Alosa sapidissima (American shad): 121712324 Help Entry 121712324         CDS       T11137                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism asad  Alosa sapidissima (American shad) Pathway asad04020   Calcium signaling pathway asad04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:asad00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     121712324 (ryr3)    04020 Calcium signaling pathway     121712324 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:asad04040]     121712324 (ryr3) Ion channels [BR:asad04040]  Voltage-gated cation channels   Ryanodine receptor    121712324 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_1 EF-hand_6 EF-hand_7 Motif Other DBs NCBI-GeneID:  121712324 NCBI-ProteinID:  XP_041952430 LinkDB All DBs Position 6:28647496..28763086 Genome browser AA seq 4846 aa AA seqDB search MAEGGEGEDEIQFLRTEDEVVVQCVAAIQKENRKFCLAAEGLGNRLCFLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLAKCGPNGEGTPGHEKWAVQGGGHRTLLYGHAILLKHSF SGMYLTCLKTSRSQTDKLSFDVGLQEDSVGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSSERYLHLSMANGNIAVDASFMQTLWNVQPTCSGSNIAVGYVQGGHVMRLFHGHDESLT IPGADKKEDQQRIVNYEAGKGGSRARSLWRLEPLRISWSGGNLRWGQPFRLRHLSTGHYL GQTDDRGLVLLDREQSNTAATSFCFRASKEKVESGSKRDIEGMGVAEIKYGDSVCFVMHV ATGLWLSYQAPDAKSSRLGPLKRRAFLYPEGHMDDGLILQLCQHEESRAARIIRNTTFLF SQFIKALDNLQGEKSNEVSLPVGEVLESLNDLIAYFQQPDSELEHEEKQRQLRSLIKRQD LFKEEGMLALLVKCINCLNFYNSAAHFEEFAGVEAGEAWKSILNLLYELLAALIRGNRAN CTQFSRNLDWLVSKLERLESSSGILEVLHCILVESPEALNIIQKAHIKSIISLLYKHGRN HKILDVLCSLCVCNGVAVRANQNFICDHLLPRRDLLLQTRLVNDVQSMRPNIFLGINEGS AQYKKWYFELMIDQVDHFMTAEPTHLRVGWATTKGYAPYPGGGEGWGGNGAGDDLYSYSF DGLHLWSGRIPRAVASINQHLLSGDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNIDGF FFPVVSFSAGVKVRFLLGGRHGDFKFLPPAGYTPCYEALLPKEKMHIEPVKEYKRDHDGV RHILGTTKLLSQASFIPVPVDTSPIVLPPHLEHVRDKLAENIHELWGMNKIELGWTYGKV RDDNKRQHPCLIDFSKLPETEMNYNLQMSSETLKTLLALGCLVSHVNLNAEEDLKKIKLP KNYMMSNGYKPTPLDLSDVKLNPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSR RNPRLVPYALLDERTKRSNRDSLREAIRTLVGYGYNIDPPDQEPTHGVEKQSIDTIRFFR VEKTYAVTTGKWYFEFEALTGGDMLVGWARPASRPDVELGLDDLSYVFDGFRGRRVHKGS HFFGRTWSKGDVVGCMINMEDKSMLFTLNGEILITSSGSELCFTDFETQDGFIPVCSLGL SQIGRMNLGKDASTFKYYTMYGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPADHPHIE VTRIDGTVDTPPCLKVSHKTYGTQASNKDMVYCRLSMPVELYPGPRKNEGMEVTEAPKKD GGQIDYGSITKYYYSVRVFAGQDPTSVWVGWVTPDYHYYSKNFSLSKIRTVTVTLGDERG RVHESLRRSNCYMVCGRDIGLGSSSSHSNVDLEIGCFIDLASGLISFTANGKQLPTTYQV EPNTKLFPAAFILPTSPNLLQFEFAKIQDAMPLSSAIFKSLHRNPVPQCPPRLDVQTIVS VLWSRMPNTFLSVETARVSERHGWVVQCLEPLQMLAVHIPEENRCVDIMELSENKTLRQF HYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLTGQLREGFYDVLISIHLDR AKEARLMMKDEYIIPVTSETRSIRLFRDESKSHTLPGVGLSTTLAPGLTFSPPCFISTKR EQHLYSPQIPLAKLKAKAISMLTEAVHGGGVHIRDPVGGSVEYQFVPIIKLISTLLIMGA LTSDEVRLVLLLIEPNVFQEAEEQSGTLAVEARPGKEEVTGTEGKAVEAGEEEAKEAKQP TRGLLEKHLPESVKLQMCVLLHYFCDCELKQRIEAIVAFADTYVSKLQYNQKFRYNELML ALNMSAAVTAKKTREFRSPPQEQINMLLNFSLGDDCPCPEEIQDELHIFHDDLRIHCGIP IEDEEEEPDTSIKGRLMSLVYKIKGRPQKTEKEPTEQEQAAPTNLKELISQTMVTWAQEC LVQDPQLVRTMFSLLRRQYDGIGELLRSMKKSYTISAASVQDATHLLASLGQIRSLLSVR MGLEEERLMIDGLSDIMNNKVFYQHPNLMRVLGMHETVMQVMVNVLGGDDKSQIAFPAMV ASCCRFLCYFCRISRQNQKAMFDHLSYLLENSCVGLASPAMRGSTPLDVAASSVMDNNGL ALALEEPDLEKVVTYLAGCGLQSCAMLVNRGYPDIGWNPMEGERYLSFLRFAVFVNGESV EENANVVVKLLIRRPECFGPALRGEGGQGLLAAMQEAIKISQDPALDLPTVPEGGLPEAI EGEEEEEVTHIGNAIMSFYSALIDLLGRCAPEMHLISKGKGEALRIRAILQSLVPTKDLV GIISIPLKMPIVNKDGSVTEPDMSASFCPEHKAPMVLFLDRVYGIEDQAFLLQLLEVGFL PDLRASASLDTEVLSTTETALAMNRYIGSAVLPLLTRCAHLFSSTEHYAMLIDSTLHTIY RLSKGRSLTKAQRDAIEECLLAICSHLRPSMLQQLLRRLVFDVPLLTEYCKMPIRLLTNH YEQNWKYYCLPTGLGSYGIASEEELLLTKKLFWGLFDALSQKKYDSDLFKLAMQCLCAIS GALPPDFVDASPVSVLEKQTSVDAQGNFDPKPISTANISLPEKLEYIANKYAEHSHEKWS SEKLAQGWNRGEKVDNEAKTHPLLQPYKSLSEKERETYRYPVKESLKSMLAMGWTIERTK EGEAMFQQRESEKQRKISESGAYTPTPLDLDNVVLSRELQGMVEIVAENYHNIWSKKKKA ELTSKGGGTHPLLVPYDTLTAKEKYRDREKAQELFKFLQVNGYAISRDHQSMEQDSANME KRLASKFLKRLLSYVDSAQEFIAHLEAMASSGKTDKSPHEQEIKFFAKILLPLIDQYLKN HCLYFLSTASKNLSSSGYATNKEKERIASLFCKLAALVRHRISLFGADSPTMVSCLHILA QSLDFRTVMKSGSELVKAGVRTFFENAAEDLEKTLENLKLGKLTQRSQIKGVSQIINYAT TALLPILTALFQHVSQHHFGPDLLLDDVQLSCYRILTCLYCLGTGKNSFVEKQLPVLGEC LSTLVAAMPVAFLEPHLNTHNPLSVFNTKTPREKAILSMPDSVTEMCPDVPELDGLLKDI SDLSESGARYSEMPQVIEVILPMLCTYLSTWWDKGPDDNSGGGSSGRCTSVSSEHISSML GNILRILNNNLGIEDAPWMKRLAVFTQPVISMAGPDLLKSHFLPTLEKMKKKTVKVVSEE EALKAETKSDTQEMELQILDEFAVLCRDLYAFYPMLIRYVDNFRSKWLKEPDADSTSLFN MVAEIFILWCKSHNFKREEQNFVVQNEINNLAFLTVESKTKMAKSGGQDQERKGRRRKRE LYSVQTSLIVAALKKLLPIGLNMCTPGEQELITLAKIRYGLKDTDDEVKDQLRQNLHLQE KSEDPAVQWQVNLYKDVVVKSEGPPDPERIVERVQGLSAALFHLDAVELPLRSKKNLAQK LLSKQRKRAVVACFRMAPLYNLPRHRCINFFFLAYLRFWIEAEEYFFEEKLVQDLAKTPI KVVDEEEEEEAEVKPDPLHQLILHFSHNALTERSHLDEDPLYIAYADMMAKSCAEDEEEE EDEEGGKSFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTGTLKLGISI LNGGNVIVQQKMLDYLKLKRDAGFFKSLTGLMQACSVLDLNAFERQNKAESLGMVSEEGS INSSRKASKVLQNDDFTKDLFRFLQLLCEGHNSDFQNFLRTQTGNTTTVNIIISTVDYLL RLQESISDFYWYYSGRDVMDEAGQYNFSKALAVAKQVFNSLTEYIQGPCIGNQQSLAHSR LWDAVVGFLHVFANMQMKLSQDSSQIELLKELMDLQKDMVVMMLSLLEGNIVNGTIGKQM VDTLVESSSNVEMILKFFDMFLKLKDLTTSDNFKEYDPESKGIISKKEFQKAMENQKQYM QSEIDFLLCCCEADENDMFNYEEFVDRFHEPAKDIGFNVVVLLTNLSEHMPHDSRLAMFL DLAESVVNYFEPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNE GGESEKMEMFVNFCEDTIFEMQLASQISEPDSVERPEEEEEEEEEPEEEEEGVESQSAFS