Bubalus kerabau (carabao): 129622085 Help Entry 129622085         CDS       T11435                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism bke  Bubalus kerabau (carabao) Pathway bke04020   Calcium signaling pathway bke04371   Apelin signaling pathway bke04713   Circadian entrainment bke04921   Oxytocin signaling pathway bke04970   Salivary secretion bke05010   Alzheimer disease bke05012   Parkinson disease bke05020   Prion disease bke05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:bke00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     129622085 (RYR3)    04020 Calcium signaling pathway     129622085 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     129622085 (RYR3)   09154 Digestive system    04970 Salivary secretion     129622085 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     129622085 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     129622085 (RYR3)    05012 Parkinson disease     129622085 (RYR3)    05020 Prion disease     129622085 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     129622085 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bke04040]     129622085 (RYR3) Ion channels [BR:bke04040]  Voltage-gated cation channels   Ryanodine receptor    129622085 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Other DBs NCBI-GeneID:  129622085 NCBI-ProteinID:  XP_055394974 LinkDB All DBs Position 10:complement(33591300..34053209) Genome browser AA seq 5083 aa AA seqDB search MAGTADWDIKNCKDFASEPGLYKEEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPT SEAKYVPPDLCVCNFVLEQSLSVRALQEMLANTGENGGEGQGRKRKKEEKSRRKFKTSCG NFQNEEDQSEPYLFIPGALRSPRHLYITEEKGQRPSTRGLVSVAAQGGGHRTLLYGHAIL LRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDD LILVSVSSERYLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGH DECLTIPSTDQNDSQHRRIYYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLT TGHYLALTEDQGLILQDRGKSDTKSTAFSFRASKEKLDSSHKRDIEGMGVPEIKYGDSVC FVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRN TTALFSQFVSGNSRTAAPVTLPIEEVLQTLHDLIAYFQPPEEGMQHEGKQNKLRSLKNRQ NLFKEEGMLALVLNCIDRLNIYNSIAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRN NCAQFSNNLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGR NHKVLDVLCSLCLCDGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEG SAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYG FDGLHLWSGRIPRAVASINQHLLKSDDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDG LFFPVVSFSAGVKVRFLLGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEG IRDLLGTTQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGK IRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEDDLKKVKL PKNYMMSNGYKPAPLDLSDVKLLPPQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKN KRNPRLVPYSLLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRF FRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQ GSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIDNGFVPICSL GLSQIGRMNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPQ IEVVRIDGTMDAPPCLKVTHKTFGTQNSSATMIYCRLSVPVECHSSFSHSPCMDSDAFQK RQCPAPRSSPRSQKRQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTL GDERGRVHESVKRSNCYMVWGGDIVATSQRASRSNVDLEIGCLVDLAMGMLSFSANGREL GTCYQVEPNTKVFPAVFLLPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLD VQTIQPVLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQ EDLMRFHYHTLRLYSALCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLI SIHLASAKERKLMMKNEYIIPITCTTRKIRLYPDESKRHGLPGVGPRTCLKPGFRFSTPC FITTNEEHQKQSPEIPLELLKTKALGMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGT LLIMGVFDDDDVRQILLLIDPSVFGEHSGETEEGAEKEEGMQVEEKAVEAGEKASREAPI KGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQENQKFRYNELMQA LNMSAALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPL EEEEEEEEDSSWTGKFCALVQRIKGAPKPEKEQPTEEGERCPRMCEAELDLEAVIRAACL TCVTASSRNVHDMEGATLKELISQTMIRWAQEDQIQDAELVRMMFNLLRRQYDSIGELLQ ALRKTYTISQTSVSDTISLLAALGQIRCLLSVRMGKEEELLMINGLGDIMNNKVFYQHPN LMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYL LENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLEKVVTYLAGCGLQSCPMLL AKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGN GLLAAMQGAIKISENPALDLPSQGYKREVSTEDDEDEEIVHMGNAIMSFYSALIDLLGRC APEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCP DHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYICS AVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRP SMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTE KLFWGIFDSLSHKRYDPDLFRMALPCLSAIAGALPPDYLDTRISATLEKQVSVDADGNFD PKPINTVNFSLPEKFEYIVTKYAEHSHDKWACDKSQNGWKYGISLDENVKTHPLIRPFKT LTEKEKEIYRWPARESLKTMLAVGWTVERAKEGEALVQQRENEKLRSVSQASQGNSYSPA PLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKMELESKGGGSHPLLVPYDTLTAKEKFR DREKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRFAYKFLKKVLKYVDSAQEFIAHLA IVSSGKNEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSSPLKPLSSSGYASHKEKEMV ASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENA AEDLEKTLENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVAQHQFGVDLLLG DVQLSCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNRYNPLSVF NTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAESGARYTEMPHVIEVILPMLCN YLSYWWERGPEHLPPSAGPWCTKVTSEHLSVILGNILKIINNNLGIDEASWMKRIAVYAQ PIISKARPDLLRSHFIPTLEKLKKKAIKTVQEEEQLRADSKGDTQEAELLILDEFAVLCR DLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEIFILWCKSHNFKREEQNFVIQNE INNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDFYSIQTSLIVAALKKMLPIGLNMCTPG DQELISLAKSRYSYKDTDEEVKEHLRNNLHLQEKSDDPAVKWQLNLYKDVLKSEEPSNPE KTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSI NLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEEVEKQPDPLHQIILHFSRNAL TERSKLEDDPLYTSYASMMAKSCQSGEDEDEEEDKEKTFEEKEMEKQKTLYQQARLHERG AAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSG LMQSCSVLDLNAFERQNKAEGLGMVTEEGTREKVLQNDEFTRDLFRFLQLLCEGHNSDFQ NFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQ IFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLL QDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEY DPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYIDFVDRFHEPAKDIG FNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISES SRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSADRP DEEEEEDGNSSYLLEVEGEEEEEEKSFECASAFAMACASVKRNVANFLKRATLKNLRKQY RKVKKMTFKDLVKVFFSFFWTLFVGLFHLLFTIVGGIIQVLWSTVFGGGLIEGAKNIRVT KILGDMPDPTQFGIHDDALEAERAEVPEPGIATELVHFVKGEKGDADIMSNLFGLHPKKE GGLKHGPEVGLGDLSEIIGKDEPPTLESTVRKKRKVQAAEMKAAHEAEGKIESEKADMED GEKEDTAKEEEQAEALWADVTKRKKRRCGQKVEKPEAFMANFFKGLEIYQTKLLVSTLAL VPLGCGRWHGQTSERWPLTVVVSPFDYAGVSTGHRNGERQGSSGCDFQRTRTLGHSLAPV GHYLARNFYNLRFLALFVAFAINFILLFYKKNGTVSKGMVKPGFKHIETEVIQTGRQVQR ASGQRDPQGGSFKGADLGVPAVCILDQVTEEPLEEETEDVANLWNSFNDEEEEEAVVFFV LQESTGYMAPALRALAVIHTVISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQ PSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFS PVEETKAEAASLVLSSIDMKYHVWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLL DIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDM KCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQG LIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMY LINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 15252 nt NT seq  +upstreamnt  +downstreamnt atggctgggacagctgattgggacatcaagaattgtaaagacttcgcttctgaaccagga ctctataaagaggaagatgaagtggtcctccagtgcatcgccaacattcacaaggagcaa aggaagttctgcctggcagccgagggacttgggaatcgcctgtgcttcttggaacccact tcagaagccaagtatgttcctccagatctctgcgtctgcaactttgtgctggaacagtcc ctctctgtcagagccctgcaggaaatgcttgccaacacaggtgaaaatggcggtgaaggg caggggagaaaaagaaaaaaagaagaaaaatcaagaaggaaatttaagacatcttgtggg aacttccagaatgaagaagaccaatcagagccttacctctttattcctggggccctgaga tccccccgtcatctgtatattacagaagagaagggacaacgcccatcaaccagaggtctc gtctcagttgcagcacaagggggtggccacaggaccctgctgtatggccacgcaattctc ctgcggcactccttcagtggcatgtatctaacatgtttgaccacatcaagatcccagacg gataaacttgcctttgatgtaggtctacgggaacatgccacaggagaagcctgttggtgg accattcatcccgcttccaagcagagatctgagggagaaaaggttcgaattggtgatgac ctcatcctcgtcagcgtgtcctctgagagataccttcatctctcaatatcaaatggtaac atacaagtggatgcctcctttatgcagacactctggaatgtacatcctacgtgctcagga agtagcatcgaagaaggatacctacttggtgggcatgtagtacgtcttttccatggtcat gatgagtgtttgacgataccatctacagatcagaatgattcccagcacaggaggatatac tatgaagccgggggagctggcacgagagctagatcgctatggagagtggaaccccttcgg ataagctggagtggcagtaacatcagatggggacaggctttccgactccggcatctcacc acaggccactacctggccttgacagaagaccaaggccttatactgcaagaccggggaaag tcagacaccaagtccacggccttctcttttcgagcatccaaggagaaattggattccagt cacaagcgagatatagaaggcatgggagtcccagaaatcaagtatggagactctgtctgc tttgtccaacatatagccagtggtctgtgggtgacctacaaagcacaagatgccaagaca tcccgcctgggacctctgaaaagaaaggtcatactccatcaggaaggtcacatggatgat