Anolis sagrei ordinatus (Brown anole): 132765794 Help Entry 132765794         CDS       T09595                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism asao  Anolis sagrei ordinatus (Brown anole) Pathway asao04020   Calcium signaling pathway asao04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:asao00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     132765794 (RYR3)    04020 Calcium signaling pathway     132765794 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:asao04040]     132765794 (RYR3) Ion channels [BR:asao04040]  Voltage-gated cation channels   Ryanodine receptor    132765794 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 CCDC106 Motif Other DBs NCBI-GeneID:  132765794 NCBI-ProteinID:  XP_060616051 LinkDB All DBs Position Unknown AA seq 4881 aa AA seqDB search MAEGSEGGEDEIQFLRTDDEVVLQCVANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCICNFVLEQSLSVRALQEMLANTGDNSSEGAAQGGGHRTLLYGHAILLHHSFSGMYL TCLTTSRSQTDKLAFDVGLQENAAGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVAYGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVLRLFHGHDECLTIPSTE QNDSPHKRLFYESGGAGVRARSLWRVEPLRISWSGSNIRWAQPFRLRHITTGQFLALTED LGLVLLDREKADTKTTSFCFRASKEKLESIHKRDIEGMGVPEIKYGDSVCFVQHVASSLW LTYKAQDAKTTRLGPVKRKVILHQEGHMDDGLTLQRCQHEESQAARIILNTTRLFSQFIS GNNRTSSPITLPIEEVLQTLQDLITYFLPPEEELEHEDKQNKLRSLKNRQNLFKEEGMLA LVLNCIDRLNVYYSTAHFTGVGREENSTAWKEILNLLYKLLAALIRGNRNNCAQFSNNLD WLISKLDRLESSSGILEVLHCILIESPEALNLIEEGHIKSIISLLDKHGRNHKVLDVLCS LCLCNGVAVRANQNLICDNLLPRRDLLLQTRLVNDVTSMRPNIFLGIAEGSAQYKKWYFE LIIDQVDPFLTAEPTHLRVGWASTLGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGR IPRAVASVNQHLIASEDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVSFSA GVKVRFLMGGRHGEFKFLPPTGYVPCYEALLPKEKMKLEPVKEYKRDSNGIRDLLGTTQF VSQANFIPCPIDTSQIVLPLHLEKIRDKLAENIHELWGMNKIELGWTYGKIRDDNKRQHP CLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIVHTNPGAEEDLKKIKLPKNYMMSNGY KPAPLDLSEVKLLPPQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVPYT LLDERTKKSNRDSLREAVRTFAGYGYNIEPPDQELADQTVEKISIDKIRFFRVEQSYAVK TGKWYFEFEAVTGGDMRVGWARPGCRPDLELGADDQAFVFEGSKGQRWHEGSGFFGRNWQ PGDVVGCMINLDDKSIIFTLNGELLITNKGSELAFADFEINNGLVPICSLGLSQIGRMNF GRDASTFKYYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKNHSHIAVTRIDGNI DSPPRLKVTHKTFGTQNSNADMIYCRLSMPIEFHSSFNYITSLELVDGFQKRKQIQEFPF HAITYYYSVRIFAGQDPSSVWIGWVTPDYHFYSEHFNLNKNCTVTVTLGDERGRVHESVK RNNCYLVWGGEAAVNSQRSGRGNVDLEIGCLVELASGMLSFTANGKELGTFYQVEPNTKL FPAVFLQPTSTNLFQFELGKLKNTMPLSAAIFKSEERNPIPQCPPRLDVQTITPVVWSRM PNYFLKVDADRVSDRHGWMVQCLEPLQMMALHIPEESRCIDILELCEQEDLMRFHFHTLK LYSSVCALGNNRVAYALCSHVDISQLFYTIDNQYLPGLLRSGFYDLLISIHLEYSKEAKL MMNNEFIIPITDETRKIKLFPDESKRHGLPGVGLSTCLKPDFKFSTPCFILSQEDHQKPS