AACASVKRKISNFRQMLTLRSMRKQFKAVRKLTIREMITGFFGFFWMLFTGFFKGIYNVI FGFFHIIWTSIFGGGLVEGAKNIKVTDILGNMPDPTQFGIHGDILEAEKADIGELAATAD MVQMVSGEPMEVDLMMELMGGPSKRDGKHELGLGDVCEIKPTESAAPEKKKSKKAEVKES EPEKADTENQEKEEKAKEEAPAEPAAKDKPVRKPRRGGDQEESPAFMASFIAGLEVYKTK MLNYLARNFYNLRMLALFVAFAINFILLFYKVTADEVDEDEDSWENGDDEEDNDEGLEYF VLQESTGYMAPTLTFLAISHTVISLLCVLGYYYLKVPLVVFKREKEIARSLEFEGIYITE QPSDDDIKGQWDRLVINTPSFPSNYWDKFVKRKVINKYGDMYGAERIAELLGLDKSALDF DPTIETVAPEASLVSWLSSIDTKYHTWKMGVVLTDNSFLYLVWYTTMSTLGHYNNFFFAA HLLDIAMCFKPLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDE PDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPSELYRILFDITFFFFVIVILLAI IQGLIIDAFGELRGQQDQVKEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFF LMYLINKDETEHTGQESFVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14541 nt NT seq  +upstreamnt  +downstreamnt atggctgagggtggagaaggggaagatgaaattcagttcttaagaactgaagatgaagtg gttgtgcagtgtgtcgccgcaatccagaaagagaaccgcaagttttgcctggcagcggag ggacttggaaaccgactctgtttcttggaaccgacctctgaggctaagtatgtccctcca gacctgtgcatctgcaactttgtgctggagcagtcgctgtcagtacgggccctgcaggag atgctggccaagtgtggccccaacggcgaagggactcctggtcatgaaaaatgggcggtg caagggggtggacaccggacccttctgtacggtcatgccatcttactgaagcactccttc agcggaatgtaccttacgtgtctgaagacatcaaggtctcagacagacaagctatctttt gacgtgggtctacaggaggactccgtgggagaggcctgctggtggacgatccaccctgcg tcgaagcagaggtccgagggggagaaggtccgcattggtgacgatctgattctggtcagc gtgtcttcagagagatacctgcacctgtccatggccaatgggaacattgcggtggacgcc tccttcatgcagaccctctggaacgttcagccgacctgctcaggcagtaacatagcagtg ggttatgttcagggtggtcatgtgatgcgcctgtttcacggacatgatgagagcctcacc ataccaggggcagacaaaaaagaggaccagcagaggatagtgaattatgaagcaggcaaa gggggctccagggccaggtctctgtggagattggagcctcttcggatcagttggagtggg ggtaatttgagatgggggcagcctttccgcctccgccatctttccactggccactacctg ggccagacggacgaccgcggcctggtcctgctggaccgcgagcagtccaacaccgcggcc acgtcattctgcttcagggcctccaaggaaaaagtggagtctggctcgaagcgagatatc gaaggcatgggggtggctgagattaagtatggagactcggtctgcttcgtcatgcatgtg gccaccggactttggctgtcctatcaagcgccggacgccaaatcctctcgcctcgggcct ctcaagagaagggcctttctatacccagagggccacatggacgatgggctaatcctgcag ctctgccaacatgaggagtccagggctgcccgcatcatccgcaacaccactttcctcttc agtcagttcatcaaggctttggacaatctgcagggagagaagagcaatgaggtgagcctg cccgtgggtgaagtgctggagtctctgaacgacctcatcgcctacttccagcagcccgac tcggagctggagcacgaggagaaacagcggcagctgcgctccctcatcaagcgccaggac ctcttcaaggaggagggaatgctggcactcctggtcaaatgcatcaactgtctgaacttc tacaacagcgctgctcactttgaggagtttgccggagtagaggctggagaagcctggaag agcattctaaacctgctgtacgagctcctggccgccctcatccgtggcaacagggccaac tgtacacagttctcccgcaacctggactggctggtcagcaaactggagaggctggagtcg tcatcaggaattctagaggttcttcactgcattctggtggagagccccgaggccctgaac