Brachyistius frenatus (kelp perch): 138632848 Help Entry 138632848         CDS       T10614                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism bfre  Brachyistius frenatus (kelp perch) Pathway bfre04020   Calcium signaling pathway bfre04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:bfre00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     138632848    04020 Calcium signaling pathway     138632848  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bfre04040]     138632848 Ion channels [BR:bfre04040]  Voltage-gated cation channels   Ryanodine receptor    138632848 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  138632848 NCBI-ProteinID:  XP_069574799 LinkDB All DBs Position Unknown AA seq 4890 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVACIQKENRKFCLAAEGLGNRLCYLEPTSEAKYVPP DLCICTFVLEQSLSVRALQEMLAKSGQNSEGRLIRKAAHSGGHKTLLYGHAILLRHSFSS MYLACLKTSRSQTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVS SERYLHLSISNGNIQVDASFMQTLWNVHPICSGSNIEEGYLLGGHVMRFFHGHDEVVTIP GSDQSEEQQRIVNYETGKAGAKARSLWRLEPLRISWSGSHIRWGQPLRLRHLTTGHYLAL TDDRGLVLQDRERSDTVATAFCFRASKEKLEQSPKRDIEGMGVAEIKYGDSLCFIMHVAT GLWLSYQAPDVKSSRLGPLKRRACLHSEGHMDDGLTLQRCQHEESCAARIIRNTTLLFNR FIRDLDCLGVKNRALVALPVEEVLQTLNDLITYFQLPDAELEHEERQIKLRSLKNRQNLF KQEGMLTLVSNCIDRLNVYNSAAHFGECAGSEAGAAWKDILNLLYELLAALIRGNRNNCT QFSNNLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLYKHGRNHK ILDVLCSLCVCNGVAVRTNQNLICDHLLPKRDLLLQTQLVNDVQSMRPNIFLGVSEGSAQ YKKWYYELMIDQVDHFVTSEPSHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYGFDG LHLWSGRIPRAVASMNQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFF PVVSFSAGVKVRFLLGGRHGDFKFLPPSSYAPCYEALLPKEKMKVEPVKEYKRDVEGVRD LLGTTQFMSQASFIPTPVETSQIVMPPHLEKVRDKLAENIHELWGMNKIELGWSYGKIRD DNKRQHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCRVVQVNPNAEESLKKIKLPKN YMMSNGYKPSPLDLSDIKLTPGQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSKRN PRLVPYVLLDERTKKSNRDSLREAIRTLIGYGYNIEPSDQESGQVVERLSIDKIRFFRVE RTYAVTTGKWYFEFEAVTGGDMRVGWARPGCKPDLELGTDELAFVFDGYRGHCLNMGSRL FGRCWHAGDVVGCMINMEDKSMIFTLNGEILITTKGSELCFTDFETEDGFIPVCSMGLSQ VGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPKDHNHIAVT RIDGTIDSPPCLKVTHKTFGTQNSNADMVFCRLSMPVEFHSFFKLSPVVDMNGVHEEDIL KVKHRYPLRSVRHSDESRRVDYSSITTYYHSVRVFAGQDPACVWVGWVTPDYHYYSNNFN LSKNRAVTVTLGDERGRVHESVRRSNCYMVWGGDVTSAAHTSSRSNVDLEIGCMIDLATG LVTFTVNGKETSTSYQVEPNTKLFPAVFVRPTSPNLFQLELAKIKNAMPLSSAIFKSEHK NPVPQCPPRLDVQTINAVLWSRMPNTFLKVETARVNERHGWVVQCVEPLQMLAVHIPEEN RCVDIMELSEQEDMRTFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSG MLREGFYNVLISIHLETAKEARLMMKDEFIIPVTAETRSIRLFSDASKKHLPPGVGLSTS LKPRLNFAPPCFISIKREHLFSPQIPLDSLKEKSILMLTEAVQGGGHHIRDPVGGGVEYQ FVPILKLISTLLTMGVLVSEDVHKILLLIDPNVFREAHEEGATGATDKEGLTGSEDKAVE AGEEEAAKEAKQPMKGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSFSDNFVSKL QYNQKFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLTFSMGEDCPCPTDIQEELY DFHNQLQLHCGIPMEEDEDEQDSSIKGRLLILVNKIKGQSHKAEEPTEKEQAAPSNLKEL ISQTMVSWAQECHIQDSELVRKMFSLLRRQYDSIGELLRAMRKTYTISGVSVQDTINLLA ALGQIRSLLSVRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRILGMHETVMEVMVNVLGG DKSQEIAFPRMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLD VAASSVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLAKGYPDIGWNPIEGERYLSF LRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISETPALDL PGSVQGVGSDVFSTVRSADGDDEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGE ALRIRAILRSLVPTEDLVGIISIPLKMPIVNKDGSVTEPDMSASFCPDHKAPMVLFLDRV YGIEDQSFLLHLLEVGFLPDLRAAASLDTEGLCTTETALAMNRYIGSAMLPLLTRCAPLF AGTEHYATLIDSTLHTIYRLSKGRSLTKAQRDAIEECLLSVCKHLRPSMLQQLLHRLVFD VPLLTDYCKMPLRLLTNHYEQNWKYYCLPSGWGSFGTASEDELLLTKKIFWGVFDSLSQR KYDPELFKMAMPCLSAIAGALPPDYVDASITTTVEKPVSVDAQGNFDPKPINTANIALPE KLEHFANKYAEHSHEKWSAEKVLLGWKYGDCVDEKMKIHPQLRTYKGLTEKEKEIYRWPI RESVKSMLAMGWSIDRTKDGESMSQQRESEKMRKISQSSQANGFNPSPIDTSNVVISREL QGMVEVVAENHHNIWAKKKKSDLGSRGGGTHPLLVPYDTLTAKEKARDREKAQDLFRFLL INGYSITRGLKDLEHDSSSMEKRFAYKFLKKLLKYVDSAQEFISHLEAMAASGKTDRSPH EQEIKFFAKVLLPLIDQYFKNHSLYFLSSPNKNLSSSGYASNKEKEMVTSLFCKLAALVR HRISLFGSDSTTMVSCLHILAHTLDTRTVMKSGSELVRVGLRTFFENAAEDLEKTFENLK LGKFSHSRSQMKGVSQNINYTTVALLPILTALFEHITQHHFGVDLLLDDVQVSCYRILTS LYALGTGKNIYVERQLPALGQCLATLAGAMPVAFLEPLLNSYNPCSVFNTKSARERAILR IPDSVEEMCPGMPRLDGLMKDINDMAESGARYTEMPHVIEVVLPMLCNYLSYWWERGPEN QPASGGSICCTTVTSEHLSLILGNILKILNNNLGIDEASWMKRIAVYVQPIISKARADLL KSHFLPTLEKLKKKTVKVVAEEELLKADSKGDTQEAELLILDEFAVLCRDLYAFYPMLIR YVDNNRSRWLKEPDSDSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDN KTKMSKSGGQDQERKHKKRRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTR YLLKDTDDEVKDHIHQNLHLREKSEDPAVRWQLNLYKDIVMRTDWPPDPERVVDRIQRIS AAVFNLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLLAYQRI WIETEEYSFEEKLVQDLAKTQPKEEEEEEEEIRKQPDPLHQLILHFSHNALTECSSLEED PLYIAYADMMAKSCDEGEEEEEEEGKEKTFEEKEMEKQKMLYQQARLHDRGAAEMVLQMI SASKGRLDAIVTFTLKLGISVLNGGNILVQQKMLDYLKEKRDVGFFKSLSGLMMSCSVLD LNAFERQNKAEGLGMVTEEGSINVSERGSKVLQNDEFTTDLFRFLQLLCEGHNNDFQNFL RTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDVIDEAGQRNFSKALAVAKQVFN SLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLQKDM IVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDSFKEYDPE SKGVISKKDFQKSMENQKQYSQSEIEFLLSCAEADENDMFNYEQFVERFHEPAKDIGFNV AVLLTNLSEHMPHDGRLATFLDLAESVLSYFEPYLGRIEIMGGAKRIERVYFEISESSRT QWEKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASLISEPDPVERPEED EDDKQNVVEKQEEEEDENIMMESSSAFTIACISMRKSLCHFRQLLTLKSMRRQYRKFRKM SVREMVRGFFSFFWMIITGLFHFVYSLVWGFFHILWTTMFGGGLVEGAKNMKVTDILGNM PDPTQFGIHGDVLETEKMEANDASVLAEMAQMAQGEAAEADLMAELLNIQPKREGKHGAE PGLGDVSEVVVGDAPSIASAVKQKKAQMAAKKSVTNGDYKSDSEKGDSEDGEKKDHDKSK DETPPERSVEGKKVPKKRLGPKKEPPEVFMASFFAGLEVYQTKMLNYLARNFYNLRFLAL FVAFAINFILLFYKVTGDYSDDEDPWNGQGRAEEEEDDGALEYFVLQESTGYMAPTLRCL AILHTIISFLCVVGYYYLKVPLVVFKREKEIARKLEFAGLYITEQPSDDDIKGQWDRLVI NTPSFPNNYWDKFVKRKVIKKYGDLYGAERIAELLGLDKSALDFNPTEETVAKEASLVSW LSSIDAKYHIWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTIL SSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHM YVGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQ EQVKEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQE SYVWKMYQERLWDFFPAGDCFRKQYEDQLG NT seq 14673 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtggagaaggagaggatgaaattcagttcctccgaactgatgatgaagtg gtgcttcagtgcgtggcctgcatccagaaggagaatcgcaagttctgcctggctgctgag gggctgggcaaccggctgtgttacctggagcccacatccgaggcgaagtatgttcctcca gacctctgcatctgtacctttgtactggaacagtctctgtctgtgcgggccctgcaggag atgctggctaagagcggacagaacagcgaagggaggctcataaggaaggcagcgcacagc ggcggacacaagaccctactgtatggacacgccatcctcctgcggcattccttcagctct atgtacctggcctgtttgaagacatcaaggtcacagacagataaactgtcctttgatgtc ggcctgcaggaggattcaacaggtgaggcgtgctggtggacgatccatcctgcctccaaa cagagatctgaaggagagaaagtgcgcatcggtgatgacctcatcctcgtcagcgtgtcc tcagagcgataccttcacttatccatctccaatggcaacatccaagtggatgcgtccttc atgcagactctgtggaacgtccatcccatctgctccgggagcaacatagaagaaggctac ttgttgggtggtcacgtgatgcggttcttccatggacatgacgaggtggtgaccatccca ggatcagaccagagtgaagagcagcagaggatagtcaactatgagacgggtaaagccggt gccaaggcgaggtccttgtggaggctggagcctctccgaatcagctggagcgggagccac atccgctggggtcagcccctccgactacggcacctaaccaccggtcactacctggccctg actgatgacagggggctggtgctgcaggaccgggagaggtccgacaccgtcgccacagcc ttctgctttagagcctccaaggagaagctggagcagagccccaagcgggacattgagggc atgggggtggcggagattaaatacggggactcgctctgcttcatcatgcacgtggccaca ggtctctggctctcctaccaggcacctgatgtcaaatcgtctcgtctgggtcccctcaag agaagagcatgcctacactctgaaggtcacatggatgacggcttgaccctccagcgctgt caacacgaagagtcctgcgctgcgcggatcatccgcaacaccacgctgctctttaatcga ttcatcagagacctggactgtctgggtgttaaaaatagggcactggttgcgctgcctgtc gaggaggtgctccaaaccctcaacgacctcatcacctatttccagctccctgatgctgag ctggagcacgaggagaggcagatcaagctgcgctcactcaagaacaggcagaaccttttc aaacaagaaggcatgctgactctggtgtccaactgcatcgaccgtctgaacgtctacaac agcgcggcccacttcggggagtgtgccgggtctgaggccggagccgcctggaaggacatc ctcaacctgctgtacgagctgctggcggcattaatccgagggaaccggaacaactgcacc cagttctccaacaacttggactggctggtgagcaagctggagagactggagtcttcctca ggcatcctggaagttctgcactgcattctaattgagagcccagaggcgctcaacatcatc cagagaggacacattaagtccatcatatcgctgctctacaagcatggacgcaaccacaag