PEIPLDMLKSRAISMLTEAVYCSGAHIRDPVGGKVEFQFVPVLKLIGTLLIMGVFDDHDV KQILLLIDPYVFGEPKEETQEKTEKEDVTQIEEKAVEAGEKAIKETKTPIKGLLQTRLAE SVKLQMCELLNYFCDCELKHRVEAIVSFADTYVSKLQYNQKYRYNELMQALNMSAALTAR KTKEFRSPPQEQINMLLNFQLGEDCPCPDEIREELYEFHDDLLMHCGIPLDEEEVEDKDI SWAGKLRSLIYKIKGAPKTEERETTEEEEKYPTTLKKLISRTMVSWAQEDQIQDPELVRI MFNLLRRQYDSIGELLLALRKSYTISAASVQDTINLLAALGQIRSLLSVRMGKEEELLMI NGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQIAFPKMVASCCRFLCYFC RISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALEEPDLEK VVTYLAGCGLQSCPMLLAAGYPDTGWNPIEGERYLSFLRFAVFVNGESVEENASVVVKLL IRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKRDFSLDEDEEEEGVVHM GNAILSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPT VNKDGTVSEPDMSAGFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVGFLPDLRACASLDT VSLSTTETALALNRYICTAVFPLLTRCASLFSGTEHYVSLIDSTLHTIYRLSKGRSLTKA QRDTIEECLLAICHHLRPSMLQQLLRRLVFDVPSLNEYCKMPLKLLTNHYEQCWKYYCLP SGWGNYGIAAEEELHLTEKLFWGIFDSLSSKFLSLLQKYDPDLFRMALPCLSAIAGALPP DYLDIQITTILEKQTSVDAEGNFDPKPVNTVNFILPEKLEYIVNKYAEHSHDKWACDKSN SGWKYAASLDENMKMHPLIRPFKTLTDKEKEIYRWPARESLKTMLAMGWSIERTKEGESI VQQRENEKLRSVSQSSQGNGYSPAPLDLSNVVLSRELQGMVEIVAENYHNIWAKKKKIEL ESKGGGSHPLLVPYDTLTAKEKARDREKAQELFRFLLVNGVAITRGLNDMALDASSMEKR FAYKFLKKILKYVDSAQDFIAHLEAIVTSGKTEKSPHDQEIKFFAKVLLPLLDQYFTNHC LYFLSSPTKPLSSSGYASNKEKEMVASLFCKLAALVRHRISLFGNDATTMVSCLHILAQS LDTRTVMKSGSELVKAGLCAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTV ALLPILTSIFEHVAQHHFGTDLLLGDVQVSCYRILCSLYSLGTGKNIYVERQRPALGECL ASLAAAIPVAFLEPSLNLYNPLSVFNTKTARERAILGISETVEEMCPEIPNLDDLMKEIN NLAESGARYTEMPHVIEVTLPMLCNYLSYWWEKGPENICEGTGPCCTMVTSEHLSIILGN ILKIINNNLGIDEATWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAIKIVMEEEQ LKADSKTDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKKPDSDSDELFRMV AEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDNKSKMSKQIVRRGMAMQVKSGGHDQ ERKKSKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSCKDTEEEVKE HLRNNLHLQEKSDDPAVKWQLNLYKDVLKTDEPADPEKTVERVQRISAAVYHLEQVEQPL RSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQKYWIETEEYSFEEKL VQDLATLPQKSEEEEEEIEKHPDPLHQIILHFSRNALTERSKLENDPLYTAYSAMMAKSC QSGEDDDEEEEEKEKTFEEKEMEKQKTLYQQSRLHERGAAEMVLQMISASKGEMGPMVVE TLKLGIAVLNGGNSVVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGL GMVTEEGTLIVRERGEKVLQNDEFTKDLFRFLQLLCEGHNNDFQNYLRTQMGNTTTVNII ISTVDYLLRLQESISDFYWYYSGKDVIDESGQRNFSKALAVTKQIFNSLTEYIQGPCIGN QQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLKDMVVMLLSLLEGNVV NGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTSSEAFKEYDPESKGVISKKEFQKA MEGQKQYTQSEIEFLLSCAETDENDMFNYADFVERFHEPAKDIGFNVAVLLTNLSEHMPN DSRLQTLLDPAGSVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQ FIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDTTDRPEEEDEDEHCYVREVGE DEKEEQSLESASAFALACATAKKNATVFLKTIRLKNLRKQYRKVRKMTLKELVKVFFSFL WMLFIGFFQMIFAIIWGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDVL ESEKAEVTEHGITAEIVQFVKNEKEESDILSDIFGIHTKKESGSKHGHDVGLGDIADIIG SETPPSLESAVHKKKKAQTGEIGKDDESETRTESEKADIENGEKQDKIKDDVYSENLEVE ESKKRKRRRGQRIEKPDAVMANFFKVLEVYQTKMLHCLARNFYNLRFLALFVAFAINFIL LFYKVTEEPFEEMEEDSDLWHALDEDEDEDGVVFYVLQESTGYMAPTLRALAVIHTIISF VCVIGYYCLKVPLVVFKREKDIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNY WDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEHTELEEASLISWLSSVDAKYR IWKLGVVFTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQ LVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGG IGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMET KCFICGIGNDYFDTTPHGFEMHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQE RCWDFFPAGDCFRKQYEDQLG NT seq 14646 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggcagcgaaggaggcgaagacgaaatacagttcctacgaactgatgatgaa gtggtgcttcagtgtgttgccaacattcacaaagaacaacgaaagttctgcctggcagct gagggacttggaaatcgcctgtgctttttagagccgacttcagaagctaaatatgtccct cccgacctttgcatctgtaattttgtgctggaacagtctctatctgtgagagccctccag gaaatgcttgccaatacaggagacaattccagtgaaggggctgctcaaggtggtggtcat aggacattactgtacggccatgctatcctgcttcatcattcattcagtggaatgtatttg acttgtttgactacatcaagatctcagacggataaacttgcatttgatgtggggctacaa gagaacgcagcaggtgaagcatgctggtggactatacatcctgcttctaaacaaagatct gaaggagaaaaagtgcggattggagatgatcttatcctggttagtgtgtcttctgaaaga tacctgcatctgtctgtagcatatggaaacatacaagtggatgcctcctttatgcaaact ttgtggaatgtgcatccgacttgttcaggaagtagcattgaagaaggatacctacttggt gggcatgtattacgtttgtttcatggccacgatgagtgtttgacaatcccatcgacagaa cagaatgattctccacataaaaggctattttatgaatcaggaggagctggtgtccgggca aggtctctatggagagtggaaccacttagaataagctggagtggaagtaacatacgttgg gcacagccctttcgtcttcgacacattacaacaggacagtttttggccctgactgaagac ctgggtttagtcttattagacagagaaaaggctgacacaaagacaacttcattttgtttt agagcatcaaaggaaaaactggagtccattcacaaacgcgatattgagggcatgggagtt cctgaaataaagtatggtgattctgtttgttttgtgcagcatgtagccagtagtttgtgg ctgacgtacaaagcacaggatgctaaaacaacacgtttaggaccagtgaaaagaaaggtt atattacatcaagaaggacacatggatgatggtctcacattgcaaaggtgtcaacatgag gagtcccaggctgctagaataattctaaatacaacaagattatttagtcaatttataagt ggaaacaatagaacttcatctcccatcactttgcccattgaagaagttcttcagactctg caagacctgattacatattttctacctccagaggaggagctagaacatgaggataaacaa aataaacttcgttcactcaagaacagacaaaatctatttaaagaagaggggatgttggca ctggttttgaactgcattgatagattaaatgtctattatagcacagctcactttacaggc gttggtagagaagaaaatagtacagcatggaaagaaattctcaatcttctttacaagcta ttggctgctctcattcgtggtaatagaaacaattgtgctcaattttccaataatcttgat tggctgattagtaaattggaccgactagaatcttcttcaggaattttggaagtgttacat