atcatccagaaagcgcacattaaatccatcatctctctgctgtacaagcacggacgcaac cacaagattctggatgtcctctgctcgctctgcgtttgcaatggtgtggccgtccgagcc aatcagaacttcatctgtgaccacctcctccctcggcgagatctgctcctgcagacacga ctggtcaatgatgttcaaagcatgcgacccaacatcttcctgggcattaacgaggggtct gcccagtataagaagtggtactttgagctgatgatcgaccaggtggaccacttcatgacc gccgagcccacccaccttcgcgttggctgggccaccaccaaaggctacgccccgtacccc gggggtggtgagggatggggagggaacggcgcgggcgatgacctctactcctacagcttc gacgggcttcacctctggtcaggtcgtattcccagggcggtggcgtccatcaaccagcac ctgctgagtggcgatgacgtggtgagctgctgccttgacctgggcgccccgagcatgtcc ttccgcatcaacgggcagccggtgcagggcatgttcgaagacttcaacatagacggcttc ttcttcccggtcgtcagcttctcagcaggggtcaaggttcgcttcctgttgggtggccgc catggcgacttcaagttcctgccgcctgccggctacacgccgtgctacgaggccctgctc cccaaagagaagatgcacattgagccggtgaaggagtacaagcgtgaccacgatggcgtc cgacatatactgggcaccacgaagctcctgtcccaagcctccttcatacccgtccccgtg gacaccagcccgattgttttgccccctcacctagaacatgtgagggacaagctcgctgaa aacatccatgagctctggggcatgaataagatcgaactcggctggacttatggcaaggtg cgagatgacaacaagagacagcacccctgtctcattgacttctccaaattgcccgaaacc gaaatgaattataacctgcagatgtcatccgagacattaaagaccttactggctttgggg tgcctggtttcccatgtcaacctcaatgcagaagaggatctgaaaaaaatcaaacttcct aagaactatatgatgtccaacggttataaacccacgccactggacctttctgacgtgaag ctgaatcctggtcaggaagttctggtagataaattggccgagaacgctcacaacgtttgg gccaaagatagaatcaaacaaggatggacctatggcatacagcaggatctgaagagcaga cgcaatcctcgcctggtgccatatgctttactagatgagcgcactaaaagatccaaccgc gacagtctccgtgaggctatccgaacactggtcggatatgggtacaacatcgaccctcca gaccaagagcctacccacggagtagagaagcagagcatcgacacaatccgcttcttccgt gtggagaagacttacgcggtcaccactgggaagtggtactttgagtttgaggctttgaca ggcggagacatgctagtgggctgggccaggcccgcctccaggcctgacgtagagctggga ttggacgacctctcatatgtgtttgatggtttccggggccgacgtgtacacaaaggaagt catttctttggtcgcacctggagcaagggtgatgtggttgggtgtatgatcaatatggag gacaagtccatgctctttactctgaatggagaaattcttatcaccagcagtggctctgag ctgtgcttcactgactttgaaactcaggacggcttcatcccagtgtgtagcctgggactc tcccagatcggacgcatgaacttgggtaaggacgccagcacctttaagtactacaccatg tatggcctccaggagggatttgagcccttcgccgtcaacatgaaccgcgaggtcaccatg tggtttagcaaacgcctgcccaccttcgtcaacgtgccagcggatcacccacacattgag gtgaccaggatcgatggtactgtggacacacccccgtgcctaaaggtgtcccataagacc tacggcacacaggccagcaacaaggacatggtgtactgtcgactgagcatgcccgtcgag ctctacccagggccaagaaagaacgaaggtatggaggtaaccgaagcgcccaagaaagac ggtggccagattgattatgggagcatcacaaagtactattactctgtgagagtgtttgct ggtcaggatcccacttctgtgtgggtgggctgggttacccctgactaccactactacagc aagaatttcagcctcagcaagatccgcaccgtcaccgtaacccttggagacgaacgaggt cgtgtccacgagagtttgaggaggagtaactgctacatggtgtgtggaagggacatcggg ctcggctcgtcctcatcccactccaatgttgaccttgagatcggctgcttcatagacctg gcctctggtctcatctcattcactgccaatggcaagcagttgcccaccacttaccaggtg