Balaenoptera musculus (blue whale): 118890725 Help Entry 118890725         CDS       T09887                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism bmus  Balaenoptera musculus (blue whale) Pathway bmus04020   Calcium signaling pathway bmus04371   Apelin signaling pathway bmus04713   Circadian entrainment bmus04921   Oxytocin signaling pathway bmus04970   Salivary secretion bmus05010   Alzheimer disease bmus05012   Parkinson disease bmus05020   Prion disease bmus05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:bmus00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     118890725 (RYR3)    04020 Calcium signaling pathway     118890725 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     118890725 (RYR3)   09154 Digestive system    04970 Salivary secretion     118890725 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     118890725 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     118890725 (RYR3)    05012 Parkinson disease     118890725 (RYR3)    05020 Prion disease     118890725 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     118890725 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bmus04040]     118890725 (RYR3) Ion channels [BR:bmus04040]  Voltage-gated cation channels   Ryanodine receptor    118890725 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  118890725 NCBI-ProteinID:  XP_036699818 UniProt:  A0A8B8WRB9 LinkDB All DBs Position 2:98221556..98773638 Genome browser AA seq 4866 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCVANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSRMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSLSSER YLHLSISNGSIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIYYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQHEESQAARIIRNTTALFSQ FVSGNSRTAAPVSLPIEEVLQTLHDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSIAHFAGIARQESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSVISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASVNQHLLKSDDVVSCCLDLGAPSISFRISGQPVQGMFENFNTDGFFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIRQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIDDGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAVWFSKRLPTFVNVPKDHPQIEVVRID GTVDSPPCLKVIHKTFGTQNSGASMIYCRLSVPVECHSSFSHSPCLDSDAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQRASRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQSIQPVLW SRMPSSFLKVETERVSERHGWVVQCLEPLQMMALYIPEENRCVDILELCEQEDLMWFHYH TLRLYSALCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGFLRSGFYDLLISIHLASAKE RKLMMKNEYIIPITSSTRKIHLYPDESKRHGLPGVGPRTCLKPGFRFSPSCFVMTSEEHQ KQSPEIPLELLKTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHSGGTQGGAEKEEVTQVEEKAVEAGEKAGKEAPGRGLLQTRLP ESVKLQMCELLSYLCDWELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEEEED ASWTGKFRALVYKIKGSSKPEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDAELVR MMFSLLRRQYDSIGELLQALRKTYTISQVSVSDTVSLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTEDHEDEEEIVH MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP SLNKDGSISEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD TVSLSTTEAVLALNRYICSAVLPLLTRCAPLFAGTEHYSSLIDSTLQTIYRLSKGRSLTK AQRDTIEECLLAICNHLKPSMLQQLLRRLVFDVPQLSEYCKMPLKLLTNHYEQCWKYYCL PSGWGSYGLAVEDELHLTEKLFWGILDSLAHKRYDPDLFRMALPCLSAIAGALPPDYVDT RISATLEKQVSVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQNGWKY GISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALFQQRE NEKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG GSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGVVVSRGIKDMELGASSMEKRFAYKF LKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLS SPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGNDATTMVSCLHILAQTLDTRT VMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPI LTSIFEHVSHHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAA AIPVAFLEPTLDRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEINDLAES GARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNILKII NNNLSIDEASWMKRIAVYAQPIISKARADLLRSHFIPTLEKLKKKAVKTVQEEEQLKADS RGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPNADSDQLFRMVAEVFI LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDLYSIQTS LIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYKDTDEEVKEHLWNNLHLQEKSDDPAV KWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKR AVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEE TEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYASMMAKSCQSGEDEEEEEDKEKTFE EKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQ KMLDYLKEKKDAGFFQSLSGLMQCCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKV LQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFY WYYSGKDVIDESGKHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLH VFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTN VEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKKEFQKAMEGQKQYTQSEIDFLLSC AEADENDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLTYF EPYLGRIEIMGEAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELF VNFCEDTIFEMQLASQISESDSADRPEEEEEENEDSSYMLEVEGEEEDDKSFECASAFAM ACASVKRNVANFLKRATLKNLKKQCRKVKKMTLKELVKVFFSFFWTLFVGLFHLLFAILG GIFQILWSTVFGGGLIEGAKNIRVTKILGDMPDPTQFGIHDDAMEAERAEVPEPGIATEL VHFVKGERGDAEIMSDLFGLQSKKEGGLKHGPEVGLGDLSEIIGKDEPPTLESTVREKRK AQAAETKAAHEAEGKVESEKADMEDGEKENTAKEEEQAEAGWADVTKRKKRWCGQKIEKP EAFMASFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETED IANLWNSFNDEEEEEAVVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKVPLVV FKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGD LYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLY LAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLY TVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEM YRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTT PHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQ YEDQLG NT seq 14601 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagttcctgcggactgaagatgaa gtggtcctccagtgcgtcgccaacgttcacaaggagcagaggaagttctgcctggcagct