Bubalus bubalis (water buffalo): 102411895 Help Entry 102411895         CDS       T05912                                  Symbol PCLO Name (RefSeq) protein piccolo isoform X3   KO K16882   protein piccolo Organism bbub  Bubalus bubalis (water buffalo) Pathway bbub04911   Insulin secretion Brite KEGG Orthology (KO) [BR:bbub00001]  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     102411895 (PCLO)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:bbub04131]     102411895 (PCLO) Membrane trafficking [BR:bbub04131]  Exocytosis   Calcium ion-dependent exocytosis    Others     102411895 (PCLO) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  zf-piccolo C2 PDZ FYVE_2 FYVE_CARP1-2 Motif Other DBs NCBI-GeneID:  102411895 NCBI-ProteinID:  XP_025146821 LinkDB All DBs Position 8:37013484..37404739 Genome browser AA seq 5141 aa AA seqDB search MGNEASLEGEGLPEGLAAAAAAAAGGGAGGAGSPLHTVIPAGMEADLSQLSEEERRQIAA VMSRAQGLPKGSVTPAAAEPPSMHRKQELDSSQPPKQPGKPPDPGRPIQPGLSKSRTTDT LRSEQKLPGRSPSTISLKESKSRTDFKDEHKSSVMPGFLSEVNPLSAVSSVVNKFNPFDL ISDPDASQEEASKKQKIAQKEQGKPEGVTKPPSQQQSPKTVPKQPGPVRAPLHQEGSPKS GSSQPPEKSKSQPPETGKPAQGFPQAPQTDQAKLPLQRDVSRPQTKQTDPGRGESAKPSL QSPSKPPIQQGSPGKSPAQQPGPEKRTIPQPGPAKPLAQQLGTAKPLAQAPGAAKSLVHQ PGPQSPAQPPGPAKHPAQQVGTTKPQAQLSGLGKTPPQQPGPTKPPPQQPGPVKPPPQQL GPAKPSPQQPGPAKPPPQQPGPPKPPPQQPGPAKPPPQQPGPAKPPPQQPGPAKPPPQQP GPTKPLPQPPGSAKPPPQQPGPTKPPSQQPGPAKPPPQQPGPAKPPPQQPGPAKPSAQQS TKPVSQTGAGKPLQPPTFPSAAQTPVHGLPKTICPLCNTTELLLHVPEKANFNTCTECQT TVCSLCGFNPNPHLTEMKEWLCLNCQMQRALGGNLAPIPSSPQPKPKTTPVPASAVSKPP TPSQQVSPKKDTTPKQDVSKVAESKKPPPLVKQPTLHSPHPVASQQPPEAESSSKPVPPK EPSVSSEPAKVSTADDKPEQPKAGKPATDIASSSSTATGPDIPGSKIPSKDQEKTTPPLK PDSAKPSQSFPPTGEKVTPVDSKVIPRPASDTKIISHPGPTPESKDQKQVDPIQKKDEPK KAQTKMSPKPDTKPMPKGALTPQGPRPPTGQTAPLSPQPPKPQEQSRRFSLNLGSITDAP KSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGSHSQGGPAAPTKQVPPPSQPPTS QGPPKSTAPPAPAKVLPVKKEIKAPVIEKLEPKAEQVSTVKRTETEKKPLPTKDSKPSTG EPQKVVLPPKLEETPKPESACPLCKTELNISSKDPANFNTCTECKKQVCNLCGFNPTPHL TEIQEWLCLNCQTQRAISGQLGDMGKMPPTQAGPKASPMPVPAEQPFQETATPAPVKVKK KEQEEKPETEKTISEKVKETPSGEKIPPKETIDQIREESKGEKDKTSAPQEKKSPPEDKK PPSEDKKPLPEEKKPPLEEKKPTPKDKKPALEDKKPALEDKKLAPGTKALVLEEEQKHDL LKTQVQIAEVKSEGRVPPEAVEEKKPQLMETEDLPASAPRRLPKEDDGMTQKIKVQPQAP GMTKPDRTESGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPSD EKDLLKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLVEEKSEKKTQPHEVSPE QPKDQQKTQSLVEKLESTVSEEELKESQEEGDTFKKESQQDIPSRKDQEKPEFVDELATR RQPYDSIEDSSESENSPVPQRKGRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSAD EDVSDSEDDEFIRNQLKEISSSIESQKKEETRGKGKGTGGKHRRLTRKSSASFDDDAGRR HSWHDEDDETFDESPELKYRETKSQESEELVVAGGGGLRRFKTIELNSTIADKYSAESSQ KKTALYFDDEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPS HKKGESKQQRKARHRSHGPLLPTIEDSSEEEELREEEELLKEQEKQRELEQQQRKSSSKK SKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSIESD PEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGGQKALKSAEEMYEEMMHKSQ KYKAFPAANERDEMFEKEPLYGGMLIEDYIYESLVEDTYNGSVDSSLLTRQEEENGFLQQ RGREQKMRLPEQIYEDPMQKITDLQKEFYELENLHAVLPQEDIVSSSFIIPESHEIVDLG SMVTSTSEEKKLLDADAAYEELMKRQQMQLTPGSSPTQPLIRDDMTESTVDFDRVPDASL TSSVLSGASLTDSTSSTTLSIPDVKITQHFSAEEIEDEYVTDYTREIQEIIAHESLILTY SEPSESATSVPPSDTPSLTSSVSSVCTTDSSSPITTLDSMTTVYTEPVDIVAKFEDAEEI SSSTYFPGSIIDYPEDINIPLDQTTIQDGRTSKDHIVISLSDIEPSLIESVGTKLGGLIA DTVSTDLSISEKDAVKKARKETGDGLILEVLEAYRDSRKESEAELTEISLPDTVFDQTPS SVKTLTMKEQVSTTCFLPEEVLGQAKPASQLPSGTPPIFSLPTKTRPFLRSSSLDVSAQP PPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTIHPRKKLAVTAPVSATTAATSLVDSVTTV ETTSAPRSDGLPMTKVYTTAPPPVPPKPSLIPSGLVFTHRPEPSKPPLAPKPAVPQPPVT TPKLTDTYPKPTGLPLTTSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLMETYVV ITLPSEPGTPTDSSPSQAITSWPLGSPPKDLISMEPVFSVVPPMTAVEISTSSQQSLYIS RALETFAAIPVTTLSSFQATSASVTQFHPTEVSKAEVPTARSTVPSVGLSSVSISFPPEP LALDHLRLEKQQHKEDVQLQLVGDAIDLRTVPKVDVKVTEKCMDLSASAVDVKRQTTTSE MYGRQISAVQPSIINLSATSSGVTPISLVTETVTVVTCTATASYTTGTESLVGLELATAA PLQLTTSKHVEPLYRVPSGQTFPTIREEAPINLSLSTSAHPVTSAPTKPVTAPPVGVTNG WTDSSTSQSITDGEVVDLSTSKTHRTVVTMDEASSNVVTKIIEDDEKPVDLTAGRRAVCC DMVYKLPFGRSCTAQQPATTLPEDRFGYRDDHYQYDRSGPYGYRGIGGMKPSMSDTNLAE AGHFFYKSKNAFDYSGGTDAAVDLTSGRITTGEVMDYSSKTTGPYPETRQVISGVGISTP QYSTARMTPPPGPQYGVGSVLRSSNGVVYSSVATPIPSTFAITTQPGSIFSTTMRDLSGV HTNDAVTSLSALHQSQPMPRSYFLTTGASETDIEVTGIDISASLQTITMETLTAETIDSV PTLTTASEVFSEVVGEESALLIIPEEDKQQQQLDLERELLELEKIKQQRFAEELEWERQE IQRFREQEKIMVQKKLEELQSMKQHLLYQQEEERQAQFMMRQETLAQQQLQLEQIQQLQQ QLHQQLEEQKIRQVYQYNYDPSGTASPQTTADQAILEGQYVAPEGGQFWATEDATTTASA VVAIEIPQSQGWYTVQSDGVTQYIAPPGILSTVSEIPLTDVIVKEEKQPKKRSSGAKVRG QYDEMGENLADDPRCFKKIVDSGVQTDDEDSADRSYVSRRRKTKKSVDTSVQTDDEDQDE WDMPTRSRRKARVGKYGDSPAEADKAKTPSKVSSIAVQTVAEISVQTEPVGTIRTPSIRA RVDAKVEIIKHISAPEKTYKGGSLGCQTEADSDTQSPQYLSATSPPKDKKRPTPLEIGYS SHLRADSTLQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDM AKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYTEGYTAKGSQTATTSGTQKKVK RTLPNPPPEETSTGTQSAFSTMGTVSRRRICRTNTMARAKILQDIDRELDLVERESAKLR KKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSS TRPTRIESQHAIERPRTAPQTEFNQFIPPQTQTESQLVPPTSPYTQYQYSSPALPTQAPT PYTQQSHFQQQTLYHQEVSPYQTQPTFQAVATMSFTPQAQPTPTPQPSYQLPSQMMVIQQ KPRQTALYLEPKITSNYEVIRNQPLMIAPVSTDNTYAVSHLGSKYNSLDLRIGLEERSSM ASSPISSISADSFYADIDHHTSRNYVLIDDMGEITKGTAALSTAFSLHEKDLSKTDRLLR TTETRRSQEVTDFLAPLQTSSRLHSYVKAEEDPMEDPYELKLLKQQIKQEFRRGAESLDH LAGLSHYYHADTSYRHFPKSEKYSISRLTLEKQAAKQLPAAILYQKQSKHKKSLIDPKMS KFSPIQESRDLEPDYSSYMTSSTSSIGGISSRARLLQDDITFGLRKNITDQQKFMGSSLG TGLGTLGNTIRSALQDEADKAYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEA EALDVSFSHASPSGRTKPTSLPISQSRGRIPIVAQNSEEESPLSPVGQPMGMARAAAGPL PPISADTRDQFGSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREE TDWFDKPRESRLDNGHGLDRKLPERLVHSRPLSQHQEQIIQMDGKTVHYIFPHARIKITR DSKDHTVSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLVEGMQVLEWNGI PLTSKTYEEVQSIISQQNGEAEICVRLDLNMLSDSENPQHLELHEPPKAVDKAKSPGVDP KQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGSPSVSKKKHSSS KPTDAAKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRG QVMVVQNASAEYKRRTKYVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSND FLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQSPKPSVIKSRSHGIFP DPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVTQTHLEDAGAAIAAAEA AVQQLRLQPTKPTNHRPAESSVSTGSSGSSFGSGYSVDSEGSSSTAGETNLFPIPRIGKM GQNGQEPIKQTGVGIGLADTEVKTQVMGEIKIALKKEMKTDGEQLIVEILQCRNITYKFK SPDHLPDLYVKLYVMNISTQKKVIKKKTRVCRHDREPSFNETFRFSLSPAGHSLQILLFS NGGKFMKKTLIGEACIWLDKVDLRKRIVNWHKLLVSPTQTH NT seq 15426 nt NT seq  +upstreamnt  +downstreamnt atgggcaacgaggcgagcttggaaggggaagggctccccgaagggctggcggcggctgca gcggcagcagccggaggaggggctggcggggcggggagccccttgcacaccgtgatcccg gccggcatggaagcggatctgagccaactgagcgaagaggagaggagacagatcgctgct gtcatgtcaagggcgcaggggctgcccaaaggaagcgttaccccggccgctgcggagccg ccttccatgcacaggaaacaagagttggatagtagtcaacctccaaagcaaccaggaaaa ccaccagaccctgggcgtccaattcagcctggtctcagtaagagtagaactacagacact ctgaggtcagagcagaaattgcctggaagaagtccttccactattagcttgaaagaatcg aaatccagaactgattttaaggatgagcacaagtctagtgtgatgcctggcttcctctca gaggttaaccctttaagtgctgtctcctctgttgtaaataaattcaatccttttgatttg atatcagaccctgatgcctcccaggaggaagcctccaagaaacaaaaaatagctcagaag gaacaaggaaaacccgagggagtcacaaagcctccatcacaacaacagtctcccaagaca gttcctaagcagccaggacctgtgagggctccgcttcatcaggaaggttctccaaaatcc ggatcctctcagccaccagaaaaaagtaaatcacaacctccagaaacaggaaagccagct cagggcttcccccaggctcctcagacagaccaggcaaaattgccacttcagagagatgta tctaggcctcagactaaacagacagacccaggaaggggtgagtcagctaaaccctcactg cagagcccctccaagccacctattcagcaaggaagtcctggaaaatctccagcccagcag cctggacctgaaaaacgtaccataccacagcctgggcctgcaaagcctctagctcaacaa ctgggaacagcaaagcccctggcccaagctccaggggcagcaaaatccctggttcaccaa cccgggccacagtctccagctcagccgcctgggccagcaaagcatcctgctcagcaggtt gggacaacaaagcctcaggcccagttgtccggcctaggcaagacgccacctcaacagcct ggcccaacgaaaccccctcctcaacagccgggcccagtgaagccccctcctcaacagctg ggcccagcgaagccctctcctcaacagcctggtccagcgaagccccctcctcaacagcct ggtccaccgaaaccccctcctcaacagcctggtccagcgaagccccctcctcaacagcct ggtccagcgaagccccctcctcaacagcctggtccagcgaagccccctcctcaacagcca ggcccaacgaaaccccttcctcaacctccaggttcagcaaagccccctcctcaacagcca ggcccaacgaagcccccttctcaacagcctggtccagcgaagccccctcctcaacagcca ggacctgcaaagccccctcctcaacagccaggacctgcaaagccctcagctcagcaatct acaaaaccagtaagccaaacaggagctgggaaacctctgcagccaccaacgtttccatct