gagcccaacaccaagctgtttcctgcagcattcattctgccaacaagccctaatttgctc cagtttgagtttgcaaagatccaggatgccatgcccttgtcgtcggccatcttcaagagc ttgcacaggaacccagtgccccagtgcccgccgcggctggacgtgcagaccatcgtctcc gtgctgtggagccgcatgcccaacaccttcctgtcggtggagacggcgcgggtcagcgag cggcacggctgggtggtgcagtgcctggaaccgctgcagatgctggccgtgcacatcccc gaggagaacaggtgtgttgatatcatggagctgtcggagaacaagactctacgccagttc cactaccacactctgaagctctactgcgccctgtgcgccctgggcaacacacgggtggcc cacgccctctgcagccatctggaccaatcacagctcctctacaccatcgacaaccaatac ctgaccgggcagctgcgtgagggcttctacgacgtgcttatcagcatccacctggacagg gccaaggaggcacgcctaatgatgaaggacgaatacatcatcccggtcacctcggaaacg cgcagcatccgtctcttccgcgatgagtccaagagccacacgctgcccggtgtgggcctg agcaccacgctggcgcctggactgaccttctcgccgccctgcttcatcagcaccaagcgc gagcagcatctgtacagcccacagatcccgctggccaagctcaaggccaaggccatctcc atgctgaccgaggccgtgcatggcggcggcgtgcacatccgcgaccctgtagggggcagc gtggagtaccagtttgtgcccatcatcaagctcatcagcacgctgctcatcatgggcgca ctgaccagcgacgaggtgcgcctcgtcctgctcctcatcgagcccaacgtcttccaggag gccgaggagcagtccggcacgctggcggtggaggccagaccggggaaggaggaggtgacc ggtactgaggggaaggctgtggaggctggggaggaggaggccaaggaggccaaacagccc acgaggggcctcctggagaagcatctgcctgagtcggtcaaactgcagatgtgtgtgctg ctgcactacttctgtgactgtgagctgaagcagcgcattgaggctattgtggccttcgcc gacacctacgtgtccaagctgcagtacaaccagaagttcagatacaacgagctgatgctg gctctcaacatgtctgctgccgtcaccgccaagaagacccgggagttccgctcccctccg caggaacagattaatatgctgctcaacttcagccttggggatgactgtccctgccctgag gaaattcaagatgagctgcatattttccatgacgacttgagaatacactgtggaatccca attgaagatgaggaggaggaaccggacacctccatcaaaggccgcctgatgtccctcgtc tacaaaatcaaaggccggccacagaaaaccgagaaggaaccaacagagcaggaacaagct gctcccaccaacctgaaggagctcatctcccagaccatggtgacgtgggcgcaggagtgc ctggtgcaggacccgcagctggtgcgcaccatgttcagcctgctgcggcggcagtacgac ggcatcggcgagctgctgcgctccatgaagaagagctacaccatcagcgccgcctcggtg caggacgccacccacctgctggcgtcgctcggtcagatccgctcgctgctcagcgtgcgc atgggcctggaggaggagaggctcatgatcgacgggctcagtgacatcatgaacaacaaa gtgttctaccaacatcccaacctgatgagagtcctgggtatgcatgagactgtcatgcaa gtgatggtcaacgtcctaggaggagacgacaagtctcagatcgccttccccgccatggtg gccagctgctgccgcttcctgtgctacttctgtcggatcagccggcagaaccagaaggcc atgttcgaccacctgagctacctgctggagaacagctgcgtggggctggcctcccccgct atgcgaggctccacgcccctggacgtggctgcgtcctctgtgatggataataacggcctc gccctcgcgctggaagagccggacctggagaaggtggttacatacctggctggctgtggg cttcagagctgtgccatgctagtgaacaggggctaccctgacatcggctggaaccccatg gaaggggagcgatacctctccttcttgcgcttcgccgtcttcgtcaacggcgagagtgtg gaggagaacgccaatgtggtggtgaagctgcttattcgacggcccgagtgtttcggccca gctttgagaggcgagggcggtcaaggcctgctggccgccatgcaggaggccatcaaaatc tctcaggacccggctctggacctccctactgtgcctgagggaggactgccagaggccatt gagggtgaggaggaggaggaggtgacacacattggcaatgccatcatgtccttctactct