIAEGKPNTVRWLKDGEE IRPSTRFHIKKQDDGSCSLIIDNVTQKDTGIYTCEAVNKFGTISYNGNVTVETSPRPIPQ VHVKPATALVPEIGTESELEPVSEPLRLEGGSLRQVYDLPKVDQHVGAKEKRRSLISASS VSCPSDYDTAPDGAESLSDFGSRDFPIKEKELKKAPSGSELPETTEELPSIDLQPQKPSS QLQIQAGGIAVSRSPSPKYSPSHKPSANESLSESDGEEDRGEIFDIYVAKCDCNPTGGHK ETFVLKEGQYVEVLDSVHPTRWLVRTKPTKITPARQGWVSPAYLEKRGREPFSMLLEPQL YERAGREPSQDEFKNTVSELIQGLLSGEEEFVRELSFFVSHHLRFIETSSKVPLPIFSQK EYMFRNIKEITNFHERSVLPKLMECSTDDDVAMCFVSQASDFEKYLQYIVGQSQAEACLN EKNTQHFFQKYQETELARRHTEVLSVSTYLQRPLERIEMYKSLLKELIRNKAKFKRSCCL LEDAFSVVSSLPWRAENMEQVAMIENYPAPLSGLGEPIRQGPFTVWEESPGTKLSFRGQQ RHVFLFKDCVIFCKLKKDPDTHGDTYIFKNKMKLGDIEVKESVEGDERAWGLWHEHRGTV RKITLQSRSVLLKLSWLKDLRELHQCSCLPSRCAPHFDLLLGDCTTKLGQTVKLSCKVTG SPRPEVTWYKDGQAVEVDEQHMVSESNTGSCCLVLTGVSMEDSGQYMCYATSCMGNASTL AKIVVDVPPSFKIKLQNVQLDIGKDVQFQCSTLCTPLPRIRWFKNSKLLENQKKYQIDCE PQTGVLTLTIKRAGKVDLGLYECELWNKIGSAKCKAELCRPPATPTEPVPEKAPPVSAKE LEAESETWSGSLVKNWFQMDLTPSGICKMLFQPGYAEPATASTGGAGPKQKKDMAPKKAE TVSKKAETVSKKPAAVAETVAVAEEEEEIETDPPSIQVPIEDQCVKLGQPASFTTIITGQ PQPEIYWLKDGMEVLPSENVEMVFFGARSSLNVFSVTREDCGTYTCEAENSTGLVDCHAQ LTLESEVPEVATLEGTEVELGRRKLLSVYEVHDEIGRGTFGVVKKVSHRATGEPFAAKFL PLKSSTRTRAFQERDLLSRIAHPRVACLLDFFVTRRTLVLVTEMCSSQGLLDHLLMKGSV KETEVQMFIQQVLEGIAHIHSLSILHLDIKTDNILMVSPAREEVKIIDFGFCQEIDSSRH QYSKFGTPEFVAPEVVHQEPVTTGTDIWALGVVAYLCLTCHCPFFGENDRATLMRVAEGT LFWDTPEVTCRSPEAQDFLRKVLHPVPEMRPSAFECLSHEWFQGQSADEEPGDINTKNLR SFISRRKWQRSLTCLGSVLTLRPMVDLLDAPPEEVSVTAPREPQEPSSTSQSSGSSSEYD EADAWECFQHFSPEDEDWDEDEDEEDEEELEEEELEEEGEYDPHAQVPERGRTLAELGRA RLDEEEELILERRSGQRGALVFPTGKPGDQPQQRSSSPSLYLSEGDESSVGSESRAAIIP RGRLIRSTFYNSSQQLSPMSARHMLLRDKQHAARKQERGRKPLRSSLSGRLNEPLIEYVE DAPEAGVGGAGEGGVRGQRRGSVHSAMLKSCSFDSGVSLTHPLPYQRRSRSLDESTRRSR ASAELREPGEEEEEEEEDTAFSHKDDFTDEEAQQSVSPQPAEVSDARRRQSVVAKVKPRT QRAGEEEVAEEDSTVDSQPQAPERTREASRPLAGGENLSSSQASLAESYEPGSGVSSRTG SLDDFSPGRLAAPRRRLSSSGMTSPSSFLHGSDEEEEEQEEARKPPTPPSRRYGSRLSLQ VERGDLSLKRSPSRLSDQVPTTIPGSGEVLQRHASAPALEVKPPSGKSPKIGLMKLFRRQ SWTGHSSSQPEGVDRKQKEAEQAVPKSPMLTLKKKMRASASSLTKLFTRQSSKEEKKGGP IYKGPSPVAPEKKQKAHTRSAPALTASAPSSPQKKAAKLLKSIKVPTFKKSKEVAVRPAR PDVHQLAGGGVLLVWRPVKSSETFTYCLQYSTAGGVVEWKLLAEDVTDSCYTVTTLPKGP GYVFRVGCVTKTGAGPFSDPTILAFMVVQHEDSHIPLIQKESLRSKVIVSGAQGAHKIYS FLSEINRGRFSVVAQCREEQSQQHLAAKITPYRAEQRQLVLREYQLLKRLNHPHLVQLHS AIISPDYLVLLEELCAGRELLYNLAERDAYAEMDVSELLVQILSAVDYLHSRRMMHLDLK SDNMLVTDGNVVKIVDLGSAQLYTPGQAVNVEHLKELTESKVYIVLPKAPEILEGQGVGP ETDIWAIGVLAFIMLSADSPFHADLNWERDRNIKKGKIQFGRCYPGLSEGAINFMKSTLN NKAWGRPSAGECLQNPWIRGDARAAARPRDSMVCFSTDKLQAFLQEREVKRDHIRTKAKV PLLQ NT seq 18015 nt NT seq  +upstreamnt  +downstreamnt atgaatgataagacaaacccaaagctcaacatggcattgaagaagattcaggtggtgagg ggtctggaggatctagaactgctggaaacagagtcctgctcattcgaggtgactctcagc