gggttaactctgcagagatgccagcgtgaggagtcccaggctgctcggatcatccggaac acgaccgccttattcagccagtttgtaagtggaaacagtcgcacagctgccccggtcacc ctgccaatagaagaggtcctgcagaccttacatgacctgattgcctacttccagcccccg gaggaggggatgcagcatgaaggcaagcagaacaagctccgctcactcaaaaacagacag aatcttttcaaggaagagggaatgttagcccttgtgttaaactgcattgatcgcttaaat atctacaatagcatagcacactttgcagggatcgccagggaggagagtgggatggcctgg aaagaaattctgaaccttctctacaaattgctcgctgctcttattcgtggaaacagaaac aactgtgctcaattctccaataaccttgattggctgatcagcaaattggacagactagaa tcttcctcaggtatcttggaagttttgcactgcatcctcattgaaagcccagaagcctta aacctgatagcagagggccacatcaagtccatcatctccctgttggataagcacggacgg aatcacaaggttctggatgtgctgtgttccctctgtctctgcgatggggtcgcagtgaga gccaaccagaatctcatctgtgacaacttgctgccccggagaaacctgctcctgcagacg cggctgattaatgacgtaacaagtattcggccaaacatcttcctgggagttgctgaaggc tcagcacagtacaagaagtggtacttcgagcttatcatcgaccaggtggaccccttcctc acagcagagcccacgcatctgcgggtgggctgggcctcttcctctggctacgctccttac cctggaggtggagaaggatggggaggcaatggtgttggtgatgacctatactcctacggc tttgatggacttcacctttggtcaggtcgcatacccagagccgtggcctccatcaaccag cacctcctaaagtcagacgacgtggtaagctgttgcctggacctgggggcacccagcatc tctttccgcatcaacgggcagcctgtgcaggggatgtttgagaacttcaacacagatggg ctcttcttccctgtggtgagcttttcagcaggtgtcaaagtccgtttcctgctgggtgga cgtcatggagaatttaagttcctgcctccctctggctatgccccttgctatgaagcctta cttccaaaagaaaagatgagattggagcctgtcaaagagtataaacgtgatgctgaagga attcgagatctgttgggtaccacccagttcctctcccaagcatctttcatcccatgccct atagataccagtcaggttgttttaccacctcatctagagaaaatacgagacaggctggct gaaaacatccacgagctttggggaatgaataaaatagagcttggctggacttttggcaag atacgggatgacaataaaagacaacacccctgccttgttgagttttcaaagctgcctgaa actgagaagaattataacctacaaatgtcaactgaaaccttaaaaactctcctggccctg gggtgccacattgctcatgttaacccagctgctgaggacgatctcaagaaggtcaaatta cccaaaaactacatgatgtccaatggctataagccagcccctttggatttgtctgatgtg aagctgttaccgcctcaagaagttttagtggataagcttgcagaaaatgcacacaatgtc tgggcaaaagacagaataaaacaaggatggacctatggcattcaacaggatttaaagaac aaaagaaatccacgtttggtgccatattcattgctggatgagcgtaccaagaagtcaaac agggacagccttcgtgaagctgtccggacgtttgttggttacggctataacattgagcca tcagaccaagagctagctgacccagctgtggagaaagtcagcatagacaagatccgcttt ttccgggtagagcgctcttatgccgtgagatctggaaagtggtatttcgagttcgaggtg gtgaccggaggcgacatgcgtgttggctgggcccggccaggctgccgacctgacattgag ctgggggcagatgaccaagccttcgtgtttgaaggcagcaggggccagcgttggcatcaa gggagtgggtattttggacggacctggcagccaggagatgtggttggatgtatgattaac ctggatgatgcttcaatgatcttcacgctgaatggggagctgctgatcaccaacaaaggc tctgaacttgccttcgctgactacgagattgacaatggctttgtgcccatctgctctctg gggctgtctcagatcggccgcatgaatctcgggatggacgccagcaccttcaagttttat accatgtgcggcctccaagagggctttgagccttttgctgtcaacatgaatcgcgatgtg gccatgtggttcagcaaacgcctcccaacatttgtcaacgtgcccaaggatcatccgcag atagaggtcgtgaggatcgacggcaccatggatgcccctccgtgcctcaaggtgacccac aagacattcggcacccagaacagcagtgccaccatgatctactgccgcctgagcgtgccc gtcgagtgccactcctccttcagtcacagcccctgtatggacagtgatgctttccagaaa