KEGG PATHWAY: bbut04623

KEGG

PATHWAY: bbut04623

Entry

bbut04623                   Pathway

Name

Cytosolic DNA-sensing pathway - Buteo buteo (common buzzard)

Description

Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell.

Class

Organismal Systems; Immune system

Pathway map

Cytosolic DNA-sensing pathway

Organism

Buteo buteo (common buzzard) [GN:bbut]

Gene

IKBKG; LOW QUALITY PROTEIN: NF-kappa-B essential modulator [KO:K07210]

NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]

POLR3G; DNA-directed RNA polymerase III subunit RPC7 [KO:K03024]

RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]

POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform X1 [KO:K03009]

CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]

POLR3A; DNA-directed RNA polymerase III subunit RPC1 isoform X1 [KO:K03018] [EC:2.7.7.6]

CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]

CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]

CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]

NFKBIA; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734]

NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]

[KO:K01370] [EC:3.4.22.36]

POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 [KO:K03016]

IL18; LOW QUALITY PROTEIN: interleukin-18 [KO:K05482]

POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 [KO:K03013]

DNASE2B; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]

POLR3GL; DNA-directed RNA polymerase III subunit RPC7-like [KO:K03024]

MLKL; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]

ZDHHC1; palmitoyltransferase ZDHHC1 isoform X1 [KO:K20027] [EC:2.3.1.225]

POLR3C; DNA-directed RNA polymerase III subunit RPC3 isoform X1 [KO:K03023]

ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]

POLR3D; DNA-directed RNA polymerase III subunit RPC4 [KO:K03026]

POLR3F; DNA-directed RNA polymerase III subunit RPC6 [KO:K03025]

POLR1C; DNA-directed RNA polymerases I and III subunit RPAC1 isoform X1 [KO:K03027]

IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]

MAVS; mitochondrial antiviral-signaling protein [KO:K12648]

CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]

IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]

POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007]

FADD; FAS-associated death domain protein [KO:K02373]

IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]

GSDME; gasdermin-E isoform X1 [KO:K22146]

POLR3H; DNA-directed RNA polymerase III subunit RPC8 isoform X1 [KO:K03022]

POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 [KO:K03014]

POLR3B; DNA-directed RNA polymerase III subunit RPC2 isoform X1 [KO:K03021] [EC:2.7.7.6]

RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]

IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]

STING1; stimulator of interferon genes protein [KO:K12654]

G3BP1; ras GTPase-activating protein-binding protein 1 isoform X1 [KO:K17265] [EC:5.6.2.5 5.6.2.3]

DDX41; putative ATP-dependent RNA helicase DDX41 [KO:K13116] [EC:5.6.2.7]

SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [KO:K22544] [EC:3.1.5.-]

TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]

POLR3E; DNA-directed RNA polymerase III subunit RPC5 [KO:K14721]

POLR3K; DNA-directed RNA polymerase III subunit RPC10 [KO:K03019]

Compound

DNA

Cyclic GMP-AMP

Reference

Authors

Yanai H, Savitsky D, Tamura T, Taniguchi T

Title

Regulation of the cytosolic DNA-sensing system in innate immunity: a current view.

Journal

Curr Opin Immunol 21:17-22 (2009)
DOI:10.1016/j.coi.2009.01.005

Reference

Authors

Vilaysane A, Muruve DA

Title

The innate immune response to DNA.

Journal

Semin Immunol 21:208-14 (2009)
DOI:10.1016/j.smim.2009.05.006

Reference

Authors

Takeshita F, Ishii KJ

Title

Intracellular DNA sensors in immunity.

Journal

Curr Opin Immunol 20:383-8 (2008)
DOI:10.1016/j.coi.2008.05.009

Reference

Authors

Takaoka A, Shinohara S

Title

DNA sensors in innate immune system.

Journal

Uirusu 58:37-46 (2008)
DOI:10.2222/jsv.58.37

Reference

Authors

Takaoka A, Taniguchi T

Title

Cytosolic DNA recognition for triggering innate immune responses.

Journal

Adv Drug Deliv Rev 60:847-57 (2008)
DOI:10.1016/j.addr.2007.12.002

Reference

Authors

Kaiser WJ, Upton JW, Mocarski ES

Title

Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors.

Journal

J Immunol 181:6427-34 (2008)
DOI:10.4049/jimmunol.181.9.6427

Reference

Authors

Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J

Title

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.

Journal

EMBO Rep 10:916-22 (2009)
DOI:10.1038/embor.2009.109

Reference

Authors

Wang Z, Choi MK, Ban T, Yanai H, Negishi H, Lu Y, Tamura T, Takaoka A, Nishikura K, Taniguchi T

Title

Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.

Journal

Proc Natl Acad Sci U S A 105:5477-82 (2008)
DOI:10.1073/pnas.0801295105

Reference

Authors

Stetson DB, Ko JS, Heidmann T, Medzhitov R

Title

Trex1 prevents cell-intrinsic initiation of autoimmunity.

Journal

Cell 134:587-98 (2008)
DOI:10.1016/j.cell.2008.06.032

Reference

Authors

Schroder K, Muruve DA, Tschopp J

Title

Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.

Journal

Curr Biol 19:R262-5 (2009)
DOI:10.1016/j.cub.2009.02.011

Reference

Authors

Krieg AM

Title

AIMing 2 detect foreign DNA.

Journal

Sci Signal 2:pe39 (2009)
DOI:10.1126/scisignal.277pe39

Reference

Authors

O'Neill LA

Title

DNA makes RNA makes innate immunity.

Journal

Cell 138:428-30 (2009)
DOI:10.1016/j.cell.2009.07.021

Reference

Authors

Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S

Title

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

Journal

Nat Immunol 7:40-8 (2006)
DOI:10.1038/ni1282

Reference

Authors

Cao X

Title

New DNA-sensing pathway feeds RIG-I with RNA.

Journal

Nat Immunol 10:1049-51 (2009)
DOI:10.1038/ni1009-1049

Reference

Authors

Sun L, Wu J, Du F, Chen X, Chen ZJ

Title

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

Journal

Science 339:786-91 (2013)
DOI:10.1126/science.1232458

Reference

Authors

Gao M, He Y, Tang H, Chen X, Liu S, Tao Y

Title

cGAS/STING: novel perspectives of the classic pathway.

Journal

Mol Biomed 1:7 (2020)
DOI:10.1186/s43556-020-00006-z

Reference

Authors

Benjamin P, Sudhakar S, D'Arco F, Lobel U, Carney O, Roux CJ, Boddaert N, Hemingway C, Eleftheriou D, Mankad K

Title

Spectrum of Neuroradiologic Findings Associated with Monogenic Interferonopathies.

Journal

AJNR Am J Neuroradiol 43:2-10 (2022)
DOI:10.3174/ajnr.A7362

Reference

Authors

Place DE, Lee S, Kanneganti TD

Title

PANoptosis in microbial infection.

Journal

Curr Opin Microbiol 59:42-49 (2021)
DOI:10.1016/j.mib.2020.07.012

Reference

Authors

Jiang W, Deng Z, Dai X, Zhao W

Title

PANoptosis: A New Insight Into Oral Infectious Diseases.

Journal

Front Immunol 12:789610 (2021)
DOI:10.3389/fimmu.2021.789610

Reference

Authors

Wang Y, Kanneganti TD

Title

From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways.

Journal

Comput Struct Biotechnol J 19:4641-4657 (2021)
DOI:10.1016/j.csbj.2021.07.038

Related
pathway

Ubiquitin mediated proteolysis

Apoptosis

Necroptosis

NOD-like receptor signaling pathway

RIG-I-like receptor signaling pathway

KO pathway

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