gcagcacagactccagtacacggcctccctaaaaccatctgccctctttgcaataccact gaacttctgttgcatgttccagaaaaggccaattttaacacgtgcactgagtgtcagacc actgtttgtagcctctgtggttttaatcccaatcctcatttaactgagatgaaagagtgg ctctgtttaaactgtcagatgcagagagctctaggaggtaacctggctccaattccatca tcaccccagcccaaaccgaagactacccctgttcctgcatcagcagtgagcaagccaccc actccgtcacagcaggtttctccaaagaaagacactacccccaaacaggatgtctcaaag gtagctgagtctaaaaagcccccaccactagtgaaacaaccaacccttcacagtccccac ccagtcgcatcccagcagcctcctgaggcagagtcctcatccaagccagtccctcccaaa gagccttctgtctcatctgaaccggccaaggtctccacggctgatgataaaccagagcag cccaaggcaggaaagccagccacagacattgcgtcttcatcatcaacagcaacaggaccg gacattccaggctccaaaataccatcaaaggatcaagagaaaacaactcctcctctaaaa ccagactctgccaaaccttctcagagttttccaccaacaggagaaaaagttaccccagta gattctaaagtcatacctcgacctgcatcagatacaaaaattatttcacatcctggacct actccagagagcaaagatcaaaaacaagttgatccaattcagaaaaaggacgaacccaag aaagcacaaaccaaaatgagtcctaagccagacaccaagccgatgccaaaaggggcactg acaccccaaggtccacgaccccccactggacaaactgcccctctatctccacagccccca aagcctcaggaacagtcgagacgttttagcctaaatcttggaagtattactgatgcccct aaatcacagcctacaactcctcaagaaacagtgactgggaaactctttggatttggagca tccatctttagccaggcatcaaatctgatctccacagcaggccagcctgggtctcattca cagggtgggccagcggccccaacaaaacaagtccctcctccttcacaaccacctacttct caagggccacccaaatccacagcaccgccagcacctgcaaaggttctacctgtgaaaaag gaaatcaaagctccagtaattgaaaaactagagcccaaagctgaacaagtttcaacagta aaaagaacagaaacagaaaagaagcctctgcctactaaggacagcaaaccttccacgggg gaacctcaaaaggttgttcttccccccaaactggaagaaacccccaaaccagaatcagcc tgtcctctctgcaaaactgaactcaacataagttctaaggatcctgctaacttcaacact tgcactgaatgtaagaaacaagtgtgtaatctctgtggatttaaccctacaccacacttg accgagattcaagaatggctttgtttaaattgccaaacccagagagcaatatcaggacag ctgggagacatgggcaaaatgcctcctacacaggcaggaccaaaagcctcacctatgcct gtccctgcagaacaaccatttcaggaaacagcaacgcctgccccagtaaaagtgaaaaag aaggagcaagaagaaaaacctgaaactgaaaaaaccatttcagaaaaggtaaaagaaaca ccttcaggtgaaaaaattccccctaaggaaaccatagatcaaatccgagaggagagtaaa ggagagaaagacaaaacttcagcccctcaagaaaaaaagtcaccccctgaagacaaaaag ccaccttctgaagacaaaaagccactccctgaagaaaaaaagccacctcttgaagaaaaa aaaccaacccctaaagacaaaaagccggctcttgaagacaaaaagccggctcttgaagac aaaaagttagccccaggaacgaaagcattggttctagaggaagaacagaaacatgactta cttaaaactcaagtacaaattgctgaagtaaaatctgaaggcagagtgcctccagaagca gtggaagaaaagaaaccgcaactgatggagacggaagatttaccagccagcgcacctcgg cgtttgcctaaagaagatgatgggatgactcaaaaaataaaagtacagccacaggcacca ggcatgacaaagcctgatcggacggaatctggaaaggaaaaaacagaaaaggaagatgac aaatcagacacttcaagttctcagcagccgaaaagcccacaaggtcttagtgacacagga tattcttctgatggaatatcaagttcacttggtgaaattccaagtcttattcccagtgat gaaaaggatttgctcaagggactcaaaaaggactccttttcacaagaaagcagcccttcc agcccctcagatttggctaagttagaaagtacagtcctatctattttagaagctcaggca agtacacttgttgaagaaaagtcagaaaagaaaacacagccccatgaggtttctcctgag