gcactcattgacctgctgggacgctgtgcccctgagatgcatctcatcagcaagggcaaa ggggaagcgctgcgtatccgtgccatcctgcagtctctggtgccaaccaaggaccttgtt ggcatcatcagcatcccactcaagatgcccattgtcaataaagacggctcggtgacggag ccggacatgtcggccagcttctgccccgagcacaaggcgccaatggtgctgttcctggac cgcgtgtatggtattgaagaccaggccttcctgctccaactgctggaggtgggcttcctg ccggacctgcgcgcctctgcctctctggacacagaggtgctgagcaccaccgagacggcg ttggcgatgaacaggtacatcggctcggccgtcctgcccctgctgacccgctgtgcccac ctgttctccagcacggagcactacgccatgcttatcgactccacgctgcacaccatctac cgcctgtccaagggccgctcgctcaccaaggcccagagagatgccatcgaggagtgcctc ctggccatctgctcacacctgcgtccctctatgctgcagcagctactgaggcgtctggtg ttcgatgtgcccctgctcaccgagtactgcaagatgcccatcaggctgctgaccaaccac tatgagcagaactggaagtactactgtctgcctacgggcctgggcagctacggcatcgcg tctgaggaggagctgctgctcaccaagaagctcttctggggactttttgatgccctctcc cagaaaaaatatgactccgacctcttcaagctggccatgcagtgcctgtgtgccatctct ggggcgctgccgcccgattttgtggatgccagccccgtgtccgtcttggagaagcagact tccgtggacgcccagggcaacttcgaccccaagcccattagcactgccaacatttccctc cctgaaaagctggaatacattgccaacaagtatgctgagcattcccacgagaaatggtct tcagagaagttggcacagggctggaatcgcggcgagaaagtggacaacgaggccaaaact catccattactccagccatataaatcactgagcgaaaaggaaagggagacttatcgctac ccagtgaaggagtccctgaaaagcatgttagctatgggctggactatcgagcggaccaaa gagggcgaggccatgttccagcagcgagagagcgagaaacagcgcaagatctccgagagc ggagcatatacacccacaccactggatctggacaatgtggttttgtccagagagttgcag ggcatggtggagatcgtagccgaaaactaccacaacatctggtccaagaagaagaaggct gagctcacgagcaaaggagggggcactcaccccctgctggtgccctatgacacactgacg gccaaggagaagtaccgcgaccgcgagaaggcccaggagctctttaaattcctgcaggtc aacggctacgctataagcagggaccatcagagtatggagcaagactcagctaatatggag aagaggttggcctccaagttcctcaagaggctgctgagctatgtggactcggcccaggag ttcatcgcccacttggaggccatggcttccagtggcaaaaccgacaaatcccctcacgag caagagattaagttctttgccaagattctgctgcccctgatagaccagtacttaaagaac cactgcctctactttctgtccactgccagcaagaacctcagtagcagtggctacgccacc aacaaagagaaggagaggattgccagtctgttctgtaagctggcagctcttgtcagacat aggatttctctctttggtgcggattctcccaccatggtgagctgcctacacatcttggcc caatctctggacttcagaacagtgatgaagtcgggctcggagctggtgaaggctggcgtg cggacgttcttcgagaatgcggcggaggacctggagaagaccctggagaacctgaagctg ggcaagctgacccagcgcagccagataaagggcgtgtcccaaatcatcaactacgccacc acggccctgctgcccattctcaccgcactcttccagcacgtttcccagcaccactttggg cccgatctgctattggatgacgtgcagctgtcctgttaccggatcctgacctgtctgtac tgtctgggcaccgggaagaactcattcgttgagaagcagctgccagtcctgggcgagtgt ttgtccactttggtggccgccatgcccgtggccttccttgagcctcacctgaacacgcat aaccccctgtccgtgttcaacaccaagaccccacgcgagaaagcaatcctgagcatgccc gatagcgtgacggagatgtgtcctgatgtgccggagctggacggcctgctgaaggacatc agtgacctgtcggagtcgggcgcccgctactccgaaatgccgcaggtgatcgaggtcatc ctacccatgctgtgcacctacctgtccacctggtgggacaagggcccggatgacaacagc