gagggacttgggaatcgcctgtgcttcttggaacccacttcagaagccaagtatgttcct ccagatctctgcgtctgcaattttgtactggaacagtccctctctgtcagagccctacag gaaatgcttgccaacacaggtgaaaatggcggcgaaggggctgcacaagggggtggccac aggaccctgctgtatggccacgcgattctcctgcggcactccttcagcagaatgtatcta acgtgtttgactacatcaagatcccagacagataaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggaccatacatcccgcttccaagcagaggtct gagggagaaaaggttcgaattggtgatgacctcatccttgtcagcctatcctctgaaaga taccttcatctctcaatatcaaatggcagcatacaagtggatgcctcctttatgcaaaca ctctggaatgtacatcctacgtgctcaggaagtagcatcgaagaaggatacctacttggt gggcatgtagtacgtcttttccatggtcacgatgagtgtttgacaataccatctacagac cagaatgattcccagcacaggaggatatactacgaagctgggggagctggcacgagagcc agatctctgtggagagtggaaccccttcggataagttggagtggcagtaacatcagatgg ggccaggctttccgacttcggcatctcaccacaggccactacctggccttgacagaggac caaggccttatactgcaggaccggggaaaatcagacaccaagtccacagccttctctttc cgagcatcaaaggaaatcaaggagaaactggattccagtcacaagcgagatatagagggc atgggagtcccagaaatcaagtacggagactctgtctgctttgtccaacatatagccagt ggtctgtgggtgacctacaaagcacaagatgccaagacatcccgcctgggacctctgaaa agaaaggtcatactccatcaggaaggccacatggatgacgggttaacactacagagatgc cagcatgaggagtcccaggctgcccggatcatccggaacacgaccgctttattcagccag tttgtaagtggaaacagccgcacagcagcccctgtcagcctgccgatagaagaggtcctg cagaccttacacgacttgatcgcctacttccagcccccagaggaggagatgcagcatgaa gacaagcagaacaagctccgctcactcaaaaacagacagaatcttttcaaggaagagggg atgttggcccttgtgttaaactgcattgatcgcttgaatatctacaatagcatagcacac ttcgcagggattgccaggcaggagagtgggatggcctggaaagaaattctgaacctactc tacaaattgctggctgctctcattcgtggaaacagaaacaattgcgctcaattctccaat aaccttgattggctaatcagcaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcctgattgaaagcccagaagccttgaacctgatagcagaaggtcac atcaagtcagtcatctccctgttggacaagcacgggcgaaatcacaaggttctggacgtg ctgtgttccctctgtctctgcaatggggtcgcagtgagagccaaccagaatctgatctgt gacaacttgctgccccgcagaaacctgctcctgcagacgcggctgattaacgatgtgaca agtattcggccaaacatcttcctgggagtcgctgagggctcagcacagtacaagaagtgg tacttcgagctaatcatcgaccaggtggaccccttcctcacagcagagcccacacacctg cgggtgggctgggcctcttcctcaggctatgccccataccccggaggcggagaaggatgg gggggcaatggtgttggcgatgacctgtactcctatggctttgatggacttcacctttgg tcaggccgcatacccagagccgtggcctctgtcaaccagcacctcctgaagtcggacgac gtggtgagctgttgcctggaccttggagcacccagcatctctttccgcatcagcgggcag ccggtgcaggggatgtttgagaacttcaacacagatgggttcttcttccctgtggtgagc ttttcagcaggtgtcaaagtacgtttcctgatggggggacgtcacggagaatttaagttc ctgcctccctctggctatgccccttgctacgaagccttacttccaaaagaaaagatgaga ttggagcccgtcaaagagtataaacgtgatgctgaaggtgttcgagatctgttgggtacc acccagttcctctcccaagcttctttcattccgtgccccatagataccagtcaggttgtt ttaccacctcacctagagaagatccgagacaggctggctgaaaacatccacgagctttgg ggaatgaataaaatagagcttggctggacttttggcaagatacgggatgacaataaaaga caacacccctgccttgtcgagttttcaaagctgcctgaaactgagaagaattataaccta caaatgtcaactgaaaccttaaaaaccctcctggccctggggtgccacatcgctcatgtc aacccagctgctgaggaggatctcaagaaggtcaaattgcccaaaaactacatgatgtcc aatggctataagccggcccctttggatttgtctgatgtgaagctgttacctcctcaagaa attttagtggataagcttgcagaaaatgcacacaatgtttgggcaaaagacagaataaga