aggcagtgcccagctccccgcagcagcccgaggagccagaagagacagtgctactatgcg atccgcatctttgccggacaggacccctcctgcgtgtgggtcggatgggtgactccggat tatcacttgtacagtgaaaagtttgacctgaataaaaactgtactgtgactgttactctg ggggatgaaagaggccgagtccacgaaagcgtgaaacgcagcaattgctacatggtctgg ggtggggacatcgtggctacatcccaaagagcgagtcgcagcaacgtggacctggagatc ggctgcctcgtggatctggcgatgggaatgttgtccttttcagccaacgggagggaactt ggcacctgctaccaggtggagcccaataccaaagtgtttccagccgtcttcctgctgccc acaagcacctctctgtttcaatttgaacttgggaagctgaagaatgccatgcccctgtcg gcagccatatttaagagtgaagagaagaaccctgtcccgcaatgcccaccacggctggat gtccaaaccatccagcctgtgctctggagccgcatgcccagcagcttcctgaaggtggag acagagagggtgagcgagcgccatggctgggtggtgcagtgcctggagcccctgcagatg atggcactccacatcccggaagagaacaggtgtgtggatatcctggagctctgtgagcag gaggacctcatgcggttccattaccatacactgagactctacagcgccttgtgcgccctg ggaaacagccgcgtggcctacgccctgtgcagccatgtggacctctcccaactcttctat gccattgacaacaagtacctccctggcctcctacgctcaggcttctatgacctgctcatc agcatccacctggccagcgctaaagagaggaagctgatgatgaagaatgagtacatcatc cccatcacctgcaccaccaggaaaatccgcctgtacccggatgagtccaagaggcacggg ctccctggagtgggcccgagaacgtgcctcaagccagggttcaggttctccaccccctgc ttcatcaccaccaacgaggagcaccagaagcagagccccgagattcccttggaacttctc aagacgaaggcgctgggcatgctgacggaggcagtgcagtgcagcggcgctcacatccgg gaccctgtcggggggtccgtggagttccagtttgtgcctgtgctgaagctcatcggaacc ctgctgatcatgggggtgtttgatgatgatgacgttcggcagatcctcctcctcatcgac ccctctgtgtttggggagcacagtggggagacggaggagggagcagagaaggaggagggg atgcaggtggaggagaaggctgtggaggctggggaaaaggccagcagggaggctcccatc aaaggcttgttgcagacccgattaccggagtccgtcaagctgcagatgtgtgagctgctc agctacctctgtgactgtgagctgcagcaccgggtggaggccattgtggcctttggtgac atctatgtctccaagctccaggaaaatcagaagttccgctacaacgagctcatgcaggcc ctgaacatgtctgcggccctgaccgcccggaagaccagggagttccgctcgcccccacag gaacagatcaacatgcttcttaactttcaactgggggagaactgcccatgcccagaagag atccgggaagagctgtacgacttccatgaggaccttctccttcactgcggggttcccctg gaagaagaggaagaggaggaagaggattcctcctggactggaaaattctgtgccttggtg cagagaatcaaaggcgctcccaagccagagaaggagcaaccaacagaggaaggagagaga tgccctagaatgtgcgaggcagagctggacttggaagcagttataagagcagcgtgtctc acctgtgttacagcatcttctcgaaatgtgcatgacatggagggggcaaccctgaaggag ctcatctcacagaccatgatccgctgggcccaggaggaccagatccaggatgcagagctg gtccggatgatgttcaaccttctgcggcggcagtacgacagcatcggggagctgctgcag gcgctgcgcaagacctataccatcagccagacctccgtgagcgacaccatcagcctgcta gctgccctgggccaaattcgctgcctgctcagcgtcaggatgggcaaggaggaggagcta ctcatgatcaacgggctgggagacataatgaacaacaaggtgttttaccagcaccccaac ctcatgagagtcctcggcatgcatgagactgtcatggaggtgatggtgaacgtgctgggt gcagaaaagtcacagattgcctttccaaagatggttgctagctgttgccgcttcttgtgc tatttctgtcgaatcagccgacaaaatcagaaggccatgtttgagcatctaagttacctg ttggagaacagcagtgtcggcctagcttccccctccatgagaggatccaccccgctggat gtggccgcttcctccgtgatggacaacaatgagttagcgctgggcttagaggagccagac ctcgagaaggtggtgacctacttggcaggctgtggcctacagagctgccccatgcttcta gccaaaggataccctgatgtcggctggaaccccattgaaggagagcgctacctgtccttc ctgaggtttgccgtcttcgtgaacagtgaaagtgtggaagaaaatgctagtgtcgtggtc