ggcggcggcagcagcggccgctgcaccagcgtctcgtccgagcacatcagctccatgctg ggcaacatcctccgcatcctcaacaacaacctgggcatcgaggacgcgccctggatgaag agactggcagttttcacccagccggtcatcagcatggcagggccagacctcctgaagagt cacttcctgcccactctggagaagatgaagaagaagacagtgaaggtggtctcggaggag gaggcactgaaggccgagaccaagagcgacacacaggagatggagctgcagatcctggac gagtttgctgtcctctgcagggacctgtatgccttctaccccatgctcatccgatacgtg gacaacttcaggtccaaatggcttaaggaacctgatgctgattccacttcgctcttcaac atggtcgcggagatcttcatcctctggtgcaaatctcataatttcaagagggaggagcag aactttgtggttcagaacgaaatcaacaacctggccttcctgactgtggagtccaagacc aagatggccaagtcgggaggtcaggatcaggagcgtaagggccggcggaggaagagggag ctctactcggtgcagacctcgctcatcgtggccgccctgaagaagctgctgcccatcggc ctcaacatgtgcacgccgggcgagcaggaactcatcacgctggccaagatccgctacggc ctgaaagacacagatgacgaggtcaaagaccagcttcgccagaaccttcaccttcaagag aagtcagaggacccggcggtgcagtggcaggtgaacctgtacaaggacgtggtggtgaag agtgaggggcctccagaccccgagcgcatcgttgagagggtgcagggactctccgccgcc ctcttccatcttgacgcggtggagctgcctctaaggagtaagaagaacctggcgcagaag ctgttgtccaaacaacgcaagcgtgccgtggtggcctgtttccgcatggcccccctttac aacttacccaggcatcgctgtattaacttcttcttcctggcctatctgaggttctggata gaggcagaggagtacttttttgaggagaagctagtgcaggacctggccaaaactcccata aaggtggtggatgaggaagaggaggaggaagcagaggtcaagcctgaccctctgcaccag ctcatcctccacttcagtcacaacgctctcacggaaaggagtcacctggatgaagatcca ctgtatatagcatatgcagacatgatggcgaagagctgtgccgaagacgaggaggaagag gaggatgaggaaggaggcaagagctttgaggagaaagagatggagaagcagaagatattg taccagcaggcccggctccatgcccgcggggcagctgagatggtgctgcagatgattagc gccagtaaaggccgccttgggccaatggtgaccggaacgctcaaactgggtatctcaatt ctgaatggcggtaacgtgatcgtccagcagaaaatgctggactacctgaaattgaaaaga gatgctggcttcttcaaaagtttaactggactcatgcaagcttgcagtgtcctggatctg aatgcattcgagagacagaacaaagcggaaagcctaggaatggtgtctgaagaaggatca atcaactcgagtcgaaaggcttctaaagtgctgcagaatgacgacttcaccaaggatctg tttaggttcctgcaactgctctgtgagggccacaattccgatttccagaacttcctccgt acccaaactggtaacaccaccacagtgaatatcatcatcagcactgtggactacctgctc cgtctgcaggagtccatcagcgatttctactggtactactctggaagagatgttatggat gaagctggtcagtacaacttctccaaagcccttgctgtagctaagcaggtgttcaactca cttactgagtacattcagggtccctgcatcggcaaccagcagagcttggcgcacagcagg ctgtgggacgccgtggtgggattcctgcatgtgtttgccaacatgcagatgaagctttca caggactcgagtcaaattgagctgttgaaagaattgatggatctgcaaaaagatatggtg gttatgatgctgtctctccttgagggtaacatagtgaatggaactattggaaaacagatg gtagacacactggtggaatcttctagcaacgtagagatgatcctcaagttctttgacatg ttcctcaaactaaaagaccttacgacctccgacaacttcaaggagtacgatcccgagagc aaagggatcatatccaagaaagagttccagaaggctatggagaaccaaaagcaatacatg caatcagagatcgacttcctcctctgttgttgtgaggccgacgagaacgacatgtttaac tacgaggagttcgtcgaccgctttcacgagcccgctaaagacatcggcttcaacgtcgtc