caaggatggacctatggcattcaacaggatttaaagaacaaaagaaatccccgtctggtg ccatatgcattattggatgagcgtaccaagaagtcaaacagggacagccttcgtgaagct gttcggacttttgttggttatggttataacattgagccatcagaccaagaactagctgac ccagctgtggagaaagtcagcatagacaagatccgctttttccgggtagagcgctcttac gcagtgagatctggaaagtggtattttgagtttgaggtggtgaccggaggagacatgcgt gtcggctgggccaggccaggctgtcggcctgacgttgagctgggggccgatgaccaagcc tttgtgtttgaaggcagcaggggccagcgttggcatcaagggagtgggtattttggacgg acctggcagccaggagatgtggttggatgtatgattaacctggatgatgcttcaatgatc ttcacgctgaatggggagttgctgatcaccaacaaaggctctgaacttgccttcgctgac tacgagattgacgatggctttgtgcccatatgctctctgggcctgtctcagatcggccgc atgaatctcgggatggacgccagcaccttcaagttttataccatgtgcggcctccaagag ggctttgagccttttgctgtcaacatgaaccgcgacgtggccgtgtggttcagcaagcgc ctcccaacatttgtcaacgtgcccaaggatcatccacagatagaggtcgtgaggatcgat ggcaccgtggacagccctccgtgcctcaaggtgatccacaagacgttcggcacacagaac agcggtgccagcatgatctactgccgcctgagcgtgccggtcgagtgccactcctccttc agtcacagcccgtgtctggacagtgacgctttccagaaaaggaaacagatgcaagaaata ctctctcatacaacaacacagtgctactacgcaattcgcatctttgctggacaggacccc tcctgcgtctgggtcggatgggtgactcccgactatcatttgtacagtgaaaagtttgac ttgaataaaaactgtaccgtgactgttactctgggggacgaaagaggccgggtccacgaa agtgtgaagcgcagcaactgctacatggtctggggtggggacatcgtggccacgtcccaa agagcaagtcgcagcaacgtggacctagagatcggctgccttgtggatctggcaatgggc atgttgtccttctcggccaacgggagggaactcggcacctgctaccaggtggagcccaat accaaagtgtttccagcggtcttcctgcagcctaccagcacctctttgtttcagtttgaa cttgggaagctgaagaacgccatgcccctgtcggcggccatatttaagagtgaagagaaa aaccccgtcccgcagtgcccaccacggctggacgtccaaagcatccagcccgtcctctgg agccgcatgcccagcagcttcctgaaggtggagacggagcgggtgagcgagcgccatggc tgggtggtgcagtgcctggagcccctacagatgatggcgctctacatccccgaggagaac aggtgtgtggacatcctggagctctgcgagcaggaggacctcatgtggttccattaccac acgctgagactctacagcgccttgtgcgccctgggaaacagccgcgtggcttatgccctg tgcagccacgtggacctctcccagctcttctacgccattgacaacaagtacctccccggc ttcctgcgctccggcttctacgacctgctcatcagcatccacctggccagcgctaaggag aggaagctgatgatgaagaatgagtacatcatccccatcaccagcagcaccaggaaaatc cacctgtacccggacgagtccaagaggcatgggctccctggggtgggcccgagaacgtgc ctcaagccagggttcaggttctccccctcctgcttcgtcatgaccagcgaggaacaccag aagcagagccccgagattcccttggagcttctcaagacgaaggcgctgagcatgctgacg gaggcagtgcagtgcagtggggctcacatccgggaccccgtcggggggtccgtggagttc cagtttgtgcctgtgctgaaactcatcggaaccctgctggtcatgggggtgtttgacgat gacgatgttcggcagatcctccttctcatcgacccctccgtgtttggggagcacagtggg ggcacgcagggcggagcagagaaggaggaggtgacccaggtggaggagaaggctgtggag gctggggaaaaggccggcaaggaggctcccggcagaggcttgttgcagacccggttaccg gagtccgtcaagctgcagatgtgtgagctcctcagctatctctgtgactgggagctgcag caccgggtggaggccatcgtggcctttggcgacatttatgtctccaagctccaggcaaat cagaagttccgctacaacgaactcatgcaggccctgaacatgtctgcggccctgactgct cggaaaaccagggagttccgctcacccccgcaggagcagatcaacatgcttcttaacttt caactgggggagaactgcccgtgcccagaagagatccgggaggagctgtatgacttccac gaggaccttctcattcactgcggggttcccctggaggaagaggaagaggaggaggaggac gcctcctggactggaaaattccgtgccttggtgtataaaatcaaaggctcttccaagcca gagaaggagcagccgacagaggaggaggagagatgccctacgacgctgaaggagctcatc tcacagaccatgatctgctgggcccaggaggaccagatccaggacgcagagctggttcgg