tgcatcttgattgaaagtccagaagcattaaatttgatagaagaaggacatatcaaatct ataatctcattgctggataaacatgggcgcaatcataaggtccttgatgtactatgctct ctctgtctctgtaatggagtagcagtgcgtgctaatcagaacttaatctgtgacaatctt cttccacgaagagatctgctcttgcaaacacgactggtgaatgatgtaacgagtatgaga ccaaacatatttctgggaattgctgaaggctcagcgcagtataagaaatggtattttgaa ctaataattgatcaagtggacccctttttaacggcagagcctacacatctacgggttggc tgggcctcaacattgggctatgctccttatcctggaggtggagaaggctggggaggcaat ggagttggtgatgacctatactcatatggttttgatggacttcatctgtggtctggtcga atacccagagctgttgcctctgtgaatcaacatttgatagcatcagaagatgtggtcagc tgttgcttggatttaggcgcacccagcatttcattccgtattaatggacagcctgtgcaa ggaatgtttgagaattttaacactgatggactttttttcccagtagtgagcttttctgca ggtgtcaaagtgcgtttcttaatgggtggacgtcatggagagttcaagtttctacctcct actggctatgtgccttgttatgaagctttgcttccaaaagagaagatgaaattggagcca gtgaaagaatataagagagattccaatggaattagagatttgcttggcacaacacaattt gtctcccaagctaattttatcccttgtccaattgacaccagccagattgttttgccactc catcttgagaagattagagataagctggctgaaaatatccatgaactttggggaatgaat aaaatagaacttggctggacttatggcaagatacgagatgataacaaaaggcagcaccct tgtctggtggaattttcaaaattacctgaaacagagaagaattataatctgcaaatgtca acagaaactctgaaaacccttttggctcttggatgccatattgtacatacaaatccagga gcagaggaagaccttaaaaaaataaaacttccaaaaaattatatgatgtcaaatggctat aagccggcccctctagatctctctgaagtaaaattgttgccaccccaagaagtactggtt gataaacttgcagaaaatgcacataatgtctgggcaaaagacagaataaaacaaggatgg acatatggcattcaacaggatctcaaaaacaaacgaaatccacgattggtgccatataca ttattagatgaacgtactaagaagtcaaacagagatagcctacgtgaagctgttcgcacc tttgctggttatggatataacattgagcctccagatcaagaactagctgaccaaactgtg gaaaaaataagcatagataagatacgtttcttcagagtggagcagtcttacgcagtgaag actggaaagtggtattttgaatttgaagcggttacaggaggagacatgcgtgttggatgg gcaagaccaggttgtcggcctgaccttgaactaggagctgatgaccaagcatttgtgttt gaaggcagcaaaggtcagcgttggcatgaagggagtggcttctttggacgaaattggcag ccaggagatgtagtgggctgcatgatcaatctagatgacaaatcaataatatttacattg aatggagaattgcttattaccaacaaaggttcagaacttgcttttgctgactttgagata aataatggtttggtgcctatatgctcactgggtctgtctcagattggtcgtatgaatttt ggaagggatgccagcaccttcaaatactatactatgtgtggtcttcaagaaggctttgaa ccttttgctgttaacatgaacagagatgttgctatgtggtttagcaaacgtttgccaaca tttgtcaatgtgcccaaaaaccactctcatattgcggtgacaagaatagatggtaacatt gacagcccaccacgcttaaaagtaacccataaaacatttggaacacagaatagcaatgca gatatgatatattgtcgcctgagcatgccaattgaatttcactcatcttttaactacatc actagtttggaacttgttgatggtttccaaaaaaggaaacaaatccaggagtttcctttt catgccataacatattattattcagtgcgaatctttgctggacaagacccatcttcagtc tggattggttgggtgactcctgactaccacttttacagtgaacattttaacctcaataag aactgtacggtaacagttactttgggagatgaaagaggcagagttcatgaaagtgtaaaa cgcaacaactgctacttggtctggggaggagaagctgctgttaactcacaaagatctggt cgtggcaatgttgatttagaaataggatgccttgttgaattggcttctggaatgctgtca