aagctgctcatcagacgccccgagtgcttcggccccgccctgcggggtgaaggaggaaac ggtctgttggcggccatgcaaggcgccattaagatctctgagaacccagccctcgacctc ccctcgcagggctacaagagggaagtcagcacagaggacgatgaagatgaagagatcgtg cacatggggaatgcaatcatgtcattttattcagctcttatagacctgctgggccgctgt gctcctgagatgcaccttatccagacagggaagggagaagccatccggatcaggtccatc ctgcgctccctggttcccactgaggacttggttggaatcatcagcatccccttgaaactg ccttccctgaacaaagatgggtcggtcagtgagccagatatggcagccaacttctgccct gaccacaaggcgcccatggtactgttcttggaccgtgtgtatggcatcaaggatcaaact tttctgctccacttgctggaagttggatttttacctgacttaagagcctctgcctctcta gatacagtttccctaagcaccaccgaggctgcactggcactgaacaggtacatatgttct gctgtgctcccgctcctcacaagatgcgcccctctctttgccgggacagagcactacact tctttgattgactctacactgcagacaatatacaggctttccaaggggcgatccctcacc aaagctcagagggacaccatagaggagtgtttgctggccatttgcaatcacttgaggcct tccatgttacagcaactcctgcgacgtctagtttttgatgtgccccaactcaatgaatac tgcaaaatgcctcttaagcttctgacgaatcactacgaacagtgctggaagtactattgt ctgccttccggctgggggagctacggtctggccgtggaggaagagctacatctgacagag aagctcttctgggggatttttgactccctctcccataagaggtatgacccagatcttttc cggatggccctgccctgtctcagtgcaatagcgggggccctgccaccagattatttagat accagaatctcagccacattggagaaacaggtctcagtggacgcagatggcaactttgac cccaaacccatcaacaccgtgaatttctccttgcctgaaaaatttgaatacatcgtcacc aagtatgctgagcactcccatgataaatgggcctgtgacaagagtcagaatggatggaaa tacggaatttcactggatgaaaatgtgaagacccatccattgatccggcctttcaagaca ttaaccgagaaggagaaggaaatttatcgctggcctgccagagagtccctgaaaaccatg ctggctgtgggctggactgtagagagggccaaagagggagaagctctggttcaacagcgg gaaaatgagaagcttcgaagcgtgtcccaggccagccagggcaacagctacagccctgcc cctctggatctctccaatgtcgtgctctccagagagctccaggggatggtggaggtggta gctgagaactatcacaatatctgggccaagaagaagaagatggagctggagagcaaaggt ggtggcagtcaccctcttttggtaccctatgataccttgactgccaaggaaaagttcaga gaccgagagaaggcccaggacctgtttaaattcctccaagtgaatggcattgtggtttcc agaggtatgaaggatatggagctggatgcctcctccatggaaaagaggtttgcctataag tttttgaagaaggttctgaaatatgttgattcggctcaagagtttattgcccatttggcc attgtcagcagtgggaaaaatgaaaagtctccccatgaccaggagatcaaattctttgcc aaagttctcctcccactggttgaccagtacttcaccaatcatcgcctgtacttcctgtcc tcccctctgaagccccttagcagcagcgggtatgcctcccataaggagaaagaaatggtg gccagcctgttctgcaaactcgctgctctggttcgacacaggatttccctcttcgggagc gattctacgacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggacg gtcatgaagtcaggctcagagctggtgaaagccgggttacgggcgttctttgaaaatgca gcggaagacttagagaagactttggaaaacctgaagctcggcaagtttacccattccaga acacagatcaaaggcgtctctcaaaatattaactacaccacggtggctctgctccccatc ttgacatccatctttgagcatgtggctcagcatcagttcggggtggacttactcttgggt gatgtgcagctttcatgctaccatatactgtgcagcctctactccctcgggacaggaaag aacatctatgttgaaaggcagcgtcctgcccttggagaatgcctggcctcactggcagcc gccataccagtggcattcctggagcccacccttaaccgctacaacccgctctccgtcttc aacaccaaaacccccagggagaggtctattctggggatgccagacacagtggaggacatg tgccccgacatcccccagctggaaggcctgatgaaggaaatcaacgacctggctgagtca ggggcccggtacacagagatgccccacgtcattgaggtcattttgcccatgctctgcaac