catgggtacgtggacggctcctggaccaaggatggcacccggctcaagtccaagcccaac tgccgcatcagtacccagggcaagagacacatcctaaccctcacccgggtctccctggga gacacaggcgtgttctctttccaagcagagggtattcaaacatctgctagacttgtggtc agagccagggatatcagaatactgagggatctattggatgcagatgtgactgagagagag agtgtatcttttgtgtgtgaggtcaacctggaggatgtagctggacagtggtacatcaac aacagcagactgaaagccagagacaatgtcaaagttaaacacgaggggaaaaagcatacg ctcatcattaagtctgttaaaccggaagatgctggtgaaatcaagttcactgcagagagt gcatcttcaactgccacactaagtgttgaagaactcccagttcagatcatcaagccgctg aaggtgaagatcgccatgtacaagcaccgaggcctcctggagtgccaggtgtctcgtgcc agtgcccaggtcaaatggtacaagaataaccgcgagatcgctgcaggccagaagttccag atccacagtgatgacgtgtaccggcagctgatcatagaggatgtggcctcctctgacgag gacacctacacctgcgatgctggtgatgataagacgtcatgtcagctactggtggaggag caggccatcagcatagtgcgagggctcacctcggttgtggtgatagaaccaaaagaggcc aagttccgtgtggagaccagcataaagtcagtgcggcccccgaagtggaccctgaacggg caggttctggtggacagccaagaggtgcggatcgagaaggagggcaccatgcattggctc atcttcacgtccaccaacagcaccatgtccggccctgtgcagttcacctttggcaagagc aaatccactgcacagcttacagtcaaagagcgcccattggctgttgtccagccacttgaa gatacaaccaccaaagaacacggctcaatcactctgagctgcggctttaacccctctccc cgcctggtacgctggttcaaggggaagaacctgctgtcggactcggggaaatacagcata aaaagagaaaagaaccgggctgagctgaccattcagaacctaagaggagcggactcagga gagtaccgctgcctggctggagggtcagagagcaagggcatcctcactgtggaagtacgc agacttaagatcataaaacacctggagcatgtggaggtagaggaggatgccaacgtgacg tttacatgcgagctgaactacgaggtacccagtgtgcagtggatcctcaacgaccggatc ctccacacaaacaacatccacaagataaacagcaccgggaagatccacagcctcaccctc aggcggctgtccccgcagcagagcagggtgacctttaaagcccccggggtcagtgaagca gccatactgaaggtcaaagagaggccagctgtctttctcaggtccctggaggacatgtct ggggaggagcggagcgacatcagtctgacgtgcgaggcctccaaacccaatgtggtgccc acctggaggaaagatgagattgtcctagaggccagtgagaagtatgagatacttcagtca ggaggatccctggcccttatcattcacaatctgtgcaaggatgacgcaggggagtatgtc tgtgacctgggcaccagccagactaaagccactgtcactgttcatgatcttcacattacc attgccaaacggctgaagacaacatcagtcctcgtaggggacaactgcagctttgaatgt gtgttgtcgcacgagctgctggaggaagccttctggtttctgaatggtcagctcgtggtc agcaatggcaggatgctactctccagcaacggccggaggcacaaaatgaacatcgatgaa gtcgccatctcagacgctggtgatatcatcttcaccatcaaagacctcagctgccagact gtgttgtttgtccaagagaagcccgtaagggtgttccgggacatgctcaacttgcgggtc accccaggggaggacgccgagctgagttgcgagatcactagacccgagacgtccatcaag tggttgaaaaatggccacgtcatccgagagagtcccaagtacgagatctcccagaaggat cacctggtgaagctgatcatacacaacgccactctgatggactctggagagtactgctgt gaagctgaagggatcgctaccagggccaagctagtggtcaaagaccttcagcacacgttt gctaaggagctgcgggacacacgcgctgaggagaagagcatggtgatcctggaatgtgag accaagcagccggccaccaaggtgacctggctcaagggcatgatggttatcagcacgggc tccaagtacctgaccaagcagaagggggtctatctctccctgaccatcttcaacctggag