tttacagccaatggaaaagagctgggaactttctaccaggttgaaccaaacacaaaacta tttccagcagtttttttacagcctacaagcacaaacctgtttcagtttgaactgggtaaa ttaaagaacaccatgcctttatcagcagcaatatttaaaagtgaagagcgaaaccctatt ccccaatgtcctccacgactggatgtccaaacaatcacacctgttgtgtggagcagaatg ccaaactatttcttaaaagtagacgctgaccgggtcagtgaccgacatgggtggatggtg caatgcctagaacctttgcagatgatggcccttcatattccagaagaaagcaggtgtatt gatattttggagctatgtgaacaagaagatctgatgaggttccatttccatacgttaaaa ctttatagttcagtttgtgcactgggaaacaacagagtagcttatgcactttgcagccat gtggatatttcccagttattttatacaatagataatcaatatttacctgggttattacgt tctggattttatgacttgctgatcagcattcatttagaatactccaaagaggctaagctg atgatgaacaatgaatttataattcccattacagatgaaactagaaaaattaaattattt ccggatgaatcaaagagacatggtttgccaggagttgggcttagtacctgcctgaaacca gattttaagttttctaccccttgcttcattttgtctcaagaggatcatcagaagcctagt ccagaaataccacttgatatgcttaaatccagggctataagcatgcttacagaagcagtt tactgtagtggagctcacatacgagatcctgttggagggaaagttgagttccagtttgtt cctgtacttaaacttataggaactttgctcataatgggagtctttgatgatcatgatgtg aaacagattttacttctcatcgatccatatgtgtttggtgagccaaaagaagaaacacag gagaaaacagagaaggaggatgtcacacaaattgaagaaaaagcagtagaggctggagaa aaggcaatcaaggaaacgaaaacaccaattaaaggcttgctgcaaacaagattggctgaa tctgttaaactccagatgtgcgagctgctaaattatttctgcgactgtgagctgaaacac agagtggaagccattgtatctttcgcagacacatatgtctcaaagttgcagtataaccag aaatacagatataatgaacttatgcaagctttgaatatgtcagctgctttaactgccagg aagaccaaggaatttcgctcccctcctcaagagcagattaatatgttactaaattttcaa ctgggggaagattgtccttgtccagatgagattcgggaagagctttatgagtttcatgat gatctcctgatgcactgtggtattcctttagatgaagaagaggtggaagataaagatata tcatgggctggaaaactacgttcattgatatataaaataaaaggtgcaccaaaaaccgaa gagagagaaactacagaagaagaagaaaaatatcctactacattgaagaagttgatatct cgaactatggtttcctgggctcaggaagatcagatccaagacccagaattagttcgcatt atgtttaatctccttcgacgacaatatgacagcattggagaactgctgctggctctgagg aagtcctatactatcagtgctgcctctgtgcaggatacaataaacttactagcagcactg ggtcaaattcgctctcttcttagtgtcagaatgggaaaagaagaagaattgcttatgatt aatggccttggagatataatgaacaacaaagtattttaccagcatcctaacttaatgagg gtccttggtatgcatgagacagttatggaagtaatggtaaatgttcttggaggagacaaa tctcagattgcttttccaaaaatggtagcaagttgttgccggtttctgtgctatttttgt cgaatcagtcgccagaatcaaaaagccatgtttgaacacctcagctacttacttgagaat agcagtgtgggacttgcttctccttccatgaggggttctactccactagatgtagcagct gcctctgtaatggataataatgagcttgcacttgcattggaggagccagacttagaaaag gttgtaacctatttggcaggttgtggacttcagagttgcccaatgttgttagctgcagga taccctgacacaggctggaatccaatagagggtgaacgatatctatcctttttaagattt gcagtttttgttaatggtgaaagtgttgaggaaaatgccagtgttgttgtcaagcttctt attcgacgcccagaatgttttggtcctgcccttagaggagaaggaggaaatggtttgctg gctgctatgcaaggagcaattaagatctctgagaacccagctcttgatctcccctcccaa ggatacaagagagatttcagtcttgatgaagatgaagaagaggaaggagtagtacacatg gggaatgcaattctgtccttttactctgctcttatagatttgcttggacgttgtgcacca