tacctgtcctactggtgggagcgggggcccgagcaccttccccccagtgcagggccctgg tgcaccaaggtcacgtctgaacacctcagtgtcatcctgggcaacattctgaaaatcatc aacaacaacctgggcatcgacgaggcctcttggatgaagcgcattgcagtgtacgcccaa ccgatcatcagcaaagccaggccagacctgctgagaagccacttcatcccgaccctggag aagctgaagaagaaggccatcaagaccgtgcaggaggaggagcagctgagagctgacagc aagggcgacacgcaggaggccgagctgctcatcctggacgagtttgctgtcctctgcaga gacctctatgccttctaccccatgctcatccgctacgtggacaacaacagatctaactgg ctcaaaagccctgatgcagactctgaccagctcttccgcatggtggcagagatcttcatc ctgtggtgtaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaacgaa attaataatttggcatttttaactggagacagcaaaagcaagatgtcaaaatctggagga caggaccaggagcggaagaagacaaagcgaaggggagacttttattccatccagacctcc ctcatcgtggctgcgctcaagaaaatgctgcccattggtctgaatatgtgcaccccaggc gatcaggagctgatctccctcgcaaaatcacggtacagctataaggacacagatgaagag gtgaaggaacatctgcggaataacttgcacttgcaggaaaagtctgatgatccagctgta aagtggcaactgaacctatacaaagatgttttaaagagtgaagaaccttccaacccagaa aagacagtggagcgtgtgcagagaatttcagcagctgtcttccacctagagcaggtggaa cagcctttgaggtccaagaaggcagtctggcacaaactgctatcaaagcagcggaaacgg gcagtggtggcctgtttcaggatggcccctctctacaacttgcccaggcaccgctctatt aacctcttcctccatggctatcagagattttggatagaaacagaggagtattcctttgaa gagaaactagtacaggatttggctaaatctcccaaggtggaagaggaggaggaggaagag gtggaaaagcagccagacccgcttcatcagatcatcctccactttagccgcaatgctctc acagagaggagcaaactggaagacgaccctttgtacacctcctatgccagcatgatggcc aagagttgtcagagtggggaagacgaagacgaggaggaagacaaggagaaaacatttgaa gagaaagaaatggaaaagcagaaaaccctctatcagcaagcccggctgcatgagcgtgga gccgccgagatggtccttcagatgatcagtgccagcaaaggtgagatgagccccatggtg gtggagactctgaagttggggatcgccattctgaatgggggcaatgccggtgtgcagcag aaaatgctagattacctaaaggagaaaaaggatgctgggttctttcaaagtctttctggt cttatgcagtcttgcagtgtccttgatttgaatgcatttgagaggcagaataaagctgaa ggcctggggatggttactgaggaaggaacacgtgaaaaagtactccagaatgacgagttt acacgagatctctttagattcctgcagttactttgtgaaggacacaacagtgatttccag aacttcctgaggactcagatgggcaacaccaccaccgtgaatgtcatcatcagtactgtg gactaccttctgcgtctgcaggaatcaatcagtgatttctactggtattactcagggaag gacatcattgatgaatctggacagcacaatttttccaaagccctggcggtcaccaagcag atcttcaattctcttacagaatacatccagggcccctgcattgggaaccagcagagcctg gctcacagcaggctgtgggacgcggtggtcggcttcctccatgtgtttgctaacatgcag atgaaactctcccaggattccagtcagatcgagctgctgaaggaactcttggatctcctt caggacatggtggtgatgcttctgtccctcctggaagggaatgtggtaaatggaaccatt ggcaagcagatggttgacacactggtagagtcatctaccaatgtagaaatgatcttgaaa ttctttgacatgttcttgaaacttaaagacttaaccagctcagacaccttcaaagaatat gaccccgatgggaaaggaatcatttccaaaaaggaattccaaaaggccatggaagggcaa aagcagtacacacagtcggagatagactttctcctttcgtgcgcagaagctgatgaaaat gacatgtttaattacatcgattttgttgaccggttccatgagccagccaaggacataggg tttaatgtggcagtgttattgacaaacctctctgagcacatgccaaacgattctcgcctt aagtgtctgttggacccagcagaaagtgtactcaattacttcgaaccatacctgggacgc attgagatcatgggtggggccaagaaaattgagcgtgtttattttgagatcagcgagtcc agtcgaactcagtgggagaagccccaggtgaaggagtctaagcgacagttcatctttgac gttgtcaatgaaggcggggagcaagagaagatggagctgttcgtgaacttctgtgaggac