gtcctcctcacgaacctgtccgagcacatgcctcacgacagccgcctggctatgttcctc gacctcgcagagagcgtcgtgaattacttcgagccgtacctcggtcgcatcgagatcatg ggtagcgctaaaaggattgagagggtctactttgagattagcgagtcaagtcgcacacag tgggaaaagccgcaggtcaaggagtccaagcgacagttcatctttgacgtggtcaacgag ggcggcgagagcgagaagatggagatgtttgtcaacttctgcgaggacaccatcttcgag atgcagctggcctcgcagatctccgagccggacagcgttgagcggcccgaggaagaggag gaagaggaagaagagccggaagaggaagaggagggtgtggagtcccagtcggccttctcg gcagcttgcgcctctgtgaagcggaagatctccaacttccgtcagatgttgaccctacgc agcatgcgcaagcagttcaaggcagtcaggaagctcaccatccgcgagatgatcactggt ttcttcggcttcttctggatgctcttcaccggcttcttcaaaggcatctacaacgtcatc tttggtttcttccacatcatctggacatctatctttggtgggggcctagtcgagggtgcc aaaaacatcaaggtgaccgacatcctaggcaacatgcctgacccgactcagttcggaatc cacggcgacattctggaggcggagaaggcggacattggcgaattggcggccacggcggac atggtgcagatggtgagtggcgagccgatggaggtagacctgatgatggagttgatggga gggccgtccaagcgagatggcaaacacgaactgggcctgggtgacgtctgtgagatcaag cctaccgagtctgccgcaccagagaaaaagaagagcaagaaagctgaagtgaaggaatcc gagccagaaaaagcagatacagagaatcaggagaaagaggagaaggccaaagaggaggcg cctgcagagccggcggctaaggacaagcctgtccgcaagcccagacgtggtggcgatcag gaggagagccctgccttcatggccagcttcatcgcaggactggaggtctacaagaccaag atgctgaactatctggctcgcaacttctacaacctccgtatgctggctctgtttgtggcc tttgccatcaacttcatcctcctgttctacaaggtgactgctgacgaggtggatgaggac gaggactcctgggaaaacggtgacgatgaagaagacaacgatgagggactggagtatttt gtgcttcaggagagtaccggttacatggcacccactttgaccttcctggctatctcacac accgtcatctccctgctgtgtgtcctgggatattactatctgaaggtccctctggtggta ttcaagagggagaaggagattgcgaggagtctggagttcgaaggcatctatatcaccgag cagccgtctgacgatgacatcaaaggacagtgggatcgattggttatcaacacaccatct tttccaagcaattactgggacaaatttgtcaagagaaaggtcattaataaatatggtgat atgtacggagctgagcgcatcgctgaactccttggcttggacaagagcgccctggacttt gaccctacaatagagacagtggcacctgaggcctccctagtttcttggttgagttccatt gacaccaagtatcatacttggaaaatgggcgtggttctgactgacaactccttcctgtat ctggtgtggtacaccaccatgtccacgctgggtcactacaacaacttcttcttcgccgct cacttgctggacatcgccatgtgcttcaagcccctgaggaccatcctgtcctccgtaaca cacaatggcaaacagctggtgctgaccgttgggctgttggccgtggtggtgtacctctac acagtcgtggccttcaacttcttccgcaagttctacaacaagagtgaagatgaggatgag cctgacatgaagtgtgatgatatgatgacttgttacttgttccacatgtatgtgggtgtg agggctggcggtggcatcggtgatgagattgaagacccggccggggatccatccgaactt taccgtatcctcttcgacatcaccttcttcttcttcgtcatcgtcatcctgctggccatt attcagggtttgattattgatgcttttggagagctgagaggccagcaggaccaagtgaag gaggatatggagacaaaatgtttcatctgtggaatcggtaatgactacttcgacactaca ccccatggcttcgagactcacaccttacaagagcacaaccttgccaactacctattcttc ctgatgtatctgattaacaaggatgaaactgagcacacgggtcaggagtcgtttgtgtgg aagatgtatcaggagaggtgctgggacttcttccctgctggagactgcttccgcaagcaa tatgaggaccagctaggctaa

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