gaaatgcatcttatccaaactggaaaaggagaagctattcgaatcaggtccatcttgcgt tccctggtaccaacggaagatttggttggaataataagcataccattaaaattaccaaca gtcaacaaagatggaacagttagtgagccagacatgtctgcgggtttctgccctgatcat aaggcaccaatggtcctctttctagatcgtgtctatggtataaaggaccaaagttttctt ctccatctccttgaagttggatttttaccagatttaagagcttgtgcatcattagataca gtttctttgagtactacagagacagctcttgctctaaatagatatatttgcacagctgtg tttcccttactcacacgatgtgcttctctcttctcgggaactgagcattatgtctctctg attgattccacacttcatacaatatatcgtctatccaaaggacgctctctaacaaaagca caaagggacactattgaagaatgcttgcttgctatctgtcaccatttacgtccttccatg ctacagcagcttttgcgacggctagtctttgatgtaccttcacttaatgaatactgtaaa atgcctcttaagcttttaacaaatcactatgagcaatgctggaaatactactgtttgcct tcaggatggggaaattatggaattgcagccgaagaagagctacatttaactgaaaaactt ttctggggaatatttgattctctttcttctaagttcctatctctcctgcagaagtatgat ccagatctcttccgaatggccttgccttgtttaagtgcaatagctggggctttgccacca gattatttagacatccaaattaccacaattttagaaaagcaaacttcagtggatgctgaa ggaaactttgatcccaaacctgttaacacagtgaattttatacttcctgagaagttggaa tatattgtcaacaagtatgctgaacattcacatgataaatgggcctgtgacaagagtaat agtggatggaagtatgctgcttcacttgatgaaaatatgaagatgcatcctttaataagg ccctttaaaactttgactgacaaggaaaaggaaatctaccgatggcctgccagagaatca cttaaaaccatgctagcaatgggatggagtatagaaaggaccaaagaaggtgaatcgata gtccaacaacgtgaaaatgagaagctccgcagtgtgtcgcagtcaagccaaggaaatgga tacagcccggcaccacttgatctttcaaatgttgtactctctagagaactccagggaatg gtcgaaatagtggcagaaaactatcataacatttgggctaaaaagaagaaaattgaatta gaaagtaaaggtggtggtagtcatcctttattggtcccatatgacactttaacagccaaa gaaaaggctcgagacagggagaaagcacaagaacttttccgattccttttagtgaatggt gttgctataacaaggggcttgaatgacatggcactggatgcttcatccatggaaaagagg tttgcttataaatttctgaagaagattctcaaatatgttgattctgctcaagacttcatt gcacatttagaagccattgtcaccagtggaaaaacggaaaaatccccacatgaccaagaa atcaaattttttgccaaagttctgctaccattacttgaccagtattttaccaatcattgc ctgtactttctttcttctccaaccaaacctctcagcagtagtggatatgcttcaaataaa gaaaaggaaatggtagcaagccttttctgcaaacttgctgctcttgttagacataggatt tcactttttggtaatgatgctactacaatggttagctgcctacatatcttggctcagtca ttagatacaagaaccgtcatgaaatctggctcagaactggttaaagctgggttatgtgcc ttctttgaaaatgcagctgaagatcttgagaagacatcagaaaatcttaaacttggaaaa tttacccattcccgaacacaaattaaaggagtttctcagaatatcaactacacaacagtt gcactcttgcctattttgacatctatttttgagcatgttgcacagcatcattttggcact gatttacttttaggtgatgtccaagtttcatgttacagaattctttgcagcctatattcc cttggaactgggaagaacatttatgttgagaggcaaaggccagcactcggtgagtgcttg gcttctcttgcagcagcaattccagtggcctttcttgaaccttcactcaatctttacaat cccctctctgtcttcaacacaaaaactgccagagagagagcgattttaggcatatctgaa actgtagaagaaatgtgtccagaaattcctaacttggatgacttaatgaaagaaataaac aacttggcagaatcaggagcccgatatactgaaatgcctcatgtgattgaagtgaccttg cccatgctgtgcaattacctgtcatactggtgggaaaagggacccgaaaacatatgtgaa ggtactgggccctgctgcacaatggtcacctctgaacatcttagcataatactgggaaac attttgaaaataatcaacaacaaccttgggatagatgaagcaacctggatgaaaagaatt gcagtgtatgctcagccaatcattagtaaagccagaccagatttgttgaaaagtcatttc attccaaccctggaaaaactaaagaagaaggccataaagattgtgatggaggaagaacaa ctgaaagcagacagtaaaactgatactcaagaagcggaacttctcattttggatgaattt gcagttctttgccgagacctttatgctttttatcctatgttgatccgttacgtagacaac aacagatcaaactggcttaaaaagccagattcagattctgatgaacttttccgaatggta gctgaagtttttattctctggtgtaaatcacataatttcaagagagaagaacaaaatttt gtgattcagaatgaaatcaacaatttggcatttttgacaggagataacaagagtaagatg tcaaagcagattgttcgaaggggaatggccatgcaagtaaagtctggtggtcatgatcaa gaacgaaagaaatcaaaacgcagaggagatttgtactcaatacagacttctctaattgta gctgcgcttaaaaaaatgcttcctatcggattgaacatgtgtactcctggagatcaagaa ttaatttcgcttgctaagtccagatatagctgtaaagacacagaagaagaggtcaaagaa catttacgcaataatttgcatttacaggagaagtcagatgacccagctgtgaaatggcag ttgaatctgtacaaagacgtcttgaaaactgatgaacctgctgatcctgagaaaactgtg gaacgtgttcagaggatctcagctgctgtctatcatctggaacaggttgagcaaccatta agatcaaagaaagcagtttggcacaaactcttgtcaaagcaacgtaaaagagctgtggtt gcttgcttcaggatggcaccattgtataatctgccaaggcaccgttctattaacctgttc ctccatggctatcagaaatattggatagaaacagaggaatattcctttgaggagaaacta gttcaggatctggctactctcccacagaaaagtgaagaggaggaggaagagattgaaaag catcctgaccctctacatcagattattcttcatttcagtcggaatgctctcactgagaga agcaaattggaaaatgatcctttatatactgcatattcagcaatgatggcaaagagctgc cagagtggagaagatgatgatgaagaggaagaagaaaaagagaaaacatttgaggaaaaa gaaatggaaaagcaaaaaacactgtatcaacaatctcgacttcatgaacgtggagctgcc gagatggtactacagatgattagtgccagtaaaggtgaaatggggccaatggtagttgaa accttaaaacttggcattgctgttctaaatggaggtaactcagttgttcaacagaaaatg ttggattatctgaaggagaaaaaagatgctggattttttcagtctctatctggcttaatg caatcttgcagtgttcttgacttgaatgcctttgagagacaaaataaagcagaaggcctt gggatggttactgaagaaggaacactcatcgtacgtgagcgtggtgagaaagtactacag aatgatgagtttactaaagatctgtttagatttttacaactgctatgtgaaggccataac aatgattttcagaattatttacgtactcagatgggcaataccacaacagtgaatattatt attagcacagttgactatctattacgtcttcaggaatccatcagtgacttctattggtac tactctggaaaagatgtaattgatgaatctggacaacgtaacttctctaaagcattagct gtcaccaagcagatttttaattcacttactgaatatattcaaggtccttgtattggaaac caacagagcctagctcacagcagattgtgggatgcagttgttggctttcttcatgttttt gctaacatgcaaatgaaactttctcaggattccagccaaattgaactgctgaaggagcta ttggatcttctgaaggatatggtggtgatgctgttgtcactacttgaaggtaatgtcgta aatggcacaattggaaaacagatggtggacactctggtcgagtcatctagcaatgtggaa atgatcttgaagttctttgacatgtttctcaagctgaaagatctaacaagttctgaagca ttcaaagagtatgatccagaaagtaaaggtgtaatctcaaagaaagaattccagaaagcc atggaaggtcaaaagcaatatacacaatcagagattgagttcctgttgtcctgtgcagaa acagatgaaaatgacatgtttaattatgctgactttgttgaaagattccatgagccagcc aaagatattggatttaacgtggcagtactcttaacaaacctttcagaacatatgccaaat gattcacggcttcaaactttgttagatccagcaggaagtgttcttaattattttgaacct tacctgggacgcattgaaataatgggaggtgccaagaagatagagcgggtttattttgag atcagtgaatctagtcggacacagtgggaaaagccccaagttaaagaatcaaagcgtcag tttatttttgatgttgtaaatgaaggtggagaacaagaaaaaatggaactttttgtaaac ttttgcgaagacacaatttttgaaatgcaattggcatctcagatttctgaatcagacaca actgacagacctgaggaggaggacgaggatgaacattgctatgtgagggaagttggagaa gatgagaaagaagagcaatctcttgaatcagcttcggcttttgcattagcatgtgctaca gcaaagaaaaatgctactgtgtttcttaaaacaattagactgaaaaatctaagaaaacag tatagaaaagtgagaaagatgactttaaaagaattagtgaaagtgtttttttcctttctg tggatgctattcatagggttcttccaaatgattttcgctataatatggggtatttttcag attctttggagcactgtgtttgggggtggcttagtggaaggtgccaaaaatataagagtt accaaaattttaggagatatgcctgatccgacacaatttggaatccatgatgatgtccta gaatcggagaaagctgaagttacagaacacggcattacggctgaaattgttcaatttgta aaaaatgaaaaagaagaaagtgacatcttgtctgatatttttggcattcatacgaagaaa gaaagtggatcaaaacatggccatgacgttggccttggggatattgcagatattattgga tctgaaacgcctccttctttggaaagtgcagttcacaagaagaaaaaagcacagacaggt gaaattggaaaggatgatgaatcagaaacaagaacagaatctgagaaggctgacattgag aatggtgagaagcaagataaaataaaggatgatgtctactctgaaaatttggaagttgaa gaatccaagaaaagaaaacgaaggcgtgggcaaagaatagagaaacctgatgcagttatg gctaatttttttaaagtgctggaagtgtatcagacaaaaatgttgcactgtttggccaga aatttctacaatttgcgatttcttgcactttttgttgcatttgccatcaactttattctc ctgttctacaaggtgacagaggagccatttgaagagatggaagaagattctgatctatgg catgctttagatgaggatgaagatgaagatggagtggtgttctatgtcttacaagagagc acaggatatatggctccaacactgagagctctagctgttatccacaccatcatctctttt gtatgtgttattggatattattgcttaaaggttccccttgttgttttcaaacgtgagaag gacattgcaagaaaactagaatttgatggtttgtacattactgaacagccctctgaagat gatattaaagggcaatgggaccggctagtcataaacactccgtcttttccaaataattat tgggacaaatttgtaaaacgaaaggtaatcaacaagtatggtgatttatatggagcagaa cgcattgcagaacttttgggtctggataaaaacgctttggatttcagtcctgtagagcat actgaactagaggaagcatctcttatttcatggttaagttctgtcgatgccaagtatcgt atctggaaacttggtgtagttttcactgataattccttcttgtacttagcatggtacaca actatgtctatccttggtcactacaacaacttcttctttgctgctcacttgcttgatatt gctatgggctttaagacattacgtaccatcctgtcttctgtaactcacaatggtaaacag cttgtgttgactgttggactcttggctgtagtggtatacctatacacagttgttgcattc aacttcttccgcaaattttataacaagagtgaagatgaagatgagccagacatgaaatgc gatgatatgatgacttgttacctgttccatatgtatgtgggagtaagagcaggcggaggc attggagatgaaattgaagacccggcaggagatccatatgaaatgtacagaattgttttt gatatcacgtttttcttttttgttattgtcatcctattggccatcattcaaggtctgatt attgatgcctttggcgaattaagagaccagcaagagcaagttaaagaagacatggagacc aaatgttttatttgtggaattggtaacgactattttgacacaactcctcatggatttgaa atgcatactttacaagagcacaacctggccaactatctgttctttctgatgtatcttatt aataaggatgaaactgagcacactggacaggaatcatatgtgtggaaaatgtatcaagaa agatgctgggatttcttcccagctggagattgcttccgaaaacagtatgaagatcaactt ggatga

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