tggagcgatgaagatgtgtacacgtgtgacgttggcaccatgcagtccaaggcccagctg accgtgcacggtcggaaggtcctgattttggatgaactggaggacattgagtgtttggag ggggatacggccatgctcaggtgtcgcatctgcccgagcgacttcatcgaggtgaaatgg tacctcgacgagacgcagctgtacacgaacgaccttaatgagatccaggtgaatccggga gggtatcactctctcgccatcaagcggcttgccaggaaagactcaggcaccatctctttc gtggcgggagacaagcgatcatatgcctcgctgctcgtcagagagaggaggcccacgatc ctacggcctttggaggacacagaggcgattgagggaggaactctggttctgtcgtgtagg acgtcaaaaccgtgccacatcctgtggtataaagacggattcctggtgtggaactcctcc aggttctggaccagccggtcagggaacgaggccaggctcactatccgggaggtgattgat actgacgctggggtttatgagtgtgatgctggagcagtaagcactaaggccacagtcaca gtgaaagctgtgcctgctgagtttacccgtaagctcgaggatgtggacggcaaagagggg cagagtgtcacactgtcctgtgagttctccctgcctggcgtggtctacatctggagaaga ggagcggagacgctgagagcaggagataaatatcagatgaagcagaagaagttcgccatc ctgctcacaatcaatgatcttaaggttcatgacagtggagattacagttgtgtgtgccgg gaccaaaagacgaccgctagcctgatagtaaatgccattccaatatctttccgacgagag ctgcgtaaccaggaggtggaggagggccggagcgtgaccctgcgctgtgagctctccaag cctggggcaccgtttgagtggaagaagggggcagagaggctgaccagtgagggaccgtac cagatcaagcagagggatctgatggtggagctgatcattaagaaagccctggtgcaacac agtggcatgtacagttgtgtgtgtggagaccatataaccacagccacactcaaagttaat gctcagccggtgaccttcaggcagaagctgcggagcgtggtggtggaggagggcagtaca gtgagtctgcgctgtgagctatccaaggccggcgcctcagtggagtggaggagagcagag gcactcctctggagcggggacaaataccacatgaagcagagggacattgtggtggagatg aagatcctcaatgccacactggccgacagtggactttacagctgcatctgtggctatcag aagaccactgccactgtgacagtgaatatcattcaggtcacctttaaggaaaagctaaag gatcagacgattgaggaaggcaacaatctgaccctgcgctgtgagctctctaaggcagga gtcccagtagagtggaggaagggtggagagctcatcgaacccggagagaggtttcagatg aggctcagacaagccacggccgagctcttcatcttcgaggccgtccccgaggacagtggt gtctacagctgtgtgtatgctgaacagaagacaaaggccaccatcaaagtcactggtgta cctgccacgttcatccagtccctgaagcaccaggaggtgttggaaggaggcgaagtggtg ttccgctgtgaaatctccaaagctggagtcccagtcgagtggtaccgaggggacatgggg atccaggccgggccaaagtaccagatgaagcatgacggaaggtttgctgagctccagatt agagacctgcagcctgaggacgctgggccgtttagctgtgtgacagggggacagaaaacc acagctgaagtcaaagtgaacgcgcatccggtaacgttcaaccgagagcctcaggaccag acagcaaaggaaggggacagtgccgtgttcagctgcgagatctccaaacctggagctcca gtggagtggaggagaggcagactgattctgaagtcgggggagaaatatgagatcagacag gatggaaagtacaataagctggtggtgcggaaggtggaggagagcgacgccggcagatat acctgcaagactaaagatgcccaagtcggggcagagctcaatgtgaaagctcttcctcct acgttcataaaagagctgaagaaccttgaggctgaagaaggcaacagcgtgatgttacgt tgtgagctctccaaacccggcgcgtcggtggagtggcgcaagggagcggagctgctgcgg accggcgagaagtatcagacgaggcagagagagggcgtggtggagctgttgatcaggaaa gcccttccagaagacagtggcgtctacacctgcgtctgcaaagagcagaaaacagcagcc atcgtgtccataactgcaacccctgtgacatttaagcaaaatctgaagaatcaagaagcc gtggaagggtacaccatcaccttgagatgtgagatgtccaaaactggagttatggtcaaa