atgatgttcagcctcctgcggaggcagtacgacagcatcggggagctgctgcaggcgctg cggaagacctacaccatcagccaggtctccgtgagcgacaccgtcagcctgctggctgcc ctgggccagattcgctgcctgctcagtgtccggatgggcaaggaggaggagttgctcatg atcaacgggctgggagacataatgaacaacaaggtgttttaccagcaccccaacctcatg cgagtcctcggcatgcacgagacagtcatggaggtgatggtgaacgtgctgggtgcagag aaatctcagattgcctttccaaagatggttgctagctgttgccgcttcctgtgctatttc tgtcgaattagccgacaaaatcagaaggccatgtttgagcatctcagttacctgctggag aatagcagcgttggcctagcctccccgtccatgagaggatccaccccgctggatgtggct gcttcctctgtgatggacaacaacgagttagcgctgggcttagaggaaccagacctcgag aaggtggtgacctacttggcaggctgtggcctacagagctgccccatgcttctggccaaa ggataccctgatgtcggctggaaccccattgaaggggagcgctacctgtccttcctgagg tttgccgtcttcgtgaacagtgaaagtgtggaagaaaacgctagcgtcgtggtcaagctg ctcatcagacgccccgagtgcttcggcccggccctgcggggtgaaggaggaaatggtcta ttggcggccatgcaaggcgccattaagatctccgagaacccagccctcgacctcccctcg caggggtacaagagagaagtcagcacggaggaccatgaagatgaagaagagattgtgcac atgggcaatgcaattatgtcattttattcggctcttatagatctgctgggccgctgtgct cctgaaatgcaccttatccagacaggaaagggggaggccatccggatcaggtccatcctg cgctccctggtccccaccgaggacttggttggaatcatcagcatccccttgaaactgccc tccctgaacaaagatggatcaatcagcgaaccagatatggcggccaacttctgccccgac cacaaggcacccatggtgctgttcttggaccgtgtttatggtataaaggatcaaactttc ctgctccacttgttggaagttggatttttacctgacttaagagcctctgcctctttagat acagtttccctcagcaccaccgaggccgtgctggccctgaacaggtacatatgttctgcc gtgctcccactcctcacgagatgcgcccctctctttgctggaacagagcactactcctct ttgatcgactctacgctgcagacaatatacaggctttccaagggccgttccctcaccaaa gctcagagggacaccatagaggagtgtttgctggccatttgcaatcacttgaagccttcc atgttacagcagctcctgcgacgtctagtttttgatgtgccgcaactcagtgaatactgc aaaatgcctcttaagcttctgacaaatcactacgaacagtgctggaagtattactgtctg ccgtcaggctgggggagctacggtctggctgtggaagatgagctgcatctgacagagaag ctcttctgggggattcttgactcccttgcccataagaggtatgacccggatcttttccga atggccctgccctgtctcagtgctatagctggggccttgccaccagactatgtagatacc agaatctcagccacattggagaaacaggtctcagtggacgcagatggcaactttgacccc aagcctatcaacaccatgaatttctccttgcctgaaaagttggaatacatcgtcaccaag tatgctgagcactcacatgataaatgggcctgtgataagagtcagaatggatggaaatat ggaatttccctggatgaaaatgtgaagacccatccattgatcaggcctttcaagacatta acagagaaggagaaggaaatttatcgctggcctgccagagagtccctgaaaaccatgctg gctgtgggctggacggtagagaggaccaaagagggagaagccctatttcaacagcgggaa aatgagaagcttcgaagcgtgtcccaggccagccagggcaacagctacagccctgctccc ctggatctctccaacgttgtgctctccagagagctccaggggatggtggaggtggtagct gagaactatcacaatatctgggccaagaagaagaagctggagctggagagcaaaggtggt ggcagtcatcctcttttggtaccatatgacaccttgactgccaaggaaaagttcagggac cgggagaaggcacaggacctgtttaagttcctccaagtgaacggcgttgtggtttctaga ggtatcaaggatatggagctgggtgcctcctccatggaaaagaggtttgcctataagttt ttgaagaagatcctgaaatatgttgactctgctcaagagtttattgcccatttggaagcc attgtcagcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgcc aaagttctcctcccactggttgaccagtactttaccaatcaccgcctctacttcctctca tcccctctgaagccccttagcagcagcgggtacgcctctcataaggagaaagaaatggtg gccagcctgttctgcaaactcgctgctcttgttcgacataggatttccctcttcgggaac gatgctactacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggaca gtcatgaagtcaggctcagagctggtgaaggccgggttacgagcattctttgaaaatgca gccgaagacttagagaagacttcagaaaacctgaagctcggcaagtttacccattccaga acgcagattaaaggcgtctctcagaatattaactacaccacggtggctctgctccccatc ctgacgtccatctttgagcatgtgtctcatcatcagttcggggtggatttactcttgggt gacgtgcagatttcatgctaccatatactgtgcagcctctactcccttgggacaggaaag aacatctatgttgaaaggcaacgtcctgcccttggagaatgcctggcctcactggcagct gccataccagtggcattcctggagcccacccttgaccgctacaacccactctcagtcttc aacaccaaaacccccagggagaggtctattctggggatgccagacacagtggaggagatg tgccctgacatccctcagctggaaggcctgatgaaggaaatcaacgacctggccgagtca ggggcccggtacacggagatgccccacgtcatcgaggtgatcttgcccatgctgtgcaac tacctgtcctactggtgggagcgggggcctgagcacctgccccccagcacagggccctgg tgcaccaaggtcacctctgaacacctcagtgtcatcctgggcaacattctgaaaatcatc aacaacaacctgagcatcgatgaggcctcctggatgaagcgcattgcagtgtatgcccag ccaatcatcagcaaggccagggcggacctgctaagaagccacttcatcccaactctggag aagctgaagaagaaggctgtcaagactgtgcaggaggaggagcagctgaaagccgacagc agaggggacacccaggaggcagagctcctcatcctggatgagtttgccgtcctctgcaga gacctctatgccttctaccccatgctgatccgctacgtggacaacaacagatctaactgg ctcaaaagccccaatgctgactctgaccagctcttccgcatggtggcagaggtcttcatc ctgtggtgtaaatctcacaacttcaagagggaagagcagaattttgtgattcagaatgaa attaataatttggcatttttaactggagacagcaaaagcaagatgtcaaaatctggagga caggaccaggagcggaagaagacgaagcggaggggagacttgtattccatccagacctcc ctcatcgtggctgcactcaagaaaatgctgcccattggtttgaatatgtgcaccccaggc gatcaggagctgatctccctcgcaaaatcacggtacagctataaggacacagacgaagag gtgaaggaacatctgtggaataacttgcacttgcaggaaaagtctgatgacccagctgta aagtggcaactgaacctatacaaggatgttttgaagagtgaagaaccttccaacccagaa aagacagtggagcgtgtgcagagaatttcagcagctgtcttccacctggagcaggtggaa cagcctttgaggtccaagaaggcggtctggcacaaactgctatcaaagcagcggaaacgg gcagtggtggcctgtttcaggatggcccctctctacaacctgcccaggcaccgctctatt aacctcttcctccatggctatcagagattttggatagaaacagaggagtattcctttgaa gagaaactagtacaggatttggctaaatctcccaaggtggaagaggaggaggaggaggag acagaaaagcagccagacccacttcatcagatcatcctccactttagccgcaacgctctc acagagaggagcaaactggaagacgaccctttgtacacctcctatgccagcatgatggcc aagagttgtcagagtggggaagacgaagaagaggaggaagacaaggaaaaaacatttgaa gagaaagaaatggaaaagcagaaaaccctctatcagcaagctcggctgcatgagcgtgga gctgcagagatggtccttcagatgataagcgccagcaaaggtgagatgagccccatggtg gtggagactctgaagctggggatcgccattctgaatgggggcaacgctggcgtgcagcag aaaatgctagattacctaaaggagaaaaaggatgctgggttctttcaaagcctttctggt cttatgcagtgttgcagtgtccttgatttgaatgcatttgagaggcagaataaagctgaa ggcctggggatggttactgaggaaggaacactcattgttcgtgagcgtggtgaaaaagta ctccagaatgacgagtttacacgagatctctttagattcctacagttactttgtgaagga cataacagtgatttccagaacttcctgcggactcagatgggcaacaccaccaccgtgaat gtcatcatcagtaccgtggactacctcctgcgtctgcaggaatcaatcagtgacttctac tggtattattcagggaaggacgtcattgatgaatctggaaagcacaatttttccaaagcc ctggcggtcaccaagcagattttcaattctcttacagaatacatccagggcccctgcatt gggaaccagcagagcctcgcgcacagtaggctatgggatgcagtggtcggcttcctccat gtatttgctaacatgcagatgaaactctctcaggattccagtcagatcgagctgctgaag gaactcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaat gtggtaaatggaactattggcaagcagatggttgacacactggtagagtcctctaccaat gtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagacttaaccagctca gacaccttcaaagaatatgaccccgatgggaaaggggtcatctccaaaaaggaattccag aaggccatggaagggcaaaaacagtacacgcagtcagagattgactttctcctttcgtgc gcagaagcggatgagaatgacatgtttaattacgttgactttgtagaccggttccacgag ccggccaaggacatagggtttaacgtggcggtgttattgacaaacctctccgaacatatg ccaaatgattctcgccttaagtgtctgttggacccagcggaaagcgtcctcacttacttt gaaccgtacctaggacgcattgagatcatgggagaggccaagaaaattgagcgcgtttat tttgagatcagtgagtccagtcgaactcagtgggagaagccccaggtgaaggagtctaag cggcagttcatctttgatgtcgtcaacgaaggcggagagcaagagaagatggagctgttc gtgaacttctgtgaagacaccatctttgagatgcagttagcgtcacagatctcagaatcg gactcagccgacaggccagaagaggaggaggaagaaaatgaagactcttcctatatgtta gaagttgagggtgaagaggaggacgacaagtcttttgagtgtgcctctgcgtttgccatg gcctgtgcctcagtgaagagaaacgtggccaactttctgaagagggccaccctgaagaac ctcaagaagcagtgtaggaaggtaaagaagatgactctgaaggagctggtgaaggtgttc ttctctttcttctggacgttgttcgtggggctcttccacttgctcttcgccatattggga ggaatctttcagattctctggagcacagtgtttggagggggcctcatagaaggcgcaaag aacatcagagtcacaaagatcctgggtgacatgcctgacccaacccaatttggtatccac gatgatgcgatggaggctgagagggcagaagtgcccgagccaggtatcgccacggaactc gtgcacttcgtaaagggggagaggggagatgcggagattatgtcagatctctttggactc cagtcaaagaaagaaggtggcttaaagcatgggcctgaagtgggtttgggtgacctctct gagattattggcaaggatgagccccccacgttagagagtactgtacgggagaaaaggaaa gcacaggcagcagagacgaaagcagctcatgaagcagaaggaaaagtggagtctgagaag gcagacatggaagatggggagaaagagaacacagccaaagaagaagagcaggccgaggct gggtgggcagacgtgaccaaaaggaagaagcgatggtgtggccagaaaattgagaagcct gaagccttcatggccagtttctttaaagggctggaaatctatcagaccaagttgctgcac tacctggccaggaatttctacaacctgaggttccttgctctgtttgtagccttcgctatc aacttcatcctgctcttttacaaggtcaccgaagaacctttagaagaagagacagaagac attgcaaacctgtggaattcctttaatgatgaggaagaggaagaagcagtggtgttcttt gtcctgcaggagagcactggatacatggcgccaacattgcgagccctggccatcatccac accatcatttctttagtctgcgtggtgggctattactgcctgaaggttcctttggtggta ttcaaaagagaaaaagaaattgccaggaagctggagtttgatggcctgtatatcaccgaa cagccttctgaagatgacatcaaggggcaatgggatcgcttggtaatcaacacaccatct tttcctaataactactgggacaagtttgtaaagagaaaggtgatcaacaagtatggagat ctctacggagcagaacgcattgctgaactcctggggttggacaaaaatgccctcgacttt agccccgtagaagagaccaaagcagaggcagcctccctggtgtcatggctaagttccatc gacatgaagtaccatatctggaagctgggagttgtttttactgacaattcctttctctac ctcgcctggtacacgaccatgtcagtcctgggccactacaacaacttcttcttcgctgct catctgctggatatcgcgatgggcttcaagactctgaggactattctgtcatctgtcact cacaatggcaaacagttggtcctgactgtcggtctcctggccgtggtggtttacctctat accgtggtggcgttcaacttcttccgcaagttctacaacaaaagtgaagacgacgatgag cccgacatgaagtgtgatgacatgatgacgtgttacctgttccacatgtacgtgggagtg agagctggaggtggcattggcgatgaaattgaagaccccgctggggacccgtacgaaatg taccgcatcgtctttgacattacattcttcttcttcgtcattgtcatcctgctggccatc atccaaggtcttattattgatgcttttggggagctgagagaccagcaggaacaagtacga gaggatatggagaccaaatgtttcatctgtgggatcggcaatgactactttgacacaacc cctcatggttttgaaacacacaccttacaagagcacaacttagccaactacttgttcttc ctgatgtatttgattaataaagatgaaacagagcacacaggtcaggaatcttatgtctgg aagatgtaccaagaaaggtgttgggatttcttccctgctggtgactgcttccggaaacag tacgaagatcagcttggataa

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