cagcctaaggaccagcagaaaactcagagtttagtggaaaaactggaatctacagtttca gaggaggagctcaaagagagtcaagaagaaggagacacttttaaaaaagagagccaacaa gacattccttccagaaaggaccaagaaaagcctgaatttgttgacgagttggctacaagg agacagccttatgattcaattgaagacagtagtgagagcgaaaactcacccgttccgcaa agaaaagggaggactagtgttggctcatcaagcagtgatgagtataaacaggaagacagc caaggatcaggggaagaggaggacttcattcgaaagcaaatcatagaaatgagtgctgat gaagatgtttcagattctgaagacgatgagttcattaggaaccagctcaaagagattagc agtagtatagaaagccagaagaaggaagaaaccagagggaaggggaaaggaacaggaggg aaacacaggcgactgactcgaaaaagtagtgcaagctttgatgacgatgcaggaagacgc cattcctggcatgatgaagatgatgagacctttgatgaaagtcctgagcttaaatacaga gaaactaaaagtcaggagagtgaagaacttgtagttgccggaggaggaggactccgtcga tttaaaacaattgaactcaacagcacgatagccgataaatactctgcagagtcatcacag aaaaaaacagctttgtattttgacgacgagccagaattagaaatggaaagcctgacagac tctccagaagatcgatcaaggggggaaggatcttctagtcttcatgcttccagcttcact cctggcacatcccctacatccgtttcttctcttgatgaagacagtgatagtagtccaagt cacaaaaaaggagagagcaaacaacaacgcaaagctcgacatagatcacacggccctctt ttacctaccattgaagattcttcagaggaagaagaattgagagaagaagaagaattattg aaggagcaagaaaagcaacgggaattagaacagcagcaaagaaagagttctagtaagaaa tcaaagaaagacaaagatgaacttcgagctcagagaaggagggaaagaccaaagacacca cccagtaatctctctcccatcgaagacgcgtctccaacagaagaattacgtcaggctgca gaaatggaggagctccatcgatcttcatgttctgaatattcacctagcatagagtcagac ccagaaggctttgaaataagcccagaaaaaataatcgaagtacaaaaagtttataaattg cccacagctgtgtctttatactcaccgacagatgagcaatctattatgcagaaagaaggt ggccaaaaggcattaaaaagtgctgaggagatgtatgaagaaatgatgcataaaagccag aaatataaagcttttccagctgcaaatgaacgagatgaaatgtttgaaaaagagcctttg tatggtgggatgctaatagaagattatatttatgagtctttagtagaagacacatacaat ggttcagttgacagcagtctgctcacaaggcaagaagaagaaaatggatttttgcagcag agagggagagagcaaaaaatgagacttccagaacagatttatgaagatcccatgcagaaa atcacagacctccagaaagagttttatgagttagaaaatttacatgctgttttgcctcaa gaagacatcgtttcaagttcttttatcatcccagaaagtcatgagattgtcgatctgggt agtatggtaacttctaccagtgaagaaaaaaaattattagatgctgatgctgcctatgaa gaactcatgaaaagacaacagatgcagttaacacctggatctagtccaacccagcccctc atcagagatgatatgacagagtccactgtggactttgatagggtacctgatgcatctttg acatcaagtgttctctccggagcatctcttacagattcaaccagcagcacaacactctcc atcccagatgttaaaataacccaacatttttcagcagaagaaattgaggatgaatatgtg actgattatacaagagaaatccaagagataattgctcatgaatcactgattttgacctat tctgaaccttcagaaagtgctacatcagtgccaccctctgacacaccctctctcacatca tctgtttcttcagtttgtaccacagatagctcttcacccattactaccctggatagcatg accacagtttatactgagccagtggacattgtagctaaatttgaagatgctgaggaaatt tcttcatcaacatatttcccaggcagcattattgactatccagaagacataaatatacct ttagatcagacaaccatacaggatggtagaactagtaaagatcacattgtgatttcctta tctgatatagaaccttctctcatagaatctgtaggaactaaactcggggggctaattgct gacactgtttctactgacttatctatatctgaaaaagatgcagtgaagaaggccagaaag gaaacaggggatggacttattctggaagttttggaagcttatagagatagtaggaaggag tctgaggctgaactgacagaaattagcttacctgacactgtgtttgatcagacaccttct tctgtaaaaactctaacaatgaaggagcaggtttcaacgacatgctttttacctgaagag gttttgggtcaagcaaaacctgcatctcagctaccatctggcactcctcccattttctct cttccaactaaaactcgtccattccttcgaagttcttctttggacgtatcagcccaaccc cctcctcctcctcctccccctcctccacctcctccccctccccctcctcctcctccccca cctcttcctccaccaacctcacctaaaccaactattcatcctagaaaaaagttagcggtt acagctccagtgagtgcaactacagcagctacatctctagtagattctgttactacagtg gagaccacgtctgctcccagaagtgatgggttacctatgacaaaagtgtataccactgca cctcctcctgttcctcctaagccatctttaattccatctggacttgtatttacacataga cccgaaccaagcaaacctccacttgctcctaaaccagcagttcctcaacctccagtcact accccaaaactaacagatacataccccaaaccaacaggtctacctttaactacaagtatg acattaaatttagtgacatcagcagactataaattgccttcccctacctctccactttcc cctcactctaacaagtcctcgccaagattttccaagtctcttatggaaacttatgtggtt atcacattgccatctgaacctggcactccaacagattcttcacctagtcaagctattacc agttggccgttgggatcaccccccaaagatctgatttccatggaaccagtattttctgta gttcctcctatgacagctgtggaaatatcaacttcttcacaacagagcctgtacatctcc agagctttggagacctttgctgctatcccggtcacaacactgtcttcatttcaagcaact tcagcttcagttacacagtttcacccaactgaagtttccaaggctgaggttccaacagca agaagtacagtccctagtgttggtctcagcagtgtctctatatcctttcctccagaacct cttgctctagatcacctccgtttagagaagcagcagcataaagaagatgtccagttgcaa cttgttggtgatgccattgacctgcgtacagtacccaaagtagatgttaaagtaactgaa aaatgtatggatctttctgcctctgcagtggatgtgaagaggcagaccacaacaagtgaa atgtatgggagacaaattagtgctgtccaaccctcaattataaatctcagtgcaacttca tcaggcgtgactcctatatccctggttaccgagacagtgactgttgttacgtgcacagct actgcaagttacaccacaggcacagaaagcctagtgggtctagaacttgcaacagcagca ccactccagcttactacatcaaagcatgtggagccactatacagagtaccaagtggccag acctttcctacaattagggaggaagcaccaataaacttatctttaagtacttctgcacac ccagtgacatcagctcctacaaaacctgttaccgcacctcctgttggtgtcacaaatgga tggactgatagctccacatcccagagcatcactgatggggaagtagtggatctcagtacc tccaaaacccatagaacagttgtaacaatggatgaagcttcttcaaatgtggtgactaaa ataatagaagatgatgaaaaacctgttgatctgaccgcaggaagaagagccgtgtgctgt gatatggtttataagttaccctttggaagaagctgcacagcacagcagcctgcaaccact cttcctgaagatcgttttggttatagggatgatcactatcaatatgatcgatcagggcca tatggttatagagggattgggggaatgaaaccttccatgtctgacactaatttagcagaa gctggacattttttctataaaagtaagaatgcttttgattattctggaggaactgatgca gcagtagatcttacttcagggagaattactacaggtgaggtaatggattattcaagcaag actacaggtccatatccagaaactcgacaagtcatttcaggagttgggattagtacccca 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actcagtacattgccccacctggcatcctgagtactgtttcagaaatacctctgacagat gtaatcgtcaaagaggagaaacaacccaagaagagaagttctggagctaaagtccgtggc cagtacgacgagatgggggaaaatctggcagatgacccccgctgctttaaaaagatagtg gacagtggggtacagactgatgatgaagattcagcagatcggagttatgtgagtaggaga aggaaaactaaaaagagtgttgatacaagtgtccaaacggatgacgaagatcaggatgaa tgggacatgcctactagatctaggaggaaagctcgtgtagggaaatatggtgacagccct gcagaggcggacaaggccaaaaccccttccaaagtctccagcatagccgttcaaacagta gcagagatatctgtgcaaactgaaccagttggaaccataagaacgccttcgatacgggca cgcgtggatgccaaggtagaaataattaaacacatttcagcacctgaaaagacttacaaa gggggcagtttaggatgtcaaacagaagcagattcagacacacaaagtcctcaatatctg agtgccacctctccacccaaagacaagaaacgcccaacacctttagaaattggttattca tctcacctccgggcagattccacactacagctggctccttccccacccaaatctccaaaa gtcctttattctcccatctcaccactttcaccaggcaaagccttagaatcagcctttgta ccttatgagaaacccctccctgatgatataagtccacaaaaagtactgcatccagatatg gctaaagttcccccagcaagtcctaagacagccaagatgatgcagcgctccatgtctgac cccaagcctctgagtccaacagcagacgaaagttccagggctccttttcagtataccgag 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gcaagcagtccaatatcaagcatatctgcagattctttctatgcagatattgaccatcat acttcacgaaattatgtcttaattgatgacatgggtgagattaccaaaggaacagcagct ctaagcactgcgtttagccttcatgaaaaagatctgtcaaaaacagaccgtctcctccga accactgagacacgtaggtctcaagaagtgacagatttcctagcacctctgcagacttcg tccagattgcatagctacgtgaaagcagaggaggacccaatggaggatccttatgagtta aagcttctgaaacaacagattaaacaagaattccgtagaggagcagagagcttagatcac cttgctggtctttcccattattaccatgccgatactagttacagacattttccaaaatct gaaaagtacagcattagtagactcacacttgaaaaacaagcagcaaaacaactaccagct gccatactgtatcaaaagcaatcaaagcataagaaatcactaattgaccctaaaatgtca aaattctcacctattcaagaaagtagagaccttgaacctgattattcgagctatatgact tcaagcacttcatctattggtggcatttcttccagagcaaggcttcttcaagatgatatt acttttggcctcagaaaaaatattacagaccaacaaaaatttatgggatcatctcttggc acaggactgggcaccttaggaaataccatacggtcagctctgcaggatgaagcagataag gcatacagcagtggcagcaggtccagaccttcttccagaccttcctctgtctatgggcta gatttatcaattaaaagagattcttctagctcttctctaagactgaaagctcaagaggct gaagctctagatgtttcctttagtcatgcatcaccttctgggagaactaagcctactagt ttgcctattagccagagtagaggaagaataccaattgtggcccagaattctgaagaggaa agtccactcagtcctgttggacagccaatgggaatggccagggctgctgctggacccctg ccaccaatatctgcagacaccagggaccagttcggatccagtcactctttgcctgaagtt cagcaacacatgagagaagaatcacggactcgaggctacgaccgtgacatagcattcatc atggatgacttccaacatgccatgtcagacagtgaagcctatcacctccgtcgtgaagaa acagattggtttgacaaacccagagagtctcgtttggacaatggacatggtctagatcga aaactgccagaaagattggtccactctagaccactcagtcaacaccaagagcaaattata cagatggatgggaaaactgttcactacatctttccacatgcaaggataaaaataacaaga gactctaaggatcacacagtttcaggtaacggattaggaattagaattgtgggtggtaaa gaaatccctggacatagcggagaaattggagcctatattgccaagattcttcctggggga agtgccgaacagacagggaaacttgtggaaggcatgcaagtattggagtggaatggaatt cctttaacttctaaaacatatgaagaagtgcagagtatcattagtcagcaaaatggggaa gcagaaatatgtgtaagactggacctcaatatgctgtcagattctgaaaatccccagcac ctagaactccatgaaccaccaaaagctgtggataaagcgaaatccccaggggttgatccc aagcagttggcagcagagctccagaaggtctcactgcagcagtcaccactggttctgtca tctgttgttgaaaagggatctcacgttcattcaggtcctacatcagcaggatccagttcc 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