tggaggaaggagaatgaactgctgactgcaggagtgaagtatgagatgaagagagaaggg aagattgtggagttgctcataaacgatgtgtctttggaggacactggcatatacagctgc tcagtaggggacctgaagactacggcagaagtgaaagtgagagctcttcctgtgaccttc aagcgagaacttcaggaccaggcctcgaaggagggcgacaccgtggtcttcaggtgtgag ctgtccaagcctggcgctcccatcgagtggaggaagggacgagtggtcctgatgcacggg gacaaatacgagatgaaacaggaaggcaaattcaccaagctggtgatatccagtgtagag gagagtgatgctgggaagtacacgtgcaaaagcaaagactctgagtcaagcgctgagctc actgtgaaagttccccccatcactttcaaaaagaagctggctaaccaggaggttgaggaa ggaaacagtatcacgttgagctgcatgctgtcgaaaccaggcatcccagtagagtggaga aagggagatgaggtcctcaagtctgggcaaacctaccaaatcatacagaaagacgcaacc atggaactcttcataaagaaggcacagaaggaagacagtggtgtctacagctgtgtgtgt ggagaccagaaaaccaaggccaccattaaaatatttgcgattcctgtgacgttcaagcaa agtctgaagaaccaggaggcctcggagggaggagtggtgatcctgaggtgtgagctctcc aaggccggcgtctcggtggagtggtggaaaggcgaagacgagatcctgcccagtaccaag tacgcgattaaatacgagggtcaattcgctgagctgcaaatcaacaacgtgaaacccaag gatgttggggagtacagctgtgtgattggagagatgaggaccactgcagaagtaaatgtc agggcggctgcctctgtgtactttgagaaggagctggaggacctggaggccactgaagga gagtctgtcaccctaacttgtgagctctcaaatcccaacgccccagtgatctggaagaag gacgctgaaatgctcagccaaggggctagggtctccctagagcaacagggcaacactcat gtgttggagatccgccgggtgaggccagaggatgccggagtttacacctgtaacacgcga ggcaaggtgaccagtgcgaaacttaaggtgaaagaaaatgtgaagatagtgtcagggcta cgcgacctgagtgtcacagctggagaggacgcccacttcgtgtgtgaggtttcccatgac gactacgctgatggcgtgtggtggctgggctccaccgtcctgcagaggaacgagatgaac cagatgagctgccgaggccgggagcatcacctggtgctcaccagggccaccgccgaggag gccgggatcgtggcgtttgccgtggggaatgagagaacctcagctcgcctgcgtgtgcta agcaaacccaaagtcttaatcgagcagaagttgaaagacaccaccatcttcgagggaggc acggccactctatcctgtgtgacttctgacatgcgcaccccagttgcctggaagcggaaa aacgtggttctcttagcgggagaaaagtatgagctgcgtaaggaagggaaactgaacctt ctgctgattcacagtgtagaaaaagaagacactgggctatacacgtgtgacactggtgat atgcagtgcagcgctactctcactgtcaaagagcatcccctgcgtttccaagaagagtta caaggcaaggaggttgaggaaggcgacacagttctcttatgctgtgagctctctaagcct ggcgtgcgggtggaatggaggaagggtcgtgtgctgctgagacctggtgagaagtacgag atgaagcaggatggctgtgagctccagctgcgtatccatgacgtcagcgctcaggataag ggagactacacatgctccgctggagatttgcaaactactgccattgtcaaagtgaaagag catcctcttttcttccgggaggagttgcagagccagagggtagacgagggtgagacagtg gtcctttgctgtgagctctctaagcctggcgtgcctgcggaatggaggaagggtcgggtg ctgctgagacctggtgagaagtacgagatgaggcaggatggctgtgagctccagctgcgt atccaggatgtcagcccgcaggataagggagactacacatgctccgctggagatcagcag accacaggctcactgagagtaaaagagaagcccttattcttccaggaagagctgcagagc caggaagtagatgagggggagacggtcctcctgtgctgtgagctctctaagcctggcgtg cgggtggaatggaggaagggtcgtgtgctgctgagacctggtgagaagtacgagatgaag caggatggctgtgagctccagctgcgtatccatgacgtcagcgctcaggataagggagac tacacatgctccgctggagatcagcagaccacagcccaagtcagagttaaagaacacccc ctgttttttgaaaaagaactgcagagccaggaggttgaggagggcgacacagttctctta tgctgtgagctctctaagcctggcgtgccagtggaatggaggaagggtcgggtgctgctg agacctggtggcaagtacgagatgaagcaggatggctgtgagctgcagctacgtatccag gatgtcagcccacaggataagggagactacaagtgtgcggctggagaccaatacaccaca gcttcaatcagggtgaaagagcaccccctgttcttccagggagagctgcagagccaggaa gtagatgagggggagacggtcctcctgtgctgtgagctctctaagcctggcgtgccagtg gaatggaggaagggtcgggtgctgctgagacctggtggcaagtacgagatgaggcaggat ggctgtgagctgcagctacgtatccaggatgtcagcccgcaggataagggagactacaca tgctccgctggagatcagcagaccaaagccactataacagttaaagagtaccccctcttc ttccaaaaagaactggagagcctagagtcaaaggagggtgaaacgatcttcttgaactgt gaactctctaagcctggaattccagtgcagtggaggaagggtcgggttttactaaggcct ggtggcaagtatgagatgaagcacattgattgtgaactgcagctgtgtatccatgatgtc agcccccaggataagggagactacacatgctctactggggatcagcagacaactgccttt gtaaaagtaaaagaggtgccactggtcttccacaaagagctccaaaatcaagaggcagag gagggtgacactctcattctgtattgtgaactctctaaacctggagtcactgcacagtgg aagaaggaaaacgctcctctgaggtctggtttaaagtatgaaatcaagcaaaatggctgt cagctagagctacgaatcattaatattaacccccaggataaagggtgctacacatgttct gctggtactgttcaaaccacagcctctgtggcagtgaaagaggtcaggcctgttcctaag gatgagccaaaacctaaaccagatacagttaagcctggtgtaccccctgctaaacctgtg gctaaggcagggaaagtagaactggaaaaggagacagtggtaaagcagcctgaaacggat gtcagtgataataaaaaagtggataaagatctcaggaagaaaacattaacaaggcaaaaa gtggaagatgacggcgtgtccaagattgaagagagtaactatgccaaagaggaaccgaca gaactagcccctaaagtggtctcaaggtctgttggacaacagaggcaaggttctgtcagc attcaagatgaaggcctacgggaggctgtcctaccaaaagaggcggtgaaagagcccatc aaagagcccatcaaagagaccaccaaagagaccgtcaaagagaccgccaaagagaccatc aaaggtgcagaacagctgcctgttcctccaaaaaggagaagaagtctcagacctacagag gttaaacatgaagagacagcaaaaagcaaagaaaccattaagagtcctgttgaagtgact aaagacactgctgcaattcagaaaaacaaagtagtggttagcgcatctacagacaacaaa gatgaaataacggtatctcctcaggaaagcaaggcacacatcaagagtcctaccgaagtg accaaggaacccaggaaaagcgaggaacccaccaaagaaattactgtcacaaaagaaagt gctgtttccatccagaccaatcaagaatcagtcaaaactgctaaaaagggtatagaggaa atcactgtcccagttcggagaagtaagatggctggacagatatcaaaagaaggcccagga gaaactactgctcttatccagaaaaatggggaacctagcaaagctgcagaaaacactcca gaggaatacagtgctgctgtacagaagaaagatgaatctaataagactttaagaagacct tcagaaggacaaatacctgctgttcagaagaacaatgaaccagttaaaactacaacagaa ttaccagaggtgccaactgttcctgttcgaaagaacaaagtatcaattaaagcagcagca gcacctcctgaacaacctgctgctcttgtagagacggacaaaaatgccataactggcaaa cagcctgtggatggagaacctactattgagaaaaacaaagaacccaacaaaattgcagca aaagatacagtggaatccactgttcctgttcataagaatggagaacctgtcaaacttgca acagctacaaaggatgaatccaccattactgtacagaaaaacaaagaacccactaaaatt gcaaccagacatccagaggaatccattgtttctttgcagaaaaatggagaacccatcaag cctggaacaacgcctaaagaaaattctattattcctgtgcaggagaacaaagaaccaacc aaaactggagcaagacatccagaggaatccattgtttctatacagaaggatgaagaaccc atcaagccaagtacaacacctaaagaagaatccattattcctgtgcaacagaacaatgaa cctatcaaaaccgcacaacaaactccagaagagtctaaacctgttcagataaacaagcaa cccattgtaatttcagcagggcacaaagaggaagctataatttcagagcaacaattgact gagcttgaagaacagaaagcgtcaagcatagatataaatgtagaggaggaaccagagatg ctggaagcagccatcaagatccaagcagtgttcaagggctacaagactcgcaaggacatg cggcctgtcttcaaagaagtgttcaagaaccaaagtgtggagttaaatggcaccattcgt cttcagtgtattgcagagggtaagcccaatacagtgcgttggttgaaagatggtgaggag atcagaccaagcacacgcttccatatcaagaagcaagatgatggttcctgctcactgata attgacaatgtgacccagaaggacacaggaatatacacatgtgaagcagtaaacaagttt ggaactataagctacaatggaaatgtaacagttgagacctctccaaggcctattccacaa gttcatgtaaaaccagctactgccttagttcctgaaatcggaaccgaatcggaactggaa cctgtatcagaacctttaagactggaaggaggctccttgaggcaggtgtatgatctccca aaggttgaccaacatgttggagccaaagaaaaacgcagaagtcttatttcagcgagctct gtgtcctgtccctctgattacgacacagcaccagatggggcagaatccctgtctgacttt ggctccagagacttcccaatcaaagaaaaagagttgaagaaggcaccatcaggcagtgag ctgccagaaactactgaagagcttccaagcatcgatcttcaaccccaaaagccttcctca cagcttcaaatccaggcaggtggtattgctgtgagcaggagcccatctccaaaatactca ccttcccataagccatctgccaatgagtccctctcagaatctgacggagaggaagacaga ggagagatatttgatatctatgtggccaaatgtgattgcaaccccactggtggtcacaag gagacctttgtgctgaaagaggggcaatatgtggaggttctggactctgtgcatcccaca cgttggttggtgcgcacaaaaccgaccaaaatcactccagcgcgccaaggctgggtgtca ccagcatacctggaaaagaggggaagggagccattttcaatgttattagagccacagctg tatgagagagcgggaagggaacccagccaggatgaattcaagaacactgtgagtgagctg atccagggcctgctcagtggagaggaagagtttgtgagggagctgagtttcttcgtgtcc caccatctgcgctttatagagaccagctccaaggtgcctctccccattttcagccagaag gagtacatgttccgcaacatcaaagagatcacaaacttccatgagaggtcagttcttcct aagctgatggagtgttccacagacgatgatgtggctatgtgctttgtgagccaagcgtct gactttgagaagtaccttcaatacattgtgggccagtcccaagctgaggcctgcctcaat gaaaagaacactcagcacttcttccagaaataccaggagactgagttggcacgccgacat accgaagtactaagtgtcagcacttatttacagaggccactggaaaggatagagatgtac aagtccctgctgaaggagctcataaggaacaaggccaagtttaagcgaagctgctgtctg ctggaggatgcattttctgtggtgtccagtctgccctggcgtgctgagaacatggaacag gtggccatgatagagaattaccccgccccactgagtggacttggagaacccattcgtcag ggcccgtttacagtgtgggaggagtcacctggaaccaagctatcattccgcggccaacaa cgtcacgtcttcctcttcaaagactgcgtcattttctgcaagctcaagaaagaccctgac acacacggtgacacctacatattcaaaaacaagatgaagctgggtgatattgaggtgaag gagtctgtggaaggagatgagcgggcctggggtttatggcacgagcaccgtggcaccgta cgcaagatcaccctgcagtcacgctccgtcctcctcaaactgtcctggctcaaggacctg agagagctgcaccagtgcagctgcctcccctcgcgctgtgcacctcactttgacctacta ctgggcgactgcaccaccaaacttgggcagacagtcaaattgtcctgcaaggtcacagga tctcctagaccggaagtcacctggtacaaagatggccaggctgttgaggtggatgagcag cacatggtctctgagagcaacactggctcctgctgtctggtgttgactggagtcagcatg gaggactcgggccagtacatgtgctacgccaccagctgcatggggaatgccagcaccctg gcaaagattgtggtggatgtgcctcctagcttcaagattaaacttcagaatgttcagcta gacattgggaaggatgtccagttccagtgttctacactatgcactcctttacccagaata aggtggttcaaaaacagtaagctcttggagaaccagaagaagtaccagattgactgtgag ccccagactggagtgctcacactgaccataaagagggctgggaaggtagacctggggctt tacgagtgtgagctgtggaataagatcggaagtgccaagtgcaaagctgaactttgccgt ccacctgcaactcccacagaacctgtcccagagaaagctccaccagtctctgccaaagaa ctagaggcagaatccgagacctggtccggctccctggtgaagaactggttccagatggac ttgaccccctctggcatctgcaaaatgctcttccagcccggctacgctgaaccagctact gcaagcacagggggagctgggcccaagcagaagaaggacatggctccgaagaaggctgaa acagtgtcaaaaaaggctgaaactgtgtctaaaaagcctgcagcggttgctgagacggtt gctgtcgctgaagaagaggaggaaatagagacagatccaccctccatccaggttcccata gaggatcagtgtgtgaaactcggacagcctgcaagtttcactactatcattacaggacag cctcaaccagagatttactggcttaaggatggaatggaggtgctgcccagtgagaatgtg gagatggtgttctttggggcgcggagctctctgaatgtgtttagtgtgacgcgggaggac tgtggcacgtacacctgtgaggcggagaacagtacgggcctggtggactgccatgcccag ctcacgctggagtcggaggtcccagaggtagcaacattggaggggacagaggtggaattg ggcagaagaaagctgctctcagtctatgaagtccatgatgagataggaaggggcacgttt ggagtggtaaagaaagtgtctcaccgggcgacaggagagccctttgctgccaagttcttg cctctgaagagcagcacaaggaccagggcctttcaggagagggacttactctctcgcatt gcccaccccagagtggcctgcctcctggacttctttgttacccgacgcactctggttctg gttacagaaatgtgttcttctcagggacttcttgaccatttattgatgaaagggtctgta aaggaaacagaggttcagatgtttattcagcaagttctggagggcattgctcatattcac agtctaagcatcctgcatttggatattaaaactgacaacatcctgatggtatctccagcc agagaggaggtgaagatcattgactttggattctgccaggagatagactcatccaggcac cagtacagcaagtttggaactcctgagtttgtggcaccagaagttgtccaccaggaacct gtgacaacaggaaccgacatttgggctctgggtgttgtggcttacttatgtctgacgtgc cattgcccgtttttcggagagaacgatcgggcgaccctcatgagagttgcagagggaact ctgttttgggacacccctgaggtgacgtgcaggagtccggaggcccaggatttccttcgc aaagtgctccacccagttccagaaatgcgaccatcagcctttgaatgcttgtctcacgag tggtttcagggtcagagtgctgatgaggagcctggagacataaacacaaagaacctgaga tctttcatctccaggaggaagtggcagcgctcgctcacatgcctgggttccgtccttacc ctgaggcccatggtggacctgctggacgctcctccggaggaggtgtcggtcacggcgccg cgcgagcctcaggagcccagcagcacctcccagagcagcggctcctcctccgagtacgac gaggccgacgcctgggagtgtttccagcacttcagccccgaggacgaggactgggacgag gacgaagacgaggaggacgaggaggagctggaggaggaggagctggaggaggaaggggag tacgacccccacgcacaggttccagagaggggccggacgctggcggagctgggccgagcc aggctggacgaggaggaggagttgattttggagaggcggagcggccagcggggggcactg gtgttccccacgggtaaacccggggatcagccacagcagcgcagcagcagcccgtcgctg tacctgtcggagggggacgagagctcagtgggcagcgagagccgcgcagcgatcatcccg cgcggccgcctcatccgcagcaccttctacaacagctcgcagcagctctcgcccatgtcg gcacggcacatgctgctgcgcgacaagcagcacgccgcgcgcaagcaggagcgcggccgc aagccgctccgctccagcctgtcggggcgcctcaacgagccgctcatcgagtacgtggag gacgcgcccgaggcgggcgtaggaggcgccggggaagggggcgtgcgcggtcagaggagg ggctcggtgcattcggccatgctcaagtcctgctcgttcgacagcggcgtcagcctcacg cacccgctcccgtaccaacgcaggagccgctccctggacgagtccaccaggaggtcgcgg gcgtccgccgagcttcgggagccgggcgaggaagaggaggaggaagaggaggacacggcg ttcagccataaggatgactttactgacgaagaggcgcagcagagtgtatcaccacagcca gcagaggtcagcgacgcgaggaggagacagagtgtggtggctaaagtgaagcccagaacg caaagggcgggtgaggaggaggttgcggaggaggatagcactgtggacagccagccccag gctcctgagaggacacgagaggcgtccaggcctctggccggtggggagaacttgagcagc tcccaggcttctctcgcggagtcttacgaaccaggctctggagtctccagcagaacaggc tccttggacgacttctcccctggtcgcctggccgctcccaggagacggctgtcctcctct gggatgacctcgccttcgtctttcctgcatggctccgatgaggaggaggaagagcaggag gaagctcgcaagccccctacacccccgagccggagatacggatcaaggctcagcctgcaa gtcgagaggggcgacctctccctgaagcgcagtccctcacgactctctgaccaggtgcct acgaccatcccgggcagcggcgaggtcctccagaggcatgcctctgccccggccctggag gtcaagccacccagcggcaagtcccccaagatcggcctcatgaagctgttccgtcggcag tcctggacgggccactcgtcctcccagccggagggagtggacaggaagcagaaggaagcg gagcaggccgtgcccaaaagccccatgctcacgctgaagaagaagatgagggcctcggcc tccagtctcaccaagctgttcaccagacagtccagcaaagaggagaagaaaggcgggccc atttacaaaggtccttccccagtggctccagagaagaagcagaaggcccacactcgctct gcacctgcactgaccgcctccgccccaagcagccctcagaagaaagccgccaagctctta aagtccattaaagtgcccaccttcaagaaaagcaaagaggtggcagtccgcccagcaagg ccagatgtgcaccagctggcaggaggtggcgtgttgctggtgtggagacctgtcaagtcc agcgagaccttcacctactgcctacagtacagcactgcaggtggcgttgtggagtggaag ctgttggcagaggacgtgactgacagctgctacaccgtcaccaccttgcccaagggtccg ggctatgtgttcagagtcggctgcgtcactaaaacaggagccggaccctttagtgatccc acaatcctggccttcatggtggtccaacatgaagactcccacattcctctcattcaaaag gaatcgctcagatcaaaggtcattgtatcaggggcccagggggcccacaagatttactct ttcctctctgagatcaacaggggtcgcttcagtgtggtcgcccagtgccgtgaggagcag agccagcagcacctggcggccaagatcacgccctaccgggccgagcagcggcagctggtc ctacgggagtaccagcttctcaagaggctcaaccacccacaccttgtgcagctgcattcg gccatcatcagccccgactacctggtgctcctggaggagctgtgtgccggacgggagctc ctctacaacctggctgagagggatgcctatgcagagatggatgtaagtgagttactggtg cagatcctgagtgctgtggactacctgcacagccgccgcatgatgcacctagacctcaag tcggacaatatgctggtgacggacggcaatgtggtgaagattgtggacttgggctcggcg cagctctacacgccgggccaggctgtcaacgtggaacacctcaaagagctgacggagagc aaggtttacattgtccttcccaaagctcctgaaatcttggaaggccaaggagttggacct gaaacagatatctgggcgattggcgtattggcttttatcatgctcagcgcagacagcccg tttcatgccgacctgaactgggaaagggatcgcaacatcaagaagggcaagatccagttt ggccgctgctacccaggcctgtcggaaggagccatcaacttcatgaagagcacgctcaac aacaaagcctgggggagaccctcggctggggagtgcctccagaacccctggatccgcggg gacgcccgtgccgcggccagacccagagactccatggtctgcttctccactgacaaactg caggccttcctccaggagcgtgaggtcaagcgagaccatatccgaaccaaggctaaggtc ccgcttctgcagtag

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