KEGG   PATHWAY: bpt00020
bpt00020                    Pathway                                
Citrate cycle (TCA cycle) - Bordetella petrii
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Metabolism; Carbohydrate metabolism
Pathway map
bpt00020  Citrate cycle (TCA cycle)

bpt_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:bpt00020]
bpt_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:bpt00020]
bpt_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:bpt00020]
bpt_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:bpt00020]
bpt_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:bpt00020]
Other DBs
GO: 0006099
Bordetella petrii [GN:bpt]
Bpet3784  putative Citrate synthase [KO:K01647] [EC:]
Bpet2878  putative Citrate synthase [KO:K01647] [EC:]
Bpet1284  putative Citrate synthase [KO:K01647] [EC:]
Bpet1825  gltA; gltA [KO:K01647] [EC:]
Bpet3365  acnA2; putative aconitate hydratase [KO:K01681] [EC:]
Bpet3354  acnB; Aconitate hydratase 2 [KO:K01682] [EC:]
Bpet1567  icd; Isocitrate dehydrogenase [KO:K00031] [EC:]
Bpet1832  odhA; 2-oxoglutarate dehydrogenase E1 component [KO:K00164] [EC:]
Bpet1833  odhB; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex [KO:K00658] [EC:]
Bpet2538  pdhD; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:]
Bpet3508  probable dihydrolipoamide dehydrogenase [KO:K00382] [EC:]
Bpet1834  odhL; 2-oxoglutarate dehydrogenase complex, E3 component [KO:K00382] [EC:]
Bpet3017  probable dihydrolipoamide dehydrogenase [KO:K00382] [EC:]
Bpet1515  probable dihydrolipoamide dehydrogenase [KO:K00382] [EC:]
Bpet2062  sucD; Succinyl-CoA synthase, alpha subunit [KO:K01902] [EC:]
Bpet2061  sucC; Succinyl-CoA synthetase, beta chain [KO:K01903] [EC:]
Bpet1822  sdhA; Succinate dehydrogenase flavoprotein subunit [KO:K00239] [EC:]
Bpet1823  sdhB; Succinate dehydrogenase iron-sulfur protein [KO:K00240] [EC:]
Bpet1820  sdhC; Succinate dehydrogenase cytochrome b-556 subunit, transmembrane component [KO:K00241]
Bpet1821  sdhD; Succinate dehydrogenase hydrophobic membrane anchor protein [KO:K00242]
Bpet0404  putative succinate dehydrogenase flavoprotein subunit [KO:K00244] [EC:]
Bpet0399  frdB; fumarate reductase iron-sulfur protein [KO:K00245] [EC:]
Bpet0400  hypothetical protein predicted by Glimmer/Critica [KO:K00246]
Bpet0401  sdhC; succinate dehydrogenase cytochrome b-556 subunit [KO:K00247]
Bpet3813  fumC; fumarate hydratase, class I [KO:K01676] [EC:]
Bpet0784  fumA; Fumarate hydratase class I anaerobic [KO:K01676] [EC:]
Bpet0832  fumC; fumarate hydratase class II [KO:K01679] [EC:]
Bpet1818  mdh1; Malate dehydrogenase [KO:K00024] [EC:]
Bpet2915  pckA; Phosphoenolpyruvate carboxykinase [KO:K01596] [EC:]
Bpet1829  aceE1; Pyruvate dehydrogenase E1 component [KO:K00163] [EC:]
Bpet3019  aceE2; Pyruvate dehydrogenase E1 component [KO:K00163] [EC:]
Bpet3018  aceF; Dihydrolipoamide acetyltranferase [KO:K00627] [EC:]
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Nishizuka Y (ed).
[Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1980)
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
[Cellular Functions and Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1997)
Michal G.
Biochemical Pathways
Wiley (1999)
bpt00010  Glycolysis / Gluconeogenesis
bpt00053  Ascorbate and aldarate metabolism
bpt00061  Fatty acid biosynthesis
bpt00071  Fatty acid degradation
bpt00190  Oxidative phosphorylation
bpt00220  Arginine biosynthesis
bpt00250  Alanine, aspartate and glutamate metabolism
bpt00280  Valine, leucine and isoleucine degradation
bpt00350  Tyrosine metabolism
bpt00470  D-Amino acid metabolism
bpt00630  Glyoxylate and dicarboxylate metabolism
KO pathway

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