accatctttgagatgcagttagcatcgcagatctcagaatctgactcagccgacaggcca gacgaggaggaggaagaagatggaaattcttcttatttgttagaagtggagggtgaggag gaggaggaagagaagtcttttgagtgcgcctctgcatttgccatggcttgtgcctcagtg aagagaaacgtggccaactttctgaagagggccaccctgaagaacctcaggaagcagtac aggaaggtgaagaagatgaccttcaaggacctggtgaaggtgttcttctctttcttctgg acgttgttcgtggggctcttccacttgctcttcactatagtgggaggaatcattcaggtc ctctggagcacagtgttcggagggggactcatagaaggggcaaagaacataagagtcacc aagatcctgggtgacatgcctgacccaacccagtttggtatccacgacgatgctctggaa gctgagagggcagaagtgcctgagccaggcatcgccacggaactcgtgcacttcgtaaag ggggagaagggagatgcagacatcatgtcaaatctctttggactccacccaaagaaagaa ggtggcttaaagcatgggcccgaagtgggtttgggtgacctctctgagattattggcaaa gacgaaccccctaccttagagagtactgtccggaagaaaaggaaagtgcaggcagcagaa atgaaagcagctcatgaagcagaaggaaaaatagagtctgagaaggcagacatggaagat ggggagaaagaggacacagccaaagaagaagagcaggccgaggccctgtgggcggacgtg accaaaaggaagaagcgacggtgtggccagaaggttgagaagcctgaagccttcatggcc aatttctttaaagggctggaaatctatcagaccaagttgctggtaagcactctggcgctg gtcccactcgggtgcgggcgttggcacgggcagacctcagagaggtggccactgactgtc gttgtttcaccattcgattacgctggtgtttccactgggcacaggaacggggagaggcag gggagctcgggctgtgactttcaaaggacaaggactctcggccatagtctggctccagtt gggcactacctggccaggaatttctacaacctgaggttccttgctctgtttgtagccttc gctatcaacttcatcctgctcttttacaagaaaaatggaactgtgtcgaagggcatggtg aagcctggctttaaacacattgagactgaagtgattcagacaggcaggcaggtgcagaga gccagcgggcagcgggacccgcagggtggcagcttcaaaggcgctgatctgggagtccct gcggtgtgtatcttggaccaggtcaccgaagaacctttagaagaagagacagaggatgtt gcaaacctgtggaattcctttaatgacgaggaagaggaagaggcggtggtgttctttgtc ctgcaggagagcactgggtacatggcgccagccctgcgggcgctggccgtcatccacacc gtcatctctttggtctgcgtggtgggctactactgcctaaaggtccctttggtcgtgttc aaaagagaaaaagaaatcgccaggaagctggagtttgatggcctgtatatcactgaacag ccttctgaagatgacatcaaggggcagtgggatcgcttggtaatcaacacgccatctttc cctaataactactgggacaagtttgtaaagagaaaggtgatcaacaaatatggagatctc tacggagcagaacgcattgctgaactcctgggtttggacaaaaatgcccttgactttagc ccagtggaagagaccaaagcagaggcggcctccctggtgctaagttccatcgacatgaag taccatgtctggaagctgggagttgtttttactgacaattcctttctctacctcgcctgg tacacgaccatgtcagtcctgggccactacaacaactttttcttcgctgctcatcttctg gatatcgcgatgggcttcaagactctgaggactattctgtcctctgtcactcacaatggc aaacagttggtcctgaccgttggtctcctggctgtggtggtttatctctatactgtggtg gcattcaacttcttccgcaagttctacaacaaaagtgaagacgacgacgagcccgacatg aagtgtgatgacatgatgacgtgttacctgttccacatgtacgtgggagtgagagctgga ggtggcattggtgatgaaattgaagaccctgctggggacccgtatgaaatgtatcgcatc gtttttgacattaccttcttctttttcgtcattgtcatcctgctagccatcatccaaggt cttattattgatgcttttggggagctgagagaccagcaggaacaagtacgagaggatatg gagactaaatgtttcatctgtgggattggcaatgactactttgacacgacgcctcatggt tttgaaacacacaccctgcaagagcacaacttagccaactacctgttcttcctcatgtat ttgattaacaaagatgagacagagcacacgggacaggaatcttacgtctggaagatgtac caagaaaggtgctgggatttcttcccagctggtgactgcttccggaagcaatatgaagat cagcttggataa

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