attctggacgtgctgtgctctctgtgtgtgtgtaacggtgtggctgtgcgaaccaatcag aacctcatctgcgatcacctgctgcccaagagagatctgctgctgcaaacccagctggtc aacgatgtccagagcatgagaccgaacatcttcctgggggtgagcgagggctccgctcag tataagaagtggtactacgagctgatgatcgaccaggtggaccacttcgtgaccagcgag ccctcccacctgagagtgggctgggccaacactaaaggatacgccccctaccctggagga ggagagggctgggggggcaacggagtcggggatgacctctactcgtacggttttgatgga ctccacctctggtcaggtcgtatcccacgggcggttgcgtccatgaaccagcacatcttg acctcggaggatgtggtgagctgctgtctggacctcggagcgccgagcatctcgttcagg atcaacggacagcccgtccaaggcatgtttgaaaatttcaacacagacgggctcttcttc cccgtcgtcagcttctccgcgggggtcaaggtacgcttcctgttgggtggccgacacggc gactttaagttccttcctccatcaagttacgctccgtgttacgaggctctgctacccaaa gagaaaatgaaggtggagccagtgaaagagtacaagagagatgtggaaggagtccgagat ctgctgggcaccacccagttcatgtctcaggcctccttcatccccacacctgtggaaacc agccagattgtcatgccacctcatttggagaaggttcgggacaagctggctgagaacatc catgaactgtggggcatgaataagattgagctgggatggtcatacggcaagataagggat gataataagcggcagcatccgtgcctggtggatttctccaagctgccagagacggaaaag aactacaatttgcagatgtcaacagaaactctcaagaccctgctggcgttgggttgtcgt gtagttcaagtgaatccgaacgctgaggaatccctcaaaaagataaaactcccgaagaac tacatgatgtccaatggttataagccatcccctctggacctgtctgacatcaaactgact ccaggtcaggaactgttggtggacaaactagcggagaatgcacacaatgtgtgggccaag gaccgcatcaaacagggatggacgtacggcattcagcaggatctgaagagtaagcgtaac ccccgcctggttccttatgttctgctggatgagaggaccaagaagtcgaacagggacagc ctgcgggaggctattcgcactctgattggctacggatacaacatcgagccctcagaccag gaaagcggacaagtggttgagcggctcagcatcgataagatccgcttcttcagggtagag aggacgtacgcagtgacgaccgggaaatggtactttgaattcgaggccgtcacgggagga gacatgcgagtgggctgggccagacctggatgcaagcccgatctggagctcggcacagat gagctcgctttcgtctttgatggatacaggggccactgtctgaacatgggcagccggttg ttcgggcgctgctggcacgccggggacgtggtgggctgtatgatcaacatggaggacaag tccatgatcttcactctgaacggggagattctcatcaccaccaagggctctgaactctgc ttcaccgactttgaaactgaggatgggtttattccagtgtgtagtatgggcctttctcag gtgggacgtatgaacctggggaaggatgctagcaccttcaagtactacaccatgtgcggc ctgcaggaaggatttgaaccctttgctgtcaacatgaaccgtgaggtcacgatgtggttc agcaagcgtctgccgactttcgtcaacgtaccgaaggaccacaaccacatcgcagtaacc aggattgacggcaccatcgacagccccccgtgtcttaaagtcacccacaagacgtttggc acccagaacagtaatgctgacatggtgttttgtcgtctcagcatgccggtcgagttccac tccttcttcaagctcagtcctgtcgtcgacatgaacggcgtgcacgaggaagatatcctg aaagttaaacacagatatcctttgagatctgtgaggcacagtgatgaaagcagacgcgtt gactacagcagcatcactacgtactaccactcagtgagggtcttcgcaggtcaggacccc gcctgtgtgtgggtcggatgggttacccccgactaccattactatagcaacaacttcaac ctcagcaaaaaccgagcagtgactgtaaccctcggggatgaacgaggacgagtccacgag agcgtgaggagaagtaactgctacatggtgtggggcggtgatgtgaccagcgctgcccac acctccagtcgcagcaacgtggacctggagatcggctgcatgatcgacctggccaccggc ctggtgacattcaccgtcaacggcaaggagacgtccacgtcctaccaggtggaaccaaac accaaactcttcccggctgtgtttgtgcgacccaccagcccgaacctcttccagcttgaa ctggctaaaataaagaatgccatgcctctgtcgtcagccatctttaagagtgaacacaag aacccggtgccccagtgtcccccccgactggatgtgcagaccattaacgcggtgctgtgg agccgcatgcccaacaccttcctcaaagtggaaacggctcgggtgaacgagaggcacggc tgggtggtccagtgtgtggagcccctgcagatgttggcggtgcacatacccgaggagaac cggtgcgtcgacattatggagctgtcggagcaggaggacatgaggacgtttcactaccac accttgaagctgtactgtgccctctgcgctctgggaaacacccgtgtggctcacgccctc tgcagtcacttggaccagtcgcagctcttatacaccatcgacaatcagtacctgtccggc atgctgcgcgagggcttctacaacgttctgatcagcatccacctggagacggccaaggag gcccggctcatgatgaaagatgagttcatcattcccgtcacagcggagacgcgctccatc cgtcttttttctgatgcctctaaaaagcacctcccgccgggggtggggcttagcacttct ctcaaaccccgcctcaactttgctccgccctgtttcatcagcatcaaacgggagcacctg tttagtccccaaatcccactggattcgctgaaggagaagtcaatattaatgttgacggag gctgttcaaggtggagggcaccacatccgagatcctgtgggaggaggtgtggagtaccag tttgtgcccatcttgaagctcatcagcaccttgctcacgatgggtgttttagtgagtgag gacgttcataagattctcctgctcattgacccgaacgttttcagagaggcgcatgaggag ggagcgacgggggccacggacaaagaaggactgacggggagcgaggacaaggcagtggaa gctggagaagaggaggcagccaaggaggccaaacagccaatgaaaggactgctggagaag aggctgccggagcccgtcaaacgacagatgtgcgagctgcttcactatttctgcgactgc gagctgaagcaccgcatcgaggccatcgtgtccttttccgacaacttcgtctccaagctg cagtacaaccagaagttccgctacaacgagctgatgctcgccctcaatatgtccgccgcc gttacggcaaagaagaccaaagagttcagatcgcctcctcaagagcagatcaacatgctg ctgaccttcagtatgggcgaagactgtccgtgtcctacagacatccaggaggaactctat gatttccacaaccagctgcagctccactgtggaatccctatggaggaagacgaagacgag caagattcgtctattaaaggtcgcctcctaatactggtgaacaagatcaaaggccagtcg cacaaagcagaggagcccacggagaaggagcaggcggcaccatccaatctgaaggagctc atctcccagacgatggtcagctgggctcaggagtgtcacatccaggattcggagctcgtc cgcaagatgttcagcctgctgaggaggcagtacgacagcatcggggagctgctccgggcc atgaggaagacgtacaccatcagtggcgtctcggtccaggacaccatcaacctcctggct gccctcggtcagatcagatctctgctgtctgttcgtatgggaaaggaggaggagaagctc atgattgatgggttgggtgacatcatgaacaacaaggttttctaccaacatccgaacttg atgagaattctgggcatgcacgagacggtcatggaggtcatggtcaatgtgctcggagga gacaagtcccaggaaattgccttccccaggatggtggccagctgttgtcgcttcctgtgt tacttctgtcggatcagccgtcagaaccagaaagccatgtttgaccacctcagctacctg ttggagaacagcagtgtgggcctcgcttcaccagcgatgagaggctccacgcctctagat gtggctgcttcctctgtaatggacaacaacggcctggctctggcgctggaagaaccggat ctggacaaggtggtcacctacctggctggctgcggtcttcagagctgtccgatgctgctg gcgaaaggttatccagacatcggctggaaccccatcgagggagagcgttacctctccttc ctgcgctttgctgtctttgtcaacggagagagtgtggaggagaactccagcgttgtggtc aaacttctcatccgtcgtccggagtgtttcggacctgccctgagaggagagggcgggaac gggctgctggctgccatgaaggaagccattaagatctccgagacgccggctttggacctg ccgggctccgtccagggagtcggctcggacgtgttttccaccgtgaggtctgctgacggg gatgatgaggaggaggtggtccacatgggcaacgccatcatgtcattctactctgcgctc attgacctgctgggacgttgtgcccctgagatgcatctcatcaacaaagggaaaggagaa gctctgcgtattcgtgccatcctgcgctctctggtgccaactgaggatctcgtgggaatc atcagcataccactcaaaatgcccatcgtcaacaaagatgggtcggtgacagagccggac atgtccgccagcttttgtccagaccacaaggcgcccatggtgctgtttttagacagggtg tatggtatcgaagaccaaagctttctgcttcacctgctcgaagtgggcttcctccccgac ctgagggctgctgcctctctggacacggagggtctgtgcaccacagagacggccctggct atgaaccgctacatcggctcagccatgctgcccctcctcacccgctgcgctcctctcttc gccggcaccgagcactacgccaccctcatcgactccaccctgcacaccatctaccgcctc tccaagggacgctcgctgaccaaggcgcagagagacgccatcgaagagtgcttgctgtct gtttgcaagcacctccgtccctccatgctgcagcagctcctacaccgcctcgtctttgat gtgcccttgctcactgattactgcaagatgcctctaaggctgctaaccaaccactatgag cagaactggaagtactactgcctcccatcgggctggggcagcttcggcacggcatccgag gacgaactgctactcaccaagaagattttctggggagtgttcgactctctttctcagagg aagtatgacccagagctgttcaagatggccatgccttgcctcagtgccatagctggagct ttgccaccagactatgttgatgcctcgattactaccactgtggaaaaacctgtttctgtg gatgctcagggcaactttgaccccaaaccgatcaatactgctaacattgctcttccagag aagcttgagcattttgccaacaaatatgccgagcactcccatgagaaatggtctgcagag aaggtgttgctggggtggaaatatggagactgtgtggatgagaagatgaagattcaccct cagctcaggacctacaaaggcctgacagagaaggaaaaggagatttacagatggccaatt agagagtccgtgaagagcatgctggcaatgggttggagcatcgacaggaccaaggatgga gagagcatgtctcaacagagggagagtgagaaaatgagaaagatctctcagtcttcgcag gccaatggtttcaacccaagcccgatagacaccagcaatgtagttatatccagagaactg caggggatggtggaggtggtggctgaaaatcaccataacatctgggccaagaagaaaaaa agcgaccttggaagcagaggtgggggaacgcaccctctgctggtgccctacgacacgctg acggccaaggagaaggcccgcgaccgagagaaggctcaggacctttttcgcttcctgctt atcaatggctacagcatcacaagaggtctgaaggatttagagcacgattcctcctccatg gagaaaaggtttgcctataaattcctcaagaagctgctcaagtatgtcgactcagcgcag gaattcatttcccacttggaggccatggccgccagcggaaaaacagacaggtcacctcat gaacaggaaatcaagttttttgccaaagtacttctccctctcatcgaccaatacttcaag aaccactccctgtacttcctctcctcccccaataagaacctgagcagcagtggttacgcc tccaacaaggagaaggagatggtcaccagcctgttttgtaaactggcagctcttgtcaga cataggatttcactatttgggagtgactccaccaccatggtcagctgtctgcatatcctg gcacacactctggacaccaggacggtgatgaagtcgggctcggagctggtgagggtgggg ctgaggacgttctttgagaacgctgcagaggacctggagaaaaccttcgagaacctgaag ctggggaagttcagtcactcccgctcgcagatgaaaggagtgtcacagaacatcaactac accaccgtagctctgctccccatcctaacggctctgtttgaacacattactcaacaccac tttggagtcgacctgcttttggatgatgtccaagtgtcctgctatcgaatcctgactagc ctctatgcactgggcactgggaaaaacatctacgtagaaagacagctgccagctctcggt cagtgtctggccactctggccggggcgatgcctgtagccttcctggagccgctgctcaac tcgtacaacccctgctccgtctttaataccaagagtgccagagaacgggccatcctgaga ataccagactcagtggaggagatgtgtccggggatgccgcggctggacggcctgatgaag gacatcaatgacatggctgagtctggagcccggtacacagagatgccccatgtgatcgag gtggtgctgcccatgctgtgtaactatctgtcctactggtgggagaggggtcctgaaaac cagccagccagcggggggagcatctgctgcaccaccgtcacctcagagcacctcagcctc attcttggcaacatccttaagatcctgaacaacaacctgggcatcgacgaggcctcctgg atgaagagaattgcagtttatgtacagcccatcatcagcaaggcccgtgcagatctgctg aagagccacttcctgcccacgctggagaaactaaagaagaagacggtgaaggtggtggct gaggaggagcttctcaaggcggacagtaaaggagacacccaggaggccgagctgctcatt ctggacgagttcgccgtcctctgcagggacctgtacgccttttaccccatgctcatccgc tacgtagacaacaacaggtccaggtggttgaaagaacccgattcggactctaatgagctc ttcagaatggtcgctgagatatttatcctgtggtgcaagtcacataatttcaaaagagaa gagcagaactttgtggttcagaatgaaatcaacaacctctccttcttgactggagataat aaaacaaagatgtcgaagtcgggaggacaagaccaggagcggaaacacaagaagaggcgc ggggagttctactccatccagacctcgctgatcgtcgctgctctgaagaagatgctgccg atcggcctcaacatgtgcaccccaggcgatcaggagcttatctcactcgccaagacccgc tacctcctgaaagatacggatgacgaggttaaagaccacattcatcaaaatctgcacctc agagaaaagtcagaggaccccgccgtgaggtggcagctgaacctgtacaaggacatcgtg atgaggactgactggcctccggatcctgaacgagtggtagatcgtatccagaggatctcg gctgcagtcttcaacctggagcaggtggagcagccactgagatccaaaaaatgtgtttgg cagaagttgctgtccaagcagaggaagcgagcagttgttgcctgcttccgaatggctccg ctctataacctgccaaggcatcgctctattaacctcttcctcctggcctatcagagaata tggatagaaacagaggagtactcttttgaggagaagctagtgcaggaccttgcaaaaaca cagcccaaagaggaggaagaggaagaggaggagatcagaaagcagccagacccccttcat cagcttattctgcatttcagccacaacgctctgactgaatgcagttctctggaagaggat cctttgtatattgcctacgcggatatgatggcaaagagttgtgatgaaggtgaagaagag gaagaggaggaaggaaaagagaaaacatttgaggaaaaggaaatggaaaaacaaaagatg ctgtatcagcaggccagactgcatgaccgtggagctgcagagatggtgctgcagatgatc agtgccagcaaaggtcgacttgatgctatcgtaactttcaccctcaaactgggcatctcc gttctcaacgggggaaacatactggtgcagcagaaaatgctggactatctgaaggaaaaa agagacgttggcttttttaaaagtttgtctggactgatgatgtcatgcagtgtcctggac ttgaatgcttttgagaggcaaaacaaagccgaaggtctggggatggttaccgaagaggga tcaatcaacgtgagtgagcggggttccaaggtgctgcaaaacgatgagttcactacggat ctctttaggtttctgcagcttctctgtgagggccacaacaatgattttcagaacttcctg aggacccaaacaggaaacacaaccacagtcaacatcatcattagcactgtagactatctg ctaagactccaggagtccatcagtgatttctactggtactactccggtaaggatgtgatt gatgaggccggtcagagaaacttctccaaagcgctggcagtggccaaacaggtgttcaac tctttaacagagtatatacagggtccatgtatcgggaaccagcagagtctggctcacagc aggctgtgggatgcagtggtgggattcttgcatgtgtttgccaacatgcagatgaagttg tcccaggactccagtcagattgaattactgaaggagctgctggacctgcagaaggacatg atcgtcatgatgctctctcttctcgaaggtaacgttgtcaacggaacgattggcaaacaa atggtggacactttggtggagtcttctagcaatgtggagatgatcctgaaattcttcgac atgttcctcaagttgaaagacttgaccacctccgacagcttcaaggagtacgaccccgag agcaaaggggtgatctcgaagaaggatttccagaagtccatggagaaccagaagcagtat tctcagtcggagatcgagtttcttctctcctgcgccgaagccgatgagaacgacatgttc aactacgagcagtttgtggagagatttcacgaaccggcaaaagacatcggtttcaacgtg gccgtgttactgaccaacctctcggagcatatgccccacgacggtcgcctggcaaccttc ctcgacctggctgagagtgttctcagctacttcgagccctatttgggtcgtattgagatc atgggtggagcgaagcgcatcgagagagtctacttcgagatcagcgagtccagtcgtacg cagtgggaaaagcctcaggtgaaagagtcaaagcgtcagttcatcttcgacgtggtcaac gagggcggggagagcgagaagatggagctgttcgtcaacttctgcgaggacaccatcttt gagatgcagctggcctctctgatttcagagccggacccggtcgagcgcccggaggaagac gaagacgacaaacagaacgtggtggagaaacaagaggaggaagaggacgagaacataatg atggagtcttcctcggcgtttacgatcgcctgcatctcgatgagaaagagcctctgccac ttccgccagctgctcactctcaagagcatgaggcggcagtacaggaagttcaggaagatg agtgtgcgggagatggtgcgaggcttcttctctttcttctggatgatcatcaccggcctc ttccacttcgtctacagcctagtttggggtttcttccatatcctgtggaccaccatgttc ggtggcggcctcgtcgaaggggccaagaacatgaaggtgacggatattttgggaaacatg ccagaccccactcagtttgggatccacggggacgtgttggaaacggagaagatggaggcg aacgacgcgtcggtattggcggagatggctcagatggctcagggggaggcagcagaggcg gacttgatggctgagttgctcaacatacagcccaagagggagggcaagcacggggccgag ccaggcctgggggatgtgtcggaggtggtggtgggagatgctccatcgatcgccagcgcc gtcaagcagaagaaggcgcagatggctgcaaagaagagcgttacaaatggagactacaag tctgattcggagaaaggagattcggaagatggggagaagaaggaccacgacaagtccaaa gacgaaacccctccagagcgctcggtggaggggaagaaagtcccaaagaagaggctcggc ccgaagaaggaaccgccggaggtcttcatggccagcttcttcgctggcttggaagtctac cagactaagatgctgaactacctggccagaaatttctacaaccttcgtttcctggcactt tttgtcgcctttgccatcaacttcattcttctcttctacaaagtgactggtgattactca gatgacgaggacccgtggaacggtcaagggagggccgaagaggaggaagacgacggagcg ctggagtacttcgtcctgcaggagagcacgggttacatggcaccaacgctgcgctgcctg gcgatactgcacaccatcatctccttcctgtgtgtagtgggatactattacctgaaggtg cctctggtggtgttcaaacgggagaaggagattgcgaggaagctggagtttgccggcctc tacatcaccgagcagccgtctgatgacgacatcaaaggacagtgggacagactggtcatc aacactccttcctttccaaacaactactgggataaatttgtcaagcgcaaagtgataaag aagtacggagatctgtacggagcagagaggatagcagagctgctggggttggacaagagt gccctggatttcaaccccacagaggaaactgttgccaaggaggcttcgctggtgtcatgg ttgagctcgatcgatgcaaagtaccacatctggaaaatgggggtggtgtttactgacaat tcattcctgtatctcgtttggtacaccaccatgtccatcctgggccactacaacaacttc ttcttcgctgcccatctgttggacatcgccatgggcttcaagaccctccgaaccatcctc tcttctgtcacgcataatggcaaacagctggtgttgacggtgggcctgctggcggtcgtg gtctatctctacactgtggtggccttcaacttctttaggaagttctacaacaagagtgag gacgaggatgagccggacatgaagtgtgatgacatgatgacgtgctacctgttccacatg tacgttggcgtgagagcaggagggggcatcggggatgagatcgaggacccagctggtgac ccctatgagctctaccgcatccttttcgacatcaccttcttcttcttcgtcatcgtcatc ctcctggccatcatccagggtttgatcatcgatgcctttggggagctgagggaccagcag gaacaagtcaaagaagacatggagaccaaatgtttcatttgtgggatcggcaacgattac tttgacacgacaccccacggctttgagactcacaccttacaagagcacaatctggccaac tacctatttttcctgatgtacctcatcaacaaggatgagaccgagcacaccggccaggag tcgtacgtgtggaagatgtatcaggagcgcctctgggatttcttcccagccggagattgt